Smoking cessation treatments work for people with severe mental illness

Washington, May 21 (ANI): Scientists have found that treatment for smoking dependence is as effective among people with severe mental illnesses as it is for the general population.

They also found that offering such treatments does not appear to cause deterioration in mental health.

This is good news: people with severe mental illnesses (SMI) such as schizophrenia have some of the worst physical health of any section of the population. They are two to three times more likely to smoke, and smoking-related illnesses contribute significantly to their high sickness and death rates. Mortality rates for those with SMI are three times that of the rest of the population.

Although treatment for smoking dependence would improve the physical health of people with SMI, the medical community has traditionally ignored health promotion and worried that such treatments would worsen people”s mental states.

The authors brought together the most rigorous evidence on smoking cessation treatment among people with SMI. They were able to determine the effectiveness of smoking cessation treatment and chart any predictable adverse effects. In general, people with SMI responded well to pharmaceutical and behavioral treatments, which doubled their chance of quitting.

Because most of the studies focused on people with well controlled psychiatric conditions, it was not possible to state how well people with acute mental illness (such as those who have experienced recent hospitalisation) would respond to smoking cessation treatment.

Professor Simon Gilbody from the University of York & Hull York Medical School, who co-authored the review, said. “Schizophrenia is a devastating condition which causes people to die 25 years earlier than the rest of the population. This is a huge health inequality, and it is largely due to smoking-related illness rather than schizophrenia itself.”

Dr Lindsay Banham, who led the review, added “what this review suggests is that quit-smoking treatments like nicotine replacement therapy may work just as well for people with disorders like schizophrenia. Smoking by those with SMI has largely been ignored and people with schizophrenia are not consistently offered treatment or services. We found evidence that smoking cessation treatments are effective and safe. We hope our research leads to better services for this neglected population.”

Professor Gilbody concluded, “Despite huge expansion in smoking cessation services in recent years, people with severe mental illness have been left behind. The challenges for health services are to ensure people with schizophrenia are offered these treatments, and that services reflect the needs of this population.””

The new study has been published in the journal Addiction. (ANI)

Insurance deal secured for midwives

The Federal Government has struck a deal with a private insurance company to provide indemnity cover for midwives.

Midwives will now be able to prescribe medicines covered by the Pharmaceutical Benefits Scheme and order procedures covered by the Medicare Benefits Schedule.

Federal Health Minister Nicola Roxon says indemnity insurance will be available to privately practising midwives through Medical Insurance Group Australia.

“This is the first time since 2002 that midwives can purchase professional indemnity insurance,” she said.

“This is an important step for Australia’s midwives. It is also an important step for Australian women and their families.

“This insurance arrangement will help midwives who wish to provide high quality midwifery services to Australian women as part of a collaborative team with doctors and other health professionals.”

Meanwhile, midwives and midwife activists have met in Canberra to mark international midwives day.

The Australian College of Midwives says the nation has a shortage of at least 2,000 midwives, backed up by a recent State of the World’s Mothers report which showed Australia needs extra midwives.

The meeting, led by Canberra midwife and activist Mary Kirk, discussed the need for safe and effective maternity care.

“Australia needs more midwives,” Ms Kirk said.

“It needs midwives facilitated to practice in the full scope of midwifery practice more than ever and the evidence would show that Australia needs at least 2,000 more midwives if those high intervention rates are to be reduced.”

Ms Kirk also says more midwives are needed in rural areas to help reduce Indigenous mortality rates.

“In more populated areas it’s more related to the models of care, but for women in isolated communities, and most especially Indigenous women, if you’re going to have a poor outcome in this country you are most likely to be Indigenous.”

STOCKS NEWS EUROPE-Actelion slumps on key drug failure

Shares in Actelion (ATLN.VX), Europe’s biggest biotech company, tumble over 14 percent after the group’s key drug Tracleer failed to cut mortality rates in patients suffering from idiopathic pulmonary fibrosis.

“Positive BUILD-3 results were a cornerstone of our buy recommendation for Actelion. This miss removes a significant catalyst to being able to significantly increase revenue expectations for Tracleer going forward,” Vontobel analyst Andrew Weiss says.

For more double click on [ID:nLDE62004L]

Reuters Messaging rm://katie.reid.reuters.com@reuters.net

How economic recessions affect public health

Washington, September 1 (ANI): A new study suggests that mortality rates during economic recessions in developed countries decline rather than increase.

Publihsed in the Canadian Medical Association Journal (CMAJ), the study also suggests that in poor countries where GDP per capita is less than 5,000 dollars, economic growth appears to improve health by increasing access to food, clean water, shelter, and basic health services.

“In terms of business cycles, mortality is procyclical, meaning it goes up with economic expansions and down with contractions, and not countercyclical (the opposite), as expected,” writes Dr. Stephen Bezruchka, from the School of Public Health, University of Washington in Seattle, USA.

The author points out that studies on wealthy countries show that greater national wealth does not equate with better health for its citizens.

“The United States, with the highest GNP per capita in the world, has a lower life expectancy than nearly all the other rich countries and a few poor ones, despite spending half of the world’s health care bill,” he states.

It also has the highest poverty levels of any wealthy country, with large health disparities and poor health outcomes.

Countries like Sweden, which have strong social safety nets and strong labour protection, see smaller changes in the health of its citizens during recessions.

Bezruchka says that studies have shown that unemployment can be bad for people’s health, yet smoking, excessive alcohol consumption and overeating decline during recessions with beneficial impacts on health.

