Delay in becoming a mum may be risky

London, September 16 (ANI): Women who have their first baby at an advanced maternal age may be more at risk of complications, says a recent UK study.

The team at the University of Cambridge found women who started menstruation early, from the age of 12 onwards, were more likely to require medical assistance during childbirth such as forceps, or a Caesarean section.

The effect was taken care of if these women began a family at an early age.

But such was not the case for older mothers. Previous research also found that the risk of a medically-assisted delivery shot up with a woman’s age at the time of her first birth.

“The main significance of this study is not that menarche is usefully predictive of the risk of complications, but that the current finding sheds light on why advanced maternal age at the time of first birth might be associated with increased risks,” The BBC quoted Researcher Professor Gordon Smith as saying.

Professor Philip Steer, BJOG editor-in-chief, however, added larger investigation was required before reaching conclusions about the impact of early onset of menstruation in women.

He advised: “It is particularly important for them to ensure they lead healthy lifestyles and maintain a normal body weight, as a high BMI during pregnancy is itself associated with poor uterine contractions and an increased need for operative delivery.”

The University of Cambridge study has been published in BJOG: An International Journal of Obstetrics and Gynaecology. (ANI)

Muhammad Ali given huge Irish hero’s welcome

Belfast (Ireland), Sep.2 (ANI): Former World Heavyweight Champion Muhammad Ali was given an Irish hero’s welcome on Tuesday at Turnpike Road from where his great-grandfather Abe Grady set out for the New World almost 150 years ago.

The former three times world heavyweight boxing champion was welcomed like a returning prodigal son when he arrived in Ennis, Co Clare, and was made its first Freeman.

Clearly moved by the fervour of the welcome, he refused to be ushered into a waiting vehicle by his security guards as the crowds chanted: “Ali! Ali! Ali!”

After unveiling a monument near the spot where his ancestral home – a two-room thatched cottage – once stood, he walked with his wife, Yolanda, to meet his fans, the majority of whom were not even born when his brilliant career was dimmed by the onset of Parkinson’s disease, reports The Times.

Today Turnpike Road is lined with primly neat council houses, none prouder than the home of the late Eileen O’Grady, whose daughter, Mary, kissed and hugged her famous distant cousin.

Eileen died nine months ago, preferring to keep her association with one of the greatest sportsmen of all time a secret.

Genealogists traced the roots of Ali, formerly Cassius Clay Jr, to Abe Grady through land registry documents, which record that Grady left Ireland in the 1860s from Cappa Harbour in Kilruch, Co Clare. He settled in Kentucky, where he married a freed African-American slave.

Their son also married an African-American and one of the daughters of that union was Odessa Lee Grady, who married Cassius Clay Sr. (ANI)

Tribals lament lack of adequate medical facilities in Orissa

Dasmantpur (Orissa), Aug 27(ANI): Tribals living in Orissa’s Dasmantpur village are deprived of basic amenities and health facilities leading to several health hazards.

Locals say that the Central Government had made development plans for education, health and communication, but they are yet to see development in this regard.

The plight of the residents of the village has become manifold with the onset of monsoon, as tribals are facing the wrath of epidemics like cholera and diarrhoea.

“We are not getting the facilities provided by the government, as they get diverted en route. People here consume mango kernel during rainy season, so chances of suffering from Cholera increases,” said Subas Patika, another local.

“They cannot reach the medical centres, as there is no proper road connectivity. The river en route also swells up during rainy season. Education facilities are also very poor here,” he added.asmantpur village was in news for the last few years for the number of deaths due to cholera and diarrhoea like epidemics after floods.

“We are facing water problems. There is a tube well, but worms fall from it, in the morning. So people don’t use it for drinking. Our village doesn’t even have proper road connectivity.

The Anganwadi (government sponsored centre to help poor) does provide us some medicines,” said Keshab Chandru, a local. (ANI)

Scientists discover signaling pathway which ensures that plants remember to flower

Washington, August 21 (ANI): A team of scientists has discovered signaling pathway that ensures plants remember to flower, even without positive signals from the environment.

Scientists at the Max Planck Institute for Developmental Biology in Germany found the solution to the mystery that why do some plants blossom even when days are short and gray.

According to the researchers, an endogenous mechanism allows them to flower in the absence of external influences such as long days.

