First transgenic mouse created to mimic Parkinson’s earliest symptoms

Washington, May 4 (ANI): Researchers have created the first transgenic mouse to display the earliest signs of Parkinson’s disease using the genetic mutation that is characteristic of human forms of the disease.

The mouse model, which expresses the same mutant proteins as human Parkinson’s patients, also displays early signs of constipation and other gastrointestinal problems that are a common harbinger of the disease in humans.

Thus, researchers at University of California, San Francisco (UCSF) have said that these animals could serve as a means of investigating therapies for reversing the neurological dysfunction of the disease at its earliest stages.

For a long time, researchers have suspected that the neurological component of Parkinson’s, which causes tremors and stiffness among other symptoms, is actually a late-stage effect of a larger, systemic problem, says Dr. Robert L. Nussbaum, senior author on the paper.

“This new model validates that theory by mimicking what we know to be the genetic pathway leading to Parkinson’s, while also displaying the earliest symptoms that occur in humans. This will give us an important tool in identifying an early intervention for this devastating disease,” said Nussbaum.

The UCSF mouse model is the first to display the full gastrointestinal symptoms as well, and is consistent with the progression of the disease in humans.

The study has been published in the latest issue of the journal, ‘Human Molecular Genetics’. (ANI)

Key Crows to front Carlton

Adelaide duo Patrick Dangerfield and Kurt Tippett have been cleared of injury and will play against Carlton on Saturday.

The key Crows suffered injuries last weekend but proved their fitness at training on Friday to front the Blues at Football Park.

Dangerfield spent two nights in a hospital after injuring his neck and Tippett hurt his left ankle in Adelaide’s loss to Melbourne last Sunday.

“Both Tippett and Dangerfield at this stage are going to play, unless something happens between now and tomorrow,” Crows coach Neil Craig said on Friday.

“Patrick feels really well – no soreness, no stiffness, no headaches. He has run the last three days and trained this morning and did some competitive work out there.

“He’s been cleared medically so he’s confident to play.”

Craig confirmed 19-year-old Phil Davis will become the fourth Crow in four matches to make his AFL debut, replacing injured centre-half back Nathan Bock (hamstring).

Defensive dasher Graham Johncock also returns for a Crows side seeking their first victory of the season against the Blues, who have dumped senior duo Bret Thornton and Jarrad Waite, whose comeback from a knee reconstruction has stalled.

“We thought Bret’s form had been below par for a player of his ability and what he had produced over the years, so he has gone back to get a little bit of form at the VFL level,” Carlton coach Brett Ratten said on Friday.

“With Jarrad, it was more that maybe our expectations were a fraction high.

“His timing and things like that, he just went under a few high balls and he was just out a little bit, so we thought it would be good for him to go back as well and get the ball in his hands, take a few marks and get that timing back.

“Both players are very important to us and the quicker we can get them into form, the more that it will help us.”

The 10th-placed Blues, with one win from three starts, welcomed back skipper Chris Judd from suspension and utility Jeff Garlett for their first games this season, and have also named Simon White for his AFL debut.

Osteoarthritis tied to unequal length of leg

Washington, Apr 1 (ANI): Arthritis in the knee is linked to the common trait of having one leg that is longer than the other, claims a new study.

Developing early strategies for treatment may be possible, believes Derek Cooke, Queen”s University adjunct professor and a co-author of the study.

“Most pediatricians adopt a ”wait and see” attitude for children with limb misalignment when they”re growing,” says Dr. Cooke. “If we can spot factors creating changes in alignment early in bone development, theoretically we could stop or slow down the progression of osteoarthritis.”

To reach the conclusion, data was collected using x-ray images from more than 3,000 adults aged 50 to 79 who either had knee pain or risk factors for knee osteoarthritis as a part of the Multi Centre Osteoarthritis Study (MOST). Subjects were reassessed after a 30-month period and the researchers found that osteoarthritic changes in the knee were most significant in individuals with pronounced (more than 1 cm) leg length inequality, the shorter leg being most affected.

Leg length inequality is difficult to detect. A small leg length differential – 1 cm or less – can be corrected with a shoe insert, while a bigger one can be corrected with surgery. But because the condition often goes undiagnosed, many people don”t realize they have a leg length differential until they”re diagnosed with osteoarthritis.

Arthritis in the knees can cause pain, swelling and stiffness, and limit mobility. (ANI)

Nacre, mother of pearls, can now be mass-produced

Washington, Mar 26 (ANI): If you thought getting a natural pearl was a matter of chance, then here’s some news for you— artificial nacre, or mother of pearl, can now be mass-produced and that too at the cost of manufacturing paper.

Flameproof yet flexible, thinner than office paper but 20 times as strong, the new material could eventually make aircraft lighter and comfortably protect police from bullets.

“Natural nacre is this perfect marriage of stiffness, strength and toughness,” Discovery News quoted Andreas Walther, a researcher at the Helsinki University of Technology and a co-author of the paper.

“Our artificial nacre compares very well to the natural material,” he added.

