BrainStorm To Present at ILSI-Biomed Israel 2010

NEW YORK & PETACH TIKVAH, Israel–(Business Wire)–
BrainStorm Cell Therapeutics Inc. (OTCBB: BCLI), a leading developer of adult
stem cell technologies and therapeutics today announced that Rami Efrati,
BrainStorm`s CEO, will be presenting at the 9th National Life Science and
Technology Week ILSI-Biomed Conference, Israel 2010. The presentation will be
given on Monday June 14, 2010 during the BioPharma Session being held from 4:30
p.m. to 6:30 p.m. Israel time.

Mr. Efrati`s presentation will discuss the Company`s achievements and milestones
to date as well BrainStorm`s upcoming ALS clinical trials. Mr. Efrati along with
other members of BrainStorm will meet with pharmaceutical and biotech companies
engaged in stem cell technologies that are attending the conference.

For more information about ILSI-Biomed Israel 2010 please visit

http://www2.kenes.com/biomed/Pages/Home.aspx

About BrainStorm Cell Therapeutics, Inc.

BrainStorm Cell Therapeutics Inc. is an emerging company developing adult stem
cell therapeutic products, derived from autologous (self) bone marrow cells, for
the treatment of neurodegenerative diseases. The patent pending technology is
based on discoveries made by the scientific team led by Professor Eldad Melamed,
former Head of Neurology at Rabin Medical Center, and cell biologist Prof.
Daniel Offen, Head of the Neuroscience Laboratory at the Felsenstein Medical
Research Center of Tel-Aviv University. The technology allows for the
differentiation of bone marrow-derived stem cells into functional neurons and
astrocytes, as demonstrated in animal models. The Company holds rights to
develop and commercialize the technology through an exclusive, worldwide
licensing agreement with Ramot at Tel Aviv University Ltd., the technology
transfer company of Tel-Aviv University. The Company’s current focus is on ALS,
although its technology has promise for treating several other diseases
including MS, Huntington’s disease and stroke.

Safe Harbor Statement

Statements in this announcement other than historical data and information
constitute “forward-looking statements” and involve risks and uncertainties that
could cause BrainStorm Cell Therapeutics Inc.’s actual results to differ
materially from those stated or implied by such forward-looking statements. The
potential risks and uncertainties include risks associated with BrainStorm’s
limited operating history, history of losses; minimal working capital,
dependence on its license to Ramot’s technology; ability to adequately protect
the technology; dependence on key executives and on its scientific consultants;
ability to obtain required regulatory approvals; and other factors detailed in
BrainStorm’s annual report on Form 10-K and quarterly reports on Form 10-Q
available at http://www.sec.gov. The Company does not undertake any obligation
to update forward-looking statements made by us.

BrainStorm Cell Therapeutics
Rami Efrati, CEO, +972-3-9236384
efrati@brainstorm-cell.com

Copyright Business Wire 2010

Now, nano-based technology that can make PCs, net hundreds of times faster

Washington, May 4 (ANI): Communication devices will soon turn smaller, more flexible and more powerful, thanks to a nano-based technology that can make computers and the Internet hundreds of times faster.

Currently being created by Dr. Koby Scheuer of Tel Aviv University”s School of Electrical Engineering, the communications technology “enabler” could only be used in five or ten years in the future.

Scheuer has developed a new plastic-based technology for the nano-photonics market, which manufactures optical devices and components.

The plastic-based “filter” is made from nanometer-sized grooves embedded into the plastic.

When used in fibre optics cable switches, the new device will make our communication devices smaller, more flexible and more powerful, he said.

“Once Americans have a fibre optics cable coming into every home, all communication will go through it — telephone, cable TV, the Internet. But to avoid bottlenecks of information, we need to separate the information coming through into different channels. Our polymeric devices can do that in the optical domain — at a speed, quality and cost that the semi-conductor industry can”t even imagine,” said Scheuer.

Every optical device used in today”s communication tools has a filter.

Ten years from now, fibre optic cables that now run from city to city will feed directly into every individual home.

When that technology comes to light, the new plastic-based switches could revolutionize the way we communicate.

“Right now, we could transmit all of the written text of the world though a single fiber in a fiber optics cable in just a few seconds. But in order to handle these massive amounts of communication data, we need filters to make sense of the incoming information. Ours uses a plastic-based switch, replacing hard-to-fabricate and expensive semi-conductors,” said Scheuer.

Semi-conductors, grown on crystals in sterile labs and processed in special ovens, take days and sometimes months to manufacture. They are delicate and inflexible as well, said Scheuer.

“Our plastic polymer switches come in an easy-to-work-with liquid solution. Using a method called ”stamping,” almost any laboratory can make optical devices out of the silicon rubber mold we”ve developed,” he added.

The silicon rubber mould is scored with nano-sized grooves, invisible to the eye and each less than a millionth of a meter in width.

A plastic solution can be poured over the mould to replicate the optical switch in minutes.

When in place in a fibre-optic network, the grooves on the switch modulate light coming in through the cables, and the data is filtered and encoded into usable information.

