KPMG Hits Carbon, Paper Reduction Targets Early

Audit, tax and consultant firm KPMG has exceeded its carbon footprint reduction goal a year ahead of schedule.

The U.S. arm of global consultancy KPMG launched its Living Green program in 2008 with a range of goals centered on cutting carbon, resources and waste.

Originally planning to reduce its carbon footprint by 25 percent by 2010, KPMG lowered it by 26 percent by the end of 2009. Specifically, it cut its footprint by about 7 percent between 2007 and 2008, and by about 20 percent between 2008 and 2009.

The firm is also planning to reduce waste by 10 percent, reduce paper consumption by 15 percent, increase alternative transportation by 5 percent and have all of its new construction achieve LEED certification by 2010.

Since the start of the program, KPMG has lowered its electricity use by 9 percent, cut paper consumption by 33 percent and increased use of recycled paper by 85 percent. It also has five LEED certified offices, in Nashville, Boston, Charlotte, San Diego and Orange County, Calif.

As part of the program, the company set up local Living Green Teams in offices around the U.S. The teams created recycling programs, got involved in local environmental programs and hosted volunteer events around Earth Day.

Magnitude 5.7 quake strikes southern California

June 15 (Reuters) – A magnitude 5.7 earthquake struck a remote part of southern California, near the border with Mexico, the U.S. Geological Survey reported on Monday.

The quake was centered about 5 miles (9 km) southeast of Ocotillo, California, and occurred at 0426 GMT, the USGS said. It was felt in San Diego on the western coast of California, a witness said.

There were no immediate reports of damage or injuries.

(Reporting by Peter Henderson, Writing by Paul Simao; Americas Desk; Editing by Sanjeev Miglani)

Magnitude 5.7 quake strikes southern California

June 15 (Reuters) – A magnitude 5.7 earthquake struck a remote part of southern California, near the border with Mexico, the U.S. Geological Survey reported on Monday.

The quake was centered about 5 miles (9 km) southeast of Ocotillo, California, and occurred at 0426 GMT, the USGS said. It was felt in San Diego on the western coast of California, a witness said.

There were no immediate reports of damage or injuries.

(Reporting by Peter Henderson, Writing by Paul Simao; Americas Desk; Editing by Sanjeev Miglani)

Major earthquake hits Baja California; rattles Los Angeles

A major earthquake of 7.2 magnitudes hit Baja California in Mexico, shaking skyscrapers in San Diego and Los Angeles, whose strong tremors were felt as far as Phoenix and Las Vegas as well.

The immediate impact of the earthquake on people and buildings were not immediately known.

The quake was centred about 25 kilometre south-southwest of Guadalupe Victoria, the US Geological Service said, which initially said it measured around 6.9 magnitude, but quickly revised it to 7.2.

US Geological survey said, the earthquake occurred about 32 kilometres below the earth’s surface.

“Experts have said that such a depth increases the chances that the earth might absorb a majority of the shock, reducing the chances of damage on the surface,” The New York Times reported.

A 7.2 earthquake can cause major damage in structures, crack the ground and shift foundations.

The Los Angeles Fire Department said it was going into “earthquake” mode, checking buildings and bridges for possible structural damage and checking reports of people stuck in elevators.

“Rides were temporarily closed at the Disneyland theme park in Anaheim,” The Los Angeles Times reported.

“There were no reports of major infrastructure damage in Los Angeles, but reports were still coming in from San Diego and Mexico. San Diego fire officials were responding to at least one report of a damaged building,” the daily said in its news report posted on its website.

Sandra Bullock’s husband a ”chronic cheater”, says porn star ex-wife

New York, Mar 25 (ANI): Jesse James’ ex-wife and former porn star Janine Lindemulder has said that Sandra Bullock”s husband is “a chronic cheater.”

Talking to InTouch magazine, Lindemulder said that James—who cheated on Bullock— just can”t help himself.