A small piece of RNA, a so-called microRNA, has a central role in this process, as a decline of its concentration in the shoot apex triggers flowering.

MicroRNAs are very short RNA snippets that have emerged in recent years as essential regulators of gene function in both plants and animals.

By binding to complementary motifs in a messenger RNA, they inhibit its translation into protein. This process thus blunts the activity of the corresponding gene.

In Tubingen, developmental biologists have discovered that the common wallcress, Arabidopsis, uses this regulatory mechanism to switch from vegetative to reproductive development.

A group of related regulators, the SPL proteins, play an important role in promoting the onset of flowering.

In young plants, high levels of microRNA156 prevent production of SPL proteins.

Jia-Wei Wang and colleagues demonstrate that independent of external cues, the concentration of the microRNA declines over time, like sand running through an hourglass.

When the microRNA concentration falls below a certain level, enough SPL proteins are produced to activate the flowering process even in the absence of other regulators that measure day length or external temperature.

This in turns allows a sufficiently old plant to flower, even in an unfavorable environment.

Interestingly, the SPLs do double duty, since they have supporting roles when plants flower in response to long days.

Furthermore, both the SPLs and other regulators eventually converge on a similar set of targets crucial for flowering.

According to Detlef Weigel, director at the Max Planck Institute for Developmental Biology, “Flowering is crucial for the long-term survival of plants. The redundancy of environment-dependent and independent mechanisms ensures that plants do not wait forever until flowering.” (ANI)

Waste by-product of malaria parasite’s reproductive process linked to devastating fever

Washington, August 21 (ANI): Studying hemozoin – a crystal-like by-product released during reproduction among parasites from the Plasmodium family – may help understand why malaria leads to devastating inflammation and fever, according to a Canadian study.

Lead researcher Dr. Martin Olivier, of McGill University in Montreal, points out that, inside the human body, the malaria parasite infects red blood cells where it survives and reproduces by feeding on the cells’ contents.

Eventually, says the researcher, the cells burst and release the parasites and hemozoin.

“Our results describe the mechanism by which the hemozoin activates the immune system, resulting in the production of inflammation mediators and in the high fever that we witness in malaria patients,” said study’s first-author Dr. Marina Tiemi Shio, of the Research Institute of the McGill University Health Centre (RI-MUHC).

According to the researchers, hemozoin is first ingested by “cleaning” cells called macrophages, which leads to a chain reaction ending in the activation of the inflammasome: an important structure inside immune cells which lead to inflammation.

They say that the activation of the inflammasome leads to the production of the body’s fever mediator, interleukin beta (IL-beta).

“Our work is a milestone in that it is the first study that reveals the enzymes that act as intermediary between the hemozoin and inflammasome. Now our picture of the process that goes from infection to fever is more or less complete,” said Dr. Olivier.

“On the other hand, we also proved that malaria is too complex to be narrowed down to one single mechanism. In the absence of either IL-beta or a functional inflammsaome, the development of the disease is delayed but not completely stopped. Although the discovery of this relationship is important, there are other mechanisms at work,” he added.

Even though scientists have been familiar with the mechanisms that go from the activation of the inflammasome to the onset of the malaria symptoms, none of the previous studies has ever shown the beginning of the process.

“These results prove the primary role hemozoin plays in the development of malaria, and designates it as a favoured choice for future innovative treatments,” said Dr. Olivier.

The researchers believe it will be possible to familiarize the immune system to small quantities of hemozoin, and diminish the inflammatory response in the event of infection, according to a principle similar to that of vaccines.

The results of the study have been published in the journal PLoS Pathogens. (ANI)

Having chocolate, red wine regularly may help protect against Alzheimer’s

London, July 10 (ANI): Regular intake of chocolate, fruits, vegetables, red wine and tea could help protect against Alzheimer’s disease, according to an expert.

Dr Robert Williams, a biochemist at Kings College London, says that all contain chemicals called flavonoids that may also help existing dementia sufferers.

Flavonoids are naturally occurring antioxidants, which help beat cancer and the ageing process by protecting cells from damage. They also mop up potentially harmful oxygen molecules in the body.

New research is emerging that suggests flavonoids do not act only as antioxidants but exert their effects in other ways.

