Gulf ‘oil cloud’ triggers new dispersant concerns

(Reuters) – A large undersea cloud of dissolved hydrocarbons discovered last week near the Gulf of Mexico oil spill raises fresh questions about toxic chemicals used to fight the spill and their environmental impact.

Health

David Hollander, a University of South Florida oceanographer, headed a research team that discovered the six-mile (10-km) wide “oil cloud” while on a government-funded expedition aboard the Weatherbird II, a vessel operated by the university’s College of Marine Science.

“We were collecting samples down to two miles below the surface,” Hollander told Reuters in an interview on Friday.

“The plume or the cloud of dissolved hydrocarbons in the water was discovered northeast of the wellhead, about 35 kilometers (22 miles) to the northeast,” he said.

It was the second major deepwater plume discovered since the April 20 blowout at BP Plc’s Macondo well. Hollander said it was believed to stretch all the way from the wellhead to the site where it was first detected on Tuesday, in an area off the continental shelf south of Mobile, Alabama.

Hollander said scientists had yet to determine whether the dissolved hydrocarbons, found in oxygen-depleted waters, were the result of chemical dispersants used deep below the Gulf surface to break down oil from the leaking well.

But he said the contaminants — which could eventually be pushed onto the continental shelf before shifting slowly down toward the Florida Keys and possibly out to the open Atlantic Ocean — raised troubling questions about whether they would “cascade up the food web.”

The threat is that they will poison plankton and fish larvae before making their way into animals higher up the food chain, Hollander said.

INVISIBLE THREAT

The underwater contaminants are particularly “insidious” because they are invisible, Hollander said, adding that they were suspended in what looked like normal seawater.

“It may be due to the application of the dispersants that a portion of the petroleum has extracted itself away from the crude and is now incorporated into the waters with solvents and detergents,” he added.

“We think there could be both short-term and long-term implications … There’s a lot of unchartered territory that we’re moving into with this oil spill,” said Hollander.

He said dispersants, a cocktail of organic solvents and detergents, had never been used at the depth of BP’s well before, and no one really knows how they interact physically and chemically under pressure with oil, water and gases.

“On the surface they’re very readily or actively used and their behavior is well understood. That’s not the case at all with their use in the subsurface and especially at a mile deep,” Hollander said.

“A very-large-scale experiment is being conducted and we don’t know the implications of it,” he added.

Hollander said the amount of suspected dispersants in the cloud of hydrocarbons was likely to be known after about two weeks of further testing.

The U.S. National Oceanic and Atmospheric Administration funded the mission aboard the Weatherbird II along with the Florida Fish and Wildlife Service, Hollander said.

He said NOAA had dispatched a vessel on Thursday to probe the same subsurface plume discovered by his team.

In a statement issued on Monday, the U.S. Environmental Protection Agency said the underwater use of dispersants appeared to have been effective so far in breaking up oil from the BP spill and did not seem to have had any significant impact on aquatic life.

“EPA and the U.S. Coast Guard are taking steps that could reduce the volume of dispersants applied in the Gulf. While we do know dispersants are less toxic and shorter-lived than the oil, much remains unknown about their impact on the environment when used in these unprecedented volumes,” the statement said.

Roughly 850,000 gallons (3.2 million liters) of dispersant had been used to combat the Gulf spill as of Thursday, including 150,000 gallons (570,000 liters) released below sea level.

Antibiotic regimen found effective for Chlamydia-induced reactive arthritis

Washington, Apr 29 (ANI): A combination of antibiotics has been found to be an effective treatment for Chlamydia-induced reactive arthritis, a major step forward in the management, and possibly cure, of this disease, say researchers from University of South Florida College of Medicine.

The study results are published in the May issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology.

Reactive arthritis (ReA), also known as Reiter”s syndrome, occurs in response to an infection. According to National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the bacterium most often associated with ReA is Chlamydia trachomatis. Respiratory infections with Chlamydia pneumoniae can also trigger ReA, while associated infections in the digestive tract include Salmonella, Shigella, Yersinia, and Campylobacter. ReA symptoms usually last 3 to 12 months, although symptoms can return or develop into a long-term disease. In the past it was thought that only a small percentage of people would experience chronic symptoms of ReA.

