Senator urges release of sunscreen chemical data

(Reuters) – A senator on Sunday called on the FDA to reveal findings on a possible link between a chemical found in most sunscreens and skin cancer.

U.S. | Politics | Health

The U.S. Food and Drug Administration has been reviewing data from several studies on a potential link between retinyl palmitate (RP), a common sunscreen additive and cases of skin cancer, since July 2009, but has yet to issue any rulings or guidelines, Senator Charles Schumer said.

“With the recent reports suggesting a possible link between skin cancer and a common chemical found in sunscreens, the FDA must act now to protect consumers,” Schumer said at a news conference and in a later statement.

“Summer is here, people are soaking up the sun and the FDA needs to immediately provide guidance and reassurance to consumers,” the New York Democrat added.

The FDA’s National Center for Toxicological Research (NCTR) and the National Toxicology Program (NTP) have conducted studies that suggest a possible link between skin cancer and retinyl palmitate, Schumer said in calling for the FDA to provide its evaluation of the data and recommendations immediately.

He also pressed the agency for a time line for new sunscreen regulations.

Retinyl palmitate, a vitamin A derivative, is found in hundreds of the most popular sunscreen products.

One study found that tumors and lesions developed up to 21 percent faster in lab animals coated in retinyl palmitate-laced cream than animals treated with a cream that did not contain RP, Schumer’s office said.

(Reporting by Chris Michaud, Editing by Cynthia Osterman)

Radiation from full-body airport scanners may increase cancer risk

Melbourne, May 19 (ANI): Scientists in the U.S. have issued a warning that radiation from controversial full-body airport scanners could lead to an increased risk of skin cancer – particularly in kids.

David Agard, University of California biochemist, said that unlike other scanners, the radiation from these devices is delivered at low energy beam levels, with most of the dose concentrated in the skin and underlying tissue.

“While the dose would be safe if it were distributed throughout the volume of the entire body, the dose to the skin may be dangerously high,” News.com.au quoted Agard as saying.

“Ionizing radiation such as the X-rays used in these scanners have the potential to induce chromosome damage, and that can lead to cancer,” Agard added.

Another major concern is that a failure in the device – like a power or software glitch – can lead to an intense radiation dose to a single spot on the skin. (ANI)

Addiction to tanning can be extremely dangerous

Washington, May 19 (ANI): Tanorexia, or an addiction to tanning, can be harmful, according to experts.

Dermatologists at Loyola University Health System claim tanning addictions, among young, white females, are a legitimate health problem.

According to a study published in the Journal of the American Academy of Dermatology, approximately 20 percent of 18 – 29 year-olds use indoor tanning booths.

Anthony Peterson, director, Department of Dermatology, Loyola University Health System, said: “When a person visits a tanning booth, the body releases endorphins. These chemicals produce the same feelings of euphoria that entice drug addicts and alcoholics.”

It also explains the reason indoor tanning business is booming. Thirty million Americans visit tanning salons each year despite the risk for wrinkles and the dangers of ultraviolet radiation.

Ultraviolet radiation causes approximately 90 percent of skin cancers, and the risk for melanoma increases by 75 percent if you tan indoors before age 35.

Peterson said: “Excessive tanning is a serious health concern in our society. We have to treat this like any other addiction and educate young women about its dangers to curb this behavior.”

In one such case, Amber Peterson, 31, used to visit tanning booths every alternate day for 10 years until she was diagnosed with the deadliest form of skin cancer at age 26.

Amber said: “I was addicted to tanning. I liked the look and feel of being tan, but it could have cost me my life. Despite the warnings, no one thinks that they are going to get skin cancer. I never thought that this would happen to me. I am just lucky to have survived.” (ANI)

Wart cream may help treat skin cancer

Melbourne, May 18 (ANI): A new study has discovered another beneficial use for wart cream – as a form of treatment for recurrent outbreaks of skin cancer.

The cream contains the potent allergen diphencyprone (DPCP), and it is being used in an ongoing trial to prompt a person”s immune system to attack melanomas, which have resisted conventional treatments.

Diona Damian, associate professor at the Sydney Cancer Centre used the wart medication on 18 patients and the results were positive as two-third of them experienced full clearance of their cancers.

“In about two-thirds of the patients treated so far we”ve been able to achieve complete clearance of their skin melanomas,”” News.com.au quoted Damian as saying.

“It is still considered an experimental agent even though we are relying on it more and more, mainly because these are patients who generally have no other option. They have nothing to lose – except their tumours,”” Damian added.

