UPDATE 1-GSK seeks EU marketing approval for lupus drug

(Reuters) – GlaxoSmithKline Plc (GSK.L) has sought European regulators’ marketing approval for its experimental lupus drug Benlysta, being developed along with Human Genome Sciences Inc (HGSI.O), the companies said.

The submission to the European Medicines Agency (EMA) includes results from two late-stage trials, Human Genome said.

If approved, the drug will be the first treatment for lupus — a complex disease that causes the immune system to attack the body’s own tissue and organs — in 50 years.

GSK said it plans to submit a Biologics License Application for the drug to the U.S. Food and Drug Administration later this month.

Benlysta is being developed by GSK and Human Genome under a co-development and marketing agreement signed in 2006. (Reporting by Shailesh Kuber in Bangalore; Editing by Gopakumar Warrier)

Irish conjoined twins separated after 14-hour operation

London, May 16 (ANI): Irish conjoined twins Hassan and Hussein have been separated after a successful 14-hour operation.

The babies, who were joined at the chest, are recovering before they return home, from the hospital.

The mother of the boys Angie Benhaffaf, 36, from Co Cork in Ireland, has her hopes renewed.

“They”ll do everything, these boys. They”re my little fighters. They”ll do what other kids can do, probably even better,” the News of the World quoted her as saying.

She added: “I think they”re an absolute inspiration. Even now, they give so many smiles and cuddles, despite what they”ve been through.”

In the beginning, doctors at London”s Great Ormond Street Children”s Hospital were unconfident about the operation, as scans showed the brothers shared a heart and vital major organs.

Also, doctors had predicted, if the boys survived the surgery, they”d have to spend months in the Intensive Care Unit. Yet they were out by May 1 – just three weeks after the op.

Angie said: “When I think about the odds of what they”ve been through, it”s scary for us.

“We”re just these ordinary people from ordinary backgrounds, but what the boys have been through is so overwhelmingly miraculous, it can be quite scary sometimes.

“I still remember the surgeon, the world leader in conjoined twins, telling me the boys have made an ”unusually quick recovery”, words I”ll remember forever and take to my grave. That”s exactly what we want to hear.”

However, with more than 20 medics, including four surgeons and four anesthetists working in shifts, the surgery was eventually successful.

The father of the boys, Azzedine, said: “The day of the surgery was terrifying.

“We handed them over at 8.30am, and prayed until the amazing news at 11pm when we were told it had gone well.

“There was so much relief. People told me they thought I was going to collapse.”

However, the parents laughed that they strangely miss their children are no longer conjoined. (ANI)

Constitutional powers should not be exceeded: Manmohan Singh

New Delhi, May 8 (ANI): Prime Minister Dr Manmohan Singh on Saturday said the judiciary, legislature and executive should not exceed their respective powers as enshrined in the Constitution, but work in accord to maximise public good.

“It is assumed that none of the organs of the state, whether it is the judiciary or the executive or the legislature, would exceed its powers as laid down in the Constitution,” said Dr Singh at the national conference on ”Law and Governance” to mark the Golden Jubilee of the Bar Association of India.

“Even though their jurisdiction may be separated and demarcated, it is expected that all institutions would work in harmony and in tandem to maximise the public good,” he added.

Dr Singh reiterated the need for concerted efforts by the government, the judiciary and the Bar Association to help reduce the mounting arrears in courts and growing cost of litigation, as he said the doctrine of ”separation of powers” was acknowledged as one of the basic features of the Constitution.

“It is also commonly agreed that all the three organs of the state, namely the Legislature, the Judiciary and the Executive, are bound by and subject to provisions of the Constitution, which demarcates their respective powers, jurisdictions, responsibilities and relationship with one another,” he said.

The Prime Minister said the lawyers were an integral part of India”s system of administration of justice and they had a role, which was not confined to courts and advising clients.

“The role of lawyers is not confined to courts alone or advising the clients in business deals. It extends to being an integral part of our system of administration of justice – and justice is not just in the legal sense, but justice – social, economic and political – as set out in the preamble of our Constitution,” said Dr Singh.

Praising the efforts of the lawyers for their contribution, whether during Independence struggle, framing of the Constitution or just government, Dr Singh expressed his delight at having some former members of the Bar Association of India in his Cabinet.

