Reducing intake of niacin can prevent obesity

Washington, May 21 (ANI): Scientists in China have suggested that reducing the intake of niacin, also known as vitamin B3 or nicotinic acid, can prevent obesity.

Dietary factors have long been known to play a major role in the development of obesity. The global increasing prevalence of obesity suggests that there should be some common changes in diet worldwide.

In fact, a significant, yet, often-neglected worldwide change in dietary factors in the past few decades is the food fortification-induced

marked increase in the content of niacin.

However, the effect of long-term exposure to excess niacin on human health remains to be unclear.

Now, a research team from China has examined the role of excess nicotinamide in glucose metabolism using co-loading of glucose and nicotinamide test.

They have proved that excess niacin intake-induced biphasic response, i.e., insulin resistance in the early phase and hypoglycemia in the late phase, may be a primary cause for the increased appetite in obesity.

The study has also revealed for the first time that the obesity prevalence among US children and adolescents increased in parallel with the increase of the per capita niacin consumption with a 10-year lag, in which niacin fortification-induced sharp increase in niacin contents in grain products may play a major role.

Reducing niacin intake and facilitating niacin elimination through sweat-inducing physical activity may be a key factor in the prevention and treatment of obesity.

It seems that the long-term safety of niacin fortification needs to be carefully evaluated.

The study will be published on May 21, 2010 in the World Journal of Gastroenterology. (ANI)

Parents play vital role in maintaining child”s oral health

Washington, May 18 (ANI): A study has shown that parents play a vital role in maintaining a child”s overall health, and that educating mothers and families on oral health can help prevent early childhood tooth decay.

With all of the challenges that new parents face, they may not think much about the link between their child”s oral health and overall health.

In fact, an understanding of oral hygiene can help parents to prevent tooth decay-the single most common chronic childhood disease in America-and to create a lifetime of healthy habits for their child.

“Ideally, the oral health education for any family will begin with prenatal education and the establishment of a dental home by the time the child is 12 to 18 months of age,” Tegwyn Brickhouse, DDS, author of the study, said.

“Many people don”t realize that the oral health of the mother affects both the infant”s future oral health and the child”s overall health. In fact, some studies show that periodontal disease has been linked to pre-term labour.

“That”s why pregnant women should be evaluated for cavities, poor oral hygiene, gingivitis, loose teeth and diet,” Brickhouse stated.

After the child is born, families should become familiar with their child”s dental and oral health milestones, which will be determined by discussion with the family dentist or a paediatric dentist.

Children should have their first dental visit at age 1 or within six months of the eruption of their first tooth.

A dentist will be able to discuss when parents can expect to see a child”s first tooth and the best technique for brushing his or her new teeth.

Diet is another factor that affects a child”s oral health. Frequent and long-term exposure to liquids that contain sugars commonly results in tooth decay.

In addition to eliminating sugary drinks altogether from a child”s diet, parents can adopt other habits to prevent tooth decay due to beverage consumption.

“Parents should avoid giving their children milk, formula, juice or soda at naptime or nighttime,” Bruce DeGinder, DDS, MAGD, spokesperson for the AGD, said.

“The sugars will linger on their teeth and gums for a prolonged period of time, promoting decay,” DeGinder added.

Parents are responsible for their child”s oral hygiene practices and are advised to meet with a general dentist to determine the best way to establish and maintain their child”s oral health.

A general dentist also can provide families with oral health literature that is designed to educate both the parent and child. This education has multiple benefits.

“Healthy teeth in early childhood can provide a positive self-image and improve the child”s quality of life,” Brickhouse explained.

The article has been published in the May/June 2010 issue of General Dentistry, the peer-reviewed clinical journal of the Academy of General Dentistry (AGD). (ANI)

Crease-resistant toxin in nurses”” uniform ‘can cause cancer’

London, May 8 (ANI): Nurses in several hospitals across Wales and Scotland have reported skin rashes due to allergic reaction to the fabric of their uniforms, which contain potentially carcinogenic formaldehyde.

A leading toxin expert from Government””s Advisory Committee on Hazardous Substances until recently, Gwynne Lyons, said that the allergic reaction was caused due to formaldehyde resin, used to make the tunics crease-resistant.

“But there is also a bigger picture, in that many experts consider that formaldehyde is a known human carcinogen when inhaled over time. Therefore, whenever possible, it is high time that safer substances were used instead of formaldehyde,” The Independent quoted Dr Lyons, director of the Chemicals, Health and Environment Monitoring Trust, as saying.

Clothes manufacturers use the chemical in clothes to prevent creasing and mildew during transit. The Health and Safety Executive warn workers that it can cause skin, eye, and nose and throat irritation. Long-term exposure to high levels has been linked with nasal and lung cancer.

Alternative uniforms are being made available to nurses in Wales while the problem is investigated. (ANI)

Oz worker told to have sex by employer to fix her lung problem

Melbourne, Jul 7 (ANI): An Aussie woman, who developed mould on her lungs as a result of her sub-standard workplace, alleges that her employers asked her to have sex to cure the illness.

Regina Senger, of Townsville, said that she developed health issues after long-term exposure to toxic mould in the poorly ventilated and damp basement in which she worked.

She has launched legal action against the business for which she used to work, and the owner of the building she worked in.

