Catalyst simulations for fuel cells may make clean cars a reality

Washington, Sep 18 (ANI): University of Wisconsin-Madison researchers are working towards developing better catalyst for fuel cells in a bid to make clean cars a reality.

If successful, the researchers could make a car that runs on hydrogen from solar power, and produces water instead of carbon emissions.

Materials science and engineering assistant professor Dane Morgan and Ph.D. student Edward (Ted) Holby have developed a computational model that could optimise an important component of fuel cells, making it possible for the technology to have a more widespread use.

The researchers investigated how particle size is related to the overall stability of a material, and showed with their model that increasing the particle size of a fuel cell catalyst decreases degradation and therefore increases the useful lifetime of a fuel cell.

Fuel cells are electrochemical devices that facilitate a reaction between hydrogen and oxygen, producing electrical power and forming water.

In the type of fuel cells Morgan is researching, called proton exchange membrane fuel cells (PEMFCs), hydrogen is split into a proton and electron at one side of the fuel cell (the anode).

The proton moves through the device while the electron is forced to travel in an external circuit, where it can perform useful work, while at the other side of the fuel cell (the cathode), the protons, electrons and oxygen combine to form water, which is the only waste product.

One of the many hurdles to producing efficient fuel cells for widespread use is the catalyst added to aid the reaction between protons, electrons and oxygen at the cathode.

Current fuel cells use platinum and platinum alloys as a catalyst. While platinum can withstand the corrosive fuel cell environment, it is expensive and not very abundant.

Thus, to maximize platinum use, researchers use catalysts made with platinum particles as small as two nanometers, which are approximately 10 atoms across.

These tiny structures have a large surface area on which the fuel cell reaction occurs.

However, platinum catalysts this small degrade very quickly, which means that the fuel cell doesn’t last long.

The researchers have found a possible solution to the rapid degradation problem-when it comes to catalyst particle size, sometimes smaller isn’t better.

In their modelling work, they showed that if the particle size of a platinum catalyst is increased to four or five nanometers, which is approximately 20 atoms across, the level of degradation significantly decreases.

This means the catalyst and the fuel cell as a whole can continue to function for much longer than if the particle size was only two or three nanometers.

“Fuel cells are just one of many energy technologies – solar, battery, etc. – with enormous potential to reduce our dependence on oil and our carbon emissions. Computer simulation offers a powerful tool to understand and develop new materials at the heart of these energy technologies,” said Morgan. (ANI)

‘Buy one, get one free boob implant’ billboard in Wisconsin raises stink!

Washington, Sept 4 (ANI): A Wisconsin cosmetic surgeon is raising eyebrows – thanks to the expert’s buy one, get one free breast implant offer!

A large billboard along Highway 41 has been erected by Hotchandani Laser and Vein Center in Appleton promoting the “unique” offer.

“In today’s economy we’re trying to come up with creative ads that’ll get people in the door,” Christine Martens, who works for Jones Sign and came up with the billboard for Hotchandani Laser and Vein Center, said.

Jones Sign says it has done its job by attracting clients.

“He’s already paid for the ad,” Martens said.

The owner of the cosmetic center, Dr. Gope Hotchandani, said: “This is a little different.

“It took me by surprise. We want to make sure we have a positive impression of what we’re doing. Kind of catchy, but borderline.”

However, a few in downtown Appleton are not too happy with it, reports Fox News.

“Very definitely too much, if it’s going to be on a billboard where teenagers see it,” Linda Naden said.

“I don’t have a problem with it,” Jim Wingrove said. “They advertise everything else.” (ANI)

Scientists identify ‘tipping points’ at which sudden shifts to new conditions occur

Washington, September 3 (ANI): In a new research, scientists have identified ‘tipping points’ at which sudden shifts to new conditions occur in the world.

The research was done by Martin Scheffer of Wageningen University in The Netherlands and co-authors, including William Brock and Stephen Carpenter of the University of Wisconsin at Madison and George Sugihara of the Scripps Institution of Oceanography in La Jolla, California.

They found that abrupt changes in ocean circulation and Earth’s climate, shifts in wildlife populations and ecosystems, the global finance market and its system-wide crashes, and asthma attacks and epileptic seizures share generic early-warning signals that indicate a critical threshold of change dead ahead.

The team found that similar symptoms occur in many systems as they approach a critical state of transition.

“It’s increasingly clear that many complex systems have critical thresholds – ‘tipping points’ – at which these systems shift abruptly from one state to another,” according to the scientists.

Especially relevant, they discovered, is that “catastrophic bifurcations,” a diverging of the ways, propel a system toward a new state once a certain threshold is exceeded.

