UPDATE 1-Australian Sigma gets bids for two drug arms – report

MELBOURNE, July 19 (Reuters) – Australia’s Sigma Pharmaceuticals (SIP.AX) has received three bids for its Herron drugs arm and three bids for its Orphan Australia drugs business, as it seeks an improved bid from South Africa’s Aspen Pharmacare (APNJ.J), a newspaper reported on Monday.

Sigma declined to comment on the report.

The company is battling to pay off A$100 million in debt by March under pressure from its lenders after it broke its loan covenants, reporting a loss for the year to January 2010. The first A$40 million is due in September.

The bidders for Herron and Orphan are local and overseas-based drug and healthcare companies, The Age newspaper reported.

Their bids are dependent on the outcome of talks with Aspen on its A$648 million ($563 million) offer.

Sigma’s shares jumped 1.2 percent to A$0.425, bucking a slide in the broader market on hopes it might be able to ease its debt woes, but remained well below Aspen’s offer price of A$0.55 a share.

Orphan licenses specialty drugs from foreign pharmaceutical companies to treat life-threatening diseases, which are mostly sold to hospitals. Herron owns a portfolio of over-the-counter pain killers and vitamins, which struggled to expand sales last year due to tough competition in supermarkets. (Reporting by Sonali Paul; editing by Balazs Koranyi)

Deals of the day — mergers and acquisitions

(Reuters) – The following bids, mergers, acquisitions and disposals involving European, U.S. and Asian companies were reported by 0530 GMT on Monday.

(For Reuters columns on deals, click on [DEALTALK/])

** China’s Shougang Group (000959.SZ) is pushing ahead with the takeover of Tonghua Iron & Steel Group in Jilin province, a company official said. To read more, please double click on [ID:nTOE66B030]

** Embattled Australian drug maker Sigma Pharmaceuticals (SIP.AX) wants South Africa’s Aspen Pharmacare (APNJ.J) to improve its A$648 million ($567 million) bid but declined to extend Aspen’s exclusive negotiations. [ID:nSGE66B00C] (Compiled by Tina Kwan in Singapore)

UPDATE 2-Australia’s Sigma presses Aspen to up $567 mln offer

MELBOURNE, July 12 (Reuters) – Embattled Australian drug maker Sigma Pharmaceuticals (SIP.AX) wants South Africa’s Aspen Pharmacare (APNJ.J) to improve its A$648 million ($567 million) bid but declined to extend Aspen’s exclusive negotiations.

In its first detailed response since Aspen on July 7 cut its offer by 8 percent to A$0.55 a share, Sigma on Monday gave a mixed message.

Australia’s generic drugs market leader said it was willing to work with Aspen to come up with a better proposal, but made clear it was not about to cave in despite its debt woes.

“Aspen has also been advised that such discussions should not be interpreted as a willingness on the part of the board to recommend to Sigma shareholders an offer of A$0.55 per share,” Sigma’s general counsel Sue Morgan-Dethick said in a statement.

The move initially sent Sigma’s shares down 3.3 percent, but the shares rebounded to trade flat at A$0.455, holding 17 percent below Aspen’s offer price, reflecting continued doubts that a deal will go ahead.

The broader Australian market .AXJO was up about 0.4 percent.

Simon Marais, chief investment officer at Orbis Investment Management, Sigma’s second-largest shareholder, said the board was doing the right thing but should give shareholders the opportunity to look at the A$0.55 a share offer.

“We would evaluate it. That’s far from saying we would take it. We’re not saying it’s good. We’ll at least look at it,” he said.

Marais declined to say what Orbis would consider to be a fair price for Sigma.

Orbis has been snapping up Sigma’s beaten down shares over the past two months and now owns a 9.25 percent stake, behind the group’s largest shareholder Lazard Asset Management, with 9.5 percent. Lazard Asset Management declined to comment.

VALUATION

Aspen pared its offer last week following a review of Sigma’s books and a profit warning from Sigma about its generic drugs business. [ID:nSGE666016]

The new offer is well below broker JPMorgan’s and Wilson HTM’s valuations at 75 cents and 66 cents a share respectively.

However analysts said those valuations could change when the outlook for Sigma is clearer. The company warned about its profits outlook two weeks ago suggesting that its profit forecast of A$80 million for the year to January 2011 would be hard to achieve due to tough competition in generic drugs.

“If competition worsens, there’s downside risk to our 75 cents valuation,” JPMorgan analyst Anasuya Ramesh said.

Sigma said it is reviewing expressions of interest for parts of the company, including its generics business, and told shareholders to take no action.