The device can also be used in the gyros of planes, ships and rockets; inserted into cell phones; and made a part of flexible virtual reality gloves so doctors could “operate” on computer networks over large distances.

The study has been published in the journal Optics Express. (ANI)

New finding paves way for diagnosis of multiple sclerosis before it strikes

Washington, April 30 (ANI): A breakthrough finding may lead to earlier diagnosis, more effective intervention, and perhaps even a cure for multiple sclerosis (MS), an autoimmune disease.

Prof. Anat Achiron of Tel Aviv University”s Sackler Faculty of Medicine and vice-dean of research at Sheba Medical Center has discovered a new way of detecting MS in the blood through her research at Sheba.

The findings is expected to pave the way for a diagnosis of MS before symptoms can appear, allowing for earlier treatment.

“We are not yet able to treat people with MS to prevent the onset of the disease but knowledge is power. Every time we meet a new patient exhibiting symptoms of MS, we must ask ourselves how long this has been going on. We can diagnose MS by brain MRI, but we”ve never been able to know how ”fresh” the disease is,” Achiron said.

If doctors can predict the onset of MS early enough, intervention therapies using immunomodulatory drugs such as Copaxone or beta-interferon drugs that stave off MS symptoms, might be used.

“We theorized that if we looked at the gene expression signature of blood cells in healthy people, we could look for possible biological markers that characterize those who subsequently developed MS,” said Achiron.

Examining blood samples of twenty 19-year-old Israelis who were inducted into the army as healthy soldiers, and the nine of them who later developed MS, Achiron and her team at Sheba were able to use a “high throughput analysis” using more than 12,000 gene transcripts expressions.

The screening compared similarities and differences in the blood of those who developed MS and those who did not, eventually establishing biological markers.

The study has been published in the journal Neurobiology of Disease. (ANI)

Now, virtual muscle machine to treat kids with disabilities

Washington, Apr 28 (ANI): A retired dancer turned occupational therapist is pioneering a new “virtual” method to analyse movement patterns in children ? and more effectively treat those with debilitating motor disorders.

Dr. Dido Green of Tel Aviv University”s Department of Occupational Therapy in the School of Health Professionals is using a “virtual tabletop” called the Elements System, to “move” kids with disabilities and provide home-based treatments using virtual reality tools.

Combining new three-dimensional exercises with two-dimensional graphical movement games already programmed into the tabletop (which resembles an early video game), she has not only reported success, but also enthusiasm among her young patients.

“I”ve been working with children with movement disorders for the last 20 years. By the time I meet these children, they”re sick of us. They”ve been ”over-therapied,” and it”s difficult to get them to practice their exercises and prescribed treatment regimes,” said Green.

“The virtual tabletop appealed to children as young as three and as old as 15. The movement-oriented games allowed them to ”make music” and reach targets in ways that are normally neither comfortable nor fun in the therapeutic setting,” she added.

Green found that children with partial paralysis and motor dysfunction resulting from disorders such as cerebral palsy may be helped by giving them a new interface to explore.

Building upon earlier research she conducted at the Evelina Children”s Hospital in London, she found that virtual reality applications enhance the skill sets learned by her patients.

Combined with new technology involving 3D Movement Analysis, Green hopes to develop this virtual tabletop–type game into new and effective therapy treatment regimes.

“Traditional approaches are labour-intensive and their results limited. Our research aims to create a complete system for therapist, parent and child. It could bring daily treatments into the home and provides therapists with a complete solution to track and analyse improvements or setbacks in the most accurate way to date,” said Green.

She found some impressive results in children who attended sessions with her interface for three days a week over a period of about one month.

In future, Green hopes to develop the technique for remote rehabilitation, enabling children to practice movements at home with parental supervision. (ANI)

Coming soon: System that warns driver of an impending accident

Washington, April 21 (ANI): Scientists are working to develop a system that can warn a driver of an impending accident.

With just a half second”s notice, a driver can swerve to avoid a fatal accident or slam on the brakes to miss hitting a child running after a ball. However first, the person behind the wheel must perceive the danger.

Now, a new research shows that a rapid alert system can help mitigate the risks, fatalities and severe injuries from road accidents.

Prof. Shai Avidan of Tel Aviv University”s Faculty of Engineering is currently collaborating with researchers from General Motors Research Israel to keep cars on the road and people out of hospitals.

Avidan and his team are working to develop advanced algorithms that will help cameras mounted on GM cars detect threats, alerting drivers to make split-second decisions.

The challenge is to develop a system that can recognize people, distinguishing them from other moving objects — and to create a model that can react almost instantaneously, says Avidan.

Ultimately, he is hoping computer vision research will make cars smarter, and roads a lot safer.

Cars are not much different from one another. They all have engines, seats, and steering wheels. But new products are adding another dimension by making cars more intelligent. One such product is the smart camera system by MobilEye, an Israeli startup company.

Avidan was part of the MobilEye technical team that developed a system to detect vehicles and track them in real-time.

