Brisbane man ‘fired for being too fat’

Melbourne, May 19 (ANI): A Brisbane man has claimed that he was sacked from his factory job for being morbidly obese and has lashed back at his former employers.

According to News.com.au, Lance Pedersen, 57, was fired from his job at Golden Circle”s Northgate factory on Monday after he was deemed unfit to perform duties which he says were not part of his initial job description, The Courier-Mail reports.

“It pretty well shattered me; it”s turned my life upside down. My partner and I have got a mortgage . . . it”s hard to survive on just one wage,” News.com.au quoted Pedersen as saying.

Pedersen, a forklift worker, who says he has lost 8kg in recent times, was told he would be moved to work on the beverage line to pack and monitor drinks when workers took their lunch breaks.

But after undergoing the company’s medical test, he has been declared unfit, reasons being obesity and severe osteoarthritis of the knees.

Mr Pedersen, who spent 14 years with the company, has filed for unfair dismissal with Fair Work Australia, claiming his employer gave him no warnings about his health, which had never been a problem before.

“He”s more than capable of doing the job he was originally employed to do, in fact he could do it tonight.

“He”s got a report from his own GP, who says he is well aware of his condition and he is more than capable of doing the job he”s been employed to do,” said Duncan Pegg, The National Union of Workers organiser.

A spokesman for Heinz Australia, which owns Golden Circle, explained that the company had to look after their employees’ health and so couldn’t let Pederson work at the plant anymore.

Pederson on the other hand has argued that if he’s let off the hook on medical grounds, no other company would be ready to employ him in the first place.

“If I went to another place to seek employment I”d have to disclose that Golden Circle put me off on medical grounds. As soon as you say that, the other place will just say: sorry, we don”t need you.” (ANI)

Smoking, obesity, alcohol affect survival of non-Hodgkin”s lymphoma patients

Washington, May 14 (ANI): People with non-Hodgkin”s lymphoma—who smoked, consumed alcohol or were obese before their cancer diagnosis—had poorer overall survival, as compared to patients who did not have these risk factors, a new study found.

The finding by researchers from Mayo Clinic in collaboration with six other U.S. institutions, was made after accounting for clinical and demographic factors, and also when considering only deaths due to this kind of lymphoma.

For example, non-Hodgkin”s lymphoma patients with a 20-plus-year history of smoking had a 76 percent higher risk of death compared to never smokers; patients who consumed more than 43 grams of alcohol per week had a 55 percent higher risk of death compared to nondrinkers; and obese patients (defined as a body mass index of 30 or higher) had a 32 percent higher risk of death compared to patients with normal weight for their height.

While smoking and obesity had already been found to increase the risk of developing non-Hodgkin”s lymphoma, this is the first U.S. study to look at their role on survival after being diagnosed with non-Hodgkin”s lymphoma, the researchers say.

For alcohol, the researchers found that use was associated with poorer survival, which is opposite of the effect for developing non-Hodgkin”s lymphoma, where alcohol appears to lower risk.

The findings mirror conclusions found in three smaller studies, according to the study”s lead investigator, Dr. James Cerhan.

These are the first data from North American patients, and the only study to simultaneously look at all three lifestyle factors, he said.

“This now raises the hypothesis that changing these behaviors after diagnosis might improve survival, but this needs to be tested in a clinical study. In the meantime, patients in active therapy should discuss any lifestyle changes with their health care provider. Long-term survivors outside of therapy should consider the general public health guidelines that recommend smoking cessation, moderate or no alcohol use, and attaining a healthy weight,” he added.

“It is important to note that patients who had quit smoking 20 years or more before diagnosis had no higher risk of death than patients who had never smoked,” said Cerhan.

The study was published in a recent online edition of Cancer. (ANI)

Fat infants of fat moms may signal future obesity risk

Washington, May 5 (ANI): A new research has revealed that more babies are being born with more body fat at the same time when body mass index (BMI) has increased among pregnant women.

Researchers from Children”s Mercy Hospitals and Clinics in Kansas City, Mo., analysed data from 1990 to 2005 and looked at more than 74,000 births.

They found that the ponderal index, a measurement of newborn body fat composition, correlated with the mother”s BMI and also increased over the study period. Babies with a higher ponderal index tend to have more body fat.

“Health care providers need to pay closer attention to the body mass index of women before they get pregnant, and equal attention to how much weight they gain during the pregnancy,” said lead author Felix Okah, professor of paediatrics and director, Neonatal-Perinatal Medicine Fellowship Program, Children”s Mercy Hospitals and Clinics.