Aspen, which is about 19 percent owned by the UK’s GlaxoSmithKline (GSK.L), is keen to expand in Australia. A bigger beachhead in Australia would give it better access to fast-growing Asian markets, analysts say.

Its senior management, who own about one-fifth of the company, have built up a reputation for not paying too much in for acquisitions. [ID:nSGE6660JV]

Lazard (LAZ.N) is advising Sigma and Investec (INLJ.J) is advising Aspen. ($1=1.142 Australian Dollar) (Reporting by Sonali Paul; editing by Balazs Koranyi and Dhara Ranasinghe)

Coming soon: Harry Potter theme park

London, Sep 16 (ANI): Harry Potter fans can soon experience the thrills of the adventures of the hugely popular boy wizard, for a new theme park based on the hit franchise is set to open next year.

The theme park, called ‘The Wizarding Worlds of Harry Potter’, is set to open in spring 2010 at Universal Studios, the Orlando resort has announced.he park is being developed in coordination with J.K. Rowling, the author of the immensely successful books, which have been adapted into films.

Recreating the fabled Hogwarts school that Potter and his friends attend, as well as the nearby village of Hogsmeade, the theme park promises a “completely immersive environment” for visitors.

“All of the action and adventures of Harry Potter’s world will come to life here at Universal Orlando Resort,” the Telegraph quoted Tom Williams, chairman and CEO of Universal Parks and Resorts, as saying.

“The Wizarding World of Harry Potter will be unlike any other experience on earth,” he added.

In fact, visitors at a replica of the Three Broomsticks, one of Hogsmeade’s popular pubs, will be treated to traditional British fare and have the chance to sip on Butterbeer – Potter’s tipple of choice.

The park will also feature theme rides, including the ‘Flight of the Hippogriff’, which will simulate a training flight on the magical, quick-to-offend creature.

Those who lobed the fast-paced wizard sport Quidditch, will also have a chance to participate in a simulated Triwizard Tournament, as well as examine Quidditch equipment and even the elusive Golden Snitch at several Hogsmeade shops.

“Harry Potter continues to spark the imaginations of fans of all ages and we really have seen the anticipation continue to build for The Wizarding World of Harry Potter,” said Brad Globe, president of Warner Bros. Consumer Products. (ANI)

Soon, wheelchairs controlled by tongues

Washington, July 1(ANI): Scientists have developed a novel headset that makes it possible for a person suffering from spinal cord injury to precisely control a wheelchair or computer using the tongue.

The “tongue drive”, being trialled at Georgia Tech University, Atlanta, could also give astronauts a third hand in difficult situations like spacewalks.

Invented by electrical engineer Maysam Ghovanloo and Xueliang Huo, the device works by using two sensors to track a 5-millimetre-wide magnet attached to the tip of the user’s tongue.

The magnet is attached to a person’s tongue using surgical adhesive.

The sensors – implanted in a wireless headset – accept fluctuations in the strength of the magnetic field as the tongue moves, and transmit the signals on to a computer, where they are interpreted and acted upon.

By moving the tongue in predefined patterns, the user can steer a cursor on a screen, direct a wheelchair, and can even on switch on a TV.

Conventional methods include “sip and puff” devices, which are operated by blowing or sucking on a straw held in front of the mouth.

However, according to the Ghovanloo, tongue-drive system can accept a wider variety of commands.

“Some don’t like their sip and puff because it sits right in front of their face, and is like a signal of their disability,” New Scientist magazine quoted Ghovanloo as saying.

“Our design can be made less conspicuous,” Ghovanloo added.

The researchers say that they are in talks with a dental expert about installing them into a plastic retainer that fits inside the user’s teeth. (ANI)

Orange Juice more harmful for teeth than whitening

Washington, July 1 (ANI): Orange juice and other acidic fruit juices are more harmful for teeth than using whitening products, according to researchers at Eastman Institute for Oral Health.

Dr. YanFang Ren has found that the effects of 6 percent hydrogen peroxide, the common ingredient in professional and over-the-counter whitening products, are insignificant as compared to acidic fruit juices.

In fact, he and his colleagues have discovered that orange juice markedly decreases hardness and increases roughness of tooth enamel.

Using a new focus-variation vertical scanning microscope, the researchers could see extensive surface detail like never before.

“The acid is so strong that the tooth is literally washed away. The orange juice decreased enamel hardness by 84 percent,” said Ren.

However, the researchers found no significant change in hardness or surface enamel from whitening.

Weakened and eroded enamel may speed up the wear of the tooth and increase the risk for tooth decay to quickly develop and spread.

“Most soft drinks, including sodas and fruit juices, are acidic in nature. Our studies demonstrated that the orange juice, as an example, can potentially cause significant erosion of teeth,” said Ren.