He is now extending that research to develop the next generation of smart cameras — cameras that are aware of their surroundings.

His goal is a camera capable of distinguishing pedestrians from other moving objects that can then warn the driver of an impending accident.

The research has been published in leading journals, including the IEEE Transaction on Pattern Analysis and Machine Intelligence. (ANI)

Laser security for the Internet developed

Washington, March 24 (ANI): Experts have come up with a new security system for Internet using a special laser that may help keep hackers’ prying eyes off for good.

Scientists at Tel Aviv University have developed a digital security tool with existing fiber optic and computer technology that transmitts binary lock-and-key information in the form of light pulses.

The device, invented by Dr. Jacob Scheuer, TAU’s School of Electrical Engineering, allegedly ensures that a shared key code can be unlocked by the sender and receiver, and absolutely nobody else.

Dr. Scheuer explained: “Rather than developing the lock or the key, we”ve developed a system which acts as a type of key bearer.”

The researchers continued: “The trick is for those at either end of the fiber optic link to send different laser signals they can distinguish between, but which look identical to an eavesdropper.”

Dr. Scheuer added: “We”ve already published the theoretical idea and now have developed a preliminary demonstration in my lab. Once both parties have the key they need, they could send information without any chance of detection. We were able to demonstrate that, if it”s done right, the system could be absolutely secure. Even with a quantum computer of the future, a hacker couldn”t decipher the key.”

The findings were due to be presented at the next laser and electro-optics conference at the Conference for Lasers and Electro-Optics (CLEO) in San Jose, California. (ANI)

More sensitive sensor paves way for better prosthetic limbs, cars and missiles

Washington, Mar 23 (ANI): Get ready for more thrilling videogames, better functioning prosthetic limbs, cars that can detect collisions and dangerous turns before they occur, and missiles that can reach a target far more precisely—all thanks to sensitive sensors being developed by researchers at Tel Aviv University”s Faculty of Engineering.

Prof. Yael Hanein, Dr. Slava Krylov and their doctoral student Assaf Yaakobovitz, have set out to make sensors for microelectromechanical systems (MEMS) significantly more sensitive and reliable than they are today.

The new MEMS sensing device, which can “feel” and sense the movement of individual atoms, uses small carbon tubes, nano in size — about one-billionth of a meter long.

Creating these tiny tubes using a process involving methane gas and a furnace, Hanein has developed a method whereby they arrange themselves on a surface of a silicon chip to accurately sense tiny movements and changes in gravity.

In the device, a very tiny nanometer scale tube is added onto much larger micrometer-scale MEMS devices.

Small deformities in the crystal structure of the tubes register a change in the movement of the nano object, and deliver the amplitude of the movement through an electrical impulse.

“It”s such a tiny thing. But at our resolution, we are able to feel the motion of objects as small as a few atoms,” said Hanein.

“Originally developed mainly for the car industry, miniature sensors are all around us. We”ve been able to fabricate a new device where the nano structures are put onto a big surface — and they can be arranged in a process that doesn”t require human intervention, so they”re easier to manufacture. We can drive these nano-sensing tubes to wherever we need them to go, which could be very convenient and cost-effective across a broad spectrum of industries,” said Hanein.

Until now, the field of creating sensors for nanotechnology has been primarily based on manual operation requiring time-consuming techniques, explained Hanein.

The researchers have developed a sensitive but abundant and cost-effective material that can be coated onto prosthetic limbs, inserted into new video games for more exciting play, and used by the auto industry to detect a potential collision before it becomes fatal.

The market for MEMS devices, which take mechanical signals and convert them into electrical impulses, is estimated to be worth billions.

“The main challenge facing the industry today is to make these basic sensors a lot more sensitive, to recognize minute changes in motion and position. Obviously there is a huge interest from the military, which recognizes the navigation potential of such technologies, but there are also humanitarian and recreational uses that can come out of such military developments,” said Hanein.

For example, more sensitive MEMS could play a role in guided surgery.

The technology has been published in the Journal of Micromechanics and Micro-engineering. (ANI)

Magical tricks may help treat children with locomotor disabilities

Washington, Mar 16 (ANI): A researcher at Tel Aviv University has found a new approach to help kids with paralysis and motor dysfunction improve their physical skills and inner confidence — magic.

Dr. Dido Green developed an innovative yet remarkably simple series of therapeutic exercises for children and young adults based on sleight-of-hand tricks used by professional magicians.

Green and her magicians used sponge balls, elastics and paper clips to teach the children how to perform the challenging, fun and engaging exercises.

“Children with motor disorders like hemiplegia — or paralysis on one side of the body — perform routine exercises with their hands and wrists to be able to carry out basic functions such as opening a door, doing up their zipper, or closing buttons. Not only did the kids get a kick out of the magic tricks, they loved doing the exercises every day,” explained Green.

Green is hoping to create summer “magic camps” for disabled children in both the U.K. and Israel, and will further investigate the benefits of magic for improving motor development of children with disabilities.

Her initial research looked at a sample of nine children.