“I feel sorry for Sandra because she was so in love with Jesse that she was blind and gullible,” the New York Daily News quoted Lindemulder as saying.

Lindemulder, 41, is in a halfway house in Oregon after being charged with tax evasion.

“[Bullock] once said, ”I finally have a man who has my back.” And all I could think was, ”No, you have this man who does it behind your back,”” she said.

James, who married the Oscar-winning Bullock in 2005, had an 11-month affair with a tattooed stripper from San Diego named Michelle “Bombshell” McGee.

The 45-year-old actress has been in hiding since the affair was made public last week, cancelling two overseas premieres for her movie, “The Blind Side.”

Lindemulder, who has a daughter with James, said he first cheated on her just weeks after they were married in 2002. (ANI)

California Police Drain Pond Searching for Missing Girl

ESCONDIDO, Calif. — Police say they are draining a pond in a park north of San Diego in their efforts to find a girl who vanished about a year ago in the same region where 17-year-old Chelsea King disappeared last week.

Escondido police Lt. Craig Carter says investigators on Friday located a bag near the pond that three children reported finding in May — three months after 14-year-old Amber Dubois vanished while walking to school. The children told their parents the bag contained what looked like human hair, but the parents didn’t think that was significant at the time.

Carter says the bag doesn’t appear to be connected to the Dubois case, but an FBI evidence response team will analyze the contents.

Natural hydrogel may boost spinal cord healing

Washington, Sep 18 (ANI): A jab of biomaterial gel into a spinal cord injury site may significantly improve healing, according to researchers at the Barrow Neurological Institute at St. Joseph’s Hospital and Medical Center.

Dr. Mark Preul and Dr. Alyssa Panitch have found in a study that injection of an engineered hydrogel made up mainly of hyaluronic acid (a naturally-occurring body substance) into the spinal cord injury site decreases scarring, and promotes a realignment of the spinal cord fibres around the injury site.

The hyaluronic acid, which forms a scaffold-like configuration may help to structurally stabilize the spinal cord injury site.

The researchers traced cells in the brain stem after injury, and found much higher levels in the hydrogel treated animals as compared to animals that did not receive the treatment, and approached nearly normal levels.

Treated animals had higher functional scores than their non-treated counterparts.

“Spinal cord injury is devastating to civilian and military populations – especially to the young. There has been little progress toward paradigms of regeneration and few results that show real, sustained functional recovery. We’ve been so pre-occupied with regeneration, but that is a highly complicated and difficult to define goal. This project is a synergy of neurosurgeons and bioengineers that attempts repair of the SCI lesion cavity using a tissue-engineering biomaterials approach,” says Preul.

He added that the team aimed at finding ways to structurally allow the body to better heal itself.

“In this project we did not add anything to the hyaluronic acid. It may be that adding growth factors or cells into the gel matrix may allow even better results,” he said.

Preul said that the results show “we may be on a practical path that can give hope to the many people who suffer this sort of injury.”

The work was presented at the Annual Meeting of the American Association of Neurological Surgeons in San Diego where it won the Synthes Prize for Spine Research. (ANI)

Genes controlling insulin ‘alter’ body clock

Washington, Sept 18 (ANI): Scientists at University of California, San Diego have identified certain insulin-regulating genes that can also alter the timing of the body clock.

They said that the findings can lead to new approaches to treating disorders such as metabolic syndrome that can result, at least in part, from chronic disruption of the sleep-wake cycle.

“People knew that the clock regulates many different processes, but what they didn’t realize what that when you tweak those processes, it feeds back and alters the clock,” said Steve Kay, Dean of the Division of Biological Sciences at the University of California, San Diego, who led the study along with John Hogenesch of the University of Pennsylvania.

A molecular clock controls daily physiological rhythms in many types of cells, even cells grown in culture.

By engineering cultured cells to glow yellow when a particular clock gene switched on, the team made the cycle visible. They then interfered with every human gene to see which would shift the clock. They found that hundreds altered the timing.

