It’s the Procedure

After participating in a three-month study on the difference a checklist could make in preventing complications during surgery, 250 healthcare providers — surgeons, anaesthesiologists, nurses, and others — were polled. In an anonymous survey, 80 per cent said that the 19-point checklist had been easy to use, and that it did not hold up their work, and also had “improved the safety of care”; 78 per cent responded that its use had in fact averted an error. Twenty per cent said the checklist was not easy to use, was time-consuming and had no significant impact on safety of care. But here’s the catch. The staff were now asked, “If you were having an operation, would you want the checklist to be used?” Ninety-three per cent said yes. Do the math.

Those 250 respondents were among the staff of eight hospitals around the world which had signed on to a World Health Organisation study Atul Gawande was associated with, and the results on the safety dividend of checklists during surgery were published in the New England Journal of Medicine in January 2009. Since then, there has been a rapid increase in the number of hospitals and medical teams to have adopted a checklist.

And Gawande, a Boston-based surgeon and staff writer for The New Yorker, is both a rousing narrator of how old-fashioned checklists have become the new thing in cutting-edge medicine and an advocate for its multi-disciplinary use. But as he makes his case — in the competently detailed style of The New Yorker — he also, perhaps inadvertently, shines a light on the uncommunicative nature of super-specialist medicine. To the non-medical person, the surprise is not that checklists are so pervasive and useful in aviation, restaurants, disaster management, architecture, etc. The surprise is how late and resistant hospitals have been in adopting this simple tool.

Example: in 2001, Peter Pronovost, a critical care specialist at Johns Hopkins Hospital, came up with a checklist to reduce central line infections (from catheters placed in a patient’s veins). As Gawande tells it, the list was studiedly basic: “Doctors are supposed to (1) wash their hands with soap, (2) clean the patient’s skin with chlorohexidine antiseptic, (3) put sterile drapes over the entire patient, (4) wear a mask, hat, sterile gown, and gloves, and (5) put a sterile dressing over the insertion site once the line is in.” You’d think there was no checklist in place because all this is obvious, but Pronovost found that in one out of three patients, one of these steps had been skipped. And when he convinced his hospital to institute the checklist, the 10-day line-infection rate dropped from 11 per cent to zero.

As more detailed checklists have been adopted, Gawande explains that they establish a higher standard of baseline performance — and there are two types of checklist, do-confirm (performing procedures and then pausing to tick off the stuff that needed to be done) and read-do (carry out tasks as they are ticked off). But in the super-specialist and hierarchal nature of the modern hospital, they also compel communication, which can be crucial. Drawing lessons from modern architecture and the aviation industry, Gawande underlines the utility of checklists in making sure that decision-making and accountability radiate from the centre (or the superspecialist) in what are complex tasks involving many people and diverse skills. And the issue, he says, for medicine today is managing extreme complexity. That complexity has been handled by dividing tasks among various specialties, and a checklist is a way of coherently re-assembling those pieces to the benefit of patients. They provide, he says, “a kind of cognitive net”.

Call it the M&M principle. The American band Van Halen’s contracts with concert promoters had a clause that a bowl of M&M chocolates be kept backstage, but that there be no brown candy. This provision, which Van Halen reportedly invoked on at least one occasion to cancel a show, was, Gawande finds, drawn from the checklist manifesto. David Lee Roth wrote in his memoir that Van Halen shows involved so much equipment and therefore attention to detail, that the drill for each concert was very complicated. So, they put in that brown M&M embargo into the manual as a test: “When I would walk backstage, if I saw a brown M&M in that bowl, well, we’d line-check the entire production.”

Diabetes reaching epidemic proportions in China

Washington, March 25 (ANI): A new Tulane University study has found that diabetes has assumed epidemic proportions in China.

The study, carried out by Tulane University researchers and their colleagues in China, estimates that 92.4 million adults age 20 or older (9.7 percent of the population) have diabetes and 148.2 million adults (15.5 percent) have prediabetes, a key risk factor for the development of overt diabetes and cardiovascular disease.