“We had a hunch that learning magic tricks could do wonders for kids” movement problems, but we wanted to see if the kids would actually practice them,” said Green.

The children practiced ten minutes a day over four to six weeks, resulting in a significant and measurable change in motor skills. “It was a big enough effect to make us want to marry the concept of magic with more specific treatment regimes important for motor learning,” added Green.

In the next part of the study, Green will bridge the worlds of behavioural therapy with science. She plans not only to give a large group of U.K. and Israeli kids intensive magic training to help improve their motor skills, but also to look into their brains to see if there is a neurological effect.

“We”ll be using functional MRIs to see how extensive practice — using the magic tricks as motivators — affects centres in the brain. Having information from the MRI can help us see what works, and for how long a treatment regime will need to be carried out to have sustained changes,” said Green. (ANI)

New drug kills cancer like a vampire slayer

Washington, Sept 18 (ANI): Scientists at Tel Aviv University have developed a novel drug that delivers anti-cancer compounds straight to the tumour.

Lead researcher Dr. Ronit Satchi-Fainaro believes that the new invention may alleviate particularly malicious forms of cancers like osteosarcomas and bone metastases and combat resistance to anti-cancer drugs like Taxol, keeping other normal healthy cells around the tumor safe.

Most of us have small tumors in our body at all times. They start the size of a pinhead and usually remain at that size as dormant and asymptomatic tumors. Then, at some point, cancer cells proliferate and the tumor grows in mass.

At that point the tumor cells migrate to the bones and start recruiting blood vessels using a chemical attractant in order to draw blood for their continued growth in a process called angiogenesis.

The researchers looked into the chemical that causes the blood, or endothelial cells, to gravitate to the activated, newly malignant cancer cells.

According to Satchi-Fainaro, the innovative drug delivery system delivers compounds like Taxol known to stop blood vessel growth to cancerous tumors.

She bound existing cancer drugs to an inert polymer that doesn’t react with the immune system.

“Like a stealth airplane,” she says, the polymer passes through the body’s defense system unnoticed.

Then, programmed to find the tumour using the bisphosphonate drug Alendronate, a drug that binds to bones, the carrier delivers its cancer-killing payload.

The study conducted over animal models, found that the researchers were able to reverse the growth of bone cancer tumors.

In a second study, she found that loading her polymer with the anti-cancer drug Taxol could inhibit tumour growth by 50pct, compared to a Taxol dose that had no effect on tumour growth at all.

The study is published is published in prestigious journals Angewandte Chemie and PLoS One. (ANI)

Scientists give evolutionary explanation for fertility problems

Washington, September 9 (ANI): While environmentalists blame pollution and psychiatrists people’s stressful lifestyles for fertility problems in about 10 per cent of all couples hoping for a baby, Tel Aviv University researchers have now come up with a different suggestion.

Dr. Oren Hasson, an evolutionary biologist in the university’s Department of Zoology, says that the reproductive organs of men and women are currently involved in an evolutionary arms race, and the fight is yet not over.

“The rate of human infertility is higher than we should expect it to be. By now, evolution should have improved our reproductive success rate. Something else is going on,” says Dr. Hasson.

The researchers combined empirical evidence with a mathematical model, and came to the conclusion that the bodies of men and women have become reproductive antagonists, not reproductive partners.

Writing in the journal Biological Reviews, Dr. Hasson points out that, over thousands of years of evolution, women’s bodies have forced sperm to become more competitive, rewarding the “super-sperm” – the strongest, fastest swimmers – with penetration of the egg.

The researcher further states that men, in response, are over-producing these aggressive sperm, producing many dozens of millions of them to increase their chances for successful fertilization.

However, according to Dr. Hasson, these evolutionary strategies demonstrate the Law of Unintended Consequences as well.

“It’s a delicate balance, and over time women’s and men’s bodies fine tune to each other. Sometimes, during the fine-tuning process, high rates of infertility can be seen. That’s probably the reason for the very high rates of unexplained infertility in the last decades,” the researcher said.

Dr. Hasson says that the unintended consequences have much to do with timing.

The researcher says that the first sperm to enter and bind with the egg triggers biochemical responses to block other sperm from entering.

This blockade is necessary because a second penetrating sperm would kill the egg, adds the researcher.

However, says Dr. Hasson, in just the few minutes it takes for the blockade to complete, today’s over-competitive sperm may be penetrating, terminating the fertilization just after it’s begun.

Women’s bodies, too, have been developing defences to this condition, known as “polyspermy”.

“To avoid the fatal consequences of polyspermy, female reproductive tracts have evolved to become formidable barriers to sperm. They eject, dilute, divert and kill spermatozoa so that only about a single spermatozoon gets into the vicinity of a viable egg at the right time,” says Dr. Hasson.

The researcher notes that any small improvement in male sperm efficiency is matched by a response in the female reproductive system.

“This fuels the ‘arms race’ between the sexes and leads to the evolutionary cycle going on right now in the entire animal world,” the researcher says.

