Scientists developing 3-in-1 ”dipstick’ test for early detection of parasitic diseases

Washington, March 23 (ANI): Scientists are trying to develop a 3-in-1 ”dipstick” test for early detection of parasitic diseases such as Chagas” disease, leishmaniasis, and African trypanosomiasis (sleeping sickness).

Most cases of these diseases are identified at a late stage, and together they cause tens of thousands of deaths each year and untold suffering. The drugs used to treat late-stage infections are often toxic and have potentially fatal side effects.

Ellen Beaulieu, a medicinal chemist in the Center for Infectious Diseases in the Biosciences Division of SRI International in Menlo Park, Calif., said: “Early diagnosis is the key to improving treatment of these diseases.

“Diagnosis with conventional tests is difficult in developing countries where these diseases occur. We hope that our low-cost, simple test will play a role in helping poorer parts of the world combat these diseases and the poverty they engender.”

The new test exploits the common heritage of the parasites that cause Chagas, leishmaniasis, and African sleeping sickness. All three are closely related members of what scientists know as the trypanosomatidae family. Working together with Mary Tanga, Senior Director of Medicinal Chemistry in SRI”s Biosciences Division, Beaulieu and colleagues developed special dyes that allow detection of an early disease stage. Moreover, the test does not require the use of sophisticated lab equipment, and can produce results in as little as one hour.

Initial tests under laboratory conditions show that the dyes reveal the presence of the parasite marker and glow in ultraviolet light from a simple, handheld lamp. SRI researchers are now trying to improve the sensitivity of the dyes.

The goal is to develop a “dipstick” test that allows detection of the parasite metabolite using a simple paper strip like those used in urine tests for diabetes. Such a test could allow health workers in remote areas to diagnose the diseases by dipping the strip in a drop of blood and exposing it to ultraviolet light.

The test was described at the 239th National Meeting of the American Chemical Society. (ANI)

Researchers operate biomedical robots from different locations worldwide via Internet

Washington, September 18 (ANI): Experts from the University of Washington and SRI International have jointly developed a new software protocol, to standardize the way biomedical robots are managed over the Internet.

Nine research teams from universities and research institutes around the world recently made a successful demonstration of biomedical robots operated from different locations in the U.S., Europe, and Asia with the help of the ‘Interoperable Telesurgical Protocol’.

In a 24-hour period, each participating group connected over the Internet, and controlled robots at different locations.

The tests performed demonstrated how a wide variety of robot and controller designs can seamlessly interoperate, allowing researchers to work together easily and more efficiently.

The demonstration also evaluated the feasibility of robotic manipulation from multiple sites, and was conducted to measure time and performance for evaluating laparoscopic surgical skills.

“Although many telemanipulation systems have common features, there is currently no accepted protocol for connecting these systems. We hope this new protocol serves as a starting point for the discussion and development of a robust and practical Internet-type standard that supports the interoperability of future robotic systems,” said SRI’s Tom Low.

The protocol is expected to allow engineers and designers that usually develop technologies independently, to work collaboratively, determine which designs work best, encourage widespread adoption of the new communications protocol, and help robotics research to evolve more rapidly.

Its early adoption may encourage robotic systems to be developed with interoperability in mind, and avoid future incompatibilities.

“We’re very pleased with the success of the event in which almost all of the possible connections between operator stations and remote robots were successful. We were particularly excited that novel elements such as a simulated robot and an exoskeleton controller worked smoothly with the other remote manipulation systems,” said Professor Blake Hannaford of the University of Washington. (ANI)

Scientists detect giant atmospheric waves using auroras like flashlights

Washington, May 27 (ANI): Scientists, using auroras like flashlights, have exposed giant atmospheric waves crashing just above Earth that can endanger satellites.

When strong winds crash into mountains or large atmospheric disturbances such as thunderstorms and hurricanes, the “explosion” sends invisible “shock waves” of air rippling outward in all directions at hundreds of miles an hour.

The atmospheric waves can travel hundreds of miles upward into the highest reaches of the atmosphere. There, they crash against the ionosphere like surf breaking on a beach.

But instead of stopping at the “beach,” the atmospheric waves spur smaller, weaker waves inside the ionosphere that generate heat.

This heat in turn creates electrical disturbances that can affect the motions and functions of satellites.

According to a report in National Geographic News, the giant air ripples have been detected before, but never so precisely or so far into the atmosphere.

The breakthrough comes courtesy of a new radar system called the Advanced Modular Incoherent Scatter Radar, recently installed near the North Pole in Alaska and Canada.

There, the system has a front-row seat for the aurora borealis, or northern lights.

Auroras flicker into being when charged particles from the sun strike Earth’s magnetic field and are funneled to the Poles, where the particles interact with the atmosphere to colorful effect.

By tracing an aurora’s charged particles, the new radar system can paint a better picture of the invisible atmospheric waves.

“The radar has the ability to take a three-dimensional snapshot of the waves,” said study author Michael Nicolls, an atmospheric scientist at SRI International, an independent, nonprofit research institute in California.

“From that, we can figure out which direction the waves are propagating and we can gain knowledge of where and how they are depositing their energies,” he added.

According to Nicolls, those insights could lead to better understanding of space weather and its effects on Earth systems such as power grids as well as GPS and other forms of satellite communications. (ANI)

Now, artificial muscles to restore wink and smile

Washington, Mar 12 (ANI): People who lose control over their facial muscles have now got a new lease of life, for scientists have now developed a technique that could restore their ability to wink, and eventually may help them smile by implanting an artificial muscle in their temple.

Developed at the University of California, Davis and SRI International, the technique has shown promising results on cadavers.

The researchers say that the novel technique may eventually help living people suffering from stroke, Mobius Syndrome, or battlefield injuries gain control over the muscles in their face.

“The concept is very exciting; thousands of people could benefit from this. Theoretically it could have a wide range of applications if it turns out to be useful,” Discovery News quoted Wayne Larabee, a surgeon and editor of the Archives of Facial Plastic and Reconstructive Surgery, as saying.

One can lose the ability to control facial muscles in many ways-while those with Mobius Syndrome, are born without the ability to make facial expressions, others have facial tumours removed, and lose the nerve that extends out of the brain near the ear and spreads out on the face.

One of the most common and aesthetically pleasing options to restore a wink is to embed a small 1.2-gram, chip of gold in the eyebrow. The weight of the gold works to pull the eye closed, rather than relying on muscle.

Other surgical options include transplanting an entire section of muscle, nerve, artery and vein and sewing it to the face or co-opting the jaw muscle to pull the eye closed. Both give faster control but look unnatural and have safety risks.

“Our goal was to find a way to reanimate the face while minimizing the risk to patients,” said Travis Tollefson, a surgeon at UC-Davis, who along with Craig Senders, have successfully tried the technique in human cadavers and gerbils.

For their study, the researchers began with the same incisions that would implant a gold chip into the upper eyelid, but instead of gold, they implanted a “sling” of Gore-Tex, the same waterproof and breathable fabric commonly found in outdoor pants and jackets.

Then the surgeons placed another sling at the lower eye by using the same incision for a lower eyelid reduction. Both slings are anchored by the nose, and attached to an artificial muscle hidden in the temple.

The artificial muscle used for the technique was three-layered and consisted of a soft acrylic or silicon centre sandwiched between two layers of charged, FDA-approved black silicon.

When an electric current passes through the silicon it draws the two outer layers together, squishing the soft inner layer into four to five times its original size. This draws the sling back and closes the eye.

A similar set up could be used to draw up the corners of the mouth into a smile. (ANI)