UPDATE 1-Crucell starts work on RSV vaccine

AMSTERDAM, June 24 (Reuters) – Dutch biotech Crucell (CRCL.AS) (CRXL.O) said on Thursday it would start the development of a universal respiratory syncytial virus (RSV) vaccine as part of its collaboration with Johnson & Johnson.

Crucell sold an 18 percent stake to U.S. diversified health care company J&J (JNJ.N) for 302 million euros last September as part of a flu vaccine development deal and in February said it will boost R&D funding by more than a third.

On Thursday, the company said it would start a discovery programme aimed at the development of an RSV vaccine to prevent severe infections with the most common RSV strains in infants and the elderly.

“We expect that an RSV vaccine will be the next frontier in children’s vaccines for inclusion in the routine immunisation of newborns,” Chief Executive Ronald Brus said in a statement.

While the partnership with J&J focuses on the development of and commercialisation of a universal influenza vaccine, it also included innovation programmes directed against three other disease targets.

The universal RSV vaccine has now been selected as one of the innovation programmes, while selection of the other two targets is ongoing, Crucell said.

Crucell said RSV is the most important cause of viral lower respiratory illness in infants and children and that RSV-induced disease is the last of the major paediatric diseases for which no preventive vaccine is available. (Reporting by Aaron Gray-Block; Editing by David Cowell)

Climate change report highlights Indigenous health risks

A new report has found the health of Indigenous Australians living in coastal areas such as the Torres Strait could be at risk due to climate change.

The report commissioned by the Federal Government found climate change will elevate existing health risks for Indigenous people and create a whole new set of health problems.

They include respiratory illness and increasing incidence of heat stress and dehydration.

The loss of livelihoods and population displacement will also have a serious impact on the health and nutrition of those living in remote island communities.

Climate Change Minister Penny Wong delivered the report while touring the Torres Strait.

Air pollution sending children to hospital

Air pollution accounts for at least 4 per cent of hospitalisations of babies and children, a new Australian Institute of Health and Welfare (AIHW) report estimates.

The report’s author, Dr Adrian Webster, says the study examines the extent of the link between air pollution and asthma attacks.

“Four per cent of around 3,500 hospitalisations of [newborns] to 14-year-olds were related to the amount of particulates in the air,” he said.

“This is an estimate based on the methodology we’ve developed.

“In relation to adults we only looked at nitrogen dioxide [as] unfortunately we couldn’t resource the research required to do it for particulates.

“We found about 3 per cent … [were] hospitalised due to nitrogen dioxide levels in the air.”

The report is based on data from Melbourne in 2006 and is limited to two pollutants.

Dr Webster says there are several other pollutants that exacerbate asthma symptoms, so it is likely the total effect is worse than the report suggests.

“We are breaking air pollution in total down to its component parts, so the overall impact of air pollution is likely to be much greater than that,” he said.

“But unfortunately we weren’t able to look at the total picture because of a lack of research in the area.”

Associate Professor Bin Jalaludin from Liverpool Hospital, who specialises in the effects of air pollution on respiratory illness, says his research has found that young children are especially vulnerable on high pollution days.

“On high pollution days there are more [admittances] in most departments in Sydney [for] children, especially aged one to four,” he said.

“[For] articulate matter we found an increase of about 1.3 per cent, for nitrogen dioxide about 3 per cent and for ozone about 1 per cent.”

Setting the standard

The AIHW report has attempted to devise a standardised method of measuring the effects of pollution on asthma sufferers.

Dr Webster says similar studies have been conducted but the results have not been consistent.

National Asthma Campaign representative and associate professor of the John Hunter Hospital, Peter Walk, says the current system is inadequate.

“There is a lack of standardisation for measuring air quality … the requirements to report the results really don’t exist in Australia and those standards requirements vary enormously,” he said.

“So we really have what could be a potentially very important public health issue, but there isn’t a standardised way of measuring this or looking at the outcomes for individuals.”

Professor Jalaludin agrees, saying a standardised measure would allow policy-makers to better understand the effects of air pollution and come up with ways to improve health and reduce health costs.

“It may tell us the number of deaths … hospitalisation … and emergency department visits we might be able to avoid if we reduce air pollution,” he said.

“We could work out how much money we might be able to save if we are able to avoid some health affects, or if we can avoid deaths due to air pollution.”

Laughter may be the ‘worst’ medicine for asthmatics

Melbourne, Aug 24 (ANI): A good laugh is considered to be the best medicine, but a new research suggests that it may trigger serious asthma attacks.

This makes laughter a serious matter for 40 percent per cent of Australia’s 2 million asthma sufferers, according to a new study.

The online poll of 200 sufferers, conducted by drug company AstraZeneca’s, has backed university research that revealed laughter can spark the chronic respiratory illness in up to half of asthmatics.

A more serious concern from this research is that three quarters of asthmatics believe their asthma is well managed but the majority put up with lifestyle restrictions because of their illness.

The survey reflected both a University of NSW 2004 study published in the Journal Of Asthma and a New York University 2005 study Laughter May Trigger Asthma Attacks.

