Structure of ”swine flu” virus found

Washington, Mar 25 (ANI): The structure of a key protein from the virus that caused last year”s “swine flu” influenza epidemic has been solved by a team of scientists from The Scripps Research Institute and other institutions.

The development explain why young people have been more vulnerable than older individuals in recent pandemic.

The structure reveals that the virus shares many features with influenza viruses common in the early 20th century.

The team”s findings were published in the March 25, 2010, issue of Science Express, an advance, online publication of selected research papers from the prestigious journal Science.

In the study, the team describes the structure of the hemagglutinin (the influenza virus envelope protein) from the H1N1 swine flu virus that triggered the pandemic in 2009 and is still circulating in the human population. The team then compared the swine flu hemagglutinin protein with a range of different human H1N1 flu viruses in the past century.

“Parts of the 2009 virus are remarkably similar to human H1N1 viruses circulating in the early 20th century,” said Scripps Research Professor Ian Wilson, who was the senior author of the study. “Our findings provide strong evidence that exposure to earlier viruses has helped to provide some people with immunity to the recent influenza pandemic.”

The information should be useful for scientists and public health officials as they respond to current and future pandemics. (ANI)

Novel vaccine strategy may offer protection against flu viruses

Washington, May 19 (ANI): Researchers at the University of Pittsburgh suggest that vaccines made up of virus-like particles (VLPs) could provide stronger and longer-lasting protection against flu viruses than conventional vaccines.

VLP vaccines can be developed and produced twice as quickly as conventional vaccines, the researchers said.

In early clinical trials, VLP vaccines appear to provide complete protection against both the H5N1 avian influenza virus and the 1918 Spanish influenza virus, said Ted Ross, an assistant professor at the University of Pittsburgh’s Center for Vaccine Research.

Adopting the new vaccine strategy may allow public health officials to respond more quickly to emerging influenza pandemics, say researchers.

The current injectable vaccine for seasonal influenza is a trivalent, inactivated vaccine. It consists of three different influenza strains that are grown in eggs and then inactivated, or killed, by chemicals that break them into tiny pieces.

Because they no longer look like the circulating virus, conventionally made vaccines strains do not elicit as strong an immune response as VLP vaccines.

VLPs can be quickly and easily produced in several ways, including growing them in cell cultures or in plants.

Also, if the genes in the disease virus are identified, then researchers can generate particles for a vaccine without an actual sample of the agent.

“The sequence for the recent H1N1 ‘swine flu’ virus was online and available to scientists long before physical samples could be delivered,” r. Ross said.

“It would have been possible to produce VLPs in quantity in as little as 12 weeks while conventional vaccines require physical samples of the virus and production can take approximately nine months,” he added.

The study has been presented at the 109th General Meeting of the American Society for Microbiology in Philadelphia. (ANI)

Ocimum Biosolutions to introduce new test for H1N1 flu

Hyderabad, May 4 (ANI/Business Wire India): Ocimum Biosolutions announced the launch of a microarray-based test (research use only) for the latest version of the H1N1 flu.

The company reported that it updated its custom chip probes using sequence information from the latest strain of the swine flu from the NCBI site.

Most of these sequences have been submitted worldwide in the past 96 hours.

The CDC and US Food and Drug Administration have authorized the emergency use of an RT-PCR based molecular diagnostic assay to identify cases of swine flu in the current outbreak in the US.

The microarray (research use only) was developed on Ocimum’s custom OciChipT array platform three years ago when the first cases of the avian flu outbreak occurred.

This has been updated with the latest sequence information posted last week and the probes have been redesigned.

This test will be available for use after the validation is completed. Ocimum said that it can also provide an RT-PCR based molecular diagnostic assay for use in India and Asia.

Anu Acharya, CEO, Ocimum Biosolutions said, “Our Bioinformatics team in India has redesigned the OciChipT array probes to match the latest sequence information available. The RT-PCR assay and the microarray will quickly identify the H1N1 virus in patients diagnosed with Influenza A as some older tests may not pick up this new strain.”