“There have been some intriguing epidemiological studies that show the consumption of flavonoid-rich vegetables, fruit juices and red wine delays the onset of the disease,” the Daily Express quoted Williams as saying.

Williams and his colleagues have focused their own cellular studies on a flavonoid called epicatechin, found in many foodstuffs, including cocoa.

“We have found that epicatechin protects brain cells from damage but through a mechanism unrelated to its antioxidant activity and have shown in laboratory tests that it can also reduce some aspects of Alzheimer’s disease pathology,” he said.

Central to the development of Alzheimer’s disease is beta-amyloid peptide, a substance normally produced in the brain but which in Alzheimer’s is deposited abnormally.

Williams has shown that flavonoids can protect brain cells against the toxic actions of beta-amyloid.

“The challenge now is to identify the single flavonoid or combination of flavonoids that exert the most positive effects,” he said.

Williams will present his findings at the British Pharmacological Society’s Summer Meeting in Edinburgh. (ANI)

Locusts’ brains may provide clues to curing migraines, stroke

Washington, July 4 (ANI): Queen’s University biologists have revealed that insight into the locust’s brain may offer a novel way to manipulate human brain to stave off diseases like migraines, stroke, and epilepsy.

The researchers said that a similarity in brain disturbance between the insect and human sufferers of migraines, stroke, and epilepsy could open pathways for development of new drug therapies.

The study showed that the ability of the insect to resist entering the coma, and the speed of its recovery, can be manipulated using drugs that target one of the cellular signalling pathways in the brain.

“This suggests that similar treatments in humans might be able to modify the thresholds or severity of migraine and stroke,” said Gary Armstrong, who is completing his PhD research in Biology professor Mel Robertson’s laboratory.

“What particularly excites me is that in one of our locust models, inhibition of the targeted pathway completely suppresses the brain disturbance in 70 per cent of animals,” Dr. Robertson added.

The same researchers previously showed that locusts go into a coma as a way of shutting down and conserving energy, when conditions are dangerous.

The cellular responses in the locust are similar to the response of brain cells at the onset of a migraine. (ANI)

Monsoon break brings respite to farmers

Jalpaiguri/Shimla, July 3 (ANI): After a long dry spell, farmers in different parts of the country finally heaved a sigh of relief as the monsoons arrived.

The onset of monsoons in Jalpaiguri in West Bengal raised hopes for the farmers waiting to sow their crops.

The region received almost 300 mm of rainfall in the past two days. The farmers were worried due to the delay in monsoons.

“I am happy that it has rained finally. The crops are more or less fine. We will start sowing jute. We were very anxious when it did not rain for a long time. We hope there will be a good yield and we can sell our crops in the market,” said Khagendranath Burman, a farmer.

With only 40 per cent of farmland irrigated, most of small farmers rely on the monsoon to water their crops.

The Indian Meteorological Department had mentioned that rainfall received for the month of June has been 45 per cent less than the normal.

In Jalpaiguri, the rain is still below average but enough for the farmers to start sowing.

“Average June rainfall in this area is around 650 mm, out of which we have received, in the last two days around 300 mm. Before that, in the last 25 days, we received around 150 mm. So 450 mm rain, we already received. So I think next one or two days, we will get little bit more,” said Subir Sarkar, a meteorologist.

Even in Shimla, the rain showers have brought much needed relief to the farmers. Now, they are ready to sow.

“We will start sowing maize. And amongst vegetables, we are sowing cauliflowers, french beans and tomatoes. It has rained enough for these crops.

We have started ploughing our fields and are ready for sowing.” said Swaroop, a farmer.

The monsoon is crucial for summer-sown crops ranging from paddy, soybean, sugarcane and cotton. (ANI)

No drought in the country: Pawar

New Delhi, June 28 (ANI): Union Agriculture Minister Sharad Pawar on Sunday said there is no drought-like situation in the country due to a delay in the onset of monsoon rains.

“There is no drought-like situation in the country due to delay in monsoons and the loss would be more than made up for in the rains during July and August,” Pawar said.

He also denied rumours of a price rise, adding that food procurement was better this year compared to last year.

The government had enough reserve food stocks to tackle a drought-like situation should it exist, Pawar said.

Pawar’s reassuring comments came even as the media played up fears of a drought.