The results of the trial were presented at the Australasian College of Dermatologists Annual Scientific Meeting in Darwin this week. (ANI)

Wrinkles, not skin cancer risk, scare indoor tanners

Washington, May 18 (ANI): Young women were more likely to stay away from indoor tanning if they were warned that the practice could increase their risk of getting leathery, wrinkled skin, than being warned about risk of melanoma, the deadliest form of skin cancer, a study found.

The study found a 75 percent reduction in indoor tanning visits if girls were warned of skin deterioration and turning unattractive.

“They””re not worried about skin cancer, but they are worried about getting wrinkled and being unattractive,” said June Robinson, a professor of dermatology at Northwestern University Feinberg School of Medicine and senior author of the study.

The study examined the best strategy to wean college-age women who are considered addicted or pathological tanners from tanning salons.

“The fear of looking horrible trumped everything else. It was the most persuasive intervention, regardless of why they were going to tan,” said Robinson.

The research showed warning them about the effects on their appearance caused a 35 percent drop in their indoor tanning visits, which were measured at intervals up to six months after the intervention.

Joel Hillhouse, lead author of the paper, noted that some women in the study eventually stopped tanning.

“It was a progressive kind of thing. At first the women said they tried sunless tanning as an alternative, but over time they gave up tanning altogether,” he said.

Between 25 to 40 percent of older adolescent girls visit tanning salons, according to the study””s authors.

The study included 435 college women, ages 18 to 22, who visited tanning salons.

Within this population, researchers focused on women who visited salons up to four times a week – more than what is needed to maintain a tan – and who tanned for psychological reasons, not just for a special event.

These tanners included one group who strongly disliked the natural colour of their skin, which was related to a psychological condition called body dysmorphia.

“They thought their skin was disgusting when it was pale,” said Hillhouse.

The other group, who said tanning made them feel happier and more relaxed, showed symptoms of seasonal affective disorder (SAD) on a diagnostic psychological test.

“They were self medicating their own depression,” said Robinson, noting that lying in a tanning bed produces internal opioids.

The women received a 25-page booklet, authored by Hillhouse, that discussed the effect of tanning on appearance and explained how ultraviolet rays destroy collagen in the skin.

The booklet also offered many alternatives to meet the women””s needs for tanning, such as taking an exercise class for socializing and relaxation or getting a spray-on tan or self-tanning cream application at a spa.

After reading the booklet, the women reported their attitudes and behaviours twice a week in diaries.

The study results surprised researchers.

“The hypothesis was because this was an appearance intervention, it would have less of an effect on the people tanning for mood problems. We found the opposite. The intervention worked just as well for people with seasonal affective disorder as for people who didn””t like their skin color. That means it””s a really good intervention for everyone,” said Hillhouse.

Robinson stressed it was also important to offer women alternatives to tanning salons.

The study has been published in Archives of Dermatology. (ANI)

Scientific breakthrough could offer melanoma cure

London, May 16 (ANI): A long-awaited jab, being hailed as a scientific breakthrough which could offer a cure for cancer, is to be tested on the first British patients within weeks.

According to researchers, it can reverse and even cure melanoma, one of the deadliest forms of the disease, most commonly associated with skin cancer, reports The Daily Express.

Professor Lindy Durrant of Nottingham University, who is heading research into the treatment, said: “This is huge. We could now have a vaccine that can target a tumour and kill it without damage to surrounding healthy tissues or cells.

“In the short term, this could cure some patients with the disease and in the long term the jab could be used to prevent people developing it in the first place.”

Trials will begin at hospitals in Manchester, Nottingham and Newcastle.

Brainchild of vaccine company Scancell, the treatment will be given to patients with advanced skin cancer which has spread to other parts of the body, and also to those in the earlier stages of the disease. (ANI)

Too much driving may up skin cancer risk

Washington, May 8 (ANI): Too much driving may increase the risk of skin cancer, according to a new study.

Among a group of about 1,050 patients in Saint Louis, facial skin cancers were found to occur more often on the left-side — the side that”s next to the window while driving, reports Live Science.

What’s more, the findings were most significant for men.

“Drivers need to be aware of the amount of sun exposure they receive behind the wheel,” said study researcher Dr. Scott Fosko, chair of dermatology at Saint Louis University School of Medicine. “The cumulative effect of being exposed to the sun builds up over many years.”