Solicitor Rebecca Jancauskas, of Shine Lawyers, said that her client suffered headaches, respiratory, and sinus problems as a result of her job while tests revealed that she had mould growing in her lungs, placing her at risk of cancer.

“Obviously she is very concerned about the long-term health implications,” News.com.au quoted her as saying.

She said that Senger was directed to work alone in the basement of the Townsville business after starting as a property manager in October 2007, and repeatedly complained about the sub-standard conditions, which included mould on the walls and carpet and a “pervasive, pungent odour”.

Jancauskas said that her client’s pleas to be transferred and her complaints of ill health, such as persistent headaches, were ignored, and on one occasion, Senger alleges that she was told having sex would cure her health woes.

“That just demonstrates the employer’s flagrant disregard of the problems and of her symptoms,” Jancauskas said.

Senger left the employer in March to receive treatment for her conditions, but had been forced to take up part-time work to support her children.

She has lodged a compensation claim against her employer, and has instructed Shine Lawyers to launch court proceedings against the buildings owners.

“We think this should serve as a wake-up call to owners of premises that if they subject their employees or tenants to sub-standard work or living conditions they will be brought to account,” Jancauskas said.

“In cases like this when the impact on all spheres of the plaintiff’s life has been severe the compensation could be significant,” she added. (ANI)

Farmers advised to use ear protection while feeding ‘squealing’ pigs

London, May 26 (ANI): Farmers have been advised to use ear protection when feeding pigs, to protect them from ‘deafening’ squeals.

The noise made by pigs during mealtimes can reach more than 100 decibels, louder than a chainsaw or powerdrill, the Health and Safety Executive has warned.

It has produced a leaflet entitled Farmwise – An Essential Guide to Health and Safety in Farming, recommending farmers to wear earmuffs or stay away from pigs while they are eating, reports the Telegraph.

The leaflet said: “Large numbers of pigs in a building can create noise levels of 100 decibels or above, especially at feeding time,” according to the leaflet.

The leaflet also suggested that even short-term exposure could be harmful, particularly if workers are exposed to other sources of noise during the day.

“Use mechanical or automated feeding systems to reduce the need to enter the building when it is noisiest, e.g. at feeding time. Make sure any work requiring entry is done during quieter periods,” the leaflet added.

HSE inspector Tony Mitchell said that the noise in pig farms only becomes a problem where hundreds of pigs are kept in close confinement in giant sheds.

“If you can imagine a shed with three to 400 hungry sows waiting for you to come and feed them and they are all squealing at the same time, the noise they make can be quite dramatic,” he said.

“But it’s not an issue if you have an automated feeding system you can switch on from the outside. Once the pigs are feeding they are quiet.

“If you are feeding pigs with a barrow of feed with a scoop for each pig you could be exposed to that noise for quite some time,” he added. (ANI)

Even short-term exposure to pollutants can increase cancer risk

Washington, May 18 (ANI): Exposure to environmental pollutants even for a short period can prompt genes to undergo reprogramming, and thereby increase an individual’s risk of developing cancer and other diseases, say Italian scientists.

University of Milan researchers have shown that inhaling certain environmental pollutants can damage DNA as early as three days.

“Recently, changes in gene programming due to a chemical transformation called methylation have been found in the blood and tissues of lung cancer patients,” said investigator Dr. Andrea Baccarelli, assistant professor of Applied Biotechnology at the University of Milan.

“We aimed at investigating whether exposure to particulate matter induced changes in DNA methylation in blood from healthy subjects who were exposed to high levels of particulate matter in a foundry facility,” Baccarelli added.

The researchers compared the blood samples of 63 healthy subjects who worked in a foundry near Milan, and found significant changes in four genes associated with tumour suppression.

“The changes were detectable after only three days of exposure to particulate matter, indicating that environmental factors need little time to cause gene reprogramming which is potentially associated with disease outcomes,” said Baccarelli.

“As several of the effects of particulate matter in foundries are similar to those found after exposure to ambient air pollution, our results open new hypotheses about how air pollutants modify human health.

“The changes in DNA methylation we observed are reversible and some of them are currently being used as targets of cancer drugs,” he added.

Baccarelli said that study results indicated that early interventions might be designed to reverse gene programming to normal levels, reducing the health risks of exposure.

The findings were presented at the 105th International Conference of the American Thoracic Society in San Diego. (ANI)

Molecule that contributes to development of smoking-related lung disease identified

Washington, Apr 25 (ANI): Researchers have identified a molecule which contributes to the development of smoking-related lung disease.

Long-term exposure to compounds found in smoke can lead to both cardiovascular and lung disease.

Although lung exposure to cigarette smoke leads to immune cell recruitment and tissue fibrosis, how cigarette smoke causes these changes is unknown.

The researchers sought to determine if osteopontin, a molecule that attracts immune cells, mediates cell recruitment in smokers,

Prasse et al compared osteopontin levels from smokers with different types of lung diseases, healthy smokers, and healthy non-smokers.

They found high levels of osteopontin expression in patients with interstitial lung disease, whereas healthy smokers had lower levels, and healthy non-smokers produced no osteopontin.

Moreover, expressing osteopontin in rat lung resulted in recruitment of immune cells, resulting in symptoms similar to smoking-related interstitial lung diseases. These results indicate that osteopontin may be pathogenic in smoking-initiated lung disease.

The researchers said ” that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production].”

Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease.

The study appears in The American Journal of Pathology. (ANI)