All issues with SC to be resolved amicably: Pak PM

Lahore, May 21 (ANI): Pakistan Prime Minister Yousaf Raza Gilaniis hopeful that all issues with the Supreme Court will be settled soon.

Gilani denied any rift between his government and the judiciary on the issue of upholding the sentence of Interior Minister Rehman Malik by the Lahore High Court and awarding of the presidential remission soon after.

He said the government would accede to and act upon the Supreme Court verdict whatever it was in the original case, adding that all issues with the apex court would be resolved amicably.

Replying to o a question, he said there was no confrontation among the two state institutions.

Gilani said his government would look into the matter of extension in the service of Chief of Army Staff General Ashfaq Kayani, as and when the time comes, the Daily Times reported.

During the meeting with senior journalists, Gilani shared his opinion on a number of national and international issues and also discussed policies of the coalition government. (ANI)

New biomarker can bring rapid relief from major depression

Washington, Sept 11 (ANI): Scientists from University of California have identified a biomarker that can help accurately predict whether a particular drug will be effective in treating major depression.

During the study, the researchers measured changes in brain-wave patterns using quantitative electroencephalography (QEEG), a non-invasive, computerized measurement that recognizes specific alterations in brain-wave activity.

These changes precede improvement in mood by many weeks and appear to serve as a biomarker that accurately predicts how effective a given medication will be.

The new non-invasive test would help predict within a week whether a particular drug will be effective.

The added benefit of the biomarker test is that it ispainless and fast – about 15 minutes – and only involves the placement of six electrodes around the forehead and on the earlobes.

The researchers recruited a total of 375 people who had been diagnosed with major depressive disorder (MDD) and prescribed the antidepressant escitalopram, commonly known as Lexapro.

Then they examined a biomarker called the antidepressant treatment response (ATR) index – a specific change in brain-wave patterns.

The study showed that the ATR predicted both response and remission with an accuracy rate of 74 percent, much higher than any other method available.

The researchers also found that they could predict whether subjects were more likely to respond to a different antidepressant, bupropion, also known as Wellbutrin XL.

“Until now, other than waiting, there has been no reliable method for predicting whether a medication would lead to a good response or remission,” said Dr. Andrew Leuchter, professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA and lead author of the study.

“And that wait can be as long as 14 weeks. So these are very exciting findings for the patient suffering from depression,” said Leuchter.

The study results appear in the journal Psychiatry Research. (ANI)

Experimental drug gives new hope for rheumatoid arthritis patients

Washington, June 27 (ANI): A drug in development for the treatment of rheumatoid arthritis has been found to be well tolerated and effective in a clinical trial, say researchers.

The trial of the drug called masitinib was carried out by researchers from several French hospitals. It involved 43 patients with arthritis resistant to current treatments.

Reporting their findings in BioMed Central’s open access journal Arthritis Research and Therapy, the researchers have revealed that treatment with masitinib significantly reduced the severity of active arthritis.

“In choosing which interventions to use for the management of rheumatoid arthritis, it is important to recognise that treatment should aim to keep the disease in remission and not be used intermittently to manage exacerbations. We are encouraged from this study that masitinib not only appears to be effective, but that within the first 3 months of treatment the worst of its side-effects were over, possibly making it suitable for long-term treatment regimens,” said Olivier Hermine, one of the researchers.

“The results of this study also help establish the critical role of mast cells in the pathogenesis of rheumatoid arthritis and demonstrate their viability as a therapeutic target. There is sufficient compelling evidence to warrant further placebo-controlled investigation,” he added.

The researchers have revealed that masitinib inhibits the activity of mast cells, a component of the immune system thought to be involved in the pathogenesis of rheumatoid arthritis.

The clinical improvement described in the study was supported by laboratory evidence of reduced inflammation.

The authors found that adverse effects of the treatment were mainly mild to moderate.

Alain Moussy from AB Science, a pharmaceutical company who are developing masitinib for multiple indications in human and animal medicine, said: “This is a milestone article for us, being the first publication of masitinib in a human study.”

Moussy added: “Our preclinical studies have shown that masitinib selectively targets cell receptors known to be involved in various disease processes but does not affect those associated with toxicity, particularly cardiotoxicity.” (ANI)

Intervention ‘effective in treating patients with pain, depression’

Washington, May 27 (ANI): An intervention including individually tailored antidepressant therapy and a pain self-management program could benefit those suffering from pain and depression, a new study has suggested.

Kurt Kroenke, M.D., of Indiana University School of Medicine and the Regenstrief Institute, Indianapolis, and colleagues conducted a study to determine if a combined pharmacological and behavioral intervention improves both depression and pain in primary care patients with musculoskeletal pain and co-existing depression.