According to Dr. Hasson, sperm have also become more sensitive to environmental stressors like anxious lifestyles or polluted environments.

“Armed only with short-sighted natural selection, nature could not have foreseen those stressors. This is the pattern of any arms race. A greater investment in weapons and defences entails greater risks and a more fragile equilibrium,” Dr. Hasson argues.

He says that infertile marriages can be stressful, but unlike birds, humans have the capacity for rational thinking.

He advises infertile couples to openly communicate about all their options, and seek counselling if necessary. (ANI)

New discovery hints ancient Egypt and Israel had ties during Early Bronze Age

Jerusalem, Sept 2 (ANI): The discovery of a rare, four-centimeter-long stone fragment at the point where the Jordan River exits Lake Kinneret, has suggested a link between ancient Egypt and Israel around 3,000 BCE during the Early Bronze Age.

According to a report in the Jerusalem Post, Tel Aviv University (TAU) and University College London archeologists found the fragment.

The piece, part of a carved stone plaque bearing archaic Egyptian signs, was the highlight of the second season of excavations at Tel Bet Yerah (Khirbet el-Kerak). he site lies along an ancient highway that connected Egypt to the wider world of the ancient Near East.

The dig, carried out within the Beit Yerah National Park, was completed there last week by a joint team headed by TAU’s Raphael Greenberg and David Wengrow from England.

Earlier discoveries, both in Egypt and at Bet Yerah, have indicated that there was direct interaction between the site – then one of the largest in the Jordan Valley – and the Egyptian royal court.

The new discovery suggests that these contacts were of far greater local significance than had been suspected.

The archeologists noted that the fragment, which depicts an arm and hand grasping a scepter and an early form of the ankh sign, was the first artifact of its type ever found in an archaeological site outside Egypt.

It has been attributed to the period of Egypt’s First Dynasty, at around 3000 BCE.

Finds of this nature are rare even within Egypt itself, and the signs are executed to a high quality, as good as those on royal cosmetic palettes and other monuments dating to the origins of Egyptian kingship.

This year’s excavations also provided new insights into contacts between the early town and the distant north, when large quantities of “Khirbet Kerak Ware” (a distinctive kind of red/black burnished pottery first found at Tel Bet Yerah) were found in association with portable ceramic hearths, some of them bearing decorations in the form of human features.

“The hearths are very similar to objects found in Anatolia and the southern Caucasus, and most were found in open spaces where there was other evidence for fire-related activities,” noted Greenberg.

“The people using this pottery appear to have been migrants or descendants of migrants, and its distribution on the site, as well as the study of other cultural aspects, such as what they ate and the way they organized their households, could tell us about their interaction with local people and their adaptation to new surroundings,” he added. (ANI)

Novel device to wash away bedsores, chronic ulcers

Washington, Aug 27 (ANI): Researchers at Tel Aviv University have developed a unique device, called Dermastream, which could heal bedsores and chronic ulcers in bedridden elderly and infirm.

When ill, such people are prone to painful and dangerous pressure ulcers, and diabetics are susceptible to wounds caused by a lack of blood flow to the extremities.

“The problem is chronic,” said Prof. Amihay Freeman of TAU’s Department of Molecular Microbiology and Biotechnology.

And thus, he developed Dermastream, that uses a solution to whisk away dead tissue, bathing the wound while keeping dangerous bacteria away.

The device provides an enzyme-based solution that flows continuously over the wound, offering an alternative treatment to combat a problem for which current treatments are costly and labour-intensive.

Freeman said that Dermastream has already passed clinical trials in Israeli hospitals and may be available in the U.S. within the next year.

Dermastream employs a special solution developed at Freeman’s TAU laboratory, thus offering a new approach to chronic wound care- a specialty known as “continuous streaming therapy.”

“Our basic idea is simple. We treat the wound by streaming a solution in a continuous manner. Traditional methods require wound scraping to remove necrotic tissue. That is expensive, painful and extremely uncomfortable to the patient.

And while active ingredients applied with bandages on a wound may work for a couple of hours, after that the wound fights back. The bacteria build up again, creating a tedious and long battle,” said Freeman.

Dermastream “flows” under a plastic cover that seals the wound, providing negative pressure that promotes faster healing.

The active biological ingredient, delivered in a hypertonic medium, works to heal hard-to-shake chronic wounds.

Freeman said that while traditional bandaging methods may take months to become fully effective, Dermastream can heal chronic wounds in weeks.

Dermastream is intended for use in hospitals, nursing homes, outpatient clinics and homecare.

Freeman has founded a company that is currently collaborating with a Veterans Association hospital in Tucson, AZ, to bring the technology to the U.S. market.

“My solution helps doctors regain control of the chronic wound, making management more efficient, and vastly improving the quality of their patients’ lives,” concluded Freeman. (ANI)

Crying can strengthen personal relationships

Washington, Aug 25 (ANI): While crying is known to be a symptom of physical pain or stress, it has emotional benefits too and can make interpersonal relationships stronger, says a Tel Aviv University evolutionary biologist.