The comments assume significance in the wake of the southwest monsoon advancing further into some parts of Maharashtra, Andhra Pradesh and the southern regions of Chhattisgarh and Orissa.

The weatherman has forecast rain or thundershowers in some parts of northwest India, including Uttar Pradesh and Rajasthan, which are experiencing severe heat-wave conditions.

Even as Manipur declared itself to be drought-hit, the Centre said it had put in place a Crisis Management Plan to deal with the drought the country may face in the wake of the delayed monsoon.

The annual rainfall system is expected to cover some more parts of Bihar, Jharkhand, Madhya Pradesh, West Bengal and Sikkim in the next three or four days.

Mumbai, which experienced heavy rain on Friday, got some light showers early on Saturday. Delhi too is likely to receive rainfall over the next two to three days. (ANI)

Monsoon reaches Orissa’s southern coast

Bhubaneshwar, June 26 (ANI): People of Orissa can take a sigh of relief as the much-awaited monsoon touched its southern coast, and will cover entire state in a day or two, say officials.

“Monsoon has delayed, actually because earlier its ONSET was on 25th May. Now monsoon has revived and today it has covered some parts of south Orissa and conditions are also favourable for covering remaining parts of Orissa during next two-three days,” said S. C. Sahoo, director, Bhubaneswar meteorological centre.

Meanwhile, people in Bhubaneshwar enjoyed pre-monsoon showers.

“It’s raining after so many days so I am feeling very nice. It was difficult to move in scorching sun. Now its much better,” said Swagatika, a local resident.

Students and office goers felt respite after a long period of rising mercury and scorching sun.

“Even though its late, its better late than never. So just enjoy the monsoon. And it will bring relief to students and also to office going people and also to farmers out here,” said Sourav, a student.

According to the National Meteorological Department, the total rainfall from the crucial June-September monsoon would be only 93 percent of the long-term average, coming in below normal for the first time in four years.

Four of 36 national zones were still to receive any monsoon rain. Rains were normal in two areas and excess in three during the week, while 27 zones recorded deficit to scanty rains.

The monsoon hit the southern coast on May 23, ahead of the normal date of June 1, but has since progressed weakly. (ANI)

New plasma torch may improve root canal treatment, reduce infection rates

Melbourne, June 24 (ANI): Scientists at the University of Southern California (USC) have come up with the world’s smallest plasma torch that may one day make root canal treatment faster and less painful, besides reducing the chance of infection after the procedure.

“Our goal is to guarantee that you won’t have to see a doctor for a follow-up visit,” ABC Science quoted says Professor Chunqi Jiang Jiang, who has reported this work in the online edition of the journal Plasma Processes and Polymers, as saying.

“One problem is that between 8 per cent and 10 per cent of patients have an infection post-operation. This is intended to eliminate the chance of an infection,” the researcher added.

Plasma, or ionized gas, is one of the four basic states of matter, the other three being solid, liquid and gas.

The researchers reveal that the trick to creating plasma at room temperature is to pulse it. They say that a continuous stream of plasma very quickly heats up the surrounding air.

According to them, pulsing the plasma allows the tiny electrons in it to heat up and move around, while keeping the much larger and heavier atom nucleus from heating up.

“If you have a piece of paper with bacteria on it and you apply cold plasma to it, the paper won’t burn but the bacteria will die,” says Professor Mounir Laroussi, of Old Dominion University in Virginia, who has studied the effect of cold plasmas for years.

“Cold plasma can kill bacteria on a variety of surfaces such as teeth or skin,” Laroussi adds.

The researchers say that upon being used in the mouth, the free electrons of plasma create single atoms of pure oxygen, ozone and other reactive forms of oxygen, all of which search for other atoms to bind with in the organic biofilms inside decayed teeth.

Biofilms are basically walled colonies of bacteria. In the human body, they can trigger the onset of an infection, and even protect the harmful bacteria from the most powerful antibiotics.

The researchers have revealed that cool, pulsed and purple plasma takes about five to ten minutes to clear an infected tooth of biofilms as compared to bleach, the conventional method for cleaning an infected tooth, which takes 30 minutes.

While about 10 per cent of patients treated with bleach are still infected, tests using the plasma torch on a few dozen human teeth have shown no signs of infection.