“We just suddenly discovered 350 new genes that affect the clock that weren’t known before,” Kay said.

However, subsequent screening to confirm the genes’ effect on a second clock gene narrowed the list to 200.

Seven genes involved in insulin control also influenced the rhythms of the clock.

“What came out very strongly was this close relationship between circadian regulation and insulin signalling. There’s a reciprocal relationship between circadian dysfunction and metabolic dysfunction,” said Kay.

The researchers suggest that genetically altered mice with malfunctioning clocks become obese and develop diet-induced diabetes.Understanding this close relationship between circadian regulation and metabolic homeostasis should provide novel ways of identifying new therapies for metabolic disease,” Kay added.

The study appears in journal Cell. (ANI)

Uncle Sam serves up tax bill to Philippoussis

Melbourne, Sep.6 (ANI): Tennis ace Mark Philippoussis is being chased by the US taxman and has sold his Williamstown family home to avoid having it repossessed.

It has now emerged that the US Internal Revenue Service has pursued the Scud for about 1.4 million dollars during the past decade.

US records show the IRS still wants about 500,000 dollars for tax debts dating back to 2003.

Philippoussis, who according to his mother is playing in a tournament in San Diego, revealed to the Sunday Herald Sun in May that his money was gone, he was depressed and he was battling to save the family home from repossession.

“Money came in left, right and centre; you just thought that’s how it was for everyone and that’s how it always will be,” he said at the time.

The Davis Cup hero put his Williamstown home on the market to avoid having it repossessed over his unpaid 1.3 million dollar mortgage, but it was passed in for 775,000 dollars in July.

Wayne Elly, of Hocking Stuart, yesterday confirmed Scud’s house had sold recently for about the asking price of 950,000 dollars.

Philippoussis once owned at least five properties in the US, selling the last one in 2005 at a loss.

Official US records suggest he still owes about 180,000 dollars for the 2004 financial year and about 317,000 dollars from 2003.

A former tax debt for about 918,000 dollars dating back to 2001 was satisfied in 2004, according to the Palm Beach County records office.

The IRS would not comment this week, but a US tax expert said the documents suggested the agency was confident it could recoup the debt. (ANI)

Here’s what ups amyloid beta production in Alzheimer’s patients’ brains

Washington, September 4 (ANI): A new class of medicines to effectively treat Alzheimer’s disease may soon be available, for an international research group has shed light on how a fragment of a protein increases the production of the amyloid beta protein in the brain.

The researchers say that knowing that the N60 fragment of the RanBP9 protein increases the production of the amyloid beta protein, which is present in excessive amounts in the brains of people with Alzheimer’s disease, gives scientists a more specific focus for developing new drugs.

Most experts believe that if the creation of amyloid beta protein can be halted or slowed, the devastating effects of Alzheimer’s disease may also be stopped or slowed too, according to background information in a research article published in the FASEB Journal.

David Kang, assistant professor of neurosciences at the University of California, San Diego, and one of the researchers involved in the work, said: “Our study suggests that targeting RanBP9 expression and/or N60 fragment generation may lead to novel strategies to combat this devastating disease.”

During the study, Kang and his colleagues examined extracts from brains with Alzheimer’s disease and age-matched healthy controls.

The researchers found that the N60 section of RanBP9 was increased in Alzheimer’s brain.

“Alzheimer’s might seem hopeless to some, but this research shows that we’re closer than ever to unraveling both the protein tangles and mysteries surrounding this devastating disease,” said Dr. Gerald Weissmann, the Editor-in-Chief of The FASEB Journal. (ANI)

What we believe is what we see in people

Washington, Sep 3 (ANI): “Seeing is believing” goes the old adage, but scientists have now said that “believing is seeing” also holds true when it comes to perceiving other people’s emotions.