“Professional drivers learn to wear proper safety equipment be it gloves, steel-toed boots or safety glasses when appropriate,” Fosko said. “Sunscreen should be added to the list. An ounce of sunscreen applied as prevention on the road can be worth a lot of time and expense parked in a doctor”s office later on.”

The study will be published in a forthcoming issue of the Journal of the American Academy of Dermatology. (ANI)

Skin cancer-treating prescription drug could boost effects of HIV vaccines

Washington, May 6 (ANI): A new weapon in the fight against hepatitis C and HIV is available in the form of a prescription drug, say researchers.

The drug already approved to treat genital warts and skin cancer can apparently boost the effectiveness of future vaccines for these bacterial and viral diseases.

John Pesce and colleagues at the Naval Medical Research Center and UC-Berkeley note that vaccines prepared from weakened or inactivated viruses or bacteria have had enormous success in preventing polio, influenza, and other diseases.

However, vaccines containing living or weakened viruses cannot be used for HIV, hepatitis C, and other devastating diseases due to safety concerns.

Scientists are instead trying to develop a new generation of vaccines, made with DNA or proteins from infectious agents that can prevent illness without carrying a risk of causing the diseases.

These vaccines will be weaker than conventional vaccines and require a new generation of ‘adjuvants,’ ingredients that boost a vaccine”s immunogenicity.

The report identifies a promising candidate in the form of imiquimod, an immune-boosting drug already in general use.

The scientists coated imiquimod with dextran-based microparticles in hopes of increasing the efficiency of cellular uptake by cells associated with immune response initiation.

Sure enough, the coated drug significantly boosted levels of inflammatory cytokines in laboratory cultures of immune cells from mice.

The findings have ‘broad significance’ and open the door to more extensive testing of the approach, they indicate.

These findings appear in ACS” Molecular Pharmaceutics, a bi-monthly journal. (ANI)

Govt defers solarium debate

The ACT Greens have attacked the Government for delaying their bill tightening restrictions on solariums.

The proposed laws would stop people under 18 and those with very fair skin from using solariums.

The Government has adjourned debate, saying it is planning to introduce national regulations.

Greens MLA Amanda Bresnan says that is a poor excuse.

“The national regulations have been promised for over two years, New South Wales and Victoria got sick of waiting, they went ahead with their own regulations and legislation,” she said.

“This is a preventative health measure ready to go but I don’t think it would have mattered what we put forward.

“The Government wouldn’t have supported it because they want to claim credit.”

Jordan’s hubby injects himself with cancer-related fake-tan drug

London, Apr 30 (ANI): Katie Price’s husband Alex Reid injects himself with a fake-tan drug, which is linked to cancer.

The recently married couple will be shocked to hear that regular use of Melanotan can lead to the killer disease.

And for Jordan, 31, it could be far more terrifying, for she has suffered her own cancer scare when she had a tumour removed from a finger.

Alex, 34, injects the drug straight into his stomach, meaning it gets into his bloodstream quickly.

However, Melanotan, which is only available on the Internet for around 25 pounds, is “untested and unlicensed”.

Its main ingredient was developed to guard against skin cancer, but medics believe that long-term use can cause the disease.

“It may give you a nice tan at the moment but we don’t know what kind of long-term effects it could have,” the Daily Star quoted Florence Palmer, from the Medicines and Healthcare Products Regulatory Service, as saying.

Alex’s habit came out via Celebrity Big Brother housemate Vinnie Jones, 45, who called it “weird”. (ANI)

Red-haired and freckly people most likely to use sunbeds

London, Apr 29 (ANI): Red-haired people with freckles are among the most likely to use sunbeds, it has been claimed.

Nina Goad, from the British Association of Dermatologists, said: ””People with very pale skin will never tan through UV exposure, they will only ever burn. If you are very pale and you want a tan, you will most likely find self tan products far more effective.

””Pale skinned people are also at far higher risk of skin cancer than other groups, so it is alarming that they are the most inclined to use sunbeds. This shows the pressure on pale skinned people to tan and the lengths that people will go to for a bronzed look.””

According to the survey of 1064 adults from across the UK, conducted for the British Association of Dermatologists, only one in four people who like to tan used cosmetic products to do so, reports The Telegraph.

Around 70 percent said they sunbathed while 4 percent used sunbeds.