“Adult diseases like obesity may have their foundation during the foetal period, so efforts to safeguard the health of the foetus could translate to future adult health for these newborns,” Okah added.

The findings were presented at the Paediatric Academic Societies annual meeting. (ANI)

Study debunks smoking makes you slimmer myth

A new research debunks the myth that smoking makes people slimmer.

According to a four-year analysis by researchers at the University of Navarra, people who never smoked put on less weight than active smokers or those who stop smoking.

The researchers have evaluated the link between the two cardiovascular risk factors: the ‘nicotine habit’ and the increase in weight when smokers stop the habit and when they continue smoking.

The results ‘are crucial for considering prevention programmes,’ says Francisco Javier Basterra-Gortari, main author of the study and researcher at UNAV.

The data, resulting from an analysis of 7565 people over 50 months, is based on age, sex, initial body mass index and lifestyles (sedentarism, changes in physical activity, energy/fibre intake, snacks between meals and consumption of fizzy drinks, fast food and alcohol).

Weight gain in people who stopped smoking during the study was higher the more cigarettes they smoked a day when the investigation began. Those who continued smoking also gained more weight during this period than the non-smokers.

The authors confirm that nicotine addiction is not an effective way of preventing obesity.

“In fact the increase is demonstrated, especially in ex-smokers and in smokers who continue,” says Basterra-Gortari.

The association between being overweight and nicotine addiction is especially harmful for cardiovascular health. Therefore, abandoning the nicotine habit has been linked to a decrease in the risk of cardiovascular illnesses and cancer.

However, experts argue that weight gain after stopping smoking is, often, a reason for not quitting the nicotine addiction, especially among women.

Most of the investigations that have studied this link have observed that, although there is an increase in weight after stopping smoking, there are notable variations in weight gain.

The study has been published in the Revista Espanola de Cardiologia.

Vitamin K may help keep non-hodgkin lymphoma at bay

Washington, Apr 20 (ANI): People who have higher intakes of vitamin K from their diet have a lower risk of developing Non-Hodgkin lymphoma, a new study has found.

Non-Hodgkin Lymphoma is a cancer of the immune system.

At the 101st Annual Meeting of the American Association for Cancer Research (AACR), researchers at the Mayo Clinic campus in Minnesota report that the risk of developing Non-Hodgkin lymphoma was approximately 45 percent lower for participants who had vitamin K intakes in the top quartile of intake in the study, compared to participants who had intakes in the bottom quartile. This association remained after accounting for other factors such as age, sex, education, obesity, smoking, alcohol use and intake of foods with high amounts of antioxidants.

Vitamin K is a fat-soluble vitamin and is derived from either plants (phylloquinone or vitamin K1) or bacterial synthesis.

“These results are provocative, since they are the first work we have done on the connection between vitamin K and Non-Hodgkin lymphoma, and this is a fairly strong protective effect,” says the study”s lead investigator, James Cerhan, M.D., Ph.D., a cancer epidemiologist. “However, as with all new findings, this will need to be replicated in other studies.” (ANI)

Fat fast becoming top health challenge

Health experts say obesity is quickly becoming Australia’s biggest public health challenge.

A new study has found obesity has overtaken smoking as the leading cause of preventable diseases in Western Australia.

Health experts have described the figures as alarming and say the obesity epidemic has now reached crisis point.

Australia has one on the highest rates of obesity in the world, with more than 60 per cent of adults and one in four children overweight or obese.

Professor Mike Daube, the president of the Public Health Association of Australia, says the epidemic is on the rise.

“We’re aware of the problem [but] we’re not doing enough about it,” he said.

“It’s taken us 60 years since we knew about the dangers of smoking to get to this fairly encouraging decline. We need to move faster than that on obesity.”

Professor Daube says the Federal Government spends just 2 per cent of the country’s health expenditure on prevention, which is not enough.

He says there should be more health and physical education in schools, as well as a curb on junk food advertising.

Tim Gill, the principal research fellow at the Boden Institute of Obesity Nutrition and Exercise at University of Sydney, says Australia has been slow to respond to the obesity problem.

“When we had the alarm bells ring 15 years ago very, very little was done and it’s only really in recent times that we’ve started to take this problem seriously,” he said.

“As a consequence, we’ve now seen probably a generation of young adults go through a period of time where obesity wasn’t seen as a serious issue… and now they’re the people who are starting to develop these chronic diseases, particularly type 2 diabetes, which is driving what we’re seeing here in terms of the cost of illness.”