Psychologists from the US, New Zealand and France have found that the way we initially think about the emotions of others biases our subsequent perception (and memory) of their facial expressions.

Thus, once people interpret an ambiguous or neutral look as angry or happy, they later remember and actually see it as such.

The study “addresses the age-old question: ‘Do we see reality as it is, or is what we see influenced by our preconceptions?’ Our findings indicate that what we think has a noticeable effect on our perceptions,” said co-author Piotr Winkielman, professor of Psychology at the University of California, San Diego.

“We imagine our emotional expressions as unambiguous ways of communicating how we’re feeling, but in real social interactions, facial expressions are blends of multiple emotions – they are open to interpretation. This means that two people can have different recollections about the same emotional episode, yet both be correct about what they ‘saw.’

So when my wife remembers my smirk as cynicism, she is right: her explanation of the expression at the time biased her perception of it. But it is also true that, had she explained my expression as empathy, I wouldn’t be sleeping on the couch,” said coauthor Jamin Halberstadt, of the University of Otago in New Zealand,

“It’s a paradox. The more we seek meaning in other emotions, the less accurate we are in remembering them,” added Halberstadt.

The researchers pointed out that implications of the results go beyond everyday interpersonal misunderstandings – especially for those who have persistent or dysfunctional ways of understanding emotions, such as socially anxious or traumatized individuals.

Other applications of the findings include eyewitness memory-a witness to a violent crime, for example, may attribute malice to a perpetrator – an impression that researchers say will influence memory for the perpetrator’s face and emotional expression.

The researchers showed experimental participants still photographs of faces computer-morphed to express ambiguous emotion and instructed them to think of these faces as either angry or happy.

Faces initially interpreted as angry were remembered as expressing more anger than faces initially interpreted as happy.

Interestingly, the ambiguous faces were also perceived and reacted to differently.

The researchers measured subtle electrical signals coming from the muscles that control facial expressions, and discovered that the participants imitated – on their own faces – the previously interpreted emotion when viewing the ambiguous faces again.

This means that when viewing a facial expression they had once thought about as angry, people expressed more anger themselves than did people viewing the same face if they had initially interpreted it as happy.

“The novel finding here is that our body is the interface: The place where thoughts and perceptions meet. It supports a growing area of research on ‘embodied cognition’ and ‘embodied emotion.’ Our corporeal self is intimately intertwined with how – and what – we think and feel,” said Winkielman, of UC San Diego,

The study has been published in the journal Psychological Science. (ANI)

‘Invisibility cloak’ metamaterials could shrink cellphones antennas

London, Aug 22 (ANI): An international team of physicists have revealed that metamaterials, which are currently being used to make real-life invisibility cloaks, may soon shrink cellphone antennas, leading to smaller gadgets.

The new metamaterial antennas could be tuned to a range of different frequencies as required.

It could be tuned to work efficiently across a small frequency range, and retuned to a different band for roaming.

Tom Driscoll at the University of California, San Diego along with Dimitri Basov and collaboraters from Duke University in Durham, North Carolina, and ETRI in the Republic of Korea developed the new “frequency-agile” design by attaching a thin film of vanadium dioxide to a gold metamaterial structure.

They found that applying a voltage to the film alters the frequency at which the gold metamaterial interferes with light waves, tuning it to a new “setting”.

This occurs because voltage causes nanoscale “puddles” of conducting vanadium metal to form within the insulating vanadium dioxide.

They interact with the design’s electrical properties and alter the metamaterial’s tuning.

“The effect continues after the electrical current is gone because the metal puddles, once formed, will not readily disappear without some cause,” New Scientist quoted Driscoll as saying

He added that there is evidence to suggest the effect should last for months or more.

“Metamaterials are often narrowband, but at least with this scheme one could adapt the material to new frequencies,” said Ulf Leonhardt, a metamaterial researcher at the University of St Andrews in the UK.