The plasma torch is also not as expensive as laser systems that are used as high-tech solutions to biofilms.

While laser systems costing up to 25,000 dollars, the plasma torch could retail for as little as 1,000 dollars, provided it passes official clinical trials.

Laroussi, who used to test cold plasmas effect on teeth, skin and wound healing, says that the trick to regulatory acceptance and commercialisation is ensuring that only harmful cells are killed.

“We can kill bacteria on teeth and on wounds. But we have to ensure that we are not creating a worse problem in nearby healthy cells as well,” says Laroussi.

Initial tests have shown that surrounding healthy tissue remains intact, although more testing is needed to definitively prove this.

Meanwhile, the USC researchers are concentrating on getting the funding necessary to continue with their research. (ANI)

Rain ritual in Akola

Akola (Maharashtra) June 23 (ANI): The delay in onset of monsoon is giving sleepless nights to farmers in Akola district of Maharashtra, as their plants are dying due to water scarcity.

Children of the region are seeking divine help by performing traditional rituals to end the continuing dry spell.

As per the ritual, children tie neem tree leaves around their waist and beg for rain.

Semi-clad children tying frogs with tree leaves also hopped around the entire village, chanting couplet as “Dhondi, Dhondi pani de (God give us rain).

Farmers said that this traditional ritual was meant to please the rain Gods.

Akola falls under Vidarbha region of Maharshtra, where hundreds of farmers committed suicide due to debt-burden and poverty in recent years. Now delay in monsoon rains have added to their woes.

Meanwhile, the weather department said that monsoon might cover Maharashtra by first week of July. By Ravi Patil(ANI)

Window for stroke treatment widens

Washington, May 29 (ANI): After a stroke, a patient gets very little time to get treatment. Now, a new study has shown that stroke medications can benefit patients up to 4.5 hours after they experience first symptom.

It is believed that if a patient arrives at the emergency room within three hours of experiencing stroke symptoms, doctors can administer a potent clot-busting medication and often save critical brain tissue.

But if more than three hours have passed, current clinical guidelines say the medication should not be used.

However, by combining data from multiple clinical trials, Dr Maarten Lansberg, assistant professor of neurology and neurological sciences at Stanford University School of Medicine showed that treatment can benefit patients up to 4.5 hours after they experience their first symptom.

A stroke, or brain attack occurs due to a sudden drop in blood flow to the brain. Most strokes are ischemic, meaning they’re caused by a blocked artery.

For these strokes, a medication called tissue plasminogen activator, or tPA, can open blocked blood vessels and help restore blood flow to the brain.

Among a total of 1,622 patients who arrived at the hospital between three and 4.5 hours after their symptoms started, the study showed that treatment with tPA improved the likelihood of a favourable outcome by 31 percent.

“A favourable outcome means that patients are either completely back to normal or they have minimal symptoms, like some numbness or a slight facial droop,” Lansberg said.

“But they can do everything in their normal life that they were able to do before the stroke happened,” he added.

Another study, led by Lansberg further supported the findings. Out of 100 patients treated three to 4.5 hours after the onset of stroke, the study estimated 16.9 patients would benefit and only 3.4 would be harmed.

“Although this is not as good as treatment at an earlier time, it is still a highly significant benefit for patients treated in this group,” said Lansberg.

However, the FDA has not approved tPA for use more than three hours after the onset of symptoms.

“Until these data came out, we were treating patients up to three hours,” said Lansberg.

“Now, after carefully explaining the risks and benefits, we give patients the option to get treatment up to 4.5 hours after their symptoms start,” he added.

The findings are published in the journal Stroke. (ANI)

Giant volcanic eruption 260 mln yrs ago may have caused global mass extinction

Washington, May 29 (ANI): Scientists at the University of Leeds in the UK have uncovered a previously unknown giant volcanic eruption that led to global mass extinction 260 million years ago.

The eruption in the Emeishan province of south-west China unleashed around half a million cubic kilometers of lava, covering an area 5 times the size of Wales, and wiping out marine life around the world.

Unusually, scientists were able to pinpoint the exact timing of the eruption and directly link it to a mass extinction event in the study.

This is because the eruptions occurred in a shallow sea, meaning that the lava appears today as a distinctive layer of igneous rock sandwiched between layers of sedimentary rock containing easily datable fossilized marine life.