“The Bar Association of India too has a larger objective beyond the furtherance of professional interests. It aims at promoting public and national welfare in manifold directions and upholding the Constitution of India and the Rule of Law,” added Dr Singh. (ANI)

‘Organ collector’ Jude Law cut up pig to prepare for ‘Repo Men’ role

London, March 20 (ANI): Jude Law cut up a pig and took out its organs to prepare for his role in new film ‘Repo Men’.

The ‘Alfie’ star apparently wanted to make his character perfect.

“I brought a side of a pig because pig flesh is very much like human flesh and he taught me how to cut through that with scalpels,” the Daily Express quoted him as saying.

Law reportedly sought help from one of London”s top surgeons to guide him through the operation. (ANI)

Steve Jobs admits of a liver transplant

San Francisco, Sep 10(ANI): The Apple chief executive Steve Jobs, making his first public appearance since his return to work in June after six months’ medical leave, has admitted of a liver transplant.

Jobs admitted this on the sidelines of a press conference San Francisco, where he was announcing a new iPod nano.

“I’m very happy to be here. As some of you may know, about five months ago I had a liver transplant. I now have the liver of a mid-20 (-year-old) person who died in a car crash and was generous enough to donate their organs. I wouldn’t be here without such generosity,” The Independent quoted Jobs, as saying.

“I hope all of us can be as generous and think about becoming organ donors,” he added.

Jobs was diagnosed with a rare, treatable form of pancreatic cancer in 2004. However, Apple had initially claimed that Jobs had a “common bug”, which eventually became a “hormonal imbalance”. A few days later Apple said the problem was “more complex” than he had thought.

The details of his medical problem were only made clear through documents leaked to the press, in which there were suggestions that Jobs had undergone a liver transplant in Memphis, Tennessee.

It is also said that Jobs had moved to Memphis due to the short transplant waiting list in Tennessee, and wanted to be near by if a liver became available. (ANI)

Lucknow police raid more places to uncover illegal blood racket

Lucknow, Aug 25 (ANI): Lucknow police has raided a private hospital here and recovered a few packets of illegal blood.

“We have found two-three packets of blood. We have also recovered equipments used to collect blood. Nobody is present here for interrogation at present,” said Sunil Pal, Inspector, Sarojni Nagar, Lucknow.

On August 22, six persons allegedly involved in running a blood racket were arrested from the city.

At least 70 pouches containing blood along with plasma, empty pouches, syringes and fake stamps, stickers and authority letters of the Chattrapati Shahuji Maharaj Medical University were recovered from the possession of the accused on August 22.

Police is probing over a dozen private-run nursing homes and pathology labs involved in trafficking illegal blood.

Trading in blood or organs is illegal in India. While organs can be obtained only by donation, blood can be voluntarily bartered or bought from registered blood banks. Blood banks are regulated by the government as many unscrupulous dealers fleece poor people, buying blood and paying them only a paltry sum. (ANI)

Fat in liver, not belly, could determine heart disease risk

Washington, Aug 25 (ANI): Measuring liver fat may be a better way to determine a person’s risk for developing diabetes and heart disease than measuring belly fat, according to researchers at Washington University School of Medicine in St. Louis.

Having too much liver fat is known as nonalcoholic fatty liver disease.

The researchers say that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body’s ability to metabolize sugar.

They also have increases in production of fat particles in the liver that are secreted into the bloodstream and increase the level of triglycerides.

For years, scientists have noted that where individuals carried body fat influences their metabolic and cardiovascular risk.

Increased fat inside the belly, known as visceral fat, is linked to an higher risk of diabetes and heart disease.

“Data from a large number of studies shows that visceral fat is associated with metabolic risk, which has led to the belief that visceral fat might even cause metabolic dysfunction,” says study’s lead author Samuel Klein.

“However, visceral fat tracks closely with liver fat. We have found that excess fat in the liver, not visceral fat, is a key marker of metabolic dysfunction. Visceral fat might simply be an innocent bystander that is associated with liver fat,” he added.

Klein says most of our body fat, called subcutaneous fat, is located under our skin, but about 10 percent is present inside the belly, while much smaller amounts are found inside organs such as the liver and muscle.

In the study, the researchers compared obese people with elevated and normal amounts of liver fat. All subjects were matched by age, sex, body mass index; percent body fat and degree of obesity.