The study included 250 patients who’d had low back, hip or knee pain for three months or longer, and at least moderate depression. The patients were randomly assigned to either an intervention or usual-care group.

Patients in the intervention group received 12 weeks of individually tailored antidepressant therapy, followed by six sessions of a pain self-management program. This was followed by a six-month period in which their symptoms were monitored and treatments reinforced with the goal of preventing relapse, the study authors said.

After 12 months, intervention group participants were more likely to report overall improvement in their pain compared with usual care patients (47.2 percent vs. 12.6 percent), twice as likely to experience depression response (37.4 percent vs. 16.5 percent), nearly four times as likely to experience complete remission of depression (17.9 percent vs. 4.7 percent), and less likely to have major depression (40.7 percent vs. 68.5 percent), the researchers found.

Intervention group patients were also more likely to experience a composite response at six months (23.6 percent vs. 7.9 percent) and at 12 months (26 percent vs. 7.9 percent). A composite response is defined as a reduction of 50 percent or more in depression and reduction of 30 percent or more in pain.

“It is possible that pain improvement in our trial reflected a main effect of improved mood (i.e., an antidepressant effect on mood rather than an analgesic effect), and that as depression lifts, patients may experience pain as being less intense and less disabling,” the authors said.

“Conversely, it is also possible that the improvement in depression was mediated by an improvement in pain (i.e., as pain improves, patients feel less depressed) or that both depression and pain lessened as a result of treatment effects on a common pathway,” they added.

The study appears in the May 27 issue of JAMA. (ANI)

Ted Kennedy’s brain cancer in remission

Washington, May 20 (ANI): Senator Ted Kennedy’s cancer is in remission, and he will be returning to the Senate after the Memorial Day recess, Senate Majority Leader Harry Reid told reporters here on Tuesday.

Reid indicated that he had spoken recently with Kennedy’s wife to discuss his condition. Asked by a reporter if the brain cancer was in remission, Reid said: “As far as I know it is, yes.”

Kennedy still has to undergo a few more treatments before returning to a full Senate schedule.

“He’s doing fine. He’s going through another regimen of treatment, which is not unusual. This is something that was expected. He wanted to have the treatment next week. They had to move it up a week, as I understand it,” Politico quoted Reid, as saying.

Hours after the Kennedy story hit several media outlets, a Reid spokesman later cautioned that the senator wasn’t giving a medical diagnosis.

“Senator Reid will leave the diagnosing to doctors,” spokesman Jim Manley said.

Kennedy has been largely absent from the Senate during his battle with brain cancer, even though he has returned for a few key events, like President Barack Obama’s Inauguration. (ANI)

Eminem’s dying mother wants to end their decade-long feud

London, Apr 23 (ANI): American rapper Eminem’s dying mother Debbie Mathers has expressed her wish to end the decade-long feud that has been going on between them.

The feud started when Eminem, real name Marshal Mathers III, rapped about raping and killing his mum.

His mom tried to sue him for slander and wrote revenge book ‘My Son Marshall, My Son Eminem: Setting the Record Straight on My Life as Eminem’s Mother’.

But now seriously ill after undergoing heart surgery, Debbie is desperate to reconcile with her 36-year-old son and his 13-year-old daughter Hailie before she dies.

“My daughter Debbie is very sick. Her dying wish is to reconcile with her son and see her granddaughter. It’s do or die and Marshall needs to see her before it’s too late,” the Daily Star quoted Debbie’s mother Betty Kresin as telling the National Enquirer.

“She needs heart bypass surgery and she should weigh about 120 pounds, but she’s some 50 pounds below that. Her breast cancer is in remission, but I’m really scared for her.

“I have to go to her house and help her get around. She no longer has the will to live,” she added. (ANI)

DBS CEO Stanley critically ill

Singapore – Singapore’s DBS banking group said its chief executive officer Richard Stanley, who was diagnosed with leukemia in late January, is in critical condition. “Stanley’s condition has deteriorated rapidly in the last 24 hours and he is now in critical care,” DBS said in a filing to the Singapore Exchange on Friday night.

Stanley had been responding well to treatment earlier and after two rounds of chemotherapy his doctors believed earlier this week that his cancer was in remission.

“Unfortunately the unpredictability of the disease has led to severe complications due to infection,” said DBS. (dpa)

UPDATE 1-CEO of Singapore’s DBS bank in critical care

CEO went on medical leave in January

* DBS chairman has active management role

(Adds detail)

SINGAPORE, April 10 (Reuters) – Richard Stanley, the chief executive of Singapore’s DBS Group (DBSM.SI), who is suffering from leukemia, is in critical care after suffering from infection, the bank said.

