Now, a Muslim-centred biz plan!

After antagonising most of the Islamic world, the US is looking to make amends from a standpoint that matters – profit.

The US today launched a Global Entrepreneurship programme and several other ambitious projects in an effort to bridge the gap with the Muslim world and take its engagement with the community across the globe to a new level of mutual trust and friendship.

The series of announcements made by Secretary of State Hillary Clinton at the conclusion of a two-day meeting was greeted by applause from the entrepreneurs from more than 50 countries who were invited by US President Barack Obama.

Clinton said the Global Entrepreneurship Program’s first pilot programme had been launched in Egypt, and the US would soon launch a second programme in Indonesia, before expanding it to a dozen countries within the next two years.

In her speech to more than 250 entrepreneurs at the conclusion of the Presidential Summit on Entrepreneurship, Clinton specially mentioned successful Indian entrepreneur Shaheen Mistri for her educational programmes in slums.

“Entrepreneurs are tackling problems of poverty and inequity, like Shaheen Mistri, whose non-profit body provides after-school tutoring to children in slums in India,” Clinton said as she referred to stories of several similar successful entrepreneurs.

“They’re closing gaps in healthcare delivery and access to capital, like Amjid Ali, a banker who leads health and finance outreach programmes for South Asian immigrants in England.

The Global Entrepreneurship Program, Clinton said, is an initiative that will provide concrete support to new entrepreneurs, starting in Muslim-majority communities and eventually expanding to others worldwide.

“Through this programme, we will work with the United States private sector partners and local businesses, along with civil society groups, to help create successful entrepreneurial environments,” she said.

Additionally, the administration has established partnerships with two Silicon Valley-based organisations — the Global Technology and Innovation Partners, and the Innovators Fund.

Both were started by US venture capitalists and business leaders inspired by Obama’s call at Cairo to support innovation and entrepreneurship in Muslim majority communities worldwide.

“Both partnerships will launch in Egypt, Jordan, Lebanon, Turkey, and Malaysia, and will then expand from there,” Clinton said.

“These new efforts will help increase access to seed funding, venture capital, and Silicon Valley’s technology and business expertise. The State Department will help facilitate this effort by connecting these funds with local partners and institutions,” she said.

The US will be working to implement an exciting partnership with private US citizens headed by the former Secretary of State Madeleine Albright, to achieve its goals.

“This is a team of eminent Americans from across sectors and industries who will lead an effort to engage the US private sector in carrying out our vision for a new beginning with Muslims in communities globally,” she said.

Clinton also announces the launch of a new effort to expand access to mentors for aspiring and emerging entrepreneurs.

“Mentors provide invaluable support and advice, but for too many entrepreneurs, good mentors are hard to find.

“Through the e-Mentor Corps, an entrepreneur seeking a mentor can go online and find a person with the expertise they need on everything from securing financing to writing a business plan,” she said.

Several private sector groups have pledged to supply mentors from their global networks, including Intel, Ernst & Young, the Kauffman Foundation, Endeavor, TechWadi, the Young Presidents’ Organisation, and Babson College.

“… they reflect the Obama Administration’s commitment to a new approach to development, one based on investment, not aid; on supporting local leadership and ideas rather than imposing our own.

“We believe that this approach is more likely to yield lasting results in the form of greater security, dignity, prosperity, and opportunity for more people worldwide,” Clinton said.

Scientists uncover vulnerable enzyme that can be targeted to kill dangerous pathogens

Washington, August 28 (ANI): A collaborative study conducted by researchers from three institutions in the U.S. has shown that an enzyme, which is essential to many bacteria, can be targeted to kill dangerous pathogens.

Experts at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have also identified chemical compounds that can inhibit this enzyme, and suppress the growth of pathogenic bacteria.

Writing about their study in the journal Chemistry and Biology, the researchers say that their findings are essential to develop new broad-spectrum antibacterial agents to overcome multi-drug resistance.

Dr. Andrei Osterman, an associate professor in Burnham’s ioinformatics and Systems Biology program, targeted the acterial nicotinate mononucleotide adenylyltransferase (NadD), an essential enzyme for nicotinamide adenine dinculeotide (NAD) biosynthesis, which has many crucial functions in nearly all important pathogens.

The bacterial NadD differs significantly from the human enzyme.

“It’s clear that because of bacterial resistance, we need new, wide-spectrum antibiotics. This enzyme is indispensable in many pathogens, so finding ways to inhibit it could give us new options against infection,” said Dr. Osterman.

The research team used a structure-based approach to search for low-molecular-weight compounds that would selectively inhibit bacterial NadD, but not the human equivalent, by screening, in silico, more than a million compounds.

In their experiments, they tested the best predicted compounds against Escherichia coli and Bacillus anthracis (anthrax), which led them to a handful of versatile inhibitory chemotypes, which they explored in detail.

Using protein crystallography, a 3D structure of the enzyme in complex with one of the inhibitors was solved providing guidelines for further drug improvement.

“This is proof-of-concept that NadD is a good target to create antibacterial agents. This knowledge will be useful for both biodefense and public health. The next step is to find better inhibitors. We do not have a silver bullet yet, but we are certainly hitting a golden target,” said Dr Osterman.

The research was supported by a grant from the National Institute of Allergy and Infectious Diseases. (ANI)