That removes an obstacle to the wider use of metamaterial antennas. Such antennas would be attractive because they could help to shrink the size of cellphones.

Driscoll said that a tunable metamaterial antenna would allow a wireless gadget to work “outstandingly well” at the frequencies used in one country, but also carry the option of retuning for use abroad.

The findings appear in journal Science Express. (ANI)

International Medical Center to be developed at IIT Kharagpur

Washington, August 19 (ANI): Officials of the University of California, San Diego Health Sciences and the Indian Institute of Technology (IIT) Kharagpur have signed a historic preliminary agreement to collaborate in the development of an International Medical Center (IMC) at IIT Kharagpur.

This agreement – marked by a signing ceremony in Kharagpur, West Bengal, India – is the beginning of a strong educational, research and clinical partnership between UC San Diego Health Sciences and IIT, Kharagpur.

IIT, Kharagpur is the first and largest of the IIT chain of higher education institutes in India that focuses on engineering and technology.

The goal is to jointly establish a state-of-the-art medical center at IIT Kharagpur, which will be the first of its kind between a US University and an Indian Institution.

“This exciting partnership is an extension of UC San Diego Health Sciences’ traditional core mission – to provide excellent and compassionate patient care, advance medical discoveries and educate future health care providers,” said Mounir Soliman, MD, MBA, executive director of UC San Diego Health Sciences International.

“The establishment of an academic medical center to include the best in clinical care, as well as undergraduate and post-graduate programs in medical education, will be a perfect partnership – bringing together the strengths of both institutions,” he added.

According to Professor Damodar Acharya, director of IIT, Kharagpur, “In addition to IIT’s strong education and research focus in engineering and the sciences, we also are keenly interested in medical science and technology, including biotechnology, imaging, drug development and other important areas of medical research.”

“The collaboration is believed to be among the first between an IIT and a public US university in the field of medical education and research,” he said.

“The aim is to initiate technology leveraged medical education and research to provide holistic health care for the entire life cycle at affordable cost to underprivileged, poor and tribal population of the region,” he added.

The agreement describes the two institution’s collaborative plan to build a 300-bed, state-of-the-art hospital on land provided by IIT, Kharagpur. (ANI)

Scientists identify how meningitis bacteria invade the brain

Washington, Aug 19 (ANI): Scientists in the U.S. have discovered that a specific protein on the surface of a common bacterial pathogen allows the bacteria to leave the bloodstream and enter the brain, initiating the deadly infection known as meningitis.

The new finding may lead to the development of improved vaccines to protect those most vulnerable, including young infants and the elderly.

“Streptococcus pneumoniae, commonly known as pneumococcus, is responsible for half the cases of bacterial meningitis in humans,” said the study’s senior author, Victor Nizet, MD, professor of paediatrics and pharmacy at the University of California, San Diego’s School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences.

Meningitis develops when bacteria penetrate the “blood-brain barrier.”

The blood-brain barrier, comprised of a single layer of highly specialized microvascular endothelial cells, prevents most large molecules from entering into the cerebrospinal fluid, preserving an optimal biochemical environment for brain function.

The research team examined the functions of a protein known as NanA in order to discover how an entire bacterium can breech the blood-brain barrier and gain access to the central nervous system.

NanA is produced by all strains of pneumococcus and displayed prominently on the bacteria’s outer surface.

Through genetic manipulations, the researchers were able to remove the entire NanA protein, or just specific sections of the molecule, from the pathogen.

They found that while normal pneumococci were able to bind, enter and penetrate through human brain microvascular endothelial cells, mutant bacteria lacking the NanA protein -or those expressing only a truncated version of the protein – largely lost these abilities.

Conversely, when the full-length pneumococcal NanA protein was cloned and expressed on the surface of a nonpathogenic laboratory strain, the transformed bacteria gained the ability to bind and enter the same endothelial cells.