Dr. Oren Hasson of TAU’s Department of Zoology says that his analysis shows that while tears do signal physiological distress, they can also function as an evolution-based mechanism to bring people closer together.

“Crying is a highly evolved behavior. Tears give clues and reliable information about submission, needs and social attachments between one another. My research is trying to answer what the evolutionary reasons are for having emotional tears,” Dr. Hasson said.

“My analysis suggests that by blurring vision, tears lower defences and reliably function as signals of submission, a cry for help, and even in a mutual display of attachment and as a group display of cohesion,” he reports,” Dr. Hasson added.

His research investigates the different kinds of tears we shed – tears of joy, sadness and grief – as well as the authenticity or sincerity of the tears.

Dr. Hasson says crying has unique benefits among friends and others in our various communities.

Approaching the topic with the deductive tools of an evolutionary biologist, Dr. Hasson investigated the use of tears in various emotional and social circumstances.

Tears are used to elicit mercy from an antagonistic enemy, he claims. They are also useful in eliciting the sympathy – and perhaps more importantly the strategic assistance – of people who were not part of the enemy group.

“This is strictly human. Emotional tears also signal appeasement, a need for attachment in times of grief, and a validation of emotions among family, friends and members of a group,” Dr. Hasson said.

The study has been published recently in Evolutionary Psychology. (ANI)

MRI methods can show bone marrow stem cells’ viability as brain-repairing therapy

Washington, August 20 (ANI): Researchers at Tel Aviv University have offered new hope for people with incurable neurodegenerative diseases like Huntington’s, Alzheimer’s, and Parkinson’s by showing that the viability of stem cells created from a patient’s own bone marrow can be determined using MRI tracking methods.

Dr. Yoram Cohen, of TAU’s School of Chemistry, claims that he has been able to track the progress of the innovative cells called mesenchymal stem cells within the brain.

He says that initial studies indicate that it is possible to identify unhealthy or damaged tissues, migrate to them, and potentially repair or halt cell degeneration.

“By monitoring the motion of these cells, you get information about how viable they are, and how they can benefit the tissue. We have been able to prove that these stem cells travel within the brain, and only travel where they are needed. They read the chemical signalling of the tissue, which indicate areas of stress. And then they go and try to repair the situation,” he says.

During the study, Dr. Cohen and his colleagues tracked the activity of the live cells within the brain using the in-vivo MRI at the Strauss Centre for Computational Neuro-Imaging, with a view to establishing their viability as a therapy for neurodegenerative disease.

The researchers used magnetic iron oxide nanoparticles to label the stem cells, so that they could be identified as clear black dots on an MRI picture after being injected into the brain.

The stem cells were then injected into the brain of an animal that had an experimental model of Huntington’s disease, which suffered from a similar neuropathology as the one seen in human patients.

On MRI, it was possible to watch the stem cells migrating towards the diseased area of the brain.

“Cells that go toward a certain position that needs to be rescued are the best indirect proof that they are live and viable. If they can migrate towards the target, they are alive and can read chemical signalling,” says Dr. Cohen.

He believes that the benefits of using differentiated mesenchymal cells (MSC) may be numerous.

“Bone marrow-derived MSCs bypass ethical and production complications, and in the long run, the cells are less likely to be rejected because they come from the patients themselves. This means you don’t need immunosuppressant therapy,” he says.

Dr. Cohen has revealed that the next step in his research will be to develop a real-life therapy for those suffering from neurodegenerative diseases.

A researcher article on his study has been published in the journal Stem Cells. (ANI)

New video “perfection tool” to locate terrorists and identify suspects in crime scenes

Washington, July 1 (ANI): A team of scientists has developed a new video “perfection tool” to help investigators enhance raw video images to locate terrorists and identify suspects in crime scenes.

Professor Leonid Yaroslavsky of Israel’s Tel Aviv University (TAU) and his colleagues have developed the new technology.

Commissioned by a defense-related company to improve what the naked eye cannot see, the tool can be used with live video or with recordings, in color or black-and-white.

“This enhancement of resolution can be a critical factor in locating terrorists or identifying criminal suspects,” said Yaroslavsky.

The new invention enhances the resolution of raw video images from security cameras, military binoculars, and standard personal-use video cameras, improving the quality at which the images were originally recorded or transmitted.

This can mean the difference between “seeing” trees blowing in the wind and finding a terrorist hiding in those trees.

“Our video perfection tool works to improve visual quality and achieving a higher resolution of the video image,” said Yaroslavsky.

“Once a commercial partner is found, the device can be integrated into existing technology within a matter of months,” he said.

A major challenge in video analysis is that images of objects become distorted over long distances due to variations in the air that can affect our sight and the “sight” of a camera.

In the language of optical science, this is known as a “turbulent atmosphere.”

A critical image of a person or object can become unstable and almost impossible to identify with any amount of accuracy.

The TAU team exploited the fact that most parts of a video scene remain still.

While there are moving objects such as people, animals or vehicles, a major part of the video ? the background-does not move at all.