””It is ironic that in trying to meet an ideal of beauty, people are actually seriously damaging their skin.”” said Goad. ””The truth is, to a greater or lesser extent according to skin type, sun exposure increases the risk of premature ageing, including wrinkles and sunspots, and more importantly potentially disfiguring or life-threatening skin cancer.””(ANI)

Breast milk may help beat cancer

Washington, Apr 20 (ANI): Researchers at Lund University and the University of Gothenburg, Sweden claim that a substance found in breast milk can kill cancer cells.

Although the special substance, known as HAMLET (Human Alpha-lactalbumin Made LEthal to Tumour cells), was discovered in breast milk several years ago, it is only now that it has been possible to test it on humans.

Patients with cancer of the bladder who were treated with the substance excreted dead cancer cells in their urine after each treatment, which has given rise to hopes that it can be developed into medication for cancer care in the future.

Lab experiments have shown that HAMLET kills 40 different types of cancer, and the researchers are now going on to study its effect on skin cancer, tumours in the mucous membranes and brain tumours. Importantly, HAMLET kills only cancer cells and does not affect healthy cells. (ANI)

No more surgeries for Dame Elizabeth Taylor

London, March 31(ANI): Actress Dame Elizabeth Taylor, who has fought brain tumour, heart failure, skin cancer, osteoporosis, among other problems, does not want to undergo any more operations, it has emerged.

The double Oscar-winner, suffering from crippling neck pain, has apparently told her family and friends that she can’t handle even one more surgery.

“She is adamant she can’t face another operation. Some mornings find her neck in such acute pain she is barely able to lift her head,” the Daily Express quoted a source as saying.

The insider added: “She spends most of the day sitting in a chair with her head on her shoulder. It must be hellish for her but she says she is more sick of seeing the inside of an operating theatre than anything else.”

The ‘Cleopatra’ actress has been facing health problems over the past 25 years.

She has been hospital more than 100 times and twice nearly died on the operating table during surgery on her back. (ANI)

Soybeans can provide safer sunscreens

Washington, Mar 24 (ANI): Say goodbye to that petroleum based sunscreen lotion and get ready to grab a bottle of a more natural sun-protecting product, which is made of soybean oil.

Scientists have developed a new method for converting soybean oil into a highly effective bio-based sunscreen active ingredient, called feruloyl soy glycerides (FSG), which does not carry the potential health concerns of ingredients in some existing sunscreens.

The new, natural sunscreen agent could replace petroleum-derived ingredients in a variety of personal-care products.

Dr. Joseph Laszlo, who headed the research, pointed out that sales of sunscreens and other skin-care products that protect against the damaging effects of ultraviolet (UV) light have been booming.

However, concerns have arisen over certain ingredients in today”s mainstay sunscreens.

“One, for instance, is a substance known as oxybenzone that is a suspected hormone disruptor that could contribute to the disruption of aquatic species reproduction. We”re trying to provide nature-inspired skin-care materials that avoid such health concerns and at the same time have fewer adverse environmental impacts,” said Laszlo.

Sunscreens are among the substances, termed “pharmaceuticals and personal care products (PPCPs),” that constitute a relatively new family of water contaminants with potential adverse health effects on wildlife and people.

Sunscreens protect against skin cancer by shielding the body from two types of UV light. One is UV-A, which absorbs deep in the skin and is linked to reactive oxygen species (ROS) formation. The other is UV-B, which causes sunburn.

Some sunscreen ingredients generate ROS when exposed to UV-A, which can damage DNA.

For a long time, the sunscreen industry focused on offering UV-B protection to prevent sunburn.

The researchers have developed technology for converting soybean oil into a biobased active ingredient for sunscreen products.

It involves incorporating ferulic acid, found naturally in hundreds of plants, into soybean oil.

The use of ferulic acid along with vegetable oil produces a water-resistant material capable of absorbing both UV- A and UVB light.

It can also be used as an anti-aging and anti-wrinkle product, Laszlo said.

FSG is produced commercially by iSoy Technologies Corporation and used in several cosmetic products in the U.S. and Asia.

“The skin ages not just from exposure to the sun but also from air pollutants and other environmental effects. We believe that this molecule (ferulic acid) could prevent some of the damage caused by the free-radical processes involved in those environmental exposures. That”s particularly important for preserving the integrity and health of skin tissue. The approach builds on knowledge that antioxidants consumed in the diet or applied topically can prevent some of that damage,” said Laszlo.

“Our findings support the hypothesis that FSG can protect sensitive cellular components and reduce the impacts of skin sun exposure. Our work also demonstrates how agricultural materials can be used to craft safe and useful consumer products,” he said.