Almost two thirds found themselves breathless when doing housework or shopping, while half struggled to do their favourite activities.

More than one third felt tired because of disturbed sleep.

A further one in five cancelled social engagements because of their asthma.

Concord Hospital thoracic physician Professor Christine Jenkins said well-managed asthma should not hamper the enjoyment of any of life’s pleasures.

“Worryingly, these findings show that while many believe they have their asthma under control, the asthma is actually controlling them and their lifestyles,” the Daily Telegraph quoted her as saying. (ANI)

Swine flu spins out of control in UK; 100,000 more cases expected each day

London, July 3 (ANI): British Health Minister Andy Burnham has told the House of Commons here that the swine flu pandemic is so out of control, that there could be more than 100,000 new cases each day by the end of next month.

UK infections, he said, were already doubling every week and overworked doctors have said that they will no longer test for the virus.

Instead, patients will be urged to stay at home and call NHS Direct for advice.

According to The Sun, those with the most serious symptoms and patients with dangerous underlying conditions, like respiratory illness, will be given Tamiflu. The anti-viral drug cuts the severity of the illness.

Patients will choose a “flu friend” who will be given a number so they can pick up drugs from a collection point. This should help prevent the spread of the virus.

Those with milder signs may be told to lower their temperature by taking paracetamol and fluids.
The Government has 60 million doses of vaccine, enough for half the country.

There are currently 7,447 cases and three people have died. They include six-year-old Sameerah Ahmad from Birmingham.

The current policy shows the disease’s spread cannot be contained. (ANI)

Swine flu claims third victim in Australia

Victoria, June 24 (ANI): A 50-year-old woman with life-threatening cancer has become the third person to die from Swine Flu in Australia since the outbreak of the H1N1 virus.

“The woman died early today at the Peter MacCallum Cancer Centre, where she has been a long-term patient receiving treatment for cancer,” News.com.au quoted Victorian Health Minister Daniel Andrews, as saying.he woman was admitted to the hospital on last Saturday with respiratory illness, and her condition further deteriorated, requiring her to be moved to the intensive care ward on Sunday.

She had tested positive for Influenza A on Monday, and she was diagnosed positive for H1N1 Influenza 09 on Tuesday.

“Her family have been informed of the H1N1 diagnosis,” Andrews said.

He also said that a second Peter MacCallum Cancer Centre patient with H1N1 was receiving appropriate care.

“The Victorian Government is working with health services to ensure they could meet the increased demand for services throughout the flu season,” he added.

Earlier, a 35-year-old man from Victoria was posthumously diagnosed with the H1N1 virus, and the cause of death was believed to be a respiratory failure caused by the flu virus. He was the second swine flu victim in Australia. (ANI)

Swine flu claims third victim in Australia

Victoria, June 24 (ANI): A 50-year-old woman with life-threatening cancer has become the third person to die from Swine Flu in Australia since the outbreak of the H1N1 virus.

“The woman died early today at the Peter MacCallum Cancer Centre, where she has been a long-term patient receiving treatment for cancer,” News.com.au quoted Victorian Health Minister Daniel Andrews, as saying.he woman was admitted to the hospital on last Saturday with respiratory illness, and her condition further deteriorated, requiring her to be moved to the intensive care ward on Sunday.

She had tested positive for Influenza A on Monday, and she was diagnosed positive for H1N1 Influenza 09 on Tuesday.

“Her family have been informed of the H1N1 diagnosis,” Andrews said.

He also said that a second Peter MacCallum Cancer Centre patient with H1N1 was receiving appropriate care.

“The Victorian Government is working with health services to ensure they could meet the increased demand for services throughout the flu season,” he added.

Earlier, a 35-year-old man from Victoria was posthumously diagnosed with the H1N1 virus, and the cause of death was believed to be a respiratory failure caused by the flu virus. He was the second swine flu victim in Australia. (ANI)

WHO warns that border controls not enough to contain swine flu

London, Apr.29 (ANI): The World Health Organisation (WHO) has warned that border controls may not be effective enough to stop the spread of swine flu, even as several countries tightened airport checks.
More than 80 Mexicans are believed to have died from pneumonia and respiratory illness linked to the virus.

Experience from previous episodes like the Severe Acute Respiratory Syndrome (SARS) outbreak, and from computer models, showed the strategy was ineffective at controlling outbreaks said Gregory Hartl, a WHO spokesman.

In a blunt assessment of the danger from swine flu, he said: “Border controls don’t work. Screening doesn’t work.
Hartl was speaking as many Asian countries affected by the SARS outbreak in 2003, which killed almost 800 people, set up thermal scanners at airports to screen for passengers who could be feverish.

On Monday WHO raised its pandemic alert level from phase three to phase four on the scale of one to six, indicating that it has begun to spread swiftly between humans.

The organisation’s pandemic preparedness guidance documents suggest countries should consider implementing exit screening – of departing passengers – at this stage.

“We’re prepared as if there were a pandemic,” she told the NBC television channel. (ANI)