Satoshi Uchiyama, MD, a postdoctoral fellow in the Nizet Laboratory and lead author on the study, said: “Our tissue culture studies showed that the NanA protein was both necessary and sufficient for bacterial penetration of the blood brain barrier endothelial cells.”

“After infecting mice intravenously, we also found that far fewer NanA-deficient bacteria left the bloodstream and entered the brain, in comparison to mice infected with the normal pneumococcus,” Uchiyama added.

NanA is best known as an enzyme that cleaves and releases the sugar molecule known as sialic acid, which is present in abundance on the surface of all human cells.

While this enzymatic activity played a small part in promoting NanA-mediated blood-brain barrier interactions, a much stronger role was identified for the outer tip of the protein.

This tip seems to directly attach to the brain microvascular endothelial cells and then stimulate them to take in the pneumococcus.

According to Nizet, because NanA is expressed on the surface of all pneumococcal strains, it is an attractive candidate to include in a universal protein-based vaccine against pneumococcal infection.

The study is available online in the Journal of Experimental Medicine. (ANI)

Stephen Strasburg | Strasburg | Stephen Strasburg | Strasburg Nationals | Strassburg | Washington Nationals | Stephen Strasburg Winner of $15.1 Million Contract

Stephen Strasburg | Strasburg | Stephen Strasburg | Strasburg Nationals | Strassburg | Washington Nationals | Stephen Strasburg Winner of $15.1 Million Contract

Stephen Strasburg born on 20th July 20, 1988, in San Diego, California,is a right-handed power pitcher, his fastball has been clocked between 95–97 miles per hour (MPH) (153-156 km/h). His curveball is between 79 and 81 MPH (127 and 130 km/h).

Strasburg was drafted number one overall in the 2009 Major League Baseball Draft by the Washington Nationals. He is represented by agent, Scott Boras, who reportedly looked for a contract in the range of six years, US$50 million.During negotiations, the Nationals offered Strasburg a record-breaking sum for an amateur. The deal, which was in excess of $10.5 million, has drawn comparisons to Matt Harrington, who was also represented by Boras.

On August 17, 2009, Stephen Strasburg signed a record-breaking four-year, $15.1 million contract with the Washington Nationals.

Craigslist | Ebay | Craigslist Vancouver | Craigslist Chicago | Craigs List Details | Craiglist | Craigslist Centralized Network

Craigslist | Ebay | Craigslist Vancouver | Craigslist Chicago | Craigs List Details | Craiglist | Craigslist Centralized Network

Craigslist is a centralized network of online communities for free classified advertisements of jobs, internships, housing, personal advertisements, erotic services, for sale/barter/wanted, services, community,  pets categories and forums on various topics.

The service was founded in 1995 by Craig Newmark for the San Francisco Bay Area. After incorporation as a private for-profit company in 1999, Craigslist expanded into nine more U.S. cities in 2000, four each in 2001 and 2002, and 14 in 2003. September 2007, Craigslist had established itself in approximately 450 cities in 50 countries.

2007 Craigslist operated with a staff of 24 people. Its sole source of revenue is paid job ads in select cities ($75 per ad for the San Francisco Bay Area; $25 per ad for New York, Los Angeles, San Diego, Boston, Seattle, Washington D.C., Chicago and recently Portland, Oregon) and paid broker apartment listings in New York City ($10 per ad).

The site serves over nine billion page views per month, putting it in 56th place overall among web sites world wide, ninth place overall among web sites in the United States (per Alexa.com on January 10, 2008), to over thirty million unique visitors. With over thirty million new classified advertisements each month, Craigslist is the leading classifieds service in any medium. The site receives over two million new job listings each month. So it is one of the top job boards in the world.

In 2001, the company started the Craigslist Foundation, a § 501(c)(3) nonprofit organization that helps emerging nonprofit organizations get established, gain visibility, attract the attention of potential donors, and develop the skills and knowledge required for long-term success.