The study was presented at the 239th National Meeting of the American Chemical Society (ACS). (ANI)

High dietary phosphate intake may increase skin cancer risk

Washington, March 24 (ANI): A new study by researchers at Emory University School of Medicine has shown that a high intake of phosphates can contribute to tumor growth in skin cancer.

In the study, the researchers applied dimethylbenzanthracene, a carcinogen found in cigarette smoke, to the skins of mice, followed by another chemical that stimulates cell growth.

Feeding these mice a high phosphate diet (1.2 percent by weight) increased skin papilloma number by 50 percent compared with a low phosphate diet (0.2 percent).

Skin papillomas are the initial stage of skin cancer development, which may progress to full carcinoma.

“This is a very well established model for the initiation and progression of cancer, and the effects of many physiological conditions on cancer initiation have been measured this way,” said senior author George Beck, assistant professor of medicine (endocrinology) and a member of the Winship Cancer Institute, Emory University.

The study has been published in the journal Cancer Prevention Research. (ANI)

Cancer genes switched off in humans

London, Mar 22 (ANI): For the first time, researchers have used short sequences of RNA that can effectively treat skin cancer in people by silencing specific genes behind tumour production.

Mark Davis from the California Institute of Technology in Pasadena and his colleagues have used the technique, called RNA interference (RNAi), to deliver particles containing such sequences to patients with the skin cancer melanoma.

When analysing biopsies of the tumours after treatment, they found that the particles had inhibited expression of a key gene, called RRM2, needed for the cancer cells to multiply.

The researchers created the particles from two polymers plus a protein that binds to receptors on the surface of cancer cells and pieces of RNA called small-interfering RNA, or siRNA, designed to stop the RRM2 gene from being translated into protein.

The siRNA works by sticking to the messenger RNA (mRNA) that carries the gene”s code to the cell”s protein-making machinery and ensuring that enzymes cut the mRNA at a specific spot.

When the components are mixed together in water, they assemble into particles about 70 nanometres in diameter.

The researchers can then administer the nanoparticles into the bloodstream of patients, where the particles circulate until they encounter ”leaky” blood vessels that supply the tumours with blood.

The particles then pass through the vessels to the tumour, where they bind to the cell and are then absorbed.

Once inside the cell, the nanoparticles fall apart, releasing the siRNA. The other parts of the nanoparticle are so small, they pass out of the body in urine.

“It sneaks in, evades the immune system, delivers the siRNA, and the disassembled components exit out,” Natrue quoted Davis as saying.

When researchers analysed tumour samples from three of the patients who volunteered samples, they found fragments of the mRNA in exactly the length and sequence they would expect from the design of their siRNA.

And in at least one patient, the levels of the protein were lower than they were in samples of the tumours taken before treatment.

They also found that patients who were given higher doses had higher levels of siRNA in their tumours.

“The more we put in, the more ends up where they are supposed to be, in tumour cells,” said Davis.

Davis says that by targeting specific genes he hopes these treatments will not have major side effects.

“My hope is to make tumours melt away while maintaining a high quality of life for the patients. We”re moving another step closer to being able to do that now,” he said.

The study has been published in Nature. (ANI)

Study casts doubts on safety of invisible nano-sunscreens

Melbourne, Mar 8 (ANI): While nano-sunscreens are considered very effective, a new Aussie modelling study has claimed that even the most effective nanoparticles in some invisible sunscreens might be the most toxic.

Dr Amanda Barnard of CSIRO Materials Science and Engineering in Melbourne carried out her computer simulation of titanium dioxide nanoparticles.

Nanoparticles are used to make some sunscreens transparent, increasing their appeal to some consumers.

“There”s a whole range of demographics that would never ever use sunscreens if they were ugly,” ABC Science quoted Barnard as saying.

“The transparent ones do increase usage and protection from skin cancer in certain demographics, so they do have an important function,” he added.

However, she said that many doubts have been raised about the safety of such sunscreens.

One particular concern is whether the nanoparticles interact with sunlight to produce free radicals that damage tissues or DNA.

Barnard”s computer model examined titanium dioxide nanoparticles from 3 to 200 nanometres in size.

“This is the size range that would generally be used in different types of sunscreens,” she said.

The model predicted the affect of nanoparticle size and concentration on sun-protection ability, transparency and potential to produce free radicals.