A system follows a trail for so long, then often comes to a switchpoint at which it will strike out in a completely new direction.

That system may be as tiny as the alveoli in human lungs or as large as global climate.

“These are compelling insights into the transitions in human and natural systems,” said Henry Gholz, program director in the National Science Foundation (NSF)’s Division of Environmental Biology, which supported the research along with NSF’s Division of Ocean Sciences.

“The information comes at a critical time – a time when Earth’s and, our fragility, have been highlighted by global financial collapses, debates over health care reform, and concern about rapid change in climate and ecological systems,” he added.

It all comes down to what scientists call “squealing,” or “variance amplification near critical points,” when a system moves back and forth between two states.

“A system may shift permanently to an altered state if an underlying slow change in conditions persists, moving it to a new situation,” said Carpenter.

According to scientists, “In systems in which we can observe transitions repeatedly, such as lakes, ranges or fields, and such as human physiology, we may discover where the thresholds are.”

“If we have reason to suspect the possibility of a critical transition, early-warning signals may be a significant step forward in judging whether the probability of an event is increasing,” they added. (ANI)

Monkeys ‘groove to Metallica’s heavy metal music’

Washington, Sept 2 (ANI): Monkeys prefer silence to Mozart, but they are big fans of heavy metal music, in particular Metallica, a new study has found.

Music is a sure-shot way to influence human emotions. However, nonhuman primates scarcely respond to human music, and instead prefer silence.

Now, a new report by Charles Snowdon, a professor of psychology at the University of Wisconsin-Madison, and musician David Teie of the University of Maryland has shown that a monkey called the cotton-top tamarin indeed responds to music.

And the catch here is: the South American monkeys are essentially immune to human music, but they respond appropriately to “monkey music,” 30-second clips composed by Teie on the basis of actual monkey calls.

In the study, the music was inspired by sounds the tamarins make to convey two opposite emotions: threats and/or fear, and affiliation, a friendly, safe and happy condition.

The group of cottontop tamarins were played a variety of music, including Bach, Led Zeppelin and Miles Davis, but they only reacted when heavy metal rock songs by Metallica were played.

The study, published this week (Sept. 1) in the journal Biology Letters, reported that the monkeys could tell the difference: For five minutes after hearing fear music, the monkeys displayed more symptoms of anxiety and increased their movement. In contrast, monkeys that heard “affiliative” music reduced their movements and increased their feeding behavior, both signs of a calming effect.

Monkeys interpret rising and falling tones differently than humans. Oddly, their only response to several samples of human music was a calming response to the heavy-metal band Metallica.

Non-human primates don’t seem to appreciate human music, Snowdon said, although research has suggested they prefer Mozart to rock music and silence to Mozart.

The study opens a new window into animal communication, Snowdon said.

“People have looked at animal communication in terms of conveying information – ‘I am hungry,’ or ‘I am afraid.’ But it’s much more than that. These musical elements are inducing a relatively long-term change in behavior of listeners. The affiliative music is making them calmer; they move less, eat and drink at a higher rate, and show less anxiety behavior,” the expert said. (ANI)

Synthetic protein-like molecule may protect against HIV infection

Washington, Aug 18 (ANI): Researchers have used the human immunodeficiency virus (HIV) and molecular engineering to design synthetic protein-like molecule, which may be able to put a stop to unwanted biological interactions between the cells.

The pioneering study may protect cells against HIV infection.

In a bid to control protein shape, Samuel Gellman, a chemistry professor and his University of Wisconsin-Madison research team, created a set of peptide-like molecules that were successful in blocking HIV infection of human cells in the laboratory.

Adjusting molecular blueprints, Gellman and his colleagues made small structural changes to the backbones of their synthetic molecules to improve stability while retaining the three-dimensional shape necessary to recognize and interact with the HIV gp41 protein.

The resulting molecules, named “foldamers”, are hybrids of natural and unnatural amino acid building blocks, a combination that allows the scientists to control shape, structure and stability with much greater precision than is currently possible with natural amino acids.

The team found that the interaction of synthetic molecules with a piece of HIV protein gp41 physically obstructs the virus from infecting host cells.

The findings have appeared online in the August 17 issue of the Proceedings of the National Academy of Sciences.

Interactions between proteins are not only fundamental to many biological processes, but also to infections like HIV and tumours.

“There’s a lot of information transfer that occurs when proteins come together, and one would often like to block that information flow,” said Gellman.

These synthetic molecules not only interrupt protein-protein interaction, but are also highly resistant to degradation by naturally occurring enzymes, which do not recognize their unusual structure. This means even a low dose of these molecules can remain effective for a longer time.