Cultural change

Associate Professor Gill says there are many lessons to be learned from the successes of anti-smoking campaigns.

“We needed to get large structural changes in terms of the social acceptance of smoking, in terms of regulations about where and how to smoke, in terms of fiscal policies around taxation to discourage the uptake and continuance of smoking, and I think governments need to accept that they need to see obesity in exactly the same light,” he said.

“The need to change a situation that we have at the moment where we live in an environment where the wrong types of foods are so readily available and they are so cheap and they are promoted and made available wherever we go.”

Federal Health Minister Nicola Roxon says the Government is aware obesity is a growing and serious problem.

She rejects claims the Government is not doing enough and says major investments have been made.

“Some of our changes are being blocked in the Senate like the establishment of a preventative health agency that the Liberal Party have been opposing,” Ms Roxon said.

“We believe that the changes that are part of this health reform can make a significant difference to investing more at the front end of health care and maintaining people’s fitness.

“We are prepared to consider further steps which should be taken but this is a community-wide problem. It needs the community, it needs health professionals, it needs families and it needs the Government to tackle it.”

The findings of the West Australian study have been published in the Australian New Zealand Journal of Public Health.

‘Obesity crisis on our hands’

New research has found that obesity has overtaken tobacco as the leading preventable cause of disease in Western Australia.

The WA Health Department study compared the impact several risk factors had on the level of disease in 2006.

It found that obesity was responsible for 8.7 per cent of diseases that year, with tobacco contributing to 6.5 per cent.

The Department’s Veronica Hoad says smoking has previously been the largest risk factor.

“The amount of people smoking tobacco has continously declined over time, whereas the amount of people becoming more overweight and obese has increased over time, and that has resulted in more disease being caused by being overweight and obese.”

Ms Hoad says the findings are significant.

“The reason why the burden attributed to smoking has decreased is because of successful public health efforts.

“Now, if we do not stop people getting overweight and obese then we’re going to have a real problem. There’s going to be more chronic disease and death.”

Action needed

The Public Health Association of Australia president, Mike Daube, says the results are worrying and can be applied nationally.

“It’s telling us that we do have an obesity crisis on our hands.

“Trends in WA are going to be very similar to trends across the country.

“What it’s telling us is that obesity now is one of the biggest threats we face to our public health.”

Mike Daube says the findings should send a strong message that urgent action needs to be taken to tackle obesity.

“There’s responsibility for all of us, as individuals, as parents, as community members and for governments.

“They have to set the lead, they have to introduce comprehensive programs that we can all work along with.”

Serious

The Federal Health Minister Nicola Roxon has acknowkedged that obesity is a serious and growing problem in Australia.

Ms Roxon says the Federal Government has already studied the risk factors and is acting to prevent people from becoming obese.

“We’re tackling this on lots of different fronts – what’s the message to the general public, what can we do to help parents and families in giving their children healthy choices and healthy lifestyles.

“What should we do at the government level, what can our health professionals do.

“But, I think it’s a very serious growing problem that we need to keep a close eye on and invest in these areas.”

School starts too early for dozy teens

Researchers at the University of South Australia say school hours should be changed to accommodate the sleep needs of teenagers.

A study published in the Australian and New Zealand Journal of Public Health today looks at the sleep patterns of young people and its links to health problems such as obesity.

Professor Tim Olds says many teenagers are not getting enough sleep through the school week and would be better off if school started later in the day.

“It certainly seems that it’s not so much the absolute amount of sleep that teenagers are getting but the fact that they have these sort of cyclical sleep deficits,” he said.

“So they are underslept on school days and they accumulate a big sleep deficit through the week, then they get rid of that sleep deficit Friday and Saturday, then the whole thing begins again on Sunday.

“Adolescents who tend to go to bed a bit later don’t get enough sleep in the school days, so by putting back the school starting time to 10:00am or 11:00am that may remedy that.”

Weight-loss patient wants to sue doctor

A former patient of a surgeon on Queensland’s Gold Coast who is accused of malpractice says she deserves compensation.

Gold Coast surgeon Dr Russell Broadbent is accused of causing serious injuries or death after performing radical weight-loss surgery between 1999 and 2005.

Lawyers applied to the Supreme Court today to allow nine former patients to sue for damages.

Former patient Caroline Shaw says her operation was supposed to improve her quality of life.