It accepts charitable donations, and rather than directly funding organizations, it produces face-to-face events and offers online resources to help grassroots organizations get off the ground and contribute real value to the community.

For More Information visit: http://www.craigslist.org/about/sites

http://www.craigslistfoundation.org/

Panama may hold cures to cancer, malaria and dengue fever

Washington, July 11 (ANI): A team of scientists is exploring the length and breadth of Panama in search of exotic molecules that could one day lead to new treatments for human diseases like cancer, malaria and dengue fever.

The team is being led by William Gerwick from the Scripps Institution of Oceanography at UC (University of California) San Diego.

It was at the island of Coiba off Panama’s Pacific coast, where in June 2004, Kerry McPhail, then a postdoctoral scientist working with Gerwick, discovered a cyanobacterium in shallow water, a primitive photosynthetic organism with features unlike any previously encountered by scientists.

Laboratory analysis and testing revealed that the organism naturally produces a potent cancer-fighting compound.

“To the full extent that we can tell, the compound is working by a novel mechanism to kill cancer cells,” said Gerwick, a scientist with the Scripps Center for Marine Biotechnology and Biomedicine and the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences.

“It has a very unusual molecular structure unlike any we’ve seen before,” he added.

Panama’s location as a bridge between North and South America and a natural thoroughfare for a diverse assortment of migratory land and water species gives it a unique appeal to scientists.

“Despite the fact that we all know Panama because of its famous canal, I have been struck by how remote and primitive and relatively unspoiled large stretches of Panama remain today,” said Gerwick.

Lena Gerwick, a biologist and fellow Scripps researcher, believes that in addition to cancer, the Panamanian environment could be holding biomedically promising sources for treating malaria and tropical diseases such as Chagas’ disease, leishmaniasis, and dengue fever.

Such diseases have been labeled as “neglected” afflictions because they impact millions of people, but have been largely forgotten by the developed world and pharmaceutical companies due to the anticipation of poor returns, and thus few resources are made available to find new treatments for these diseases.

“If you have a lot of diverse organisms, as you find in the tropics, they produce a large diversity of natural products,” said Lena Gerwick.

“There is high competition for every species to carve out its own niche and survive. With that you find a lot of compounds used in defense and other diverse activities. Within this biodiversity might be the next cure for malaria or the next cure for tuberculosis, so there is a great need to conserve it,” she added. (ANI)

Milky Way’s “dark matter” mystery solved by astrophysicists

Washington, July 9 (ANI): A team of astrophysicists has solved a mystery that led some scientists to speculate that the distribution of certain gamma rays in our Milky Way galaxy was evidence of a form of undetectable “dark matter” believed to make up much of the mass of the universe.

In two separate scientific papers, the astrophysicists show that this distribution of gamma rays can be explained by the way “antimatter positrons” from the radioactive decay of elements, created by massive star explosions in the galaxy, propagate through the galaxy.

Thus, the scientists said, the observed distribution of gamma rays is not evidence for dark matter.

“There is no great mystery,” said Richard Lingenfelter, a research scientist at UC San Diego’s Center for Astrophysics and Space Sciences who conducted the studies with Richard Rothschild, a research scientist also at UCSD, and James Higdon, a physics professor at the Claremont Colleges.

“The observed distribution of gamma rays is in fact quite consistent with the standard picture,” he added.

Over the past five years, gamma ray measurements from the European satellite INTEGRAL have perplexed astronomers, leading some to argue that a “great mystery” existed because the distribution of these gamma rays across different parts of the Milky Way galaxy was not as expected.

To explain the source of this mystery, some astronomers had hypothesized the existence of various forms of dark matter, which astronomers suspect exists, but have not yet found.

What is known for certain is that our galaxy and others are filled with tiny subatomic particles known as positrons, the antimatter counterpart of typical, everyday electrons.

The scientists calculated that most of the gamma rays should be concentrated in the inner regions of the galaxy, just as was observed by the satellite data.