“We want to find an alternate language, an alternate way to express the information that the proteins express so that we can interfere with a conversation that one protein is having with another,” Gellman explains.

Gellman said the results of their study show that this type of approach could be very useful in designing molecules for antiviral therapies and other biomedical applications.

He said: “You don’t have to limit yourself to the building blocks that nature uses,” Gellman says.

“There’s a huge potential here because the strategy we use is different from what the pharmaceutical and biotech industries now employ.” (ANI)

Swine flu virus more dangerous than previously believed

London, July 14 (ANI): In a new, highly detailed study of swine flu virus, H1N1, researchers have found that the pathogen is more virulent than previously believed.

Led by University of Wisconsin-Madison virologist Yoshihiro Kawaoka, the study has found that the H1N1 virus exhibits an ability to infect cells deep in the lungs, where it can cause pneumonia and, in severe cases, death.

Seasonal viruses typically infect only cells in the upper respiratory system.

“There is a misunderstanding about this virus. People think this pathogen may be similar to seasonal influenza. This study shows that is not the case. There is clear evidence the virus is different than seasonal influenza,” Nature magazine quoted Kawaoka as saying.

He says that the ability to infect the lungs is a quality frighteningly similar to those of other pandemic viruses, notably the 1918 virus, which killed tens of millions of people at the tail end of World War I.

The study has also found another similarity to the 1918 virus-people born before 1918 harbour antibodies that protect against the new H1N1 virus.

Kawaoka reveals that the virus could become even more pathogenic as the current pandemic runs its course, and the virus evolves to acquire new features.

It is now flu season in the world’s southern hemisphere, and the virus is expected to return in force to the northern hemisphere during the fall and winter flu season.

For the study, the researchers infected different groups of mice, ferrets and non-human primates with the pandemic virus and a seasonal flu virus.

They found that the H1N1 virus replicates much more efficiently in the respiratory system than seasonal flu, and causes severe lesions in the lungs similar to those caused by other more virulent types of pandemic flu.

“When we conducted the experiments in ferrets and monkeys, the seasonal virus did not replicate in the lungs. The H1N1 virus replicates significantly better in the lungs,” said Kawaoka.

The study also assessed the immune response of different groups to the new virus, and, surprisingly, found that people exposed to the 1918 virus, all of whom are now in advanced old age, have antibodies that neutralize the H1N1 virus.

The study also indicated that existing and experimental antiviral drugs could form an effective first line of defence against the virus and slow its spread. (ANI)

Novel MRI technique can lead to less breast biopsies in high-risk women

Washington, June 30 (ANI): Researchers from University of Wisconsin-Madison have suggested a new method, that when applied with MRI scans of the breast, can help rid women with increased breast cancer risk of the pain and stress of having to endure a biopsy of the lump or lesion.

It is recommended that women with certain breast cancer risk factors – including inherited genetic mutations, family or personal history of breast cancer, or previous radiation therapy to the chest should receive an annual MRI screening in addition to their yearly mammogram.

During a breast MRI, which lasts about a half hour, the technician injects a contrast agent into a vein in the patient’s arm.

The contrast agent flows throughout the body, including the breasts.

Because they are growing quickly, cancerous lesions often have immature vasculature, and the contrast agent flows in and “leaks” out quickly. Conversely, benign lesions show more gradual in and out flow.

“The tricky ones are the ones that enhance quickly and then fall off more slowly,” said Wally Block, a UW-Madison associate professor of biomedical engineering and medical physics.

“Many of these lesions turn out to be difficult to classify and lead to biopsy,” Block added.

The researchers suggest that right kind of MRI scan can help identify a cancerous lesion based on characteristics about its shape.

For instance, breaks or interruptions in a lesion can indicate a benign fibroadenoma. Lumps with smooth edges often are benign, while those with jagged edges can signal cancer.

With the new technique, an MRI machine acquires data radially and generates a high-resolution, three-dimensional image that radiologists can turn, slice and view from many perspectives – enabling them to study a lesion’s physical characteristics more carefully.

Machines equipped with the technique also acquire more data in less time. (ANI)

Global demand for food, fiber and fuel may outstrip supply in next 40 years

Washington, June 26 (ANI): A new report has determined that with the caloric needs of the planet expected to soar by 50 percent in the next 40 years, planning and investment in global agriculture will become critically important.

The report was produced by Deutsche Bank, in collaboration with the University of Wisconsin-Madison’s Nelson Institute for Environmental Studies.

It provides a framework for investing in sustainable agriculture against a backdrop of massive population growth and escalating demands for food, fiber and fuel.