However, more recent data suggests that as many as 30 percent -50 percent of patients could develop a chronic form of the disease. In chronic ReA, symptoms can be severe and difficult to control with treatment, which could lead to joint damage.

The use of long-term antibiotic treatment for patients with ReA is controversial. Several reported studies have indicated that prolonged antimicrobial monotherapy is not efficacious, while other studies suggest there might be a benefit, specifically with early-stage Chlamydia-induced ReA.

The study led by J.D. Carter, M.D., focused on combinations including 2 antibiotics found to have specific effects on the Chlamydia bacteria. The first, rifampin, has excellent tissue penetration, an important weapon against intracellular pathogens such as Chlamydia. Rifampin also has been shown to interfere with chlamydial gene transcription, including the heat-shock proteins (HSPs), which can ultimately lead to the demise of the infected cell. Dr. Carter explains why this is important. “Combining this effect with antibiotics that block chlamydial protein synthesis (e.g., doxycycline or azithromycin) may allow for successful eradication of the cell harboring persistently infecting intracellular organisms. A recent pilot study conducted by our group suggested that prolonged treatment with a combination of doxycycline and rifampin significantly improves symptoms of chronic undifferentiated spondylarthritis (SpA) (with a special focus on Chlamydia) compared with doxycycline alone. The goal of the present study was to further investigate whether a 6-month course of combination antibiotics, one of which is rifampin, is effective in the treatment of patients with chronic Chlamydia-induced ReA.” (ANI)

Cactus gum may purify water cheaply, effectively

London, Apr 28 (ANI): The best way to purify water could be hiding in a cactus, according to scientists.

According to Norma Alcantar at the University of South Florida in Tampa and colleagues, an extract from the prickly pear cactus is effective at removing sediment and bacteria from dirty water, reports New Scientist.

In the study, Alcantar and her colleagues investigated the prickly pear cactus, Opuntia ficus-indica.

The team extracted the cactus”s mucilage – the thick gum the plant uses to store water. They then mixed this with water to which they had added high levels of either sediment or the bacterium Bacillus cereus.

Alcantar found that the mucilage acted as a flocculant, causing the sediment particles to join together and settle to the bottom of the water samples. The gum also caused the bacteria to combine and settle, allowing 98 per cent of bacteria to be filtered from the water.

The study has been published in Environmental Science and Technology.

The boffins now intend to test it on natural water.

Alcantar said: “The cactus”s prevalence, affordability and cultural acceptance make it an attractive natural material for water purification technologies.” (ANI)

Five cups of coffee a day ‘keeps Alzheimer’s at bay’

Washington, July 6 (ANI): Coffee drinkers have yet another reason to relish their favourite drink – it can protect against Alzheimer’s disease, say researchers.

The research team from University of South Florida has revealed that five cups of coffee not only helps reverse the effects of the disease but can treat it too.

They showed that caffeine significantly decreased abnormal levels of the protein linked to Alzheimer’s disease, both in the brains and in the blood of mice exhibiting symptoms of the disease.

“The new findings provide evidence that caffeine could be a viable ‘treatment’ for established Alzheimer’s disease, and not simply a protective strategy,” said lead author Dr Gary Arendash, a USF neuroscientist with the Florida ADRC.

“That’s important because caffeine is a safe drug for most people, it easily enters the brain, and it appears to directly affect the disease process.”

During the study, the researchers gave half the mice caffeine in their drinking water. The other half got plain water.

At the end of the two-month study, the caffeinated mice performed much better on memory tests and thinking skills.

Mice genetically induced to develop the disease also showed a 50 per cent reduction in levels of amyloid protein in their brains.

Their memories were as sharp as those of healthy older mice without dementia.

“These are some of the most promising Alzheimer’s mouse experiments ever done, showing that caffeine rapidly reduces beta amyloid protein in the blood, an effect that is mirrored in the brain, and this reduction is linked to cognitive benefit,” said Dr Huntington Potter, director of the Florida Alzheimer’s Disease Research Centre in Tampa.

Neil Hunt, chief executive of the Alzheimer’s Society, said: Previous research into caffeine and dementia has suggested that it could delay Alzheimer’s disease and even protect against vascular dementia.

“This research in mice suggests coffee may actually reverse some element of memory impairment,” Hunt added.