Through careful evaluations of obese people with different amounts of visceral fat or liver fat, Klein’s team determined that excess fat inside the liver identifies those individuals who are at risk for metabolic problems.

The study has been published online in the journal PNAS Early Edition. (ANI)

Radiologist turns real body parts scans into masterpieces!

London, Aug 24 (ANI): In a unique form of art, a radiologist in Hong Kong presents scanned images of various parts of human body as pictures in galleries.

Kai-hung Fung uses 3D computed tomography to picture the many organs of his patients and claims that he makes it look as real as possible by avoiding using any effects.

“The pictures I create are generated directly from the medical 3D workstation, representing what I see on it. I do not use software such as Adobe Photoshop to further change the image,” the Telegraph quoted him as saying.

He added: “My aim is to preserve the direct relationship between the data and the artwork.

“It is a true integration of art, science and technology and can be studied both scientifically and enjoyed as a visual art.

“The imagery is packed with information. Each line or point represents specific anatomical structures in the body in normal or diseased state. It creates an unusual perspective.”

Fung first presented his work at Pamela Youde Nethersole Easter Hospital after which it made it to galleries across the world. (ANI)

Meet the Indian photographer who has five kidneys!

London, July 07 (ANI): An Indian photographer is living with five kidneys after members of his family donated three and doctors decided to leave his non-functioning organs inside him.

Jaswant Singh, who lives in Punjab, has had three transplant operations after his own kidneys failed; his two sisters and mother donated their organ to keep him alive.

His older sister, Harjindar Kaur, gave her own in the first operation in 2002 after the failure of both his kidneys.

Two years later, when the organ once again succumbed, his 27-year-old younger sister, Ranvir Kaur made another sacrifice.

And then finally, the mother Amar Kaur, 56,stepped forward after the poor man’s kidney gave way for the third time.

“It is very difficult to explain how much I have suffered. Sometimes I could not work for months at a time. I couldn’t go far from my home or eat outside, this time my mother, gave me her bean shaped organ.” the Telegraph quoted him as saying.

He had been placed on dialysis, in between the operations.

The family had spent Rs 900,000 before doctors at India’s National Kidney Hospital were so touched by the young photographer’s tragic story and the determination of his family, that they performed Singh’s most recent transplant surgery for free.

Jaswant is very grateful to his family, he said: “I was not able to afford the surgeries myself by running a photography shop. But I am thankful to my family. They sold their farmland to pay for my surgeries. My father sold about eight acres of land. ”

And he hopes he becomes well, he added: “I hope my body doesn’t reject this kidney, I do not know what to do if worst happens but still I have hopes on my family, on my brother and father.

“My sisters and my mother happily donated their kidneys for me. They were not scared at all and voluntarily did it.

“My sister told me, ‘You are my brother and I will try to save your life even at the cost of my own life.’ This really moved me. I cannot give them back anything in return.

“I cannot explain it in words and there is no way that I can pay them back. My life is indebted to them and it is their greatness that I am still living.”

Jaswant’s brother is a driver and his father sells milk. (ANI)

Humans can develop echolocation like dolphins and bats

Washington, July 1 (ANI): In a new research, scientists have shown that human beings can develop echolocation, the system of acoustic signals used by dolphins and bats to explore their surroundings.

The research was conducted by a team of researchers from the University of Alcala de Henares (UAH) in Spain.

“In certain circumstances, we humans could rival bats in our echolocation or biosonar capacity”, said Juan Antonio Martínez, lead author of the study and a researcher at the Superior Polytechnic School of the UAH.

The team led by this scientist has started a series of tests, the first of their kind in the world, to make use of human beings’ under-exploited echolocation skills.

In the first study, the team analyses the physical properties of various sounds, and proposes the most effective of these for use in echolocation.

“The almost ideal sound is the palate click, a click made by placing the tip of the tongue on the palate, just behind the teeth, and moving it quickly backwards, although it is often done downwards, which is wrong,” Martinez explained.

According to the researcher, palate clicks “are very similar to the sounds made by dolphins, although on a different scale, as these animals have specially-adapted organs and can produce 200 clicks per second, while we can only produce three or four”.