“We are at a crossroads in terms of our investments in agriculture and what we will need to do to feed the world population by 2050,” said David Zaks, a co-author of the report and a researcher at the Nelson Institute’s Center for Sustainability and the Global Environment.

By 2050, world population is expected to exceed 9 billion people, up from 6.5 billion today.

Already, according to the report, a gap is emerging between agricultural production and demand, and the disconnect is expected to be amplified by climate change, increasing demand for biofuels, and a growing scarcity of water.

“There will come a point in time when we will have difficulties feeding world population,” said Zaks, a graduate student whose research focuses on the patterns, trends and processes of global agriculture.

“The solution is only going to come about by changing the way we use land, changing the things that we grow and changing the way that we grow them,” he added.

The report notes that agricultural research and technological development in the US and Europe have increased notably in the last decade, but those advances have not translated into increased production on a global scale.

Subsistence farmers in developing nations, in particular, have benefited little from such developments and investments in those agricultural sectors have been marginal, at best.

The Deutsche Bank report, however, identifies a number of strategies to increase global agricultural productions in sustainable ways, including improvements in irrigation, fertilization and agricultural equipment using technologies ranging from geographic information systems and global analytical maps to the development of precision, high performance equipment.

It also stresses on applying sophisticated management and technologies on a global scale, essentially extending research and investment into developing regions of the world.

The report says that investing in “farmer competence” is important to take full advantage of new technologies through education and extension services, including investing private capital in better training farmers.

“First we have to improve yield,” noted Zaks. “Next, we have to bring in more land in agriculture while considering the environmental implications, and then we have to look at technology,” he added. (ANI)

Land management practices in agricultural watersheds can affect carbon losses

Washington, June 20 (ANI): In a new study, scientists have determined that specific land management practices in agricultural watersheds, such as manure application, can affect carbon losses.

Dissolved organic carbon (DOC) losses from tile drains are an underquantified portion of the terrestrial carbon cycle.

This is particularly important in the eastern corn belt where tile drainage dominates the agricultural landscape.

Specific land management practices, such as manure application, can play a large role in the export of DOC as soluble organic carbon is applied to or injected into the soil surface.

As animal agriculture intensifies in the upper Midwest, measuring DOC exported through tile drains is important when evaluating carbon budgets and carbon sequestration potential.

Scientists at Purdue University have investigated the impacts of manure application, crop rotation, and nitrogen application rate on DOC losses from tile drains.

Research was conducted over a six-year span (1998-2004) at Purdue University’s Water Quality Field Station, which was designed specifically to measure drainflow and solute losses from agricultural practices.

Forty-eight drainage lysimeters were established at the field site in 1992.

Twelve field treatments included a restored prairie grass, continuous corn rotations and corn-soybean rotations fertilized at three nitrogen rates, and continuous corn rotations fertilized with lagooned swine effluent applied in the spring or fall of each year.

The study determined that annual losses of DOC were not affected by any crop management practice.

However, when drainage-inducing rainfall occurred with one month of manure application, the monthly DOC concentration of the manured plot was greater than that of non-manured plots.

Overall, drainage hydrology was determined to be the largest sole driver of DOC loss.

Greater daily drainflows were associated with higher DOC concentrations compared to lower daily drainflows.

This indicates that larger storms effectively “flush” DOC from the soil systems.

According to Dr. Matt Ruark, now an Assistant Professor at the University of Wisconsin-Madison, “Understanding the concentrations and amounts of DOC contributed to surface waters from tile drains is essential for evaluating the overall aquatic ecology of a watershed.

“This is of particular importance in the eastern corn belt, where up to 80 percent of the land in agricultural watersheds are tile drained,” he added.

Further research is required to evaluate the fate of tile drainage-exported DOC once it enters the surface water system.

The effect of manure management on the availability of DOC leached into subsurface soil is currently being investigated. (ANI)

Now, a GPS-enabled inhaler to pinpoint areas that trigger asthmatic attacks

Melbourne, Apr 13 (ANI): In a breakthrough study, scientists from University of Wisconsin-Madison have developed a GPS-enabled inhaler that can help pinpoint the areas that trigger asthmatic attacks.

“Asthma is unique in that people carry their inhalers around with them and use them at the time and place when they are having symptoms,” ABC Online quoted lead researcher David Van Sickle as saying.

To test the efficacy of the GPS device, he and his colleagues have recruited four asthmatic undergraduates.

The subjects will carry around inhalers equipped to relay location data when they were being used.

“At one time, I was worried that lugging this inhaler around would cause people to have asthma attacks. It looked like a washing machine tied on to an inhaler,” said Van Sickle.

