Ex-Nepal PM Koirala passes away

Kathmandu, Mar 20 (ANI): Formal Nepal Prime Minister and Nepali Congress President Girija Prasad Koirala died today at his daughter Sujata Koirala”s residence in Mandikatar.

A chronic patient of pulmonary diseases, Koirala was suffering from chest and urinary tract infection for months.

Minister for Irrigation Bal Krishna Khand told mediapersons that Koirala passed away at 12.10 p.m. today.

Born on 1925, Koirala 85, had been Prime Minister of Nepal four times, serving from 1991 to 1994, 1998 to 1999, 2000 to 2001, and from 2006 to 2008; he was also Acting Head of State from January 2007 to July 2008.

He had been active in politics for over sixty years and is a pioneer of the Nepalese labour movement, having started a labor movement in the Jute mills of his hometown Biratnagar.

In 1991 he became the first democratically elected Prime Minister since 1959, when his brother B. P. Koirala and the Nepali Congress party swept the country”s first democratic election.

In Nepal”s first multi-party democratic election in 1991, Koirala was elected as a Member of Parliament from the Morang-1 and Sunsari-5 constituencies. He was subsequently elected as the leader of the Nepali Congress parliamentary party and was appointed as Prime Minister by King Birendra.

During his first term, the house of representatives enacted legislation to liberalize education, media and health sectors in the country.

In November 1994 he called for a dissolution of parliament and general elections after a procedural defeat on the floor of the House when 36 Members of Parliament (MPs) of his party went against a government-sponsored vote of confidence.

This led to the Communist Party of Nepal (Unified Marxist Leninist)-led coalition coming to power in the elections that followed.

Koirala took over as Prime Minister from Surya Bahadur Thapa following the collapse of the coalition government led by Thapa. Koirala first headed a Nepali Congress minority government until December 25, 1998 after which he headed a three-party coalition government with the Communist Party of Nepal (UML) and the Nepal Sadhbhawana Party.

He again became Prime Minister in 2000 for his third term following the resignation of Krishna Prasad Bhattarai, under whose leadership party had won the parliamentary election.

After the reinstatement of the Nepal House of Representatives, Pratinidhi Sabha, on 24 April 2006 following the Loktantra Andolan, Koirala was selected to become Prime Minister by the leaders of the Seven Party Alliance.

On 1 April 2007, Koirala was re-elected as Prime Minister to head a new government composed of the SPA and the CPN (Maoist). (ANI)

Koirala”s health condition deteriorates again

Kathmandu, Mar 19 (ANI): Ailing former Nepal Prime Minister and Nepali Congress President Girija Parsad Koirala”s health condition deteriorated again on Friday.

According to Kantipur, Koirala has again suffered from respiratory problems.

A team of doctors has reached Koirala”s residence at Mandikhatar in the capital.
Koirala was discharged from Sahid Gangalal Heart Centre in Bansbari on March 17 after the increase in oxygen level in his blood.

A chronic patient of pulmonary diseases, Koirala has been suffering from chest and urinary tract infection recently. He was bedridden for months. (ANI)

Koirala to be discharged from hospital today Koirala to be discharged from hospital today

Kathmandu, Mar 17 (ANI): Doctors looking after former Nepal Prime Minister and Nepali Congress President Girija Prasad Koirala today said his condition is improving and he will be discharged from hospital this evening.

According to them, the oxygen level in his blood has increased.

Koirala was rushed to the Sahid Gangalal Heart Centre in Bansbari on Sunday evening after the haemoglobin level in his blood dropped and he complained of difficulty in breathing.

A chronic patient of pulmonary diseases, Koirala has been suffering from chest and urinary tract infection recently. He was bedridden for months.

Meanwhile, UCPN (Maoist) Chairman Pushpa Kamal Dahal is due to visit the octogenarian leader in the hospital today, the Kantipur reported. (ANI)

How to make a lung

Washington, Aug 18 (ANI): Scientists from University of Pennsylvania have shed light on how lungs are developed in the body.

They have identified a tissue-repair-and-regeneration pathway in the human body, including wound healing that is essential for the early lung to develop properly.

The researchers have also discovered two molecules in this pathway, Wnt2 and Wnt2b that play a key role in early lung development.

“We wanted to know the answer to a seemingly simple question: What is required to generate the lung in mammals?” said senior author Dr Edward Morrisey, Associate Professor of Medicine and Cell and Developmental Biology at the University of Pennsylvania School of Medicine.

“Wnt molecules are important for lung growth and we think that some of the molecules in the Wnt pathway are needed to specify lung progenitor cells and if not enough cells are ‘told’ to make a lung, an animal develops a faulty, smaller organ or even no lung,” he added.

Understanding how a lung develops is important in treating or preventing a host of lung and pulmonary diseases in children.

In the developing embryo, the lung, pancreas, liver, thyroid, and stomach all come from the foregut region, which starts out looking like a long tube.

“These organs bud from this undifferentiated tube and go on to develop into specific tissue types. The lung is one of the last to bud off the foregut during development,” said Morrisey.

The team focused on the Wnt pathway to see where and when Wnt molecules were expressed along the foregut tube, even before the lung starts to become a recognizable organ.

They found that the Wnt proteins Wnt2 and Wnt2b are expressed in the cells surrounding the foregut, right where the lung will eventually form. When they are knocked out, the animals completely lacked lungs.

Morrisey surmised that Wnt2 and Wnt2b were required to specify the early progenitors for the lung in the foregut.

The Morrisey lab showed that activation of the Wnt pathway resulted in formation of lung progenitors in both the esophagus and stomach where they are normally excluded.

“The ability of Wnt to program esophagus and stomach endoderm to a lung fate points to the critical role this pathway plays in lung development and suggests the possible use of Wnt in generating lung epithelium from non-lung sources,” said Morrisey.

The findings are described this week in Developmental Cell. (ANI)