The study is published in the Journal of Alzheimer’s Disease. (ANI)

Human blood stem cell growth factor reverses memory decline in Alzheimer’s mice

Washington, July 2 (ANI): Conducting experiments on mice genetically altered to develop Alzheimer’s disease, researchers at the University of South Florida and James A. Haley Hospital have found that a human growth factor that stimulates blood stem cells to proliferate in the bone marrow reverses memory impairment.

Writing about their work in the journal Neuroscience, the researchers revealed that the granulocyte-colony stimulating factor (GCSF) significantly reduced levels of the brain-clogging protein beta amyloid deposited in excess in the brains of the Alzheimer’s mice, increased the production of new neurons, and promoted nerve cell connections.

According to background information in the research article, GCSF is a blood stem cell growth factor or hormone routinely administered to cancer patients whose blood stem cells and white blood cells have been depleted following chemotherapy or radiation.

The report points out that GCSF stimulates the bone marrow to produce more white blood cells needed to fight infection, and that it is used to boost the numbers of stem cells circulating in the blood of donors before the cells are harvested for bone marrow transplants.

Advanced clinical trials are now investigating the effectiveness of GCSF to treat stroke, and the compound was safe and well tolerated in early clinical studies of ischemic stroke patients.

“GCSF has been used and studied clinically for a long time, but we’re the first group to apply it to Alzheimer’s disease. This growth factor could potentially provide a powerful new therapy for Alzheimer’s disease – one that may actually reverse disease, not just alleviate symptoms like currently available drugs,” said USF neuroscientist Dr. Juan Sanchez-Ramos, the study’s lead author.

The study on mice showed that injections under the skin of filgrastim (Neupogen) – one of three commercially available GCSF compounds – mobilized blood stem cells in the bone marrow and neural stem cells within the brain and both of these actions led to improved memory and learning behaviour in the Alzheimer’s mice.

“The beauty in this less invasive approach is that it obviates the need for neurosurgery to transplant stem cells into the brain,” Dr. Sanchez-Ramos said.

The promising findings in 52 elderly mice, equivalent to the human ages of 60 to 80 years, have prompted the Alzheimer’s Drug Discovery Foundation to fund a pilot clinical trial at USF’s Byrd Alzheimer’s Center.

The randomised, controlled trial, led by Dr. Sanchez-Ramos and Dr. Ashok Raj, will test the safety and effectiveness of filgrastim in 12 patients with mild to moderate Alzheimer’s disease.

“The concept of using GCSF to harness bone marrow-derived cells for Alzheimer’s therapy is exciting and the findings in mice are promising, but we still need to prove that this works in humans,” said Dr. Raj, a physician researcher at the Byrd Alzheimer’s Center at USF Health. (ANI)

Pet bites can cause potentially fatal MRSA infection

Washington, June 22 (ANI): Pet owners are at an increased risk of getting infected with the potentially fatal MRSA infection through dogs and cats, say researchers.

Dr. Richard Oehler, of the University of South Florida, says that MRSA and skin infections in dogs and cats can be spread to humans through bites.

While boys aged five to nine are at risk of dog bites the most, cat bites are more common in women and the elderly.

They usually cause deeper puncture wounds than dogs, and carry a higher risk of infection and soft-tissue abscesses.

Almost 20 pct of the bites lead to severe infections, caused by bacteria in the animal’s mouth, plus other infectious agents from the person’s skin.

“As community-acquired strains of MRSA increase in prevalence, a growing body of clinical evidence has documented MRSA colonisation in domestic animals, often implying direct infection from their human owners,” the BBC quoted Oehler as saying

“MRSA colonisation has been documented in companion animals such as horses, dogs, and cats and these animals have been viewed as potential reservoirs of infection.

“MRSA-related skin infections of pets seem to occur in various manifestations and can be easily spread to owners.”

However, any MRSA infection acquired from pets is treated with medication, as normal MRSA infections.

“Pet owners are often unaware of the potential for transmission of life-threatening pathogens from their canine and feline companions,” said the researchers.

“Clinicians must continue to promote loving pet ownership, take an adequate pet history, and be aware that associated diseases are preventable via recognition, education and simple precautions,” they added.

Prof. Enright, from Imperial College London, said: “MRSA might be on a person’s skin and, as they get bitten, it goes inside. This is probably a marginal problem. It may be of more significance in the US where community-acquired MRSA is more of an issue.”