The layer of fossilized rock directly after the eruption shows mass extinction of different life forms, clearly linking the onset of the eruptions with a major environmental catastrophe.

The global effect of the eruption is also due to the proximity of the volcano to a shallow sea.

The collision of fast flowing lava with shallow sea water caused a violent explosion at the start of the eruptions – throwing huge quantities of sulphur dioxide into the stratosphere.

“When fast flowing, low viscosity magma meets shallow sea, it’s like throwing water into a chip pan – there’s spectacular explosion producing gigantic clouds of steam,” explained Professor Paul Wignall, a paleontologist at the University of Leeds.

The injection of sulphur dioxide into the atmosphere would have lead to massive cloud formation spreading around the world, which cooled the planet and ultimately resulted in a torrent of acid rain.

Scientists estimate from the fossil record that the environmental disaster happened at the start of the eruption.

“The abrupt extinction of marine life we can clearly see in the fossil record firmly links giant volcanic eruptions with global environmental catastrophe, a correlation that has often been controversial,” said Professor Wignall. (ANI)

Significant psychological impact of child abuse seen in inpatients

Washington, May 22 (ANI): Mayo Clinic researchers have found that a history of child abuse significantly impacts a wide range of challenges facing depressed inpatients-an increase in suicide attempts, prevalence of substance use disorder, and a higher incidence rate of personality disorder.

Presenting their findings at the American Psychiatric Association 2009 Annual Meeting in San Francisco, the researchers revealed that the victims also had an earlier onset of mental illness and an increase in psychiatric hospitalisations for psychiatric issues.

The impact of child abuse already is known to increase the risk of suicide, however the literature about other characteristics of depressed victims of child abuse is scarce.

The Mayo researchers say that though their study does not confirm causality, the information stresses the importance of more aggressive approaches from the public health perspective to prevent child abuse.

“A history of child abuse makes most psychiatric illnesses worse,” according to Dr. Magdalena Romanowicz, lead author of the study.

“We found that it significantly impacts the wide range of characteristics of depressed inpatients including increased risk of suicide attempt, substance abuse, as well as earlier onset of mental illness and more psychiatric hospitalizations. This new information serves as a reminder of the importance of child abuse prevention from a public health perspective,” Dr. Romanowicz said.

The researcher has revealed that plans are under way to further examine the association between child abuse and metal illness in a larger study of patients. (ANI)

Hypertension doubles already elevated risk of heart disease in diabetics

New Delhi, May 21 (ANI): The presence of hypertension doubles the already elevated risk of heart disease in diabetics, and at the same time, increases the risk for other vascular complications such as strokes, retinal damage and peripheral vascular disease.

Detailing the specifics on the subject, Dr. Vikas Ahluwalia, president of Diabetes Care Foundation of India, says hypertension also greatly accelerates the progression of kidney disease in diabetics.

Both diabetes and hypertension are dangerous because they usually have no symptoms, he adds.

“You can be feeling fine at the same time as damage to internal organs is progressing. It is important to treat diabetes and hypertension early before one feels the symptoms and reaches a stage when things go out of control,” he opines.

There are six facts that need to be highlighted:

1. Hypertension is twice as common in Diabetes Mellitus.

2. New onset Diabetes Mellitus is 2.5 times in hypertension.

3. 20 to 40 percent of IGT patients have hypertension.

4. 40 to 50 percent of Type 2 Diabetes Mellitus have hypertension.

5. Only 1/4 of hypertension in Diabetes Mellitus is controlled.

6. Diabetes Mellitus and hypertension increases cardio-vascular risk three fold.

In Dr. Ahluwalia’s opinion, these problems can be treated at an early stage by following a prescribed diet, exercising, and taking medications as directed.

“At a later stage treatment, it is often more difficult. For example, end-stage kidney disease may require dialysis, or heart disease may require bypass surgery. Therapeutic lifestyle changes (TLC) are very important at all stages / severity and are common for both Diabetes Mellitus and hypertension,” Dr. Ahluwalia adds.

The lifestyle changes should include regular 30 minutes of moderately intense exercise after consulting your physician; No tobacco and minimal intake of alcohol; Salt restriction to less than six grams per day; Avoid high salt foods – pickles, savories; Use of K containing foods – fruits, vegetables; Weight reduction – goal ideal weight and Reduce coffee consumption.

