Constipated infants supplemented with L. reuteri Protectis had a significantly higher
frequency of bowel movements compared to the placebo group. Stool consistency improved
significantly in the L. reuteri Protectis group, although no significant difference was
seen compared to placebo.
- This is the first study to show that L. reuteri has positive effects on infants
suffering from chronic constipation, says Professor Annamaria Staiano, Department of
Pediatrics, University Federico II, Naples, Italy.
In the double-blind, placebo-controlled study 44 infants with confirmed chronic
functional constipation were randomly assigned to treatment with either L. reuteri
Protectis drops (DSM 17938, 10^8 CFU/day) or placebo for eight weeks. Outcome measures
included frequency of bowel movements per week, stool consistency and presence of
inconsolable crying episodes.
Treatment success was defined as equal to or more than three bowel movements per week.
At week two the success rate was 91 % in the L. reuteri Protectis group compared to 59 %
in the placebo group. At week four the figures were 100 % and 68 % respectively and at
week eight 100 % in the probiotic group and 73 % in the placebo group.
Stool consistency improved significantly in the L. reuteri Protectis group during the
treatment, from 86 % reported as hard at baseline to 50 % at week two and 18 % at weeks
four and eight. However, there were no significant differences in stool consistency
between the L. reuteri Protectis and placebo groups at any of the measuring points. No
differences were observed in crying behaviour between the groups at any time point,
which was expected since this population was too old to display colic.
- The results of the study again show the positive effect of L. reuteri Protectis on
infant gut function and further strengthens BioGaia’s position in the infant segment,
says Eamonn Connolly, Senior Vice President Research at BioGaia.
The study was published online on the 14th of June 2010 in the Journal of Pediatrics:
For additional information contact:
Annamaria Staiano, MD, Department of Pediatrics, University Federico II:
Eamonn Connolly, Senior Vice President Research, BioGaia: +46 8-555 293 00 or