The research builds on several recent large studies in China that have documented a rapid increase in diabetes in the population. For the current study, an oral glucose tolerance test was administered to 46,239 adults aged 20 or older from 14 provinces and municipalities throughout China in order to identify cases of previously undiagnosed diabetes. Subjects of the study who had been previously diagnosed with diabetes were identified through questioning by the study”s data collectors.

Following recent rapid economic development in China, cardiovascular disease has become the leading cause of death in the county. Diabetes is a major risk factor for cardiovascular disease, and the prevalence of diabetes in China, as this study indicates, is high and increasing.

The researchers found a higher prevalence of diabetes among urban residents in China than among rural ones, a result consistent with observations that have been made in developing countries throughout the world.

Senior author Dr. Jiang He, Joseph S. Copes, Chair and Professor, Department of Epidemiology, Tulane University School of Public health and Tropical Medicine, said: “Urbanization is associated with changes in lifestyle that lead to physical inactivity, an unhealthful diet and obesity, all of which have been implicated as contributing factors in the development of diabetes.”

With its very large population, China may bear a higher diabetes-related burden than any other country, the scientists warn.

Especially alarming is the finding that the majority of cases of diabetes (60.7 percent) are undiagnosed and untreated.

The researchers conclude that diabetes and its consequences have become a major public health crisis in China, and recommend that the country quickly develop and institute national strategies for preventing, detecting and treating diabetes in the general population.

The findings of the study have appeared in the March 25 edition of The New England Journal of Medicine. (ANI)

CSIRO chief defends climate science

The head of Australia’s peak science body has spoken out in defence of climate scientists, saying the link between human activity and climate change is beyond doubt.

The head of the CSIRO, Dr Megan Clark, says the evidence of global warming is unquestionable, and in Australia it is backed by years of robust research.

Dr Clark says climate records are being broken every decade and all parts of the nation are warming.

“We are seeing significant evidence of a changing climate,” she said.

“If we just take our temperature, all of Australia has experienced warming over the last 50 years. We are warming in every part of the country during every season and as each decade goes by, the records are being broken.

“We are also seeing fewer cold days so we are seeing some very significant long-term trends in Australia’s climate.”

Dr Clark says the long-term data across a number of measures stacks up in favour of climate change proponents and against those who say the planet is not warming.

“We can certainly look at the long-term trends and any event here or there or a storm here or there really doesn’t explain away what we are seeing in these major long-term trends,” she said.

“We are also seeing consistency. I think the consistency between our temperatures, what we are seeing in our rainfall, what we are seeing in the increase of carbon dioxide and methane in our atmosphere and of course, what we are now seeing in our oceans.

“So it is not just one measurement that is telling us. It is our observations and science that we are seeing in many areas being consistent.”

Strong evidence

Dr Clark says the evidence strongly suggests human activity is responsible for the rise.

“We know two things. We know that our CO2 has never risen so quickly. We are now starting to see CO2 and methane in the atmosphere at levels that we just haven’t seen for the past 800,000 years, possibly even 20 million years,” she said.

“We also know that that rapid increase that we’ve been measuring was at the same time that we saw the industrial revolution so it is very likely that these two are connected.”

Dr Clark says scepticism is a healthy part of the scientific process and has been considered as part of the climate change debate.

But she says the data needs to be looked at in a systematic way and the evidence backs those who say humans are contributing to global warming.

“Whenever we come into groups with very complex issues as a society, every time we have done that, we should challenge and we do challenge and it brings us back to our observations,” she said.

“It makes us re-look at what we are really seeing. It makes us ask those questions, so I think challenge is simply part of coming to understand an issue.

“But at the same time, plucking out a snow storm in the US or a flood in Queensland or a cold day somewhere and trying to use that to explain away some of these long-term trends, of course, we know is not the right way to do it.”

Dr Clark says the data the CSIRO has based its conclusions on is both long-term and solid.

“We have been recording and the [weather] bureau has been recording our climate for over 100 years,” she said.

“Our records here are extremely robust and of course, CSIRO is studying and researching and looking at those trends for over 50 years so I think we are very blessed in this country to have some very, very robust data and very long-term [data].”

