Dame Julie Andrews” fans demand refund after O2 gig

London, May 10 (ANI): Call it a major setback for the septuagenarian singer-actress but some fans of Dame Julie Andrews are demanding a refund after her much-awaited musical show at London O2 Arena last weekend turned out to be “a car crash of musical theatre”.

Several of the 10,000 audience members had walked out of the gig by the interval, with some even calling for a refund.

Although the concert had been advertised as “An Evening With Julie Andrews”, her backing group did almost all of the singing.

Dame Julie, 74, sang in full only a handful of numbers, disappeared from the stage for large chunks of the show, and concluded the performance by reading aloud from a children”s book she co-wrote with her daughter.

Staging her first concert in Britain after 30 years, Dame Julie had warned fans that her voice had not fully recovered from a botched throat operation in 1997.

However, some fans who shelled out up to 140pounds for a ticket to the O2 show were unsympathetic.

“The evening was a complete sham. She ”sang” for about 30 seconds in the first hour by which time we were so outraged we went to attempt to get a refund. Considering how the excitement and anticipation held by most of the audience, it is heartbreaking to now have a tainted view of Dame Julie,” the Telegraph quoted one commenter on an online review, as writing.

A reader of the West End Whingers theatre blog wrote: “We were six rows from the front, and were disappointed to see that every word she spoke, came from the cue cards below, stripping out any spontaneity from the experience.”

Even critics have panned Dame Julie.

Mark Shenton, who writes reviews for entertainment mag The Stage, said: “I”ve seldom seen so many walkouts during the course of a show, and the pace only accelerated in the second act.

“Not since an arena stage production of Ben-Hur last year staged a series of intentional chariot crashes here have I witnessed such an unintentional pile-up of car-crash musical theatre.” (ANI)

Scientists identify promising compound to treat epilepsy

Washington, May 5 (ANI): Scientists have identified a new anticonvulsant compound, called paxilline, which may cease the progression of epilepsy, a neurological disorder marked by abnormal electrical activity in the brain that leads to recurring seizures.

The study by Carnegie Mellon University researchers is based on a previous work in which scientists identified a specific molecular target whose increased activity is linked with seizure disorders- a potassium channel known as the BK channel.
“We have found a new anticonvulsant compound that eliminates seizures in a model of epilepsy,” said Alison Barth, associate professor of biological sciences at Carnegie Mellon’s Mellon College of Science.

She added: “The drug works by inhibiting ion channels whose role in epilepsy was only recently discovered. Understanding how these channels work in seizure disorders, and being able to target them with a simple treatment, represents a significant advance in our ability to understand and treat epilepsy.” he researchers found that after a first seizure, BK channel function was markedly enhanced.

Thus, the neurons became overly excitable and were firing with more speed, intensity and spontaneity, which led the researchers to believe that the abnormal increase in the activity of the channels might play a role in causing subsequent seizures and the emergence of epilepsy. n the current study, the researchers tested this theory by blocking the ion channels using a BK-channel antagonist called paxilline.

Using an experimental model for epilepsy, Barth tested whether paxilline could reduce or prevent experimentally induced seizures, as it could normalize aberrant brain activity induced by previous seizures.

And to their surprise, the researchers discovered that the compound was effective at completely blocking subsequent seizures. The drug is orally available, and works in the low nanomolar range,” said Barth.

As the drug is effective in low concentrations and can be taken as a pill, it could turn out to be an especially promising compound for treatment in epilepsy patients.

The researchers believe that targeting the BK channels and the abnormal brain activity that they induce might one day be used as a way to prevent the progression of seizure disorders over time, thus attacking the root cause of epilepsy.

The findings have been published in the current issue of the journal Epilepsia. (ANI)

Working at your relationship all year round only way to keep the flame alive

Washington, Feb 11 (ANI): With Valentine’s Day drawing closer, the air is filled with love. However, a leading psychiatrist has said that people shouldn’t wait for February 14 to tell their partners how much they care for them.

Dr. Catherine Birndorf, clinical associate professor of psychiatry at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, said that Valentine’s Day should serve as a reminder to devote time and energy to your relationship every day.

“Most people don’t realize a relationship is effortful and not static. It’s a dynamic evolution,” she said.

She added: “A genuine interest and curiosity about your partner is essential-take the care and make the time to keep up with him or her.”

Birndorf even came out with a few tips to help keep the fire burning between couples.

She suggested that one should let the past repeat itself. Recall favourite memories of times spent together and try to find similar activities. Whether it’s a nice dinner out, a night at the theatre, a day spent walking around town or a vacation, think about some of your best times together and create opportunities for them.

Take time out. Try to connect at least once a day, and set aside quality time once a week to do something you both enjoy.

Be a thoughtful gift giver. The best gifts aren’t the most expensive ones, but the ones that really say “I know you well” and make the other person feel special. Go the extra mile-beyond flowers and candy-to get something that is really unique to your partner.

Give in once in a while. On special occasions, let your partner choose something he or she enjoys but you may not. You may be surprised how good it feels to give selflessly and end up having a great time.

Share your thoughts. Leave a note for your partner in the morning, send a flirty text message or e-mail, or leave a sweet voicemail when you know he or she is away from the phone. These tiny acts of appreciation are sure to brighten your partner’s day.

Schedule in sex. In today’s world, you can’t always expect spontaneity. Make a date for sex and be strategic-schedule play dates for the kids or set an alarm for the early morning. Having it on the schedule will give you something to look forward to and may allow the excitement to build around it.

Never underestimate the power of a compliment. Taking a moment to tell your partner that he or she looks nice today can go a long way. Allowing him or her to start the day with an extra confidence boost will make you feel good, too. (ANI)

Carla Bruni had ‘one of those typical midlife things’ on 40th birthday’s eve

London, Jan 9 (ANI): France’s first lady Carla Bruni was as freaked out as any other woman when it came to turning 40 recently.

The model-turned-singer-songwriter had what she calls “one of those typical midlife things” on the eve of her birthday in December 2007, reports the Daily Express.

“It suddenly hit me that 40 is a symbol of adult life and at the time I really wasn’t an adult,” she says.

“It made me lose my balance a bit, as I realised I had to be an adult,” the stunner added.

“I love spontaneity and I’m a very passionate person,” she tells Psychologies magazine.

“Although I’ve grown up a lot, I hope I will always hold on to that childlike sense of wonder,” she concluded. (ANI)