He further said that dental researchers were increasingly studying tooth erosion, and investing significant resources into possible preventions and treatments.

“We do not yet have an effective tool to avert the erosive effects, although there are early indications that higher levels of fluoride may help slow down the erosion,” he said.

He advised consumers to be aware of the acidic nature of beverages, including sodas, fruit juices, sports and energy drinks. The longer the teeth are in contact with the acidic drinks, the more severe the erosion will be.

People who sip their drinks slowly over 20 minutes are more likely to have tooth erosion than those who finish a drink quickly.

He also emphasised on the need to keep good oral hygiene practices, by brushing twice daily with fluoride toothpaste, and see a dentist for a fluoride treatment at least once a year if at risk.

The findings of the study have been published in Journal of Dentistry. (ANI)

Obama administration distances itself from comedian Sykes’ 9/11 joke

Washington, may 12 (ANI): President Obama smiled at the time, but the White House declared Monday there was nothing funny about comic Wanda Sykes joking about 9/11.

Sykes skewered Rush Limbaugh at the White House Correspondents’ Dinner Saturday – likening the conservative talk show king to Osama bin Laden.

“I think there are a lot of topics that are better left for serious reflection rather than comedy,” Fox News quoted White House press secretary Robert Gibbs as saying Monday.

“I think there’s no doubt that 9/11 is part of that,” he added.

Sykes began her riff by branding as “treason” Limbaugh’s oft-repeated hope that Obama “fails.”

“He’s not saying anything differently than what Osama bin Laden is saying,” she said. “I think maybe Rush Limbaugh was the 20th hijacker. But he was just so strung out on OxyContin he missed his flight.”

That brought groans and guffaws from the crowd while Obama smiled nervously and took a sip from his glass.

Limbaugh ignored Sykes Monday on his radio show, and she also kept mum.

But earlier, Sykes took offense that she was warned “not to say the F-word or the N-word” before her bit. “They really think I was going to say that to the President?,” she told “Extra.” (ANI)

Susan Boyle inspires cocktail that leaves creamy moustache on drinkers

London, May 6 (ANI): Britain’s Got Talent’s singing sensation Susan Boyle has become so popular that she has now inspired a cocktail to be made in her honour.

The cocktail, a vodka-based mix, has a layer of cream on top that gives drinkers a creamy moustache.

Luke Dallow, the owner of a bar in New Zealand, has revealed that the cocktail has been “designed to be a little bit cheeky, just like she is.”

“When you take a sip, it’ll leave a little moustache,” the Daily Star quoted him as saying.

Dallow has made the Auckland joint HQ of the Susan Boyle Fan Club.

The Susan Boyle cocktail contains vodka, wild strawberry and sour rhubarb liqueurs, blossom water, cranberry juice and mixed berries.

It’s then topped with a creamy Frangelico layer and sprinkled with chocolate shavings. (ANI)

Jennifer Aniston poses for new Smartwater ad

Washington, May 6 (ANI): American actress Jennifer Aniston has showed that she is very much into Smartwater, after she posed for an ad for it.

Aniston, 40, posed for the Glaceau water brand, which will be placed in national magazines, and even on a giant billboard over the 405 expressway in L.A.

“We’re not ones to sip and tell, but Jen’s pretty into us (and our vapour distilled purity),” US Weekly quoted the ad as stating.

Just last year, the actress had been featured on a seven-stories tall billboard for Smartwater on Sunset Boulevard in West Hollywood. (ANI)

Italy’s elegant Forte dei Marmi still lures the jet set

Forte dei Marmi – At the turn of the century, the Tuscan coastal town of Forte dei Marmi became hugely popular with artists, aristocrats and intellectuals from all over Europe.

Nowadays, the “beautiful people” still flock here to spend their holidays among the pine trees. In downtown Forte dei Marmi, the fashionable CafĂ© Versilia on the Piazza Garibaldi was a popular haunt for famous cultural names such as English writer Aldous Huxley, Italian poet Gabriele d’Annunzio or German author Thomas Mann. The latter allegedly based the character of the sorcerer, Cipolla, in his 1929 novella Mario and Magician on someone he met on the premises.

The tranquil resort on the attractive Versilia coast continues to lure an immaculately-clad jet set and remains a byword for elegance. Guests sip a glass of prosecco under the linen sunshades which line the far-reaching golden sands.

The beach bars are abuzz in the summer months, competing for attention alongside an extensive range of water sport activities and an ambitious cultural programme. The main beach stretches five kilometres between the rivulets of Fiumetto in the south and Cinquale to the north.