Scientists map melting history of Greenland’s ice sheet

Washington, September 17 (ANI): Researchers from the Niels Bohr Institute at the University of Copenhagen have mapped the history of the melting of the Greenland ice sheet.

Numerous drillings have been made through both Greenland’s ice sheet and small ice caps near the coast.

By analyzing every single annual layer in the kilometres long ice cores, researchers can get detailed information about the climate of the past.

But now, the Danish researcher Bo Vinther and colleagues from the Centre for Ice and Climate at the Niels Bohr Institute, University of Copenhagen, in collaboration with researchers from Canada, France and Russia, have found an entirely new way of interpreting the information from the ice core drillings.

“Ice cores from different drillings show different climate histories. This could be because they were drilled at very different places on and near Greenland, but it could also be due to changes in the elevation of the ice sheet, because the elevation itself causes different temperatures,” explained Bo Vinther about the theory.

Today, the ice sheet is more than three kilometres thick at its highest point and thinning out towards the coast.

Four of the drillings analyzed are from the central ice sheet, while two of the drillings are from small ice caps outside of the ice sheet itself.

By comparing the Oxygen-18 content in all of the annual layers from the four drillings through the ice sheet with the Oxygen-18 content of the same annual layers in the small ice caps, Bo Vinther has calculated the elevation course through 11,700 years.

Just after the ice age the elevation of the ice sheet rose slightly because when the climate transitions from ice age to warm age, there is a rapid increase in precipitation.

But at the same time, the areas lying near the coast begin to decrease in size, because the ice is melting at the edge.

When the ice melts at the edge, it slowly causes the entire ice sheet to ‘collapse’ and become lower.

The calculations show that in the course of about 3,000 years, the elevation changed and became up to 600 meters lower in the coastal areas.

But in the middle, it was a slow process, where the elevation decreased around 150 meters in the course of around 6,000 years.

It then stabilized.

The new results show the evolution of elevation of the ice sheet throughout 11,700 years and they show that the ice sheet is very sensitive to the temperature.

The results can be used to make new calculations for models predicting future consequences of climate changes. (ANI)

Current CO2 levels higher than last 2.1 million years

Washington, June 19 (ANI): A new study has shown that current CO2 levels are higher than the last 2.1 million years.

The study is the latest to rule out a drop in CO2 as the cause for earth’s ice ages growing longer and more intense some 850,000 years ago.

But it also confirms many researchers’ suspicion that higher carbon dioxide levels coincided with warmer intervals during the study period.

The authors show that peak CO2 levels over the last 2.1 million years averaged only 280 parts per million; but today, CO2 is at 385 parts per million, or 38 percent higher.

This finding means that researchers will need to look back further in time for an analog to modern day climate change.

In the study, Barbel Honisch, a geochemist at Lamont-Doherty Earth Observatory, and her colleagues reconstructed CO2 levels by analyzing the shells of single-celled plankton buried under the Atlantic Ocean, off the coast of Africa.

By dating the shells and measuring their ratio of boron isotopes, they were able to estimate how much CO2 was in the air when the plankton were alive.

This method allowed them to see further back than the precision records preserved in cores of polar ice, which go back only 800,000 years.

The planet has undergone cyclic ice ages for millions of years, but about 850,000 years ago, the cycles of ice grew longer and more intense-a shift that some scientists have attributed to falling CO2 levels.

But, the study found that CO2 was flat during this transition and unlikely to have triggered the change.

A global drawdown in CO2 is one theory proposed for the transition.

“The low CO2 levels outlined by the study through the last 2.1 million years make modern day levels, caused by industrialization, seem even more anomalous,” said Richard Alley, a glaciologist at Pennsylvania State University.

“We know from looking at much older climate records that large and rapid increase in C02 in the past, (about 55 million years ago) caused large extinction in bottom-dwelling ocean creatures, and dissolved a lot of shells as the ocean became acidic. We’re heading in that direction now,” he added. (ANI)

Get slim with a breakfast of muesli with milk, tinned peaches and yoghurt

London, Apr 18 (ANI): Is your expanding waistline giving you nightmares? Well, take heart. Researchers have found that a breakfast of muesli with milk, tinned peaches and yoghurt can help weight loss.