“In a public health emergency like this, we want to make sure that we identify the right strain which is not picked up by current tests. We are ready to work with various public health labs in the India and the region that need help in setting up these assays, or running the samples in our labs. Pandemics of this sort need to be rapidly identified at the source so that public health officials can implement various measures to control the disease. Both these assays can be conducted in a few hours and avoids the risk of patients with suspected cases infecting others when the wait is longer,” added Acharya. (ANI)

Canada reports first case of pigs catching swine flu from humans

Ottawa (Canada), May 3 (ANI): The Canadian Food Inspection Agency has come out with an outstanding revelation that a farm hand has infected pigs at an Alberta farm with the swine flu virus.

The Canadian Press quoted Canada’s top veterinary officer, Brian Evans and the country’s chief public health officer, David Butler-Jones, as saying in Ottawa that the farmhand who travelled to Mexico fell ill upon his return, and apparently infected the pigs with the H1N1 influenza virus.

It’s believed to be the first known case of pigs catching the swine flu virus from humans.

The farm worker returned to Canada from Mexico on April 12 and had contact with the pigs two days later.

About 220 pigs in the herd of 2,200 began showing signs of the flu on April 24, said Evans.

All of the pigs are recovering or have recovered and the farm worker has also recovered, he added.

“So far, basically what we’re seeing in the pig is the same strain as we see in the humans. The concern is that if it’s circulating in a pig herd, that any other humans that come onto the farm might be exposed and be at risk,” David Butler-Jones said.

Public health officials and others are trying to intercept incoming workers at food lines and churches in hopes of stemming the spread of deadly swine flu.

The virus has shown no signs of mutation when passing from human to pig, Evans said.

“At this point in time, the issue of this being a human virus, having been introduced to the pigs, and the characterization of this virus, shows it is still that virus. There’s been no adaptation identified through the transfer from humans to pigs at this time,” he said.

The World Health Organization has insisted there is no evidence that pigs are passing the virus to humans, or that eating pork products poses an infection risk. (ANI)

Bob Dylan’s portable lavatory getting complains from neighbours

London, Mar 18 (ANI): American singer-songwriter Bob Dylan has landed himself in trouble with his neighbours, after his portable lavatory caused noxious fumes to travel over the wall into the house next door.

Dylan, 67, set up the portable lavatory to cater to his security staff, who patrol his estate in Malibu at night.

However, his neighbours have now complained that the stench coming from it is making parts of their house no longer habitable.

“Mr Civil Rights is killing our civil rights!” the Independent quoted David Emminger as telling reporters, as he pointed out the controversial, blue portable lavatory, which is behind a storage container next to a wire fence that marks the border of Dylan’s property.

Emminger claims that his eight-year-old son, David junior, has fallen ill from the fumes.

“It started in September. I’d go into the front yard and get nauseous,” Emminger’s wife, Cindy, told the Los Angeles Times.

“I couldn’t figure out at first where the smell was coming from, until I finally noticed that they had moved the porta-potty directly in front of my front door.

“We both have allergies and are sensitive to chemicals. It’s worse when it’s misty outside at night. We turn on the five fans, but it still gets inside our house. We’re not even using the upstairs now. We sleep downstairs,” she added.

The couple have had to install five industrial-sized outdoor fans in their front yard to blow noxious fumes back on to Dylan’s property. Malibu City public health officials are investigating the complaint, though when the city tried to send an officer to inspect the contentious lavatory in January, he was turned away by Dylan’s security staff and accused of trespassing.

“[The guard] said they were going to sue the city,” an inspector told the paper.

No comments on the matter have been made by Dylan’s spokesman or his New York-based attorney. (ANI)

NASA’s early warning system predicted outbreak of deadly virus in northeast Africa

Washington, Feb 18 (ANI): A new study by NASA scientists has determined that an early warning system, more than a decade in development, successfully predicted the 2006-2007 outbreak of the deadly Rift Valley fever virus in northeast Africa.