By using echolocation, “which is three-dimensional, and makes it possible to ‘see’ through materials that are opaque to visible radiation,” it is possible to measure the distance of an object based on the time that elapses between the emission of a sound wave and an echo being received of this wave as it is reflected from the object.

In order to learn how to emit, receive and interpret sounds, the scientists are developing a method that uses a series of protocols.

This first step is for the individual to know how to make and identify his or her own sounds (they are different for each person), and later to know how to use them to distinguish between objects according to their geometrical properties.

The next level is to learn how to master the “palate clicks”.

According to Martinez, his team is now working to help deaf and blind people to use this method in the future, because echoes are not only perceived by their ear, but also through vibrations in the tongue and bones.

A better understanding of the mental mechanisms used in echolocation could also help to design new medical imaging technologies or scanners, which make use of the great penetration capacity of clicks. (ANI)

Now, painless nanoneedles to deliver drugs to cell organelles directly

Washington, May 23 (ANI): Always dreaded those moments when the doctor got that syringe ready to painfully jab it into your arm? Well, not anymore, for scientists have now designed gold-plated nanoneedles that can deliver the medicine right into the tiny organs of cells and that too without causing any pain.

Thinner than a human hair, the new nanoneedle distributes molecules directly to the right organelles, doing away with the problem of the cell organelles’ failure to collect and use drugs released into the bloodstream.

“What we have here, is a powerful tool for delivering a very tiny amount of drugs into cells that have initially been removed from the body and can-after being injected by the nanoneedle-be placed back into the body for tracking, diagnosing, and treatment of illness,” National Geographic News quoted study co-author Min-Feng Yu, a University of Illinois molecular biologist, as saying.

However, the idea of a nanoneedle isn’t as new as it seems, for scientists have long been trying to use tiny syringes to inject cells.

But needles, developed earlier, have been relatively clumsy, damaging cells as they poked them.

Thus, to avoid building a squirting tube, the researchers designed a solid needle that didn’t need to be hollow and was cell-friendly 50 nanometres wide.

Tiny particles are attached to the nanoneedle’s thin outer layer of gold via “linker” particles. After entering an organelle, the nanoneedle releases the particles.

The researchers have said that designing nanoneedles that can be programmed to target multiple cells and automatically deliver drugs into those cells at the same time, could mean that there may be a day when nanoneedles needn’t be rocket science.

The findings have been published online by the journal Nano Letters. (ANI)

Revolutionary treatment to obtain bone marrow from stem cells on the anvil

Washington, April 17 (ANI): Researchers at Universiti de Montrial have successfully produced a large quantity of laboratory stem cells from a small number of blood stem cells obtained from bone marrow.

The research team, led by Dr. Guy Sauvageau, has taken a giant step towards the development of a revolutionary treatment based on these stem cells.

It is known that a bone marrow stem cell transplant can reconstitute the recipient’s bone marrow. The main difficulty is to obtain a sufficient number of compatible stem cells.

But these patients will be able to obtain new bone marrow within the next few years, thanks to Sauvageau and his team.

“It could be possible to envision transplants for all adults from existing umbilical cord blood banks. The stem cell content of these blood banks is currently too limited for large-scale use in adults,” Sauvageau said.

Presently, transplant recipients are condemned to take medications against rejection of the transplanted organ and suffer the side effects for the rest of their lives.

However, “mouse studies exist, showing that bone marrow stem cells can prevent the rejection typically directed against solid organs,” Sauvageau said.

Rejection occurs because the immune system cells manufactured by bone marrow attack the transplanted organ as if it were an invader.

By extrapolation from laboratory studies, it is very likely that transplanting hematopoietic stem cells collected from the organ donor and developed in the laboratory could avoid rejection of this organ.

This is why it is important to have large quantities of hematopoietic stem cells, so that compatible stem cells can be matched with the organ to be transplanted.

To produce large quantities of hematopoietic stem cells in the laboratory, the researchers identified 10 proteins out of 700 candidates.

These 10 proteins are naturally present in hematopoietic stem cells and researchers can use each of them to force these cells to multiply in the laboratory.

“The next step is to verify whether this also works in humans. Everything is already in place,” Sauvageau said.

The findings are being published in the prestigious scientific journal Cell. (ANI)

Face Transplant Patient Doing Well

Dr. Bohdan Pomahac of Brigham and Women’s Hospital in Boston, the surgeon who led the country’s second-ever face transplant operation said he is “cautiously optimistic” over the recovery of the patient and that “so far he is doing very, very well.”