Experts at the University of Nottingham suggest that the low GI breakfast with apple juice helps the body break down fat better than a high Glycaemic Index start to the day of sugary cereal and white toast, reports The Daily Express.

Scientists discovered that the type of food you eat before exercise can directly impact on your health.

A study led by Dr Emma Stevenson looked at young women after an overnight fast. In one study period they were given a breakfast of food known to cause large rises in blood glucose – those with a high GI, including cornflakes and milk, white bread and jam and a fizzy, sugary drink.

In another period, they breakfasted on food with a low GI, although both breakfasts had the same amount of calories, carbohydrate, fat and protein. The low GI breakfast was muesli, milk, tinned peaches, yoghurt and apple juice.

Three hours after eating, the women walked for an hour on a treadmill. A lunch – the same in both study periods – was then provided. Throughout the day blood samples and samples of expired air were taken.

From analyses, researchers found blood glucose levels were higher after the high GI breakfast than the low one, and had returned to normal by the time the women began to exercise.

However, plasma free fatty acids (FFA) – which show the amount of fat used up for energy – began to rise two hours after the low GI breakfast, the researchers found.

Exercise then led to a rapid increase in FFAs in both groups – but concentrations were higher in the low GI group. After lunch the concentration of FFAs was the same in both groups, but overall fat oxidation was higher in the low GI group than the high GI group.

Dr Stevenson said: “We concluded that consuming a low GI breakfast increases fat oxidation both at rest and during subsequent exercise. A low GI breakfast also had an impact on appetite, with test subjects feeling fuller for longer after they’d eaten these types of foods.” (ANI)

Fossil corals show catastrophic sea-level rise about 121,000 years ago

Washington, April 16 (ANI): A study, which is being touted as controversial, has said that fossil coral reefs at a Mexican theme park “confirm” that sea levels rose rapidly about 121,000 years ago.

Previous research on fossil reefs had shown that sea levels surged by 13 to 19 feet (4 to 6 meters) near the end of the last time period between ice ages, known as an interglacial period.

But, researchers have been unsure whether this sea-level rise happened quickly or gradually.
According to a report in National Geographic News, by mapping the ages and locations of ancient corals at Xcaret, an eco-park in the Yucatan Peninsula, Paul Blanchon of the National Autonomous University of Mexico, and colleagues, were able to chart when the reefs died and were replaced by others on higher ground.

Their data suggest that sea levels rose by about 10 feet (3 meters) in 50 years – much faster than the current annual rate of 0.08 to 0.1 inch (2 to 3 millimeters).

Because this event happened during an interglacial period, similar to the one we’re in currently, the find boosts the chances that today’s melting ice sheets could trigger rapid sea-level rise, according to the researchers.

Mike Kearney, of the University of Maryland said that it’s “within the realm of possibility” that global warming will trigger a sudden collapse of the West Antarctic ice sheet, which could lead to a rapid increase in sea levels like that predicted by the new study.

“But the big unknown is whether any of the things we think we know about the Antarctic ice sheet prove to be true,” Kearney cautioned.

“One camp says (rapid sea-level rise) could happen, another camp says it would take thousands of years. I’m not sure what the conventional wisdom is right now. It depends on who you talk to,” he added. (ANI)

UPDATE 1-China iron ore imports up on small mill deals

By Alfred Cang

SHANGHAI, April 10 (Reuters) – Deals signed by small Chinese steel makers with overseas suppliers are behind the surge in the country’s iron ore imports, the Securities Times newspaper said on Friday.

China said on Friday that it imported a record 52.08 million tonnes of iron ore in March [ID:nPEK9162], signalling that Chinese demand for the raw material remains strong.

Chinese steelmakers are still locked in annual price talks with global mining majors BHP Billiton (BHP.AX)(BLT.L), Rio Tinto (RIO.AX)(RIO.L) and Vale (VALE5.SA), and the surge in imports illustrates their growing dependence on foreign iron ore.

