Protein that speeds growth of damaged liver ‘discovered’

In a breakthrough which could help damaged livers repair naturally and quickly, scientists claim to have discovered a protein that could double the speed of liver cell growth, helping the organ to heal on its own.

A team at the Western Australian Institute for Medical Research has found that a protein, TWEAK, significantly raises the growth rate of liver progenitor cells (LPCs) – crucial stem cells in liver repair, the ‘Hepatology’ journal reported.

Lead author Dr Janina Tirnitz-Parker said when the team set out to understand how TWEAK affected LPCs, they discovered it had a dramatic effect on cell growth.

“We had LPCs growing in culture and we put TWEAK on top of them to find out what effect it might have, and what we saw was very exciting – LPCs grew twice as fast as they normally would.

“This means that there could be a potential to use TWEAK to help damaged livers repair themselves by growing new healthy cells at a much faster pace,” she said.

Head of WAIMR’s Laboratory for Liver Disease and Carcinogenesis and study co-author Professor George Yeoh said this was a significant discovery in the field and to the evolution of treatments away from liver transplants.

“This is a key finding for liver disease, because we now know what tickles liver cell growth – it could have huge benefit for patients with liver conditions by helping to regenerate their existing liver faster and possibly ruling out the need for transplants.

“If this phenomenon can be harnessed it might be possible to increase or inject TWEAK onto a patient’s liver in order to help the organ repair itself naturally, and much faster,” he said.

Genes controlling insulin ‘alter’ body clock

Washington, Sept 18 (ANI): Scientists at University of California, San Diego have identified certain insulin-regulating genes that can also alter the timing of the body clock.

They said that the findings can lead to new approaches to treating disorders such as metabolic syndrome that can result, at least in part, from chronic disruption of the sleep-wake cycle.

“People knew that the clock regulates many different processes, but what they didn’t realize what that when you tweak those processes, it feeds back and alters the clock,” said Steve Kay, Dean of the Division of Biological Sciences at the University of California, San Diego, who led the study along with John Hogenesch of the University of Pennsylvania.

A molecular clock controls daily physiological rhythms in many types of cells, even cells grown in culture.

By engineering cultured cells to glow yellow when a particular clock gene switched on, the team made the cycle visible. They then interfered with every human gene to see which would shift the clock. They found that hundreds altered the timing.

“We just suddenly discovered 350 new genes that affect the clock that weren’t known before,” Kay said.

However, subsequent screening to confirm the genes’ effect on a second clock gene narrowed the list to 200.

Seven genes involved in insulin control also influenced the rhythms of the clock.

“What came out very strongly was this close relationship between circadian regulation and insulin signalling. There’s a reciprocal relationship between circadian dysfunction and metabolic dysfunction,” said Kay.

The researchers suggest that genetically altered mice with malfunctioning clocks become obese and develop diet-induced diabetes.Understanding this close relationship between circadian regulation and metabolic homeostasis should provide novel ways of identifying new therapies for metabolic disease,” Kay added.

The study appears in journal Cell. (ANI)

High-performance, low-cost green LEDs to brighten up the future

Washington, September 6 (ANI): A scientist is aiming to develop a high-performance, low-cost green LED (Light-emitting diode).

According to Christian Wetzel, professor of physics and the Wellfleet Professor of Future Chips at Rensselaer Polytechnic Institute (RPI), “Going green means different things to different people. For companies, going green means making a profit by selling equipment and services that allow one’s customers to be more efficient and reduce costs.”

“I’m doing both of those, but I’m also trying to make an LED that literally shines green light,” he said.

First discovered in the 1920s, LEDs are semiconductors that convert electricity into light.

When switched on, swarms of electrons pass through the semiconductor material and fall from an area with surplus electrons into an area with a shortage of electrons.

As they fall, the electrons jump to a lower orbital and release small amounts of energy. This energy is realized as photons – the most basic unit of light.

Unlike conventional light bulbs, LEDs produce almost no heat.

The color of light produced by LEDs depends on the type of semiconductor material it contains.

“We have high-performance red LEDs, we have high-performance blue LEDs, and if we paired them with a high-performance green LED we would be able to produce every color visible to the human eye – including true white,” said Wetzel.

“Every computer monitor and television produces its picture by using red, blue, and green. That means developing a high-performance green LED would likely lead to a new generation of high-performance, energy-efficient display devices,” he added.

“The problem, however, is that green LEDs are much more difficult to create than I, or anyone else, imagined,” he explained.

Simple preliminary attempts to create green LEDs, by merely adding more indium (In) to the gallium nitride (GaN) materials that composed blue LEDs, were unsuccessful.

The resulting green LEDs just weren’t strong or bright enough to stand toe-to-toe with red or blue.

Wetzel and his research group have been working to tweak precisely how to add more indium, and how to grow the structure more carefully into a device, with the goal of boosting the strength and light output of green LEDs.

“They’re endeavoring, he said, to close the green gap,” said Wetzel.

Once they overcome the challenge of developing efficient green LEDs, Wetzel envisions LED technology will quickly evolve from its current applications in signs and small displays and grow into a universally adopted, globally used replacement for traditional light bulbs and compact fluorescence tubes. (ANI)

Lack of spectator interest killing Test cricket: Boycott

Melbourne, July 15 (ANI): England’s batting legend Geoffrey Boycott has warned that the lack of spectator interest is killing Test cricket, which requires radical changes to save it.

The former opening batsman said crowds at Ashes matches masked the dwindling attendances for Tests elsewhere in the world, with even the recent series between South Africa and Australia, failing to sell out.

“If you’re watching England against Australia this summer, we’re all seduced into believing Test cricket is fine because you could sell Test-match cricket twice over for huge amounts of money because it … has history and tradition,” Boycott said.

“But every other series around the world, there are declining attendances and there have been declining attendances for many years,” The Herald Sun quoted him, as saying.

“Everywhere crowds are down except in England and Australia … we have to tweak it a bit or do something to get bums on seats or their will be hardly anybody watching except television in 20 or 30 years,” he added.

The MCC cricket committee, which is made up of former and current international players called for a World Test Championship similar to the World Championships that exist in 50-over and Twenty20 cricket to reignite interest.

Although there are world Test rankings, which do ultimately lead to a team being declared the best side in the world, they have yet to become a part of the fabric of the game.

“Test cricketers want to be able to say they’re the world champions of Test cricket,” said Steve Waugh, a member of the MCC cricket committee.

“We can say it in the Twenty20 and 50-over game but Test cricket continues on and on. There’s the ranking system, but there’s no actual trophy where you can hold it aloft. Something definitely needs to be done to lift the profile of Test cricket,” he said.

Boycott added: “The idea is not just to have a world championship but to package it better.”

The International Cricket Council (ICC) announced last month that it was considering the possibility of having a day/night Test in 2010 on a trial basis. (ANI)

Grace Jones flaunts backside and gives it a tweak

New York, May 5 (ANI): Former Bond girl Grace Jones has shown that she can still be daring at the age of 60, when she bared her bottom and even gave it a tweak.

Jones was at H and M’s yacht party at the South Street Seaport celebrating its collaboration with designer Matthew Williamson.he actress/singer descended onto the stage in a glass elevator, and got the crowd shrieking after she exposed her bare backside and gave it a few firm squeezes.

“She’s still got the best legs on the planet,” the New York Post quoted one partygoer as saying. (ANI)