He also says that it is essential to set yourself blood pressure targets.

If you are a diabetic Without proteinuria, Dr. Ahluwalia says the ideal blood pressure would be – 130/80, while with proteinuria it should be 125/75.

The maximum blood pressure in the event of anyone having Diabetes Mellitus is 130/80.

He concludes that almost all Diabetes Mellitus patients require 1 drug for Hypertension.

Identify the co-morbidity – CAD, CKD, CVD.

Dr. Ahluwalia can be contacted as follows:

Dr Vikas Ahluwalia

Director- Diabetes Care Foundation Of India

diabetescarefoundation@gmail.com

Address B -4/234, Safdarjung Enclave,

New Delhi- 110029, 9910328390/26167893 (ANI)

Women more prone to ill effects of smoking

Washington, May 19 (ANI): Women are more susceptible to smoking’s lung damaging effects than men, says a new study.

Inga-Cecilie Soerheim, M.D., and colleagues from Channing Laboratory, Brigham and Women’s Hospital and University of Bergen, Norway analyzed data from a Norwegian case-control study including 954 subjects with chronic obstructive pulmonary disease (COPD) and 955 controls.

All were current- or ex-smokers, and the COPD subjects had moderate or severe COPD.

“Overall our analysis indicated that women may be more vulnerable to the effects of smoking, which is something previously suspected but not proven,” said Dr. Soerheim.

The study results have been presented at the 105th International Conference of the American Thoracic Society in San Diego.

Examining the total study sample, there were no gender differences with respect to lung function (FEV1) and COPD severity, but the women were on average younger and had smoked significantly less than men.

To explore these differences further, they also analyzed two subgroups of the study sample: COPD subjects under the age of 60 (early onset group) and COPD subjects with less than 20 pack-years of smoking (low exposure group). In both subgroups, women had more severe disease and greater impairment of lung function than men.

“This means that female smokers in our study experienced reduced lung function at a lower level of smoking exposure and at an earlier age than men,” said Dr. Soerheim.

It has long been suspected that the effect of smoking on lung function may be modified by gender. Interaction analysis confirmed that being female represents a higher risk of reduced lung function and severe COPD, but this gender effect was most pronounced when the level of smoking exposure was low.

According to Dr. Soerheim, the reason why women may be more susceptible to the effects of cigarette smoke is still unknown, but there are several possible explanations: “Women have smaller airways; therefore each cigarette may do more harm. Also, there are gender differences in the metabolism of cigarette smoke. Genes and hormones could also be important.” (ANI)

Short-term sleep aid course ups treatment adherence in sleep apnea patients

Washington, May 18 (ANI): A new study has revealed that patients with obstructive sleep apnea, who use a short-course of the sleep aid, eszopiclone, when beginning continuous positive airway pressure (CPAP) therapy are likely to adhere to the treatment for a longer time.

CPAP is recommended as the first-line therapy for most patients with OSA, and has been shown to improve sleep quality, reduce daytime sleepiness and enhance quality of life.

However, despite many benefits compliance to CPAP is extremely poor.

“We know that non-benzodiazepine sedative hypnotics promote sleep onset and continuity. Additionally, they can be safely used in patients with OSA, especially those already using CPAP,” said Anita Shah, D.O., author of the study.

“To date, the only consistently reliable predictor of long-term use has been compliance with CPAP at treatment initiation. Studies suggest that long-term adherence patterns may be established very early in the course of therapy,” she added.

During the study, the researchers examined whether eszopiclone would improve early CPAP adherence.

They conducted a prospective, double-blind, randomised, placebo-controlled trial involving 154 patients newly diagnosed with OSA who were beginning CPAP therapy.

The participants either received eszopiclone or placebo for their first 14 days of CPAP therapy.

They found significant differences between the eszopiclone group and the placebo group.

On average, patients who received eszopiclone used their CPAP devices more nights per week, and for an hour longer per night and the adherence was sustained six-months.

“Because we know that CPAP therapy improves sleep quality, reduces daytime sleepiness, enhances quality of life and may mitigate the excessive risk for cardiovascular events associated with this disorder, this small intervention could represent a profound clinical benefit to these patients,” said Dr Christopher Lettieri, principal investigator.