“It’s devastating – I’d much rather be overweight and happy than the weight I am now and miserable every day,” she said.

“Every day I suffer pain.

“My children have stopped asking me, ‘Mum how are you?’ they say, ‘Mum what’s your pain scale?’”

Dr Broadbent has denied people have died because of the surgery.

Healthy lifestyle cuts Alzheimer’s risk

London, Apr 1 (ANI): A healthy lifestyle in middle age is key to staving off Alzheimer’s disease and dementia, says a new study.

According to two senior doctors, keeping obesity, blood pressure and cholesterol under control as you age can cut the risk of developing Alzheimer’s and dementia by 20 per cent, reports The Daily Express.

The study, by Dr Tom Russ and Professor John Starr, has appeared in the journal BMJ Clinical Evidence.

Their article stated: “Consistent with the finding that there are pathological changes well in advance of the appearance of symptoms of dementia, evidence is mounting that preventative efforts must be introduced sufficiently early in life to have an effect.

“Blood pressure, cholesterol and obesity need to be adequately controlled in midlife for dementia to be prevented. Exercise is to be recommended across all age groups.”

Rebecca Wood, chief executive of the Alzheimer’s Research Trust, said: “Diet and lifestyle almost certainly play a part in every person’s Alzheimer’s risk.

“These factors remain a magnet for research because they could offer relatively inexpensive ways to fight a disease that ruins countless lives.

“By taking regular exercise and eating a healthy diet, especially in mid-life, we may help reduce our risk of developing dementia as well as reaping numerous other benefits from living a healthy lifestyle.” (ANI)

Oz lingerie labels catering to ever-growing bust sizes

Melbourne, Mar 31 (ANI): Lingerie labels in Australia are offering an ever-increasing range of sizes catering to a boom in the bust size.

Big Girls Don”t Cry Anymore owner Karen Edbrooke said the best-selling size in the store”s range had increased a cup size each of the past four years from an E to H.

“In the past 12 months the most popular has been a 16H,” the Courier Mail quoted Edbrooke as saying.

“More and more girls are coming in younger and fuller. They want to look like everyone else but they”re wearing long shirts and want to hide their bust,” she added.

The store stocks sizes 6D to 22M, and the price of the larger bras range from 69 to 89 dollars.

Triumph managing director David Gow said that five years ago the brand”s largest selling size was a 12B but 2009 sales indicated that had risen to 14C and 14D.

Honey Birdette at Paddington stocks the Pleasure State VIP range, which ranges up to a size 16G.

Karen Wilson, owner of Paddington boutique Boudoir Chic said that there has been a rise of demand for fashion to cater for larger busts.

Australian Society of Plastic Surgeons president Peter Callan said as obesity was the main reason for bigger breasts, breast reduction operations had not risen. (ANI)

Shire to target weighty woes

The Shire of Derby/West Kimberley is receiving Commonwealth funding to tackle above average levels of obesity.

The shire has been allocated more than $400,000 to launch a health program which will provide healthy cooking classes and group exercise sessions.

The shire is considering closing off a street for barbecues and aerobics classes.

The shire’s head of community development, Brad Isbister, says the key will be to find fun ways to overcome the region’s alarming obesity rates.

“Women in the Shire of Derby are one-and-a-half times more likely to be overweight or obese compared with people in other towns, which is a huge probability,” he said.

“Statistics show that 75 per cent of people living of Derby/West Kimberley are on the borderline of developing health-related diseases.”

Bligh wants ‘certainty’ from Commonwealth on future population

Queensland Premier Anna Bligh says the states need more certainty from the Commonwealth about future population to plan for infrastructure.

She says it is hard for the states to plan for growth when they do not know how many people to expect.

Ms Bligh says a national population policy would help.

“Giving states and local government more certainty about the sort of numbers we could expect to be catering for,” she said.

She says the Commonwealth should also have a federal infrastructure plan.

“It would be a very powerful tool for national prosperity, good planning and certainty for other levels of government,” she said.

A two-day summit will start on Tuesday morning in Brisbane to discuss the pressures facing south-east Queensland.

Opposition Leader John-Paul Langbroek says it is just the latest in a series of forums hosted by the State Government.

“So far we’ve seen an obesity summit, a 20-20 summit, a reef summit,” he said.

“The Premier loves having summits and then moving on to the next target.”

New strategy to treat type 2 diabetes

London, Mar 29 (ANI): A cellular pathway that fails when people become obese has been identified, and scientists believe that it could act as a new strategy for treating type 2 diabetes.