“The device is now about the size of a nine-volt battery, and the weight is insignificant.

“We had this one guy who was using his inhaler every day at work, and he was fine the rest of the time. He had never put it together that he had workplace-related asthma. It’s funny what people miss when they’re so close to stuff,” he added.

Van Sickle has received funding for a pilot program now under way in the city of Madison. (ANI)

Medical researchers face conflicts of interest

By Julie Steenhuysen

CHICAGO (Reuters) – Dr. Bruce Psaty of University of Washington in Seattle knows how easy it can be to fall under the spell of a friendly relationship with drug companies.

As an assistant professor, he published an article on using beta-blockers to treat high blood pressure that caught the attention of the pharmaceutical industry.

“My family and I were invited to a first-class resort, where I presented the results at a sponsored conference,” Psaty wrote in a commentary this week in the Journal of the American Medical Association.

He agreed to help develop a set of slides on beta-blockers and soon found himself suggesting that the drug company’s studies be featured, in part because he felt “a kind of social duty to reciprocate both the kindness and the investment made by the sponsor in the slide set.”

Psaty said his own story illustrates the subtleties of conflicts of interest. He is dissatisfied with the current debate among doctors, spurred by reports last year by Iowa Republican Senator Charles Grassley that a prominent Harvard psychiatrist failed to fully disclose hefty payments from drug companies.

“The debate has not been terribly fruitful,” Psaty said in a telephone interview. He said conflicts are sometimes hard to recognize, pointing to the work of Dan Ariely, a behavioral economist at Duke University in North Carolina.

Ariely’s research suggests that most people are comfortable with just a little bit of cheating, without considering themselves dishonest. He says subtle conflicts of interest often color decision making, yet most people — especially doctors — think they are immune.

HUMAN INSTINCT

“It’s human instinct,” Ariely said in a telephone interview. “If someone does something nice — gives you $5 million in a research grant — don’t you want to do something nice back to them?”

Ariely said return favors could come in the form of excluding a sicker patient from a clinical trial, which might affect the study results. “Not on purpose, but I’m trying to help my friends, just a little bit.”

Several states including Massachusetts, Minnesota and Vermont are tightening restrictions on gifts to doctors in the hopes of preventing such conflicts.

And a bill introduced by Senators Grassley and Wisconsin Democrat Herb Kohl would compel doctors to disclose their financial ties with drug companies or face stiff fines.

Psaty said such laws may curb some financial conflicts, but a bigger challenge will be addressing the influence drugmakers have over company-funded research supporting the safety and effectiveness of the drugs they make.

Psaty said he accepts no funding from drug companies for his research, but short of having all clinical trials funded with public money, he suggests doctors look for red flags in studies that might indicate bias.

“Was the question a good question? Did they set the study up right? Did they use the weakest possible comparator to make a drug look good in a trial?” he said.

And when a medical journal editorial disagrees with the primary interpretation of the author, “that is a potential marker of a study where there may been some bias from conflict of interest,” he said.

(Editing by Maggie Fox and Sandra Maler)

Astronauts need more intense workouts to maintain muscle fitness in space

Washington, April 3 (ANI): A new study has suggested that astronauts need to modify their workouts to avoid extensive muscle loss during missions onboard the International Space Station (ISS).

The research, sponsored by NASA, was conducted at Ball State University’s Human Performance Laboratory (HPL), US.

It suggests that changes are needed to optimize the inflight exercise regimen for astronauts to improve their muscle performance while in space for extended stays.

Average stays on the ISS run about six months, and preservation of crewmember health in zero-gravity environments is paramount for safety and mission success.

Since exercise is the primary course of action to protect the cardiovascular system, bone, and skeletal muscles, astronauts need to find the optimal exercises to stay fit.

The findings of the Ball State study were based in part on muscle biopsies taken from the astronauts, the first time this procedure has been allowed on crewmembers who have completed long-flight missions, according to Scott Trappe, HPL director.

Working with NASA, Marquette University’s biological sciences department, Wyle Integrated Science and Engineering Group in Houston, and the Medical College of Wisconsin, Trappe found that even while the crewmembers exercised, they still lost an average of 15 percent muscle mass and 20 to 30 percent loss of muscle performance.

“By clinical standards, this is a massive loss. This approaches what we see in aging populations in comparisons of a 20-year-old versus an 80-year-old,” Trappe said.

“This poses risks to the crewmembers and could have a dramatic impact on locomotion and overall health, which would impact a variety of crewmembers’ activities including future goals of planetary exploration,” he added.

Trappe and the HPL team have also been conducting NASA-funded, ground-based bed rest studies of long duration – between 60 and 90 days – parallel to their ISS research.

