Earth bacteria may contaminate Martian environs

Washington, April 28 (ANI): Scientists are expressing fears that some bacteria common to spacecrafts may even survive on Mars and contaminate the Red Planet”s environment.

The search for life on Mars remains a stated goal of NASA”s Mars Exploration Program and Astrobiology Institutes.

To preserve the pristine environments, the bioloads on spacecraft headed to Mars are subject to sterilization designed to prevent the contamination of the Martian surface.

Despite sterilization efforts made to reduce the bioload on spacecraft, recent studies have shown that diverse microbial communities remain at the time of launch.

The sterile nature of spacecraft assembly facilities ensures that only the most resilient species survive, including acinetobacter, bacillus, escherichia, staphylococcus and streptococcus.

Researchers from the University of Central Florida replicated Mars-like conditions by inducing desiccation, hypobaria, low temperatures, and UV irradiation.

During the week-long study they found that Escherichia coli a potential spacecraft contaminant, may likely survive but not grow on the surface of Mars if it were shielded from UV irradiation by thin layers of dust or UV-protected niches in spacecraft.

The scientists said: “If long-term microbial survival is possible on Mars, then past and future explorations of Mars may provide the microbial inoculum for seeding Mars with terrestrial life.

“Thus, a diversity of microbial species should be studied to characterize their potential for long term survival on Mars.”

The study has appeared in the April 2010 issue of the journal Applied and Environmental Microbiology. (ANI)

New air filter system can destroy up to 99.9 per cent of bugs on aircraft

London, September 16 (ANI): British researchers have developed an air filter system that destroys up to 99.9 per cent of infectious viruses and bacteria as well as pollutants that can circulate in the confines of an aircraft, especially on long-haul flights.

According to a report in The Times, the machine has been developed by aerospace giant BAE Systems, in collaboration with Quest International, a small company based in Cheadle, South Manchester, UK.

The device, called AirManager, uses a controlled electric field to filter out and destroy any airborne particles or germs as they pass through an aircraft’s air conditioning system, emitting only clean, sterilized air.

After four years of development and tests, BAE says it has received its first orders from a major European airline and announced the technology is also being considered for use in NHS hospitals as a way to stop the spread of “superbugs” such as MRSA and Clostridium difficile.

The air on board a passenger jet must be pressurized in order for passengers to be able to breathe, but scientists and lobby groups have previously claimed that passengers can be exposed to toxins as a result of the “bleed air” system that is used to redirect air from the engines to the cabin and cockpit.

Air inside the cabin is then circulated and re-circulated up to 30 times an hour, far more than in conventional air conditioning systems, meaning that infectious viruses and bacteria can quickly spread.

Unlike conventional filters, which are designed to sieve out particles from the air as it passes through perforated barriers at high speed, David Hallam, an engineer and founder of Quest International, said that the AirManager used an “avalanche of electrons” emitted in a closed electric field to break down and destroy the atomic structure of any pollutants or germs.

“This works with swine flu, avian flu, norovirus, MRSA, even a modified form of anthrax,” Hallam said.

Hallam said that he originally designed the “close coupled field” in the late 1990s to rid nursing homes of biological odours caused by bacteria.

But, the filter was later found to have an effect in reducing the airborne transmission of bacteria such as MRSA (methicillin-resistant Staphylococcus aureus) and Clostridium difficile.

BAE Systems expressed interest in the technology four years ago for use on aircraft and the system was recently tested on the flight deck and cabin air systems of Boeing 757 and Avro RJ passenger jets by five European airlines, with successful results. (ANI)

Mozart ‘killed by superbug like MRSA, not poison’

London, Aug 18 (ANI): Austrian composer Wolfgang Amadeus Mozart was killed by a bacterial infection akin to MRSA, claim Dutch researchers.

Mozart died at age 35 – young by even 18th century standards. His untimely death has remained a mystery ever since he passed away in the early hours of 5 December 1791.

Some claimed he was poisoned, others said he simply wore himself out by composing more than 600 pieces during his short life.

Now, a group of boffins has suggested that he died from a bacterial infection spread by soldiers which was rife in Vienna at the time, reports The Telegraph.

The researchers, who studied the city’s death register, found that the three most common causes of death among men of his age were tuberculosis, severe weight loss and a condition called ‘oedema’ or ‘dropsy’ – an accumulation of fluids causing the body to swell up.

And, Mozart’s symptoms match the last of the three, according to Dr Richard Zeger, from the Academic Medical Centre in Amsterdam, who said it could have been caused by a bacterial infection.

He said: “I think you can compare this to a superbug like MRSA or C.difficile.”

Mozart’s sister-in-law Sophie Haibel, who saw him days before he died, said he was covered in a rash – consistent with a bacterial infection – and severely swollen – consistent with oedema or dropsy.

At the time Vienna was full of soldiers from the Austro-Turkish war who had been struck down by disease.

Zeger said: “Austria was at war at the time so people were living in a bad condition and most of the deaths were among soldiers. You can see there was clearly an epidemic and we found that it started in a military hospital. There was some kind of inflammatory disease that almost everyone contracted and some people died. It was an epidemic of oedema, which is a collection of fluid.