“Given the poor adherence to CPAP therapy in many patients, any simple intervention that can reliably improve adherence should be strongly considered,” he added.

The findings were presented at the American Thoracic Society’s International Conference in San Diego. (ANI)

Nepal Vice President urges parties to focus on statute drafting process

Kathmandu, May 18 (ANI): Nepal Vice-President Parmananda Jha on Monday accused the political parties of neglecting the Constitution-drafting process and engaging themselves in power-seeking game.

Talking to reporters, Jha said the political parties should focus on the Constitution-drafting process and not on the government making and toppling games.

He mentioned that a majority government should be formed as the parties have failed to constitute a national unity government.

Objecting to the caretaker Prime Minister Prachanda’s accusation that President Ram Baran Yadav has been guided by foreign powers in the entire development since the onset of the army chief row, he said that one should not forget ground reality before making any accusations.

He said the President Yadav in his capacity as the preserver of the Constitution had ordered Chief of Army Staff (CoAS) General Rookmangud Katawal to resume his office.

“His move has not violated civilian supremacy,” Kantipur quoted him as saying.

He, however, remarked that both the Prime Minister and the President had committed mistake regarding General Katawal retirement issue. The problem had aroused, as the interim Constitution does not clearly indicate the role of President as a ceremonial one.

Meanwhile, Maoist leaders decided to stand on its stance regarding President Yadav’s move.

Issuing a press statement after the party’s secretariat committee meeting this morning, they appealed other political parties to build consensus on the issue.

The statement further said that the party is agitating on what it terms as holding civilian supremacy and would like other parties to come and forge consensus on the issue.

Maoists also threatened to continue disrupting Constitution Assembly proceedings if such consensus is not built. (ANI)

Newly found genes linked with menopause could prevent cancer, heart disease

London, May 18 (ANI): Scientists have found new gene variants linked with the age at which females experience their first menstrual period and the onset of menopause, which can even help in preventing breast and endometrial cancer and osteoporosis, and cardiovascular disease.

In the collaborative study led by Harvard School of Public Health (HSPH), the researchers have identified 10 genetic variants in two chromosomal regions associated with age at menarche (the first menstrual period), and 13 genetic variants in four chromosomal regions associated with age at natural menopause.

Menarche and natural menopause are two important physiological events in a woman’s life.

The researchers explained that an early onset of menarche and later menopause are well-established risk factors for the development of breast cancer and endometrial cancer.

On the other hand, early menopause increases risk of osteoporosis and cardiovascular disease.

Previous studies have suggested both menarche and menopause may be partially under genetic control.

And thus, to identify common genetic variants influencing these states, the researchers analysed more than 317,000 gene variants in a total of 17,438 women from the Nurses’ Health Study (NHS) and the Women’s Genome Health Study (WGHS) based at BWH.

“At these newly identified loci, fine mapping or sequencing might lead to identification of the causal variants, and thus expand our knowledge of the underlying physiology and biological regulation of these traits. Insights into the genetic factors influencing the timing of menarche and natural menopause might shed light on normal reproductive function and the prevention of the diseases associated with these two traits,” Nature magazine quoted lead author Chunyan He, a doctoral student at HSPH, as saying.

Daniel Chasman, Director of Computational Biology in the Center for Cardiovascular Disease Prevention at Brigham and Women’s Hospital, said:

“The collaboration of the WGHS and the NHS represents a great example of how large cohorts with genome-wide data can complement each other. While only one locus reached near genome-wide significance in the NHS alone, the meta-analysis of combined data had much more statistical power and revealed a total of two loci for timing of menarche and four for timing of menopause.”

Chasman, also an assistant professor at Harvard Medical School, added: “Of the loci for timing of menopause, three were already strong but not proven candidates in the NHS; these loci reached genome-wide significance in the WGHS alone, supplementing the meta-analysis by a second mode of validation through replication. The remaining locus, for timing of menopause, would not have been identified, even as a candidate, without the joint power of these two cohorts working together.

“Future collaborations will hopefully continue to leverage the combined power of the two cohorts for association studies directed at other clinical characteristics.”

Titled ‘Genome-wide association studies identify loci associated with age at menarche and at natural menopause’, the study has been published online in Nature Genetics. (ANI)