According to Trappe, “From our bed rest studies, we found that when high-intensity resistance and aerobic exercise are balanced correctly, this is an effective prescription that is quite therapeutic in protecting skeletal muscles in a simulated microgravity environment.”

“The next step is to apply what we have learned from the ISS experience and implement the next generation of exercise prescription programs into the space environment,” he added. (ANI)

Ants that carry anti fungal bacteria could be key to advances in biofuels and antibiotics

London, March 30 (ANI): In a new research, scientists have found that leaf-cutting ants that carry colonies of anti fungal bacteria on their bodies, contain a chemical which could help speed the quest to develop better antibiotics and biofuels.

In a mutually beneficial symbiosis, leaf-cutting ants cultivate fungus gardens, providing both a safe home for the fungi and a food source for the ants.

But, according to a report in Nature News, this 50-million-year-old relationship also includes microbes that new research shows could help speed the quest to develop better antibiotics and biofuels.

Cameron Currie, a microbial ecologist then at the University of Toronto in Ontario, Canada, discovered ten years ago that leaf-cutting ants carry colonies of actinomycete bacteria on their bodies.

Now, Currie, Jon Clardy at the Harvard Medical School in Boston and their colleagues reported that they had isolated and purified one of these antifungals, which they named dentigerumycin, and that it is a chemical that has never been previously reported.

The antifungal slowed the growth of a drug-resistant strain of the fungus Candida albicans, which causes yeast infections in people.

Because distinct ant species cultivate different fungal crops, which in turn fall prey to specialized parasites, researchers hope that they will learn how to make better antibiotics by studying how the bacteria have adapted to fight the parasite in an ancient evolutionary arms race.

“These ants are walking pharmaceutical factories,” said Currie, now at the University of Wisconsin, Madison.

According to John Taylor, a mycologist at the University of California, Berkeley, Currie’s continued scrutiny of the lives of ants provides insights into the web of interactions necessary for the survival of any single species.

“I think the coolest thing about this is that you start with one organism, and then you find more and more organisms involved in the relationship,” he said. (ANI)

We all have optimum running speeds at which we can cover great distances with least efforts

Washington, March 20 (ANI): The efficiency of human running varies with speed, and each individual has an optimal pace at which he or she can cover the greatest distance with the least effort, according to a study.

Karen Steudel, a zoology professor at the University of Wisconsin-Madison, says that the finding debunks the long-standing view that the energy needed to run a given distance is the same whether sprinting or jogging.

Though sprinting feels more demanding in the short term, the longer time and continued exertion required to cover a set distance at a slower pace are thought to balance out the difference in metabolic cost.

However, working in collaboration with Cara Wall-Scheffler of Seattle Pacific University, Steudel has found that the energetic demands of running change at different speeds.

“What that means is that there is an optimal speed that will get you there the cheapest,” Steudel says.

The researchers revealed that they determined peak efficiency by measuring runners’ metabolic rates at a range of speeds enforced by a motorized treadmill.

According to them, metabolic energy costs increased at both fast and slow speeds, and revealed an intermediate pace of maximal efficiency.

They say that the most efficient running speed determined in the study varied between individuals, but averaged about 8.3 miles per hour for males and 6.5 miles per hour for females in a group of nine experienced amateur runners.

Steudel believes that much of the gender difference might be due to variations in body size and leg length, which have been shown to affect running mechanics.

She says that the larger and taller runners generally had faster optimum speeds.

Steudel has also revealed that the slowest speeds – around 4.5 miles per hour, or about a 13-minute mile – were the least metabolically efficient, which she attributes to the gait transition between walking and running.

She points out that both a very fast walk and a very slow run can feel physically awkward.

The mechanics of running, which holds great interest for athletes and trainers, may also hold clues to the evolution of the modern human body form: tall and long-limbed with broad chests and defined waists.

Steudel says that modern humans are very efficient walkers and fairly good runners, and efficient locomotion probably provided our ancestors with an advantage for hunting and gathering food.

She further states that distant ancestral forms, the australopithecines, had shorter, boxier frames with stubbier legs.

“They wouldn’t have had noticeable waists – their torso looked more like the torso of an ape, except they were walking on two legs. With the genus Homo, you start getting taller individuals, larger individuals, and they started developing a more linear body form” with distinct waists that pivot easily, allowing longer and more efficient strides,” she says.

Given that human walking is also known to have an optimally efficient speed, Steudel thinks that the new findings may help determine the relative importance of the different gaits in driving human evolution.

“This is a piece in the question of whether walking or running was more important in the evolution of the body form of the genus Homo,” she says.

