No semester: science depts

New Delhi, May 26 — After the English and Mathematics departments refusing to teach modules in the science courses approved by the Academic Council to be taught under the semester system, science teachers too have now refused to teach these courses. In a meeting of the General Body of Science on Wednesday, more than 350 teachers of Delhi University comprising departments of Physics, Chemistry, Botany, Zoology, Electronics and Computer Science rejected the implementation of semester system in the 12 science courses. In the academic council meeting held on May 13, it was decided that barring BSc (H) Mathematics and BSc (H) Chemical Sciences, all the science courses will follow the semester system. The General Body of Science, which met at Kirori Mal College, has resolved to reject the semester system and the semester-based courses that they claim have been passed illegally and undemocratically by the Vice-Chancellor. They have also decided not to teach any courses under the semester-based system. “We want the courses to be taught in the annual system of exams with the old syllabus retained,” said Vinay Kumar Singh, Secretary, General Body of Science. The teachers also protested the scrapping of BSc Applied Physical Sciences courses such as Computer Sciences and Electronics and merging them into BSc Physical Science.

They have also asked the DUTA to disassociate from admissions process due to begin from Friday.

How to split up a dangerous pair of cancer proteins

Washington, August 21 (ANI): Chemotherapy that is more effective and has fewer side effects may be around the corner, for researchers at the University of Toronto Mississauga have devised a way to split up a dangerous pair of cancer proteins.

The breakthrough work was carried out in collaboration with researchers at the University of Central Florida and the Princess Margaret Hospital.

The researchers have created several molecules that inhibit Stat3, a protein that pairs with another copy of itself in cancer cells, and goes haywire.

“The molecules we have created are particularly nice because they’re showing selectivity against cancer cells but not against healthy cells. This molecule could be used in conjunction with typical chemotherapeutics, and it could mean that drugs will have less resistance-so you could use lower dosages and cause fewer side effects,” says senior study author Professor Patrick Gunning, of the Department of Chemical and Physical Sciences at the University of Toronto Mississauga.

The Stat3 protein is involved in almost all cancers, and is known to contribute to the resistance of cancer cells to current drug therapies.

“Most currently available therapeutics aim to induce cell death. We wanted to make small molecules that could try and stop this protein,” says Gunning.

In cancerous cells, Stat3 proteins bind together to work as a lethal pair, and inhibitors work to prevent this. This type of protein-protein interaction is notoriously difficult to counter.

During the study, Gunning and his colleagues targeted binding “hotspots” on a known Stat3 inhibitor called S3I-201.

The researchers chemically altered the inhibitor to produce several new variants, which they then tested on Stat3.

They found that some variants were even more powerful than S3I-201, and showed activity against prostate, breast and acute myeloid leukemia cancer cell lines.

“These are some of the most potent inhibitors in the literature so far for this particular protein. In some cases, they were more than twice as effective as the existing inhibitor,” says Gunning.

Upon using more complex cancer cell models, the researchers found that the inhibitors survived the passage across the cell membrane, and still targeted the Stat3 cancer proteins inside.

The researchers are working to make the new inhibitors even more effective, as well as more metabolically stable, meaning that they can survive the chemical defence mechanisms within the cell.

They are currently studying the use of their new inhibitors alongside traditional chemotherapy drugs.

The findings they have made thus far have been reported in ChemBioChem: A European Journal of Chemical Biology. (ANI)

Family demands steer women away from math/science careers

Washington, Mar 15 (ANI): Women opt out of math/science careers not because they lack mathematical ability, but due to family demands, says a new study.

The research led by Cornell University revealed that women choose non-math-intensive fields for their careers because they want flexibility to raise children, or they prefer less math-intensive fields of science.

“A major reason explaining why women are underrepresented not only in math-intensive fields but also in senior leadership positions in most fields is that many women choose to have children, and the timing of child rearing coincides with the most demanding periods of their career, such as trying to get tenure or working exorbitant hours to get promoted,” said lead author Stephen J. Ceci, professor of human development at Cornell.

The study showed that women with advanced math abilities choose non-math fields more often than men with similar abilities.

According to co-author Wendy M. Williams, Cornell professor of human development, the drop out rate of women in scientific fields – especially math and physical sciences is high, particularly as they advance, because of their need for greater flexibility and the demands of parenting and caregiving,

“These are choices that all women, but almost no men, are forced to make,” she said.

For the study, the researchers conducted an integrative analysis of 35 years of research on sex differences in math.

The authors concluded that hormonal, brain and other biological sex differences were not primary factors in explaining why women were underrepresented in science careers, and that studies on social and cultural effects were inconsistent and inconclusive.

They also reported that although “institutional barriers and discrimination exist, these influences still cannot explain why women are not entering or staying in STEM careers,” said Ceci.

“The evidence did not show that removal of these barriers would equalize the sexes in these fields, especially given that women’s career preferences and lifestyle choices tilt them toward other careers such as medicine and biology over mathematics, computer science, physics and engineering,” he added.

The authors recommended that universities and companies create options for women with math talents who want to pursue math-intensive careers.

These could include deferred start-up of tenure-track positions and part-time work that segues to full-time tenure-track work for women who are raising children, and courtesy appointments for women unable to work full time but who would benefit from use of university resources (e-mail, library resources, grant support) to continue their research from home.

The study appears in the American Psychological Association’s Psychological Bulletin. (ANI)