Steelmakers based in northern China’s Tangshan are importing iron ore and paying term prices after agreeing their 2009 purchase volumes late last year, the newspaper said, citing executives in the local mills.

“The CIF prices offered by iron ore giants such as Rio Tinto are very attractive,” the newspaper quoted a steel mill executive as saying. The steel mill consumes more than 5 million tonnes of iron ore a year and has already booked 2 million tonnes of imported ores.

The supply deals with overseas miners were signed on a monthly basis and also included favourable terms such as payment deferrals and discounts for bulk purchases, the newspaper said.

The contracts involve the delivery of tens of millions of tonnes of iron ore to Tangshan, home of hundreds of mostly small, private-sector steel mills, the newspaper said.

“Currently, the volumes of these contracts cannot be huge, but they will back the Chinese side into a corner during the annual price negotiations,” an analyst at Sinosteel Corp, a major state-owned trading house, told the newspaper.

“The rapid increase of iron ore imports signals that China’s iron ore demand is strong and that iron ore prices have hit bottom, and therefore, expectations for term iron ore prices (for the 2009-10 contract year) will certainly rise,” the analyst said.

REPLACEMENT

Medium- and small-sized steel mills will benefit from the switch to term prices, which are fixed and lower than those on the spot market, the newspaper said, citing an executive from another steel mill in Tangshan.

Ironically, the rapid development of Tangshan’s steel industry was partly due to the relatively cheap and plentiful iron ore resources in the region. Analysts have said that margins in these mills were high because of their flexible and efficient operations.

The small mills were rarely considered as potential clients for major overseas miners, which have targeted leading global steel makers like Japan’s Nippon Steel (5401.T), South Korea’s POSCO (005490.KS) and China’s Baosteel (600019.SS) as their main customers.

However, the global financial crisis has slashed steel demand and forced overseas steel mills to cut output, forcing miners to search for new options.

Since late last year, the miners have been expanding their sales coverage and increasing spot supplies to China’s trading houses and medium- and small-sized mills, the Securities Times newspaper said.

“With secure quality and quantity, small mills are happy to receive these offers,” said Macquarie Bank analyst Henry Liu.

“These mills may also feel that the current market conditions, in which spot prices are lower than term prices, could be short-lived, as the term prices for this year will definitely fall remarkably,” he said.

(Editing by Jacqueline Wong)

Dangerous cocktails: Trying to build muscle using pills and powder

Saarbrucken, Germany – For professional cyclists, track and field athletes and weightlifters the use of steroids and other performance-enhancing drugs is a serious offence.

But amateur athletes and people who are simply dedicated to a chosen sport routinely use pills, powders and injections, according to a German government health report.

“Doping among non-professional athletes continues to be underestimated and more widespread than is commonly accepted,” warned professor Wilfried Kindermann of the Institute for Sports and Preventative Medicine at the University of Saarland in Saarbrucken.

Recently, more large-scale studies have been undertaken to find out more about doping in fitness studios. According to these surveys, at least 10 per cent of the people who work out in gyms abuse performance enhancers such as anabolic steroids. Abuse among men is clearly greater than among women.

Anabolic steroids are the most common. The derivative of the male sex hormone testosterone leads to rapid increase in muscle mass.

“People who take the drugs for a long time see only the intended positive effects,” said Mario Thevis, a professor at Germany’s centre for preventative doping research in Cologne. “They think they have everything under control and that they are one of the people unaffected by side effects.” But these appear only after long-time use.

Joerg Boerjesson of Dorsten, Germany, was 19 when he started training excessively at the gym and taking pills. He thought he was immune from the side effects, but health problems started to appear after years of abuse. He suffered nosebleeds and stomach and intestinal cramping. Ultimately, he had to have surgery. His testosterone ingestion over time had resulted in the growth of breasts, and a suspected case of breast cancer.

Today the former bodybuilder and ex-doper considers himself a “preventologist.” He goes to schools, contributes to a German-language website specializing in helping people get off performance-enhancing drugs and assists at a telephone hotline that also helps people who want to quit.