The study has been published online in the Journal of Human Evolution. (ANI)

Earth cyclones may help explain vortices on Venus

Washington, March 15 (ANI): An international team of scientists is studying cyclones on Earth to help them better understand ‘superrotating’ vortices on the planet Venus.

At cloud top level, the entire atmosphere of Venus circles the planet in just about four Earth days, much faster than the solid planet does.

Despite this “superrotation,” some dynamical and morphological similarities exist between the vortex organization in the atmospheres of Venus’s northern and southern hemispheres and tropical cyclones and hurricanes on Earth.

First detected by the Pioneer Venus Orbiter near the northern pole and recently by Venus Express orbiter around the southern pole, an S-shaped feature in the center of the vortices on Venus is also known to occur in Earth’s tropical cyclones.

Using an idealized nonlinear and nondivergent barotropic model, the research team have shown that these S-shaped features are the manifestations of barotropic instability.

They found that similar to the S-shapes seen in tropical cyclones, the S-shapes in Venus’s vortices are transient.

Given the challenges in measuring the deep circulation of Venus’s atmosphere, the authors expect that the morphological similarities between vortices on Earth and Venus might help scientists better understand atmospheric superrotation on Venus and guide future observations.

The team was from Space Science and Engineering Center, University of Wisconsin-Madison, US, ASF, INAF, Italy, and, Max Plank Institute for Solar System Research, Germany. (ANI)

Iran has understated its uranium capacities by a third, say IAEA inspectors

Washington, Feb.20 (ANI): Atomic inspectors have found that Iran recently understated by a third how much uranium it has enriched. The officials also declared for the first time that the amount of uranium that Tehran had now amassed – more than a ton – was sufficient, with added purification, to make an atom bomb.

In a report issued in Vienna, the International Atomic Energy Agency said it had discovered an additional 460 pounds of low-enriched uranium, a third more than Iran had previously disclosed.

The agency made the find during its annual physical inventory of nuclear materials at Iran’s sprawling desert enrichment plant at Natanz, the New York Times reports.

Independent nuclear weapons experts expressed surprise at the disclosure and criticized the atomic inspectors for making independent checks on Iran’s progress only once a year.

“It’s worse than we thought,” Gary Milhollin, director of the Wisconsin Project on Nuclear Arms Control, said in an interview.

“It’s alarming that the actual production was underreported by a third,” he added.

The political impact of the report, while hard to measure, could be significant for the Obama administration.

Obama has said that he wants to open direct talks with Iran about its nuclear program. But starting that process could take months, and the report suggests that Iran is moving ahead briskly with its uranium enrichment. United Nations official acknowledged that there were longstanding suspicions that Iran could have additional uranium enrichment sites that the inspectors had not seen or heard about.

“Everyone’s nervous and worried about the possibility of Iran pursuing a clandestine capability,” he said.

The disclosure of the unaccounted third came in the atomic agency’s quarterly report to its board, which was made public on Thursday.

The report noted that Iran had now produced a total of 1,010 kilograms – or 2,227 pounds – of low-enriched uranium.(ANI)

Deep-water drilling identifying strains and slips in major earthquake fault

Washington, Feb 16 (ANI): An international project is using cutting-edge deep-water drilling technology to identify strains and slips in the Nankai Trough, a major earthquake fault off the coast of Japan.

Known as the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE), it is the first geologic study of the underwater subduction zone faults that give rise to the massive earthquakes known to seismologists as mega-thrust earthquakes.

“The fundamental goal is to sample and monitor this major earthquake-generating zone in order to understand the basic mechanics of faulting, the basic physics and friction,” said Harold Tobin, University of Wisconsin-Madison geologist and co-chief scientist of the project.

Subduction zone faults extend miles below the seafloor and the active earthquake-producing regions – the seismogenic zones – are buried deep in the Earth’s crust.

The NanTroSEIZE project, an international collaboration overseen by the Integrated Ocean Drilling Program, is using cutting-edge deep-water drilling technology to reach these fault zones for the first time.

“If we want to understand the physics of how the faults really work, we have to go to those faults in the ocean,” Tobin explained.

“Scientific drilling is the main way we know anything at all about the geology of the two-thirds of the Earth that is submerged,” he added.

The decade-long project, to be completed in four stages, will use boreholes, rock samples, and long-term in situ monitoring of a fault in the Nankai Trough, an earthquake zone off the coast of Japan with a history of powerful temblors, to understand the basic fault properties that lead to earthquakes and tsunamis.

The project is currently is its second year.

During the first stage of the project, the team found evidence of extensive rock deformation and a highly concentrated slip zone even in shallow regions that do not generate earthquakes.