Rift Valley fever is unique in that its emergence is closely linked to interannual climate variability.

Utilizing that link, researchers used a blend of NASA and National Oceanic and Atmospheric Administration measurements of sea surface temperatures, precipitation, and vegetation cover to predict when and where an outbreak would occur.

The research team included Assaf Anyamba, a geographer and remote sensing scientist with the University of Maryland Baltimore County and NASA’s Goddard Space Flight Center in Greenbelt, Maryland.

The final product, a Rift Valley fever “risk map,” gave public health officials in East Africa up to six weeks of warning for the 2006-2007 outbreak, enough time to lessen human impact.

The first-of-its-kind prediction is the culmination of decades of research.

During an intense El Nino event in 1997, the largest known outbreak of Rift Valley fever spread across the Horn of Africa.

About 90,000 people were infected with the virus, which is carried by mosquitoes and transmitted to humans by mosquito bites or through contact with infected livestock.

The 1997 outbreak provoked the formation of a working group, funded by the U.S. Department of Defense Global Emerging Infections Surveillance and Response System, to see if predictions of an outbreak could be made operational.

The link between the mosquito life cycle and vegetation growth was first described in a 1987 Science paper by co-authors Kenneth Linthicum of the U.S. Department of Agriculture and Compton Tucker of NASA Goddard.

Then, a subsequent 1999 Science paper described link between the disease and the El Nino-Southern Oscillation (ENSO).

Building on that research, Anyamba and colleagues set out to predict when conditions were ripe for excessive rainfall, and thus an outbreak.

They started by examining satellite measurements of sea surface temperatures.

One of the first indicators that ENSO will bring an abundance of rainfall is a rise in the surface temperature of the eastern equatorial Pacific Ocean and the western equatorial Indian Ocean.

But perhaps the most telling indicator of a potential outbreak is a measure of the mosquito habitat itself.

The researchers used a satellite-derived vegetation data set that measures the landscape’s “greenness.”

The final product is a risk map for Rift Valley fever, showing areas of anomalous rainfall and vegetation growth over a three-month period. (ANI)

Smokeless tobacco may not help smokers kick the butt

London, Jan 27 (ANI): A new study has cast doubt on the proposal to promote smokeless tobacco as a safer alternative to cigarettes.

Previous studies of smokers in Sweden have suggested that many have quit smoking by switching to smokeless tobacco. While not without health risks, smokeless tobacco is less harmful than cigarettes.

“In Sweden, many smokers have quit smoking by switching to snus,” the British Medical Journal quoted Shu-Hong Zhu, Ph.D., Professor of Family and Preventive Medicine in the UCSD School of Medicine as saying.

Snus is a form of moist, powdered tobacco that comes in a small sachet and is placed under the lip.

“This has piqued a lot of interest, because anything that helps people quit cigarettes could have huge benefits due to the great harm caused by smoking,” Zhu added.

“Historically, there has been no campaign to promote snus to Swedes as a safer alternative to cigarettes,” said Hans Gilljam, M.D. a Professor at the Karolinska Institutet and a study author.

“But snus has been popular among male smokers, and has helped them quit cigarettes. In fact, Swedish men have a higher smoking cessation rate than Swedish women, few of whom use snus,” Gilljam added.

However, public health officials say that smokeless tobacco should not be promoted so fast.

The researchers looked for a similar effect among the U.S. smokers. While, U.S. men are much more likely than women to use smokeless tobacco but it does not boost their rate of quitting smoking.

“With an ongoing tobacco control effort, men in the U.S. seem to be quitting smoking at higher rates than men in Sweden. And U.S. women are quitting at the same rate, unlike their counterparts in Sweden,” Zhu said.

The current study examined data from the Tobacco Use Supplement to the Current Population Survey, 2002, with one-year follow-up in 2003.

The results showed both male and female smokers in the U.S. appear to have higher quit rates for smoking than their Swedish counterparts, despite greater use of smokeless tobacco in Sweden. (ANI)