Using specially designed algorithms, the team built a software application that lets cameras and video analysis equipment stabilize images, allowing objects that are really moving to be distinguished from chaotic atmospheric changes.

“The technology will increase the odds of identifying suspects in court, but its civilian applications are equally significant,” said Professor Yaroslavsky.

Instead of sending large video files over the Internet, smaller and lower-resolution files could be sent, to be enhanced at their destination points. This could save bandwidth and time.

“It’s quite a new approach to video perfection,” said Yaroslavsky. (ANI)

Novel implant coating technique created

Washington, June 30 (ANI): An electrochemical process for coating metal implants which vastly improves their functionality, longevity and integration into the body has been developed by a Tel Aviv University researcher.

Brainchild of Prof. Noam Eliaz of the TAU School of Mechanical Engineering, the new process could vastly improve the lives of people who have undergone complicated total joint replacement surgeries so they can better walk, run and ultimately avoid rejection of the implant by their bodies.

“The surface chemistry, structure and morphology of our new coatings resemble biological material,” explains Prof. Eliaz.

“We’ve been able to enhance the integration of the coating with the mineralized tissue of the body, allowing more peoples’ bodies to accept implants,” the expert added.

His new coating resulted in a 33 percent decrease in the level of materials failure, or delamination, in these implants.

Prof. Eliaz presented his findings to the 215th meeting of the Electrochemical Society in San Francisco in May 2009. (ANI)

How cornflakes, white bread, French fries raise heart attack risk

Washington, June 26 (ANI): Exactly how cornflakes, white bread, French fries and other high-carb foods increase the risk of heart problems has now been shown by Tel Aviv University researchers.

Dr. Michael Shechter of the university’s Sackler School of Medicine and the Heart Institute of Sheba Medical Center, who led the study in collaboration with researchers from the Endocrinology Institute, looked inside the arteries of students eating a variety of foods, and visualised exactly what happens inside the body when the wrong foods for a healthy heart are eaten.

He found that foods with a high glycemic index distended brachial arteries for several hours.

Elasticity of arteries anywhere in the body can be a measure of heart health. But when aggravated over time, a sudden expansion of the artery wall can cause a number of negative health effects, including reduced elasticity, which can cause heart disease or sudden death.

Dr. Shechter used used a clinical and research technique pioneered by his laboratory in Israel to visualize what happens inside our arteries before, during and after eating high carb foods.

“It’s very hard to predict heart disease,” says Dr. Shechter, a fellow of the American College of Cardiology and the American Heart Association.

“But doctors know that high glycemic foods rapidly increase blood sugar. Those who binge on these foods have a greater chance of sudden death from heart attack. Our research connects the dots, showing the link between diet and what’s happening in real time in the arteries,” he added.

The researcher believes that the finding of his study may lead to a whole new way to show patients the effects of a poor diet on the body.

During the study, 56 healthy volunteers were divided into four groups. One group ate a cornflake mush mixed with milk, a second a pure sugar mixture, the third bran flakes, while the last group was given a placebo (water).

Over four weeks, Dr. Shechter applied his method of “brachial reactive testing” to each group. The test uses a cuff on the arm, like those used to measure blood pressure, which can visualize arterial function in real time.

Dr. Shechter revealed that before any of the patients ate, arterial function was essentially the same. He further said that after eating, except for the placebo group, all had reduced functioning.

He said that enormous peaks indicating arterial stress were found in the high glycemic index groups: the cornflakes and sugar group.

“We knew high glycemic foods were bad for the heart. Now we have a mechanism that shows how. Foods like cornflakes, white bread, french fries, and sweetened soda all put undue stress on our arteries. We’ve explained for the first time how high glycemic carbs can affect the progression of heart disease,” says Dr. Shechter.

During the consumption of foods high in sugar, there appears to be a temporary and sudden dysfunction in the endothelial walls of the arteries.

Endothelial health can be traced back to almost every disorder and disease in the body.

“(It is) the riskiest of the risk factors,” says Dr. Shechter, who practices at the Chaim Sheba Medical Center – Tel Hashomer Hospital, where he offers a treatment that can show patients – in real time – if they have a high risk for heart attacks.

Dr. Shechter recommends sticking to foods like oatmeal, fruits and vegetables, legumes and nuts, which have a low glycemic index.

He also says that exercising every day for at least 30 minutes is an extra heart-smart action to take.

The results of the study have been published in the Journal of the American College of Cardiology. (ANI)

Soon, a breath mint made from coffee

Washington, June 25 (ANI): A coffee extract can inhibit the growth of bacteria that leads to bad breath, according to a new research from Tel Aviv University.

New laboratory tests have shown that the extract prevents malodorous bacteria from making their presence felt – or smelt.

“Everybody thinks that coffee causes bad breath and it’s often true, because coffee, which has a dehydrating effect in the mouth, becomes potent when mixed with milk, and can ferment into smelly substances,” says breath specialist Prof. Mel Rosenberg of TAU’s Sackler Faculty of Medicine.