One rock core from a shallow part of the fault contains a narrow band of finely ground “rock flour” revealing a fault zone between the upper and lower plates that is only about two millimeters thick – roughly the thickness of a quarter.

Above deeper portions of the fault, the team discovered layers of displaced rock and evidence of prolonged seismic activity that suggest a region known as the megasplay fault is likely responsible for the largest tsunami-generating plate slips.

“A fundamental goal was to understand how the faults at depth connect up toward the Earth’s surface, and we feel that we’ve discovered the fault zone that’s the main culprit,” Tobin said.

The next stage of drilling will commence this May, with plans to drill additional boreholes into the plate above deep regions of the fault zone. (ANI)

New biomarker for fatal prostate cancer identified

Washington, Feb 14 (ANI): After reporting excess calcium as an indicator of prostate cancer, researchers at Wake Forest University School of Medicine and the University of Wisconsin have now identified an even more accurate biomarker of the life-threatening disease-high levels of ionised serum calcium.

The new finding can help provide some direction for men diagnosed with prostate cancer, about whether their cancer is likely to be fatal or not.

“Scientists have known for many years that most prostate cancers are slow-growing and that many men will die with, rather than of, their prostate cancer,” said Dr. Gary G. Schwartz, senior author of the study.

He added: “The problem is, how can we determine which cancers pose a significant threat to life and need aggressive treatment versus those that, if left alone, are unlikely to threaten the patient’s life? These findings may shed light on that problem.”

This is the first time that any study has examined fatal prostate cancer risk in relation to pre-diagnostic levels of ionised serum calcium.

The researchers found that men in the highest third of ionised serum calcium levels were three times more likely to die of prostate cancer than those with the least amount of ionised serum calcium.

Also, they confirmed a previous finding of a doubling of risk for fatal prostate cancer among men whose level of total serum calcium falls in the highest third of the total serum calcium distribution.

Ionised serum calcium is the biologically active part of total serum calcium. About 50 percent of total serum calcium is inactive, leaving only the ionised serum calcium to directly interact with cells.

Dr. Halcyon G. Skinner, of the University of Wisconsin, the study’s lead author, said that the findings had both scientific and practical implications.

Scientifically, it helps focus research on what it is about calcium that may promote prostate cancer.

And practically speaking, the finding may offer some guidance to men trying to decide whether or not to seek treatment for a recent prostate cancer diagnosis.

If confirmed, the findings could also lead to the general reduction of over-treatment of prostate cancer.

“These results do not imply that men need to quit drinking milk or avoid calcium in their diets,” Schwartz added.

The study appears in the journal Cancer Epidemiology, Biomarkers and Prevention. (ANI)

New biomarker for fatal prostate cancer identified

Washington, Feb 14 (ANI): After reporting excess calcium as an indicator of prostate cancer, researchers at Wake Forest University School of Medicine and the University of Wisconsin have now identified an even more accurate biomarker of the life-threatening disease-high levels of ionised serum calcium.

The new finding can help provide some direction for men diagnosed with prostate cancer, about whether their cancer is likely to be fatal or not.

“Scientists have known for many years that most prostate cancers are slow-growing and that many men will die with, rather than of, their prostate cancer,” said Dr. Gary G. Schwartz, senior author of the study.

He added: “The problem is, how can we determine which cancers pose a significant threat to life and need aggressive treatment versus those that, if left alone, are unlikely to threaten the patient’s life? These findings may shed light on that problem.”

This is the first time that any study has examined fatal prostate cancer risk in relation to pre-diagnostic levels of ionised serum calcium.

The researchers found that men in the highest third of ionised serum calcium levels were three times more likely to die of prostate cancer than those with the least amount of ionised serum calcium.

Also, they confirmed a previous finding of a doubling of risk for fatal prostate cancer among men whose level of total serum calcium falls in the highest third of the total serum calcium distribution.

Ionised serum calcium is the biologically active part of total serum calcium. About 50 percent of total serum calcium is inactive, leaving only the ionised serum calcium to directly interact with cells.

Dr. Halcyon G. Skinner, of the University of Wisconsin, the study’s lead author, said that the findings had both scientific and practical implications.

Scientifically, it helps focus research on what it is about calcium that may promote prostate cancer.

And practically speaking, the finding may offer some guidance to men trying to decide whether or not to seek treatment for a recent prostate cancer diagnosis.

If confirmed, the findings could also lead to the general reduction of over-treatment of prostate cancer.

“These results do not imply that men need to quit drinking milk or avoid calcium in their diets,” Schwartz added.

The study appears in the journal Cancer Epidemiology, Biomarkers and Prevention. (ANI)