“I talk to a whole lot of people who are intent on increasing their performance – in sports or in their professions, for example, in the military. They know exactly what they are doing and they accept the risks,” Boerjesson said.

Achieving a certain look often plays a role among steroid users who work out at the gym or at fitness studios.

“According to surveys, appearance is the main reason for using steroids for more than half the people who work out at the gym,” said Thevis. There is usually a narcissistic motivation for using steroids among people who work out in their free time, especially among bodybuilders, Kindermann added. “They would like to impress others with their athletic bodies.”

There are other supplements beyond anabolic steroids available for sale on the internet, on the black market, from fellow athletes and also through prescriptions and over-the-counter at the drug store. These include stimulants such as ephedrine, which increases performance and willingness to take risks. Growth hormones such as erythropoietin (epo), increase stamina. Acetylsalicylic acid and anti-rheumatic agents suppress pain resulting from excessive training.

“Often a cocktail concoction is taken without a doctor’s oversight,” said Thevis. People tap into internet forums and relevant literature for guidance on how to use the drugs, but the consumer has no chance to assess the interaction of the drugs, Thevis said. “He can’t check and reassess the concentration and the dosage.”

Up to 30 per cent of the substances available don’t contain what they say they contain. The long-term results of abusing the substances includes stunted growth, sexual dysfunction, enlarged heart, liver cancer and psychological consequences such as increased aggression. (dpa)

Health dept, docs discuss way out of tricky organ donation issues

CHENNAI: If the blood relative of a brain-dead patient is in need of a vital organ, can the family who is willing to sign papers for donation
demand that the organ be given to the relative? Is the doctor or hospital coordinating a cadaver organ donation liable if the organ retrieved loses it vitality? If the organs of a brain-dead person, the result of a road accident, is removed, will it mean tampering with evidence in a medico-legal case?

These and other related questions came up for a detailed discussion on Saturday when doctors from at least 50 hospitals in Tamil Nadu, mostly licensed transplant centres, met officials from the state health department at a workshop on cadaveric transplantation in Tamil Nadu’, organised by the director of medical services and rural health. The workshop was organised to discuss the Transplant of Human Organs Act 1994 and a series of government orders issued by the health department since January 2008 to promote cadaver transplant.

Over the past six months, the state has seen a rapid increase in organ donation. Forty kidneys, 14 livers, six hearts, 26 corneas, 14 heart valves and skin were harvested from 20 cadavers. Health secretary V K Subburaj said that the meeting was called to discuss problems the network faced in the last six months. “We are sure in the next few months we would be able to streamline the system for cadaver organ donation that would possibly reduce the need for any live donors,” he said.

IT secretary PWC Davidar, instrumental in issuing the government orders (GOs) while he was in the health department, discussed the GOs. “These are not just a set of rules written to be filed as orders. We want every hospital to certify brain death,” he said.

One city-based doctor wanted to know if the donor’s relatives had the right to dictate who the recipient should be. “In one case, the donor’s brother was blind and was waiting for a corneal transplant. They were willing to donate all the organs but requested that one eye be used for his brother. It was tricky situation and we did not know how to handle it,” he said.

Most government officials were for hospitals remaining firm. “With the present rules we don’t have provisions for that. We only encourage voluntary donation with no strings attached,” said Dr J Amalorpavanathan, convenor, cadaver transplant programme.

After hearing out narrations of several incidents, Davidar said that the department would look at options such as passing government orders that could deal with such special situations. “Sometimes, when the donor’s blood relative is in need of an organ, we will have to work it out as well,” he said. “We are also working on orders for organ transplant in medico-legal cases,” he said.

Presently, doctors take in only those cases where the cause of death is ascertained as a road accident. “We also take written consent from the investigating officer that the organ donation will not hamper investigations,” said Dr Amalorpavanathan.

Doctors clarified that no doctor or hospital was legally bound for the viability of the organs before or after transplants. Hospitals agreed to pay Rs 10,000 as annual fee for being a part of the organ sharing network. They decided that a website giving limited information about organ donation and organ sharing would help the public and ensure patient confidentiality.