The study appears in The Lancet. (ANI)

Rapid weight loss in old age could raise dementia risk

Washington, May 19 (ANI): Older people who are thinner or are losing pounds quickly are at an increased risk of developing dementia, especially if they started out overweight or obese, according to a new study.

The research is published in the May 19, 2009, print issue of Neurology, the medical journal of the American Academy of Neurology.

To reach the conclusion, researchers followed for eight years 1,836 Japanese Americans in Washington state with an average age of 72. During that time, 129 people developed dementia.

The research found that people with lower body mass index (BMI) scores at the beginning of the study were 79 percent more likely to develop dementia than those with higher BMI scores.

In addition, those who lost weight over the study period at a faster rate were nearly three times more likely to develop dementia than those who lost weight more slowly over time. This result was more pronounced in those who were overweight or obese to start; those with a BMI of 23 or higher had an 82-percent reduced risk of developing the disease compared to those who were normal or underweight.

The results were the same after testing for other health risk factors such as smoking, exercise and gender.

“Our finding suggests that losing weight quickly in older age may be an early sign of dementia,” said study author Tiffany Hughes, PhD, MPH, who is with the University of Pittsburgh School of Medicine but conducted the research while she was a doctoral student at the University of South Florida.

“This doesn’t mean that being obese or overweight is healthy for the mind or body, but losing weight may be a sign of emerging brain disease,” the research added. (ANI)

Cricket gets serious in the US again

Florida (US), Mar.25 (ANI): The game of cricket is getting serious attention again in the United States these days, more than a century after it first made its presence felt in the region.

Players taking part in the recently held American College Spring Break Cricket Championship in Florida feel they have brought the sport one step closer into the American mainstream.

Though cricket counts its fans by the billion worldwide, the sport does not register a pulse in the United States.

Of the five teams in attendance at this experimental event last weekend – Montgomery, from Maryland; Boston University; Carnegie Mellon, from Pittsburgh; the University of South Florida and the University of Miami, none have club team status, and the sport is not officially recognized by the N.C.A.A.

“This is an opportunity for us to really show athletic directors at a Division I level that cricket matters, cricket is a big sport and cricket has a marketing capability in this country,” the New York Times quoted Sumantro Das, an all-rounder and junior at Boston University, as saying.

Nearly 60 players drove or flew at their own expense to the lush cricket pitches of Central Broward Regional Park and played Twenty20, a version of cricket in which many stuffy traditions are left behind and matches are completed in about three hours instead of taking up to five days.

The only custom-built cricket stadium in the United States stands in this park, but securing the 5,000-seat facility was far too rich a luxury for the tournament’s shoestring budget.

Competing on the park’s manicured fields was already an upgrade over the converted soccer fields and tennis courts the players were used to.

Lloyd Jodah, the founder and president of American College Cricket, said the idea for the college tournament came to him last year as he campaigned to have cricket included in the Olympics.

Standing on Wall Street with a cricket bat in one hand and petitions in the other, Jodah, 50, an immigrant from Guyana who works selling health club memberships, met Kalpesh Patel, a Jamaican business student from the University of Miami.

Once Jodah heard how difficult it was for college cricketers to find regular games, he began toying with the idea of a nation-wide organization for collegiate clubs and founded American College Cricket. He made a group on Facebook as a way to reach out to players.

Jodah and Nino DiLoreto, 62, a former soccer player from Abruzzi, Italy, spent many evenings tracking down college cricket players, and the group swelled to more than 500 members.

At the Boston University Cricket Club, expenses for the trip became the subject of six- and seven-hour meetings. After much deliberation, and financial help from the university, the roughly dozen members agreed that the opportunity to play for a long weekend was worth 400 dollars each.

Unlike a couple of the teams, which had snazzy uniforms, the University of South Florida contingent did not even have a team until a few weeks ago. They were just a few guys who played a regular pickup game. They settled on sweatpants and green T-shirts from the college bookstore. Not having names on their shirts caused a few awkward moments when a player would run to the borrowed picnic table/scorer’s table with no idea of which of his new team mates was batting next.

But the players all knew the finer points of cricket etiquette.

Nearly all the players were born abroad. And even though the sport had a rich history in the United States until World War II, it is still widely seen here as an obscure game played exclusively by foreigners. Most who play it here are from countries that belonged to the British Commonwealth. (ANI)