By activating this pathway artificially, researchers at Children”s Hospital Boston could normalize blood glucose levels in severely obese and diabetic mice.

Epidemiologists have long known that obesity contributes to type 2 diabetes.

In previous work, Dr. Umut Ozcan showed that the brain, liver and fat cells of obese mice have increased stress in the endoplasmic reticulum (ER)— a structure in the cell where proteins are assembled, folded into their proper shapes, and dispatched to do jobs for the cell.

In the presence of obesity, the ER is overwhelmed and its operations break down.

This so-called “ER stress” activates a cascade of events that suppress the body”s response to insulin, and is a key link between obesity and type 2 diabetes.

However, until now, researchers haven”t known precisely why obesity causes ER stress to develop.

The researchers have now shown that a transcription factor that normally helps relieve ER stress, called X-box binding protein 1 (XBP-1), is unable to function in obese mice.

Instead of travelling to the cell nucleus and turning on genes called chaperones, necessary for proper ER function, XBP-1 becomes stranded.

And on further probing, the researchers found the reason— XBP-1 fails to interact with a protein fragment called p85, part of an important protein that mediates insulin”s effect of lowering blood glucose levels (phosphotidyl inositol 3 kinase or PI3K).

Ozcan”s group identified a new complex of p85 proteins in the cell, and showed that normally, when stimulated by insulin, p85 breaks off and binds to XBP-1, helping it get to the nucleus.

“What we found is, in conditions of obesity, XBP1 cannot go to the nucleus and there is a severe defect in the up-regulation of chaperones. But when we increase levels of free p85 in the liver of obese, severely diabetic mice, we see a significant increase in XBP1 activity and chaperone response and, consequently, improved glucose tolerance and reduced blood glucose levels,” Nature quoted Ozcan as saying.

When people are obese, the insulin signalling that normally increases free p85 is impaired, leading to more ER stress and more insulin resistance, ultimately leading to type 2 diabetes.

However, Ozcan thinks this vicious cycle can be circumvented through strategies that increase levels of free p85.

The findings have been published in Nature Medicine. (ANI)

Lap-band surgery off limits for under 15s

Australian surgeons have been issued with a set of guidelines for carrying out lap-band surgery on severely obese teenagers.

The Royal Australasian College of Physicians has released its advice on when teenagers should be allowed to have the controversial procedure, which involves restricting the stomach by putting a ring around it.

The guidelines endorse the operation for obese teens from the age of 15.

The chairwoman of the committee which developed the guidelines, Professor Louise Bauer, says the surgery should be considered for some teenagers as young as 15 with severe obesity.

“It is not a large number of young people, but there is a small, significant proportion of young people with severe obesity who need additional therapy,” she said.

“We are recommending that weight-loss surgery be considered in young people aged 15 years and over who have finished puberty and who have severe obesity – a body mass index greater than 40.”

Professor Bauer says there is a long-term study going back 14 years that follows up with people who have had lap-band surgery, but there is no long-term follow-up with young people.

“We know that obesity surgery can really improve life longevity for adults who have severe obesity,” she said.

“We have recommended laparoscopic banding surgery for young people because, first of all, there is experience with its use in Australia and also because it is potentially reversible.

“I think that is an important thing to think about when we are dealing with young people, particularly when we are not sure necessarily of the long-term effects.”

When buying for others, consumers go for less healthy food items

Washington, Mar 23 (ANI): Consumers choose foods that are less healthy when they are purchasing for others, a new study has found.

The study has been published in the Journal of Consumer Research.

In a series of studies on food choice, author Juliano Laran (University of Miami) discovered that consumers exert more self-control when they make choices for themselves.

In one study, participants were asked to make a sequence of four choices from 16 items that were healthy (items like raisins, celery sticks, and cheerios) or indulgent (items like chocolate bars, cookies, Doritos, ice cream, and doughnuts). Half of the participants were asked to choose four items for themselves, while the others were asked to choose four items for a friend.

“When making choices for themselves, participants chose a balance of healthy and indulgent food items,” Laran writes. “When making choices for others, however, participants chose mostly indulgent food items.”

The author conducted another study of real consumers exiting a supermarket, which confirmed the earlier results, and showed that consumers bought equally indulgent items when purchasing for their families, friends, or roommates. A final study showed that consumer choices became more balanced after they were made aware of a healthy goal when making choices for others.

The author suggests that education could help consumers make more balanced choices when they are shopping for others. He also suggests that this phenomenon may be affecting public health.