Stanley went on medical leave in January just eight months after the 48-year old former Citigroup (C.N) executive had joined Southeast Asia’s biggest banking group. DBS chairman Koh Boon Hwee has been running the bank in Stanley’s absence.

“Unfortunately the unpredictability of the disease has led to severe complications due to infection,” the bank said in a statement late on Friday. “Stanley’s condition has deteriorated rapidly in the last 24 hours and he is now in critical care.”

DBS, which is 28 percent owned by Singapore state investor Temasek Holdings [TEM.UL], said Stanley’s doctors had believed earlier this week that his cancer was in remission after two rounds of chemotherapy.

Analysts have said DBS may need to find Stanley’s successor if his illness prolongs, as the bank faces a tough business environment in its key markets, Singapore and Hong Kong, which are both in recession. {Reporting by Saeed Azhar; Editing by Jon Loades-Carter}

Henry VIII ‘was devout Catholic’

London, Apr 4 (ANI): Known as the scourge of the Catholic Church, Henry VIII has long been regarded as a religious sceptic, however, a “new extraordinary discovery” has revealed that he was a firm believer in the religion he later attempted to destroy.

A prayer roll (bede) once owned by Henry and inscribed with his own handwriting has emerged. The roll, which is around 13 feet long and 5 inches wide, will be kept for public display for the first time at the British Library’s exhibition ‘Henry VIII: Man and Monarch,’ which opens later this month and marks the 500th anniversary of Henry’s accession.

The roll is made of narrow strips of parchment stitched together, and bears Henry’s official badge of arms and the Tudor rose. It is decorated with a series of illuminations including the Trinity, the Crucifixion and scenes from Christ’s Passion.

Under the central image of Christ’s Passion is an inscription written by Henry, which reads: “Willyam Thomas, I pray yow pray for me your lovyng master: Prynce Henry.”

Inscribed with Latin prayers and religious instructions, the roll explains how the devotions are to be performed and what rewards the faithful might expect, such as remission of time in Purgatory and protection against illness.

Experts reckon that the teenage Henry gave the roll to William Thomas, one of his personal servants in his Privy Chamber, some time between 1505 and 1509, when Henry was the Prince of Wales.

Dr David Starkey, the historian, who has curated the British Library’s exhibition, described the roll as “a very exciting discovery”.

“I knew nothing of its existence until I began my research for the exhibition, so it has been a very exciting discovery. Many academic historians have long argued that Henry was sceptical of religion from his youth, and that this scepticism ultimately led to the break with Rome and the Reformation,” The Telegraph quoted him, as saying.

He added: “But what we have here, for the very first time, is absolute concrete evidence to the contrary. The Ushaw roll shows just how conservative and pious he was as a young man and how he was, in fact, two very different men before and after his divorce.

“We tend to remember Henry for all the extraordinarily revolutionary things he did, but this highlights how incredibly old-fashioned the young Henry was.

“It is proof that he actually believed in the religion characteristic of late medieval piety and believed that the sacraments carried out miracles – beliefs which he tried to destroy with the Reformation. It will surprise a lot of people.”

Dr Starkey said that Henry would have used the roll as a talisman that he carried with him, which he would have unrolled when he wished to pray. (ANI)

Early detection of second breast cancers ‘can halve death risk’

Washington, Mar 18 (ANI): A group of international researchers have shown that breast cancer sufferers who go into remission but then have their cancer return are at up to half the risk of dying from the disease if its return is spotted early.

Researchers have warned that doctors should continue to monitor breast cancer patients closely and try to identify returning ‘secondary’ tumours before symptoms appear.f detected early enough patients have a 27 to 47 per cent better chance of survival than women whose cancer is picked up later.

The team who carried out the latest study said that it was the most comprehensive assessment of how early detection could prevent deaths from secondary breast cancer.

“Intuitively, it makes sense to consider that early detection of second breast cancers will improve prognosis, since breast cancer survivors have a long-term risk of developing further disease or relapse in either breast,” Nehmat Houssami, from the University of Sydney’s School of Public Health, who led the study, said.

However, she added, there had been a “paucity of evidence” about the benefits of early identification.

According to the research, “recommendations on follow-up after treatment of early breast cancer should consider our findings, which suggest that early detection of second breast cancer events improves prognosis in this ever-increasing group of women”.

The study looked at 1,044 women who had attended a clinic in Florence, Italy, between 1980 and 2005.

While the majority of the tumours were identified by a mammogram, the results show that a significant number, 14 per cent, were picked up only by clinical examination.

The study has been published in the journal Annals of Oncology. (ANI)

Insomnia can be long lasting

Washington, Mar 10 (ANI): Insomnia can be a chronic problem lasting more than a year, a new study has found.

Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity.

Several factors such as being female, increasing age, having anxiety or depression and experiencing pain from medical conditions have been associated with insomnia.

The condition has been linked to higher health care costs, work absenteeism, disability and higher risk of hypertension and depression.

For the study, Charles M. Morin, Ph.D., of Université Laval and Centre de recherche Université Laval-Robert Giffard, Québec, Canada, and colleagues evaluated insomnia persistence, remission and relapse in 388 adults (average age 44.8) over a course of three years.

Individuals with an insomnia syndrome (insomnia symptoms at least three nights per week for at least one month causing substantial distress or daytime impairment) at the beginning of the study were compared to those with insomnia symptoms to examine the course of initial severe sleep difficulties.

“Of the study sample, 74 percent reported insomnia for at least one year and 46 percent reported insomnia persisting over the entire three-year study,” the authors write.

The group with initial insomnia syndrome had a higher persistence rate than the group with symptoms of insomnia (66.1 percent vs. 37.2 percent), respectively.

About fifty-four percent of participants went into insomnia remission; however, 26.7 percent of them eventually experienced relapse.

“Individuals with subsyndromal insomnia [insomnia symptoms] at baseline were three times more likely to remit than worsen to syndrome status, although persistence was the most frequent course in that group as well,” the authors said.

Of the 269 individuals with baseline symptoms of insomnia, after one year 38.4 percent were classified as good sleepers, 48.7 percent still had insomnia symptoms and 12.9 percent had insomnia syndrome.

Results were similar after the second and third year of follow-up. Of the 119 participants with insomnia syndrome at the beginning of the study, 17 percent were good sleepers after one year, while 37 percent had symptoms of insomnia and 46 percent remained in the insomnia syndrome group.

The study has been published in the March 9 issue of Archives of Internal Medicine, one of the JAMA/Archives journals (ANI)

‘EastEnders’ star Wendy Richard passes away at 65

London, Feb 27 (ANI): Soap queen Wendy Richard has died of cancer. She was 65.

Richard, who graced the small screen as Miss Brahms in hit BBC comedy series ‘Are You Being Served?’ and later as matriarch Pauline Fowler in soap EastEnders, had breast cancer, reports The Daily Express.

Wendy’s agent, Kevin Francis, said she remained “incredibly brave and retained her sense of humour right to the end”.

Wendy endured two battles with breast cancer in the mid-1990s and then in 2002.

The cancer went into remission after years of treatment in 2005, but last year it was discovered that the disease had returned in an aggressive form, attacking her kidneys, bones and spine.

Richard, who starred in Eastenders for 21 years, revealed in October she had an aggressive, terminal form of cancer.

Wendy was awarded the MBE for services to television in 2000 and in 2007 she was awarded a British Soap Award for Lifetime Achievement for her role in EastEnders.

She launched her television career as a regular in 1960s soap The Newcomers and later appeared in comedy Dad’s Army and two Carry On films.

Richard left EastEnders in 2006. (ANI)

Lap bands found to be cheapest weight-loss method

Melbourne, Feb 26 (ANI): Forget about diets, exercise and other weight-loss methods, for LAP band surgery is a cheaper way to fight obesity and diabetes, according to a new study.

The first of its kind Victorian study by Monash and Deakin universities has found that gastric banding can also provide more healthy years to highly obese patients, while saving the system thousands of dollars in ongoing costs.

The findings come in line with calls by doctors for weight-loss surgery to be subsidised.

Deakin University researcher Catherine Keating claimed that the immediate surgical outlay offset years of associated health costs.

“Our research shows that it costs less to treat type-2 diabetes early through gastric banding surgery than to allow the same person to live their life with the disease and face ongoing escalating treatment costs,” The Herald sun quoted her as saying.

She added: “Most importantly, these patients could enjoy a dramatic improvement in their quality of life because early treatment using gastric banding surgery results in remission of diabetes for many patients.”

For the study, the researchers followed 60 obese patients for two years and found that the lifetime health care costs of gastric banding was 98,900 dollars, as compared with 101,400 dollars losing weight through conventional methods.

Also, the researchers highlighted that patients who had the immediate benefit of lap band surgery gained an additional 11.4 years of type-2 diabetes-free life, while those relying on conventional weight loss to beat the disease benefitted for only 2.1 years.

Ray Farrugia a patient who dropped from 122kg to 81kg through lap banding, said: “It’s been brilliant. I was a happy fat guy, I never had any worries about my weight. But I could not run 50m without being out of breath. Now I can go for 5km.

“I would never have considered the surgery because it was such a big cost, but if it was subsidised people would undertake it.” (ANI)