Pomahac and his team in a 17 hour surgery Thursday replaced the man’s nose, palate, upper lip, and some skin, muscles and nerves with those of a dead donor. He added that the man who was severely injured in a freak accident several years ago has so far chosen to keep his identity a secret, is recovering as expected.

A total of seven face transplants have been reported worldwide, with three of those occurring in just the past two weeks.

At a Friday press conference, Pomahac said that the patient had not undergone immunosuppressant therapy before the operation became necessary. Late last year the hospital had publicly stated that it would not perform this kind of transplant due to ethics guidelines that they created when face transplants first became a viable option.

Immunosuppresants generally become a lifelong requirement and carry a host of possible side effects, and the hospital said it would only allow a patient to receive a face transplant procedure if he or she was already using them after a procedure such as a heart or kidney transplant.

This therapy is normally necessary in such operations to prevent the patient’s body from rejecting the organs or tissues of the donor. Such therapy is crucial to the patient’s survival, but it also comes with serious side effects, including an increased risk of infections.

Pomahac said that the hospital has obtained approval from an institutional review board for performing the operation on patients not on immunosuppressants and added that the hospital made the decision to liberalize the rule in order to help more patients in need.

“We felt it was a natural progression of the program to extend [the operation] to the patient who is not on immunosuppressants.”

The patient is now on immunosuppressants, said Pomahac and likely will be for the foreseeable future.

“The patient is now expected to take immunosuppressant medication for the rest of his life,” he said. “There is nothing on the horizon, no major medical breakthrough that would suggest otherwise.” He said that the doses would likely be reduced as time progresses.

Health dept, docs discuss way out of tricky organ donation issues

CHENNAI: If the blood relative of a brain-dead patient is in need of a vital organ, can the family who is willing to sign papers for donation
demand that the organ be given to the relative? Is the doctor or hospital coordinating a cadaver organ donation liable if the organ retrieved loses it vitality? If the organs of a brain-dead person, the result of a road accident, is removed, will it mean tampering with evidence in a medico-legal case?

These and other related questions came up for a detailed discussion on Saturday when doctors from at least 50 hospitals in Tamil Nadu, mostly licensed transplant centres, met officials from the state health department at a workshop on cadaveric transplantation in Tamil Nadu’, organised by the director of medical services and rural health. The workshop was organised to discuss the Transplant of Human Organs Act 1994 and a series of government orders issued by the health department since January 2008 to promote cadaver transplant.

Over the past six months, the state has seen a rapid increase in organ donation. Forty kidneys, 14 livers, six hearts, 26 corneas, 14 heart valves and skin were harvested from 20 cadavers. Health secretary V K Subburaj said that the meeting was called to discuss problems the network faced in the last six months. “We are sure in the next few months we would be able to streamline the system for cadaver organ donation that would possibly reduce the need for any live donors,” he said.

IT secretary PWC Davidar, instrumental in issuing the government orders (GOs) while he was in the health department, discussed the GOs. “These are not just a set of rules written to be filed as orders. We want every hospital to certify brain death,” he said.

One city-based doctor wanted to know if the donor’s relatives had the right to dictate who the recipient should be. “In one case, the donor’s brother was blind and was waiting for a corneal transplant. They were willing to donate all the organs but requested that one eye be used for his brother. It was tricky situation and we did not know how to handle it,” he said.

Most government officials were for hospitals remaining firm. “With the present rules we don’t have provisions for that. We only encourage voluntary donation with no strings attached,” said Dr J Amalorpavanathan, convenor, cadaver transplant programme.

After hearing out narrations of several incidents, Davidar said that the department would look at options such as passing government orders that could deal with such special situations. “Sometimes, when the donor’s blood relative is in need of an organ, we will have to work it out as well,” he said. “We are also working on orders for organ transplant in medico-legal cases,” he said.

Presently, doctors take in only those cases where the cause of death is ascertained as a road accident. “We also take written consent from the investigating officer that the organ donation will not hamper investigations,” said Dr Amalorpavanathan.

Doctors clarified that no doctor or hospital was legally bound for the viability of the organs before or after transplants. Hospitals agreed to pay Rs 10,000 as annual fee for being a part of the organ sharing network. They decided that a website giving limited information about organ donation and organ sharing would help the public and ensure patient confidentiality.