But that is not always true. “Contrary to our expectations, we found some components in coffee that actually inhibit bad breath,” Rosenberg added.

In the laboratory, the researchers monitored the bacterial odour production of coffee in saliva.

In the study, three different brands of coffee were tested: the Israeli brand Elite coffee, Landwer Turkish coffee, and Taster’s Choice.

Rosenberg expected to demonstrate the malodour-causing effect of coffee in an in vitro saliva assay developed by Dr. Sarit Levitan in his laboratory. To his surprise, the extracts had the opposite effect.

“The lesson we learned here is one of humility. We expected coffee would cause bad breath, but there is something inside this magic brew that has the opposite effect,” Rosenberg.

Rosenberg would love to isolate the bacterial-inhibiting molecule in order to reap the biggest anti-bacterial benefits from coffee.

According to researchers, the new study could be the foundation for an entirely new class of mouthwash, breath mints and gum.

Purified coffee extract can be added to a breath mint to stop bacteria from forming, stopping bad breath at its source, instead of masking the smell with a mint flavour, the authors said.

The findings were presented to members of the International Society for Breath Odour Research in Germany. (ANI)

Coming soon, a joystick to treat “lazy eyes” in kids

Washington, June 23 (ANI): Children suffering from lazy eye syndrome may soon get rid of the ugly eye patch, courtesy a new computer therapy developed by researchers from Tel Aviv University.

Traditional treatment for amblyopia also known as lazy eye syndrome requires the use of an eye patch, often for months at a time, before the eye is corrected.

This, according to the researchers, can lead to social stigma during a formative part of childhood; moreover it’s not 100 pct effective.

Dr. Uri Polat, Tel Aviv University’s eye and brain specialist has developed a computer therapy that could spare kids from the ugly eye patch, letting them enjoy themselves during therapy.

And, this treatment, currently available for adults only, corrects the activity of the neurons in the brain, the main operator of eye function.

The study showed that twenty hours in front of Dr. Polat’s computer treatment had the same effect as about 500 hours of wearing an eye patch.

In new treatment, special and random objects appear, keeping the patient constantly alert and expecting the unexpected.

However, the researchers have now collaborated with gaming specialists from Rochester University for developing a version of the therapy for kids.

“You see these poor kids in kindergarten wearing the patch. Everyone hates it, especially the parents who know what it’s doing to their kid’s self-esteem,” said Dr. Polat.

“As far as I know this is really a one-of-a-kind, non-invasive and effective way to treat lazy eye, without the use of an embarrassing eye patch.

“This is probably the first treatment that attempts to correct lazy eyes in adults, something that doctors had previously given up on. Doctors don’t suggest intervention after the age of nine, because it usually doesn’t work,” he Polat added.

The review was published recently in Vision Research. (ANI)

Cancer-causing Ras protein may help fight its own malign effects

Washington, June 19 (ANI): Scientists at Tel Aviv University (TAU) in Israel have found that a cancer-causing protein can also help fight tumours it causes. he researchers have shown that an oncogene called Ras-which can cause normal cells to be come cancerous when mutated or expressed in high concentrations-has the power to heal as well as harm.

Ph.D. student Oded Rechavi and his fellow researchers at the university’s Department of Neurobiology have found that Ras has the ability to transfer from cancer cells into immune cells – such as T-cells – a transfer that may be the key to creating new drugs to fight cancerous tumours.

Revealing their findings in the journal Public Library of Science One and a recent review about such cell-to-cell transferring of proteins in FEBS Letters, the researchers say that the idea that proteins can transfer between cells challenges the original theory of the cell.

“All the energy flow, metabolism, and biochemistry of life is supposed to happen within the boundaries of an individual cell. Here we show that when cells in the immune system interact with other cells, proteins are exchanged without being secreted from the cell, and act in both the immune and original cells alike,” Rechavi said.

“When Ras transfers from one cell to another, it strengthens the immune system. The immune cell that adopts the mutated Ras gets activated and reacts against the cancerous cell that donated the Ras. This does not happen for advanced tumors, but if we could control the movement of Ras, we would have a better understanding of how immune cells react against cancer,” he added.

This, according to the researcher, might provide the scientific basis for an entirely new class of cancer drugs.

The TAU researchers are trying to discover the mechanisms whereby the Ras protein is transferred, and their initial findings seem to be promising.

Rechavi is investigating a current theory that the membranes of the cells temporarily fuse together. What is certain, however, is that once T-cells acquire mutated Ras, they are able to generate clones with the ability to respond against this specific threat.

“When immune cells scan their targets they bind to their targets. When immune cells acquire normal Ras, nothing happens. But when they acquire mutated Ras from a potential tumor, it starts a cascade. This results in the production of cytokines that help the immune system and act against the cancer,” he said.

According to him, understanding the nature of this interaction between mutated Ras and immune T-cells can unlock mysteries about the nature of proteins and cells.

He has revealed that the next step will be to identify other proteins that, like Ras, are able to transfer outside of their cell of origin. (ANI)