Synthetic nacre has long been a goal for both material scientists and biologists.

In case of material scientists, man-made nacre could provide strong, lightweight, cheap and environmentally friendly material for a huge variety of products.

For biologists, synthetic nacre would provide a new way to study the complex mesh of soft protein and hard calcium carbonate that mollusks use as protection and women as decoration.

While artificial nacre has been produced before, but in small, labour-intensive amounts, said Walther.

Aiming to reduce those hundreds of steps down to one, the researchers drew on the Scandinavian nations” experience in the wood processing and paper making industry, and mixed hard clay particles and a soft, binding synthetic polymer.

The two materials are attracted to each other and arrange themselves in alternating layers.

When drawn out like paper, square feet of artificial nacre emerges in minutes.

One layer of the new nacre looks like paper but is thinner, stronger, and stiffer than paper.

However, the new nacre lacks one quantity—toughness. It tears more readily than paper, said Walter.

But, the new nacre is impervious to heat.

Synthetic nacre could be glued to a surface, or even painted on a wall, to make it flameproof.

The new nacre also blocks oxygen, making it ideal for use in electronics.

The study has been published in the journal Nano Letters. (ANI)

Laser-based processes may help create better artificial joints, arterial stents

Washington, September 16 (ANI): Scientists hope that laser-based processes may help create arterial stents and longer-lasting medical implants 10 times faster, and less expensively.

Yung Shin, a professor of Mechanical Engineering and director of Purdue’s Center for Laser-Based Manufacturing, stresses the need for new technologies to meet the huge global market for artificial hips and knees, insisting that the worldwide population of people younger than 40 who receive hip implants is expected to be 40 million annually by 2010, and double to 80 million by 2030.

Besides speeding production to meet the anticipated demand, Shin says that another goal is to create implants that last longer than the ones that are made presently.

“We have 200,000 total hip replacements in the United States. They last about 10 years on average. That means if you receive an implant at 40, you may need to have it replaced three or four times in your lifetime,” he said.

In one of their techniques, the researchers deposit layers of a powdered mixture of metal and ceramic materials, melting the powder with a laser and then immediately solidifying each layer to form parts.

Shin says that, given that the technique enables parts to be formed one layer at a time, it is ideal for coating titanium implants with ceramic materials that mimic the characteristics of natural bone.

“Titanium and other metals do not match either the stiffness or the nature of bones, so you have to coat it with something that does. However, if you deposit ceramic on metal, you don’t want there to be an abrupt change of materials because that causes differences in thermal expansion and chemical composition, which results in cracks. One way to correct this is to change the composition gradually so you don’t have a sharp boundary,” Shin said.

The gradual layering approach is called a “functionally gradient coating”.

The researchers have revealed that they used their laser deposition processes to create a porous titanium-based surface and a calcium phosphate outer surface, both designed to better match the stiffness of bone than conventional implants.

The laser deposition process enables researchers to make parts with complex shapes that are customized for the patient.

“Medical imaging scans could just be sent to the laboratory, where the laser deposition would create the part from the images. Instead of taking 30 days like it does now because you have to make a mold first, we could do it in three days. You reduce both the cost and production time,” Shin said.

According to the researchers, the laser deposition technique lends itself to the requirement that each implant be designed specifically for each patient.

“These are not like automotive parts. You can’t make a million that are all the same,” Shin said.

He says that the process creates a strong bond between the material being deposited and the underlying titanium, steel or chromium.

The researcher further reveals that tests have shown that the bond is at least seven times as strong as industry standards require.

Using computational modelling, the researchers simulate, study and optimise the processes.

The researchers, however, admit that more studies are required before the techniques are ready for commercialisation.

They have revealed that their future work will involve studying “shape-memory” materials that are similar to bone and also have a self-healing capability for longer-lasting implants.

They are also working on a technique that uses an “ultra short pulse laser” to create arterial stents, which are metal scaffolds inserted into arteries to keep them open after surgeries to treat clogs.

Since the laser pulses last only a matter of picoseconds, or quadrillionths of a second, they do not cause heat damage to the foil-thin stainless steel and titanium material used to make the stents.

The laser removes material in precise patterns in a process called “cold ablation”, which turns solids into a plasma. The patterns enable the stents to expand properly after being inserted into a blood vessel. (ANI)

‘Earthquake cloaks’ may one day make buildings invisible to devastating tremors

London, June 27 (ANI): Let alone hiding persons or objects from prying eyes, future invisibility cloaks may even conceal buildings from the devastating effects of earthquakes, if physicists in France and the UK are to be believed.

Stefan Enoch of the Fresnel Institute in Marseille, France, is the researcher behind the “earthquake cloak” idea.

A research team led by Enoch has for the first time suggested that the physics of invisibility cloaks may one day enable scientists to design a cloak that could render objects “invisible” to destructive storm waves or tsunamis.

The seismic waves of an earthquake fall into two main groups: body waves that propagate through the Earth, and surface waves that travel only across the surface.