Parents’ Hospital Lawsuit Says Teen Was ‘Killed’ For Organs

Doctors Admit Clerical Error, but Say Teen Would Not Have Recovered From Brain Damage

The parents of an 18-year-old who suffered a brain injury in a 2007 snowboarding accident say his doctors “intentionally killed” him to harvest his organs. In the lawsuit filed this week in the U.S. District Court of Western Pennsylvania, Michael and Teresa Jacobs claim that doctors “hastened” their son Gregory Jacobs’ death by delaying treatment and ultimately pulling his breathing tube, causing him to suffocate.

The couple said their son had not been formally declared brain dead when surgeons began the transplant procedure. They are seeking $5 million in damages.

“But for the intentional trauma or asphyxiation of Gregory Jacobs, he would have lived, or, at the very least, his life would have been prolonged,” the lawsuit said.

The Bellevue, Ohio, family claim that if their son had been properly treated, he would have had a “significant chance of substantial recovery.”

The parents have charged doctors at Hamot Medical Center in Erie, Pa., and a representative of the Center for Organ Recovery and Education (CORE) in Pittsburgh.

Gastric virus ‘triggers diabetes in kids’

Washington, Mar 6 (ANI): A new study has revealed that a common family of viruses (enteroviruses) in the pancreas may play an important role in triggering the development of diabetes, particularly in kids.

The study has been conducted by researchers from the Peninsula Medical School in the South West of England, the University of Brighton and the Department of Pathology at Glasgow Royal Infirmary.

Type 1 diabetes usually starts in young people and results from the destruction of the insulin-producing beta cells in the pancreas.

It has long been speculated that viruses might play a role in causing type 1 diabetes by infecting the beta cells of the pancreas.

For the study, the researchers looked at the collection of pancreases from 72 young people who died less than a year after the diagnosis of type 1 diabetes.

The study revealed that more than 60 per cent of the organs contained evidence of enteroviral infection of the beta cells.

By contrast, infected beta cells were hardly ever seen in tissue samples from 50 children without the condition.

The study has suggested that enteroviral infection of the beta cells in children with a genetic disposition to type 1 diabetes may initiate a process whereby the body’s immune system identifies beta cells as ‘foreign’ and rejects them, as it would a transplanted organ.

A further extension of the study to adults with type 2 diabetes showed that a large proportion (40 per cent) of these patients also had enteroviral infection in their beta cells.

However, a link has not been totally established and this does not mean that lifestyle and obesity do not contribute towards the disease.

Overall, the findings of this new study suggest that vaccination in childhood to prevent enteroviral infections of beta cells might be an attractive means to reduce the incidence of both common forms of diabetes.

However, there are up to 100 different strains of enterovirus and more research will be needed to identify which particular enteroviruses are associated with the development of diabetes, and whether vaccines could be developed to prevent their spread.

The study is published in the leading European diabetes journal, Diabetologia. (ANI)

Study casts light on injuries males’ mating organs cause in females

Washington, February 21 (ANI): A new study by Uppsala University scientists shed new light on the injuries that the males’ mating organs cause in females.

The researchers suggest that such injuries are the side effects of the benefits the males reap from their mating organs.

“One especially tricky case involves species where the males have mating organs that are supplied with hooks, barbs, and flukes that cause internal injuries in females during mating. This is extremely common among insects, but it also occurs in many other animal groups,” says Professor Goran Arnqvist, at the Department of Ecology and Evolution.

Writing about their work in the journal Current Biology, the researchers revealed that they studied seed beetles and their mating behaviour.

Goran says that the males’ mating organ, which is rather similar to a medieval spiked club, causes severe wounds in females during mating.

However, since it is never a good idea for a male merely to injure a female, the researchers have assumed that these structures serve another purpose, and that the injury is an unfortunate side effect.

“Females’ injuries as such do not benefit the male she mated with. It has been suggested rather that the injuries are a side effect of other benefits the males reap from the barbs. Now, for the first time, we are able to show that this is the case,” says Arnqvist.

Despite such costs, females mate with multiple males.

“We also show that males with long barbs cause more severe injuries to females, but also that these males have a greater rate of fertilization success,” says Arnqvist.