“The observed distribution of gamma rays is consistent with the standard picture where the source of positrons is the radioactive decay of isotopes of nickel, titanium and aluminum produced in supernova explosions of stars more massive than the Sun,” said Rothschild.

The scientists point out that a basic assumption of one of the more exotic explanations for the purported mystery – dark matter decays or annihilations – is flawed, because it assumes that the positrons annihilate very close to the exploding stars from which they originated.

“We clearly demonstrated this was not the case, and that the distribution of the gamma rays observed by the gamma ray satellite was not a detection or indication of a ‘dark matter signal’,” said Lingenfelter. (ANI)

Parkinson’s medications may help treat extreme drug-resistant TB

Washington, July 3 (ANI): Two drugs that are commonly used to treat Parkinson’s disease have been found to be effective in treating extreme drug-resistant tuberculosis, say researchers at the University of California, San Diego.

They have discovered that the two commercially available drugs, entacapone and tolcapone, have the potential to treat multi-drug resistant and extensively drug resistant tuberculosis.

“We have computational, and experimental data to support this repositioning,” said Dr Philip E. Bourne, professor of pharmacology at UCSD’s Skaggs School of Pharmacy and Pharmaceutical Sciences and the principle investigator on the project.

“What is exciting about this finding is that the TB target, enzyme InhA, is already well known. But existing drugs are highly toxic and of completely different chemical structure than entacapone and tolcapone.

“Here we have drugs that are known to be safe and with suitable binding properties which can be further optimized to treat a completely different condition,” he added.

While working with the TB bacterium itself, they found that the active component in Comtan tablets (entacapone) is effective at inhibiting M.tuberculosis in concentrations well below a level that is toxic to cells.

“Although we have demonstrated in the lab that Comtan is active against M.tuberculosis, additional studies are required in order to transform it into an anti-tubercular therapeutic,” said Sarah L. Kinnings, a graduate student and lead author on the study.

“Given the continuing emergence of M.tuberculosis strains that are resistant to all existing, affordable drug treatments, the development of novel, effective and inexpensive drugs is an urgent priority,” she added.

The study appears in PLoS Computional Biology. (ANI)

Incisionless procedure ‘reverses weight gain after gastric bypass surgery’

Washington, June 30 (ANI): Scientists have offered an incisionless procedure to reverse weight gain after gastric bypass surgery.

To perform the procedure, known as ROSE (Restorative Obesity Surgery, Endolumenal), a small, flexible endoscope and tools are inserted through the mouth, down the esophagus, and into the stomach pouch during an outpatient procedure.

The tools, developed by USGI Medical Inc., are used to grasp, fold and stitch tissue to reduce both the diameter of the stomach opening and the volume of the stomach pouch. No cuts are made into the patient’s skin.

Santiago Horgan, MD, professor of surgery and director of the Center for the Treatment of Obesity at UC San Diego, looked at the six-month outcomes from a national registry of 116 patients who underwent the procedure.

The data showed that 88 percent of the patients stopped regaining weight after ROSE.

Overall, these 96 patients lost an average 18 percent of their excess weight six months after the procedure. For the purposes of the registry, excess body weight is defined as anything over a body mass index rating of 55.

One patient in the study lost 66 pounds or 84 percent of her excess weight during that six-month time period. Patients who were most successful losing weight after their original gastric bypass had the best results following the ROSE procedure.

This subset of patients dropped 29 percent of their excess weight during the six months after ROSE.

“We believe this registry represents the largest collection of data showing the effectiveness, safety and durability of the ROSE procedure,” said Horgan.

“There are not many options to repair a failing gastric bypass. Invasive procedures to restore the anatomy are complicated and risky for most patients. In comparison, there were no significant complications associated with ROSE and most of the patients lost clinically relevant amounts of weight,” Horgan added.

The data was presented at the annual meeting of the American Society of Metabolic and Bariatric Surgeons. (ANI)