It was found that the size and concentrations of nanoparticles that gave the best transparency and sun protection also gave the highest potential for production of free radicals.

“Where we have the highest sun-protection factor – and it”s pretty – it [the sunscreen] is also toxic, potentially,” said Barnard.

She found that only particles less than 13 nanometres in size would minimise free radical production while maximising transparency and sun protection.

The study has been published in the latest issue of Nature Nanotechnology. (ANI)

Study shows link between vitamin D, skin cancer

Washington, Mar 5 (ANI): Researchers at Henry Ford and Wayne State University has explained a link between Vitamin D levels and basal cell carcinoma, a discovery which could lead scientists to better understand the development of the most common form of skin cancer.

In a small study, boffins found elevated levels of Vitamin D enzymes and proteins in cancerous tissue taken from 10 patients compared to normal skin tissue taken from them.

Previous studies have linked Vitamin D deficiency with certain cancers but this is believed to be the first time researchers looked at Vitamin D and basal cell carcinoma.

“This finding may help us in future research to determine whether vitamin D plays a causative or reactive role in the development and progression of skin cancer,” says Iltefat Hamzavi, M.D., senior staff physician in Henry Ford”s Department of Dermatology and the study”s lead author.

The study will be presented at the Photomedicine Society”s annual meeting in Miami, one day before the American Academy of Dermatology”s annual meeting.

Basal cell carcinoma is the most common form of skin cancer. This cancer forms in the basal cells of the deepest layer of the skin. Mohs micrographic surgery is one of the most effective treatments for removing skin cancer.

The 10 patients enrolled in the study were diagnosed with basal cell carcinoma and ranged in age from 43 to 83. All had biopsies taken of cancerous tissue and surrounding normal skin tissue. Researchers found a 10-fold increase in Vitamin D enzyme levels and a two-fold increase in Vitamin D protein levels. The enzymes and proteins help regulate levels of Vitamin D in the skin. Two genes that play a role in DNA and tumor repair also had elevated levels of Vitamin D in cancerous tissue compared to normal tissue. (ANI)

Types Of Cancer | Types Of Cancer List | Cancer List | Common Cancer Types | Common Cancer Types List | All Types Of Cancer | All Types Of Cancer List

Types Of Cancer | Types Of Cancer List | Cancer List | Common Cancer Types | Common Cancer Types List | All Types Of Cancer | All Types Of Cancer List

Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start – for example, cancer that begins in the colon is called colon cancer; cancer that begins in basal cells of the skin is called basal cell carcinoma.

Common Cancer Types :

* Bladder Cancer
* Breast Cancer
* Colon and Rectal Cancer
* Endometrial Cancer
* Kidney (Renal Cell) Cancer
* Leukemia
* Lung Cancer
* Melanoma
* Non-Hodgkin Lymphoma
* Pancreatic Cancer
* Prostate Cancer
* Skin Cancer
* Thyroid Cancer

For Information About Cancer Website : http://www.cancer.gov

For More Information About All Cancer Types Website : http://www.cancer.gov/cancertopics/alphalist

Scientists find how stem cells make skin

London, Sept 14 (ANI): Scientists at the European Molecular Biology Laboratory (EMBL) have identified two proteins that prompt stem cells to develop into skin cells.

They hope that the new findings could help understand basic mechanisms involved not only in formation of skin, but also on skin cancer and other epithelial cancers.

According to lead researcher Claus Nerlov, at some point, the stem cells at the base of the skin stop proliferating and start differentiating into the cells that form the skin itself.

To do so, they must turn off the ‘stem cell programme’ in their genes and turn on the ‘skin cell programme’.

It is believed that a family of proteins called C/EBPs might be involved in this process.

They are known to regulate it in other types of stem cell, however which C/EBP protein controlled the switch in skin was not known.

Nerlov and his group at EMBL Monterotondo have discovered two proteins called C/EBPa and C/EBP.

After removing the genes that encode C/EBPa and ß specifically in the skin of mouse embryos, the study showed that without these proteins the skin of the mice did not form properly.

“Mice with neither C/EBPa nor ß had taut and shiny skin that couldn’t keep the water inside their bodies,” Nature magazine quoted Nerlov as saying.

“They lacked many of the proteins that make skin mechanically strong and water tight, and they died of de-hydration shortly after birth,” Nerlov added.

However, a single working copy of either the gene for C/EBPa or the gene for C/EBPß was enough to ensure that skin developed properly.

The study appears in Nature Cell Biology. (ANI)