Washington, Sep 1 (ANI): The earthquake that jolted Wenchuan, China, in 2008 has had an acute impact on the brain function of physically healthy survivors, and even poses a risk to their mental health, according a new research.

Working with collaborators from universities in China, the US and Liverpool, researchers at the Institute of Psychiatry focussed on the survivors of the earthquake that occurred on May 12 last year.

The researchers wanted to gain a better understanding of how functional brain systems adapt to severe emotional stress.

Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures of the brain in stress and fear responses.

Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures.

But not much is known about potential alterations of brain function in trauma survivors shortly after traumatic events such as an earthquake.

The epicentre of the devastating earthquake was in Wenchuan, in the Sichuan Province of China.

The tremor measured 8.0 on the Richter scale and severely affected many geographical regions including Yingxiu, Wenchuan, Dujiangyan, and Shifang, where 45 million people were directly affected.

The researchers found that a significant proportion of the survivors (around 20 per cent) are likely to develop stress-related disorders, such as acute stress disorder (ASD) and posttraumatic stress disorder (PTSD).

“Given the serious and persistent impact of these highly prevalent psychiatric disorders, it is vital to develop a better understanding of the alterations of cerebral function evident in the early stages of adaptation to trauma. Such knowledge may lead to a better understanding of posttraumatic responses and the development of more effective early interventions,” said Dr Andrea Mechelli from the Institute of Psychiatry at King’s College London.

The researchers used a method known as ‘resting-state fMRI’ to examine 44 healthy survivors and 32 controls shortly after the massive psychological trauma.

They found that significant alterations in brain function similar to those observed in posttraumatic stress disorders could be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for the survivors.

The results of the study show that individuals experiencing severe emotional trauma showed hyperactivity in certain areas of the brain, and decreased functional connectivity in others, shortly after the massively traumatic Wenchuan earthquake.

Particularly, the findings indicated that traumatic experiences affect not only regional function but also dynamic interactions within brain networks.

It is not clear if this pattern of brain alteration remains the same or evolves further over the following weeks or months after the traumatic experiences.

“A better understanding of the impact of traumatic events on brain function may help us identify those in need of early treatment and reduce the long-term psychological impact in trauma survivors of national disasters, military conflict, and other causes of severe emotional distress,” said Mechelli.

The results of the study have been published in PNAS online. (ANI)