The name Forte dei Marmi translates as The Fortress of the Marble and the first settlers in this swampy area were dealers in the glossy white rock whose use in architecture goes back to classical Greek times.

In the 16th century, a certain Michelangelo Buonarotti, the Renaissance all-round genius commonly known only by his first name, was commissioned by Pope Leopold X. to draw up plans for the road to connect the marble quarries at Massa and Carrara in Apennine Mountains with the coast.

The artist set to work and both the road and a 300-metre along the pier were built so that the prized stone could be hauled aboard sailing ships. Today both locals and tourists gather at the spot to admire the spectacular sunsets.

A century later, the resort began to attract fishermen, farmers and quarry workers and it was in 1788 under the aegis of Grand Duke Leopold I that the town acquired its most notable landmark, the red brick fort in the main square “Il Fortino.”

Tourism in Forte dei Marmi only began to boom after World War II when wealthy Italian industrialists chose it as a summer retreat. Today the “Fortino” is home to the Museum for Satire and Caricature and visitors can admire exhibits dating back to antiquity as well as contemporary works. For those who want more there is even a specialised multimedia archive on the topic.

This town of around 8,500 residents – known to its admirers as “Forte” – offers an unusually rich tableau of cultural activities. There are numerous galleries and the town is a useful springboard for visits throughout Tuscany. Lucca, Florenz and Pisa are only a short ride away by local train.

There are plenty of chic cafes to visit in the central Forti and the town offers a wide range of hotel accommodation to suit all budgets. Four-star hotels line the promenade behind a fringe of oleander and palm trees while the more reasonably-priced establishments are generally found in the centre or on side streets.

The nearby Apennines offers all manner of sporting pursuits such as hiking and climbing tours while at the seaside windsurfers and kite surfers will find plenty to keep them occupied. A fine way of seeing Forti is from the saddle of a bicycle since in contrast to most places in Italy, the town has an extensive network of cycle paths. (dpa)

Justin Timberlake’s tequila brand to hit shelves soon

New York, April 30 (ANI): Pop singer Justin Timberlake’s new line of tequila called 901 is set to hit liquor store shelves.

Timberlake’s new tequila passed the sip test among some New York tequila aficionados with very discerning tastes.

They found themselves giving the drink high marks.

“It’s actually a really nice product. It has a nice richness to it, a full-body mouth feel, a nice finish,” the New York Daily News quoted Dave Kaplan, owner of East Village speakeasy-style bar Death and Co, as saying.

Head bartender Brian Miller said. “I gotta admit, I’m a little surprised. I get some vanilla [notes] … I like that.”

The spirit – named for the area code in the singer’s hometown of Memphis – is crafted from an old, non-Timberlake family recipe using 100 percent blue agave from Jalisco, Mexico.

Kaplan said that those details are a mark of quality that lands this 40-dollar tequila somewhere on the spectrum between the upscale brands Herradura and El Tesoro. (ANI)

African sunbirds have evolved to hover over plants for nectar

London, Apr 14 (ANI): Just like American hummingbirds, African sunbirds have also learnt to hover around a flower to collect nectar, and scientists have found that the tree tobacco plant prompts the birds’ ability to hang around.

Tree tobacco, the South American plant has made its way to South Africa, where sunbirds pollinate it.

The plant produces yellow, tubular flowers and like other plants with flowers of this shape, it depends on nectar-sipping birds for pollination.

In its native South America, tree tobacco is pollinated by hummingbirds, which have evolved the highest metabolism of any animal in order to generate enough energy to hover over flowers for long enough to drink their nectar.

However, to the astonishment of evolutionary biologists, there are no hummingbirds outside the Americas.

Native Old World plants with tubular flowers usually produce some sort of perch to allow birds to sip their nectar.

Sjirk Geerts of Stellenbosch University in Matieland, South Africa, noticed native malachite sunbirds hovering around tree tobacco flowers in northeastern South Africa, and decided to investigate.

Although the birds were known to hover occasionally before, but it was found that some sunbirds are now getting most of their winter food from tobacco tree flowers.

“This is the first time we have observed them making a lifestyle of it,” New Scientist magazine quoted Geerts as saying.

Earlier, the sunbirds used to migrate out of the region in winter because there was no nectar, but now they stay put.

Despite its impact on sunbird-pollinated plants elsewhere, or on sunbird numbers is not known, the researchers reckon that tobacco plant is benefiting.

The researchers put netting over some tobacco trees, and found that plants pollinated by sunbirds set three times as much seed.

The discovery sheds a new light on why hover-feeding evolved in birds in the Americas but not elsewhere.

Geerts now wants to find out if sunbirds keep hovering during the summer, when they are expending most of their energy on raising young. (ANI)