The barbs are thus extremely important to males in their competition to be able to fertilize an egg, and when females mate with two males, it is more often the male with the longer barbs that fertilizes her eggs. (ANI)

Boffins create ‘living doll’ from human cancer cells

London, Feb 6 (ANI): In a breakthrough study, Japanese researchers have developed a ‘living doll’ with the help of human liver cancer cells – a development that could allow new drugs to be tested in conditions closer to those inside the body.

The doll developed by Shoji Takeuchi, from the University of Tokyo, Japan would serve as a research model for testing new drugs.

The structure was grown using about 100,000 beads of the connective protein collagen, seeded with cells from a human liver cancer culture and tipped into a body-shaped mould, reports New Scientist.

The surface of each bead contains cells that secrete proteins and collagen that bind all the cells together.

The resulting product is much closer to living tissue.

Takeuchi plans to use it to grow structures containing multiple cell types. These could even function as whole test organs. (ANI)

Bone marrow stem cells can be used to create artificial skin

Washington, January 15 (ANI): A new study suggests that skin can be regenerated using adult bone marrow stem cells.

Reported in the journal Artificial Organs, the finding attains significance as it marks an advancement in wound healing, and may be used to pioneer a method of organ reconstruction.

With a view to determining the possibility of repairing burn wounds with a combination of tissue-engineered skin and bone marrow stem cells, the study established a burn wound model in the skin of pigs, which is known to be anatomically and physiologically similar to human skin.

Yan Jin of the Fourth Military Medical University, lead author of the study, has revealed that engineering technology and biomedical theory methods were used to make artificial skin with natural materials and bone marrow derived stem cells.

The researcher said that after the artificial skin was attached to the patient, and the dermal layer had begun to regenerate, stem cells were differentiated into skin cells.

According to Jin, the cells are self-renewing and raise the quality of healing in wound healing therapy.

Upon grafting the engineered skin containing stem cells to the burn wounds, the researcher noticed that they showed better healing, less wound contraction, and better development of blood vessels.

Skin, the human body’s largest organ, protects the body from disease and physical damage, and helps to regulate body temperature.

Any disease or burns seriously damage the skin, the body often cannot act fast enough to repair them. In certain cases, burn victims die from infection and the loss of plasma.

Skin grafts were originally developed as a way to prevent such consequences.

“We hope that this so-called ‘engineered structural tissue’ will someday replace plastic and metal prostheses currently used to replace damaged joints and bones by suitable materials and stem cells,” says Jin. (ANI)

Gene that keeps stem cells healthy identified

Washington, January 7 (ANI): Carnegie Institution scientists in the United States say that a gene, named scrawny, seems to play a significant role in keeping a variety of stem cells in their undifferentiated state.

Writing about their observations in the journal Science, the researchers said that understanding how stem cells maintain their potency has implications both the knowledge of basic biology and for medical applications.

“Our tissues and indeed our very lives depend on the continuous functioning of stem cells. Yet we know little about the genes and molecular pathways that keep stem cells from turning into regular tissue cells—a process known as differentiation,” says Allan C. Spradling, director of the Carnegie Institution”s Department of Embryology.

Along with his colleagues Michael Buszczak and Shelley Paterno, Spradling has found that the fruit fly gene scrawny—so named due to the appearance of mutant adult flies—modifies a specific chromosomal protein, known as histone H2B, which is used by cells to package DNA into chromosomes.

The researchers say that scrawny can by controlling the proteins that wrap the genes, scrawny can silence genes that would otherwise cause a generalized cell to differentiate into a specific type of cell, such as a skin or intestinal cell.

During the study, the researchers observed that mutant flies without functioning copies of the scrawny prematurely lost their stem cells in reproductive tissue, skin, and intestinal tissue.

Stem cells function as a repair system for the body, and maintain healthy tissues and organs by producing new cells to replenish dying cells and rebuild damaged tissues.

“Losing stem cells represents the cellular equivalent of eating the seed corn,” says Spradling.

He adds that the results of the study are an important step forward in stem cell research because genes that may carry out the same functions as scrawny are known to be present in all multicellular organisms, including humans.

“This new understanding of the role played by scrawny may make it easier to expand stem cell populations in culture, and to direct stem cell differentiation in desired directions,” the researcher says. (ANI)