“When your kidneys fail, they can’t secrete body fluids so fluid accumulates in your body, which causes people to swell up and get worse and worse.”

This kind of a condition could have been caused by being infected with bacteria from the Staphylococcus aureus (SA) family, or which MRSA is a more recent member.

“Mozart’s body had swollen up so badly he was not able to turn around any more in his bed, showing he had post-streptococcal complications,” said Zeger.

In those times, antibiotics like penicillin were nowhere present, so strictly speaking the bacteria would not have been a ‘super’ bug as it could not have developed any resistance in the way that methicillin-resistant Staphylococcus aureus (MRSA) has done.

Zeger postulated: “We still see the streptococcal infection today in close communities like schools and armies so that would be a good reason behind the epidemic.

“In Mozart’s time, several soldiers in the army were also musicians who might have performed in Vienna, where Mozart might have contracted it.” (ANI)

Genetic mapping shows how staph infections disrupt immune system

Washington, July 14 (ANI): Researchers have used genetic mapping to explain how the human immune system is programmed to respond to Staphylococcus aureus infections.

Infectious disease specialists at UT Southwestern Medical Center have mapped the gene profiles of children with severe S. aureus infections, to see how the pathogen alters the human immune system.

The findings of the study could open new doors for improved therapeutic interventions.t has long been unknown how the host’s immune system responded to S. aureus infection, and why some individuals are more vulnerable towards severe staphylococcal infections than others.

“The beauty of our study is that we were able to use existing technology to understand in a real clinical setting what’s going on in actual humans – not models, not cells, not mice, but humans. We have provided the first description of a pattern of response within an individual’s immune system that is very consistent, very reproducible and very intense,” said Dr. Monica Ardura, lead author of the study.

The immune system consists of two components- the innate system, which provides immediate defense against infection, and the adaptive system, whose memory cells are called into action to fight off subsequent infections.

During the study, the researchers extracted ribonucleic acid from a drop of blood, and placed it on a special gene chip called a microarray, which probes the entire human genome to determine which genes are turned on or off.

It was found that in children with invasive staphylococcal infections, the genes involved in the body’s innate immune response are overactivated while those associated with the adaptive immune system are suppressed.

“It’s a very sophisticated and complex dysregulation of the immune system, but our findings prove that there’s consistency in the immune response to the staphylococcus bacterium. Now that we know how the immune system responds, the question is whether we can use this to predict patient outcomes or differentiate the sickest patients from the less sick ones. How can we use this knowledge to develop better therapies?” said Ardura.

The researchers used blood samples collected between 2001 and 2005 from 77 children – 53 hospitalized at Children’s Medical Center Dallas with invasive S. aureus infections and 24 controls.

Ardura claimed that more research was needed because the results represented a one-time snapshot of what’s going on in the cell during an invasive staphylococcal infection.

The researchers are now hoping to understand better how various staph-infection therapies affect treatment.

The study is available online in PLoS One, the Public Library of Science’s online journal. (ANI)

‘Nano-sized assassins’ for bacterial infections in implant patients created

Washington, June 27 (ANI): Researchers have created what they call ‘nano-sized assassins’ to kill bacteria responsible for infections in implant patients.

From catheters to prosthetics, the bacteria called Staphylococcus epidermidis are known to hitch a ride on a range of medical devices implanted into patients.

According to researchers, iron-oxide nanoparticles have been shown to eliminate a bacterial infection on an implanted prosthetic device.

Inside the body, the bacteria multiply on the implant’s surface and then build a slimy, protective film to shield the colony from antibiotics.

Webster and Brown graduate student Erik Taylor have created a nano-sized headhunter that zeroes in on the implant, penetrates S. epidermidis’s defensive wall and kills the bacteria.

The study showed that 28 percent of the bacteria on an implant had been eliminated after 48 hours by injecting 10 micrograms of the nanoparticle agents.

The same dosage repeated three times over six days destroyed essentially all the bacteria.

The tests show “there will be a continual killing of the bacteria until the film is gone,” said Webster, who is editor-in-chief of the peer-reviewed journal in which the paper appears.

The finding is published in the International Journal of Nanomedicine. (ANI)

How superbugs control their lethal weapons

Toronto, May 25 (IANS) Some superbugs have seemingly evolved the ability to manipulate the immune system to their advantage.

A team of researchers from the University of Western Ontario, led by Joaquin Madrenas of the Robarts Research Institute, has discovered some processes that reduce the lethal effects of toxins from superbugs, allowing humans and microbes to co-evolve.

This discovery may lead to novel alternatives to antibiotics that specifically target the toxic effects of these superbugs.

Madrenas holds a Canada Research Chair in Immunobiology and is a professor of microbiology and immunology, and Medicine at the Schulich School of Medicine and Dentistry at Western.

Staphylococcus (staph) aureus is the leading cause of infections in hospitals and the second most common cause of infections in the general population.

By itself, it is linked to more than half a million hospital admissions a year in North America with estimated costs of more than $6 billion per year.

Among the many weapons produced by this superbug, the most potent and lethal ones are known as super-antigens. These lethal weapons cause massive and harmful activation of the immune system that leads to Toxic Shock Syndrome (TSS).