While controlling body waves will be too complex, Enoch’s team say that controlling surface waves is within the ability of conventional engineering.

Team member Sebastien Guenneau, associated with the UK-based University of Liverpool, says that the finding attains significance as it is surface waves that are more destructive.

The researchers have revealed that the new theoretical cloak comprises a number of large, concentric rings made of plastic fixed to the Earth’s surface.

They say that the stiffness and elasticity of the rings must be precisely controlled to ensure that any surface waves pass smoothly into the material, rather than reflecting or scattering at the material’s surface.

According to them, while travelling through the cloak, waves are compressed into tiny fluctuations in pressure and density that travel along the fastest path available.

The researchers believe that by tuning the cloak’s properties, that path can be made to be an arc that directs surface waves away from an area inside the cloak. When the waves exit the cloak, they return to their previous, larger size.

Unlike some of the optical invisibility cloaks studied in recent years, the new cloak is “broadband” and thus can divert waves across a range of frequencies.

The research group say that this becomes possibly by tuning different rings of the cloak to incoming waves of different frequencies. Waves pass largely unaffected through rings not tuned to their frequency.

“The outer rings remain nearly still, but the pair of rings tuned to the frequency of the wave move like crazy, bending up and down and twisting. For each small frequency range, there’s one pair of rings that does most of the work,” New Scientist magazine quoted Guenneau as saying.

Thus far, the researchers have simulated cloaks containing as many as 100 rings, even though fewer would be needed to protect against the most common kinds of earthquake surface waves.

As to how this technique can be applied to buildings, Guenneau says that they may be built into the foundations.

Even though work remains to be done to replicate the theoretical results experimentally, physicist Ulf Leonhardt at the University of St Andrews, UK, thinks that it is possible that invisibility physics may see its first real world applications of in guiding seismic or ocean waves rather than to manipulate light.

“I think this is fantastic – I really like taking ideas that have emerged from optics and using them in other applications,” he said.

A research article describing the “earthquake cloak” idea has been published in the journal Physical Review Letters. (ANI)

Shane Watson’s injury casts shadow over his Ashes chances

Melbourne, June 23 (ANI): The Ashes prospects of injury-plagued Australian all rounder Shane Watson have become bleak after he was too sore to train with the team in England today.

Medical staff is monitoring Watson closely, after he complained of general stiffness and was confined to the team rooms during a training session at Brighton.

“I pulled up a little bit stiff from training yesterday so I sat out of today’s training. We are just monitoring things – that’s the way it has been with me for the last couple of years,” Watson said.

While the latest injury concern may not prove to be serious, it is a major concern that Watson was sidelined today less than three weeks before the first Ashes Test in Cardiff starting on July 8, The Australian reports.

Watson had only recently returned from back stress fractures, before breaking down with a groin strain during Australia’s one-day series against Pakistan in the Middle-East.

The 27-year-old only returned to the bowling crease during Australia’s ill-fated Twenty20 World Cup campaign in England.

The latest setback is the last thing he needed, as he tries to win his baggy green cap back from incumbent all rounder Andrew McDonald.

Australia will fine-tune its Ashes preparations when it plays a four-day tour match against Sussex starting in Brighton tomorrow. (ANI)

Rheumatoid arthritis patients face equal risk from Type 2 Diabetes, heart disease

Rheumatoid arthritis patients face equal risk from Type 2 Diabetes, heart diseaseWashington, People with rheumatoid arthritis may be as much at risk of cardiovascular disease as that of type 2 diabetes, according to a new study.

Rheumatoid arthritis (RA) is a chronic disease that causes pain, stiffness, swelling, and limitation in the motion and function of multiple joints. Apart from joints, RA can also cause inflammation in other organs as well.

While people with RA have long been known to be susceptible to cardiovascular disease, this is the first study to compare this risk with the risk of developing type 2 diabetes.

In the study, researchers measured the frequency of fatal and nonfatal cardiovascular disease in 335 RA patients followed for three years, as compared to 1,852 people in the general population.

The researchers observed that cardiovascular disease occurred in nine percent of patients with RA and among 4.3 percent of the general population— i. e. the incidence of
3.30 people per 100 people per year for those with RA, and 1.51 people per 100 people per year for those in the general population.

Patients with type 2 diabetes and non-diabetic patients with RA have similar risk ratios for developing cardiovascular disease (2.02 and 2.22, respectively), as compared the general population,

The researchers concluded that the risk of cardiovascular disease is not only high in people with RA as compared to the general population, but it equals that of people with type 2 diabetes.

“This investigation reveals that the cardiovascular risk in RA equals that of type 2 diabetes, a well established cardiovascular risk factor for which cardiovascular risk management is mandatory. Hence, cardiovascular risk management is also necessary for RA,” explained Michael T. Nurmohamed, MD, PhD; rheumatologist and epidemiologist; VU University Medical Center.

The study was presented at the American College of Rheumatology Annual Scientific Meeting in San Francisco, California. (ANI)