“One of the reasons the population gets more and more obese is that a lot of the food we consume is chosen by other people, like friends throwing a party or parents buying for their children,” Laran writes. “Taking responsibility for their own choices instead of letting others choose could help consumers fight against obesity and lead a healthier lifestyle.” (ANI)

Married people twice as likely to become fat than their single counterparts

London, Mar 20 (ANI): Wondering what wedding present to buy for your friend? Well, a gym membership might be a good idea. A new study has claimed that people who are married are twice as likely to become obese than their single counterparts.

And Greek boffins put the blame on changed lifestyle for the increased weight, as married couples “let themselves go”.

The research was based on the study of more than 17,000 couples aged between 20 and 70, reports The Telegraph.

From analyses, it was found that married couples exercised less frequently, had less sex, had poor nutrition and were “comfortable” in their lives.

Married couples spend more time eating together, sit in front of the TV more and often order takeaway ready meals while exercising less.

The study was presented on Friday to the Panhellenic Medical Conference.

Scientists from Salonica and Ioannina Universities concluded that “abdominal obesity, or belly fat” was the worst problem among married people.

Prof Dimitris Kiortsis, one of the study”s co-authors, from Ioannina University who is also president of the Hellenic Medical Association for Obesity, said most married couples also have less sex, which is considered intense exercise that burns calories.

The expert commented: “The need to hunt for a partner is reduced”. (ANI)

Thin smokers at increased lung cancer risk

Kuala Lumpur, Mar 17 (ANI): A research has revealed that smokers who are thin are more at risk of suffering from lung cancer than people who are fat.

According to China’s Xinhua news agency, researchers from the National University of Singapore surveyed 63,257 middle- aged and elderly Chinese Singaporeans from 1993 onwards, reports Star Online.

Local English newspaper the Straits Times reported, the research examined the relationship between smokers’ body mass index (BMI) – a measure of obesity – and their chances of lung cancer.

It found that pack-a-day smokers with a BMI of at least 28 were six times as likely to get lung cancer as equally heavy people who had never lit up.

But thinner pack-a-day smokers, who had a BMI of less than 20, were 11 times as likely to get the disease as non-smokers of a similar weight and BMI.

Lung cancer is the second most common cancer in men in Singapore, and the third most common in women. (ANI)

Cellular pathway may explain obesity-cancer link

Washington, March 16 (ANI): Previous studies have shown that obesity is linked to cancer. Now, a researcher is on his way to understand the correlation.

University of Alberta researcher Richard Lamb is studying a cell pathway in the human body that regulates cell growth.

In their most recent work, Lamb and his colleagues have found that this pathway can be affected by sources not within the cell, specifically amino acid nutrients. Amino acids are the building blocks of tissues and muscle in the human body.

What makes this interesting is that these amino acids are found to be elevated in obese people.

That means this signalling pathway, called mTOR, could be hyper-activated by these heightened amino acid nutrients and this could affect how human cells respond to stress and disease among a number of other things.

Lamb and his colleagues will now investigate if cancer cells are aided by this potential hyper-activity of the pathway.

The work has been published in the prestigious journal Molecular Cell. (ANI)

Obesity associated with poor colon cancer prognosis

Washington, Mar 10 (ANI): According to a new study, obese colon cancer patients are at greater risk for death or recurrent disease compared to those who are within a normal weight range.

The study has been reported in Clinical Cancer Research, a journal of the American Association for Cancer Research.

“Obesity has long been established as a risk factor for cancer, but our study in colon cancer patients shows that obesity predicts a poorer prognosis after the cancer is surgically removed,” said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic in Rochester.

In the study, Sinicrope and colleagues evaluated 4,381 patients with stage II or stage III colon cancer who had received adjuvant chemotherapy in clinical trials. Of these patients, 20 percent were obese.

Obesity was significantly linked with poorer overall survival and was independent of other variables analyzed. The prognostic impact was stronger in men than in women, and men in the highest body mass index category for obesity had a 35 percent increased risk of death compared to normal weight patients. The weaker effect in women is consistent with studies that have shown a lower risk of developing colon cancer in obese women compared to obese men.

“We do not know if this is due to biology or the way we measure obesity,” said Sinicrope. “Body mass index is a limited measure and there is evidence that abdominal fat may be a better predictor of colon cancer risk and perhaps prognosis in men than in women. There is also the potential influence of menopausal status and hormone replacement therapy in women.” (ANI)