TSS is a very serious disease that carries a high mortality, for which we do not have a specific treatment. Scientists have been puzzled as to why, when the body is directly exposed to the TSS toxins, a human can die within hours whereas those carrying toxin-producing staph do not get sick or die.

What has the staph bug got that prevents the immune system of the host from being kicked into high gear? Madrenas and his collaborators at Western, Calgary and Chicago have identified the process that allows the bug to stay in the body without causing that massive activation of the immune system, according to an Ontario release.

“It is clear that staph superbugs have developed strategies to control the toxicity of its lethal superantigen toxins, thereby preventing TSS,” said Madrenas.

Based on these studies, Madrenas and colleagues have developed a computer model that will help predict the outcomes of encounters between staph and a host, and will reveal new aspects of these encounters.

The findings are being published in Nature Medicine and are available online.

Light-activated antibacterial coating may help fight hospital-acquired infections

Washington, Mar 31 (ANI): Scientists at the UCL Eastman Dental Institute have developed a new tool to combat hospital-acquired infections- antibacterial coating that is activated by light.

The research team, led by Zoie Aiken, have tested the new coating with antibacterial properties, and found that it could kill 99.9 percent of Escherichia coli bacteria when a white hospital light was shone on its surface to activate it.

Made of titanium dioxide with added nitrogen, the veneer-like surface, when activated by white light-similar to those used in hospital wards and operating theatres-produced a decrease in the number of bacteria surviving on the test surface.

The hospital environment is usually full of microbes responsible for healthcare-associated infections (HCAI).

Thus, there’s a need for new ways to prevent the spread of these pathogens to patients.

And it is possible to apply antibacterial coatings to frequently touched hospital surfaces to kill any bacteria present and help reduce the number of HCAI.

Titanium dioxide based coatings can kill bacteria after activation with UV light.

And the addition of nitrogen to these coatings enables photons available in visible light to be utilised to activate the surface and kill bacteria.

Aiken said: “The activity of the coating will be assessed against a range of different bacteria such as MRSA and other organisms which are known to cause infections in hospitals. At present we only know that the coating is active against Escherichia coli. However, E. coli is more difficult to kill than bacteria from the Staphylococcus group which includes MRSA, so the results to date are encouraging.

“The coating has currently been applied onto glass using a method called APCVD (atmospheric pressure chemical vapour deposition.

“We are also experimenting with different materials such as plastic. As an example, the coating could be applied to a plastic sheet that could be used to cover a computer keyboard on a hospital ward. The lights in the ward will keep the coating activated, which will in turn continue to kill any bacteria that may be transferred onto the keyboard from the hands of healthcare workers.”

The study was presented at the Society for General Microbiology meeting in Harrogate. (ANI)

Tea tree oil, silver combo can make for effective antiseptics

Washington, Mar 30 (ANI): A combination of tea tree oil and silver can make for an effective antiseptic for skin wounds, says a new study.

The research team led by Wan Li Low from the University of Wolverhampton showed that mixing tea tree oil and silver (in the form of silver nitrate) or putting them in liposomes, (small spheres made from natural lipids), greatly increases their antimicrobial activity and minimise side effects.

During the study, the researchers found that low concentrations of two agents significantly increased their antimicrobial activity.

They focused on bacteria such as Staphylococcus aureus and the yeast Candida albicans, which cause skin infections.

To reach the conclusion, researchers used microscopic spherical bodies called liposomes, made of phospholipids, the naturally occurring lipids or fats in the cell wall membranes, to deliver the silver and tea tree oil mix to infected wounds.

This lead to a controlled release and therefore, a potential to use lower, less toxic, concentrations of the antimicrobial agents to treat infected wounds.

It can also be used for treating antibiotic resistant strains such as MRSA.

Current treatments using traditional silver-based creams and dressings use relatively high metal concentrations.

The creams containing lower amounts of the agents could provide safer and readily available over-the-counter antiseptic compounds for effective treatment without damaging the surrounding skin.

The findings are to be presented at the Society for General Microbiology meeting in Harrogate. (ANI)

Infection control strategies for antibiotic-resistant organisms in hospitals

Washington, Mar 16 (ANI): Hand-washing, a clean environment, appropriate infection barriers, and early identification of patients at high risk of colonization with a transmissible microorganism are some of the infection control strategies adopted by hospitals for antibiotic-resistant organisms.

A review of the control strategies has revealed the above measures after looking at the most effective methods, and the supporting evidence to control hospital infection.

Risk factors associated with colonization of antibiotic-resistant microorganisms include increasing age of patient and severity of disease, increasing length of hospital stay, admission to an intensive care unit, and proximity to patients carrying an antimicrobial-resistant organism.

Use of broad-spectrum antibiotics and/or prolonged use of antibiotics are also risk factors.

Methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile (C.difficile), and vancomycin-resistant enterococci are the most common antimicrobial-resistant pathogens.

Resistance is more prevalent in hospital-acquired infections compared to community-acquired infections.

The detailed review is published in the latest issue of CMAJ. (ANI)