Perhaps even more importantly, adds Bezruchka, when unemployment rates soar, people have more time for friends, family, and children.

That, according to him, results in lower mortality.

“If we recognize that economic growth may not be good for our health, then we can consider means of reining in the excess wealth… and of redistributing national resources through social spending for the common good,” concludes Dr. Bezruchka. (ANI)

Non-lethal blast waves can cause brain injuries even without direct head impacts

Washington, August 27 (ANI): In a new research, scientists have discovered that non-lethal blast waves can cause human brain injury even without direct head impacts, which could lead to an enhanced understanding of head injuries and improved military helmet design.

Using numerical hydrodynamic computer simulations, Lawrence Livermore scientists Willy Moss and Michael King, along with University of Rochester colleague Eric Blackman, have discovered that non-lethal blasts can induce enough skull flexure to generate potentially damaging loads in the brain, even without direct head impact.

Traumatic brain injury (TBI) results from mechanical loads in the brain, often without skull fracture, and causes complex, long-lasting symptoms.

TBI in civilians is usually caused by direct head impacts resulting from motor vehicle and sports accidents. TBI also has emerged among military combat personnel exposed to blast waves.

As modern body armor has substantially reduced soldier fatalities from explosive attacks, the lower mortality rates have revealed the high prevalence of TBI.

But, TBIs resulting from blast waves without head impacts have not been well understood.

To tackle this puzzle, the research team used three-dimensional hydrodynamic simulations to prove that direct action of the blast wave on the head causes skull flexure, producing mechanical loads in brain tissue comparable to those in an injury-inducing impact, even at non-lethal blast pressures as low as 1 bar above atmospheric pressure.

The Army’s Advanced Combat Helmet replaced the older Personal Armor System for Ground Troops helmet.

Its Kevlar shell provides ballistic and impact protection, and its reduced edge cut, although reducing area of coverage, improves soldiers’ field of vision and hearing.

In particular, the team showed that blast waves affect the brain very differently from direct impacts.

The primary source of injury from direct impacts is the force resulting from the bulk acceleration of the head.

In contrast, a blast wave squeezes the skull, creating pressures as large as an injury-inducing impact and pressure gradients in the brain that are much larger.

This occurs even when the bulk head accelerations induced by a blast wave are much smaller than from a direct impact.

“The blast wave sweeps over the skull like a rolling pin going over dough,” said King, LLNL co-principal investigator.

Although the simulations show that the skull is deformed only about 50 microns, “this is large enough to generate potentially damaging loads in the brain,” according to Moss.

“The possibility that blasts may contribute to traumatic brain injury has implications for injury diagnosis and improved armor design,” he added. (ANI)

Heart attack death rates fall in US following hospitalization

Washington, Aug 19 (ANI): There has been a significant reduction in the death rates of heart attack patients over a decade in the US following efforts to improve care.

According to researchers, from 1995 to 2006, hospital 30-day death rates decreased significantly for patients hospitalized for a heart attack, as did the variation in the rate between hospitals.

“Over the last 2 decades, health care professional, consumer, and payer organizations have sought to improve outcomes for patients hospitalized with acute myocardial infarction [AMI; heart attack],” wrote the authors.

Lead researcher Dr Harlan M. Krumholz, S.M., of Yale University School of Medicine, New Haven, Conn. and colleagues examined 30-day mortality among patients, aged 65 years or older (average age, 78 years) who were hospitalized with an AMI.

They found that the all-cause and in-hospital death rates decreased over the study period.

“The 30-day mortality rate decreased from 18.9 percent in 1995 to 16.1 percent in 2006, and in-hospital mortality decreased from 14.6 percent to 10.1 percent,” said the authors.

“In contrast, the 30-day mortality rate for all other conditions was 9.0 percent in 1995 and 8.6 percent in 2006,” they added.

The 30-day risk-standardized mortality rates (RSMRs) decreased from 18.8 percent in 1995 to 15.8 percent in 2006.

“Between 1995 and 2006, the RSMR for patients admitted with AMI showed a marked and significant decrease, as did between-hospital variation,” said the authors.

“Although the cause of the reduction cannot be determined with certainty, this finding may reflect the success of the many individuals and organizations dedicated to improving care during this period,” they added.

The study is published in The Journal of the American Medical Association (JAMA). (ANI)

Bariatric surgery relatively safe, claims study

Washington, June 25 (ANI): After a large-scale analysis, a Duke University Medical Center researcher has said that advances in weight-loss surgery, also called bariatric surgery, have made it as safe as any routine surgical procedure.

Dr. Eric J. DeMaria, vice chair of the department of surgery at Duke, reviewed data from nearly 60,000 patients and found it resulted in low complication and mortality rates.

Compiled from the largest repository of bariatric surgery patients ever recorded, the analysis indicates complication rates hover around 10 percent – with the most common complaint being nausea/vomiting.

Total mortality rate was under one percent with 78 deaths reported among 57,918 patients.

“The complication and mortality rates are even lower than have been reported in the past,” said DeMaria.

The researchers collected the data from participants in the ASMBS Bariatric Surgery Centers of Excellence program. All follow identical guidelines.

“We believe the Bariatric Surgery Centers of Excellence program is one reason why there is an even further reduction in mortality being observed,” said DeMaria.

In this first analysis of bariatric surgery patients, the report found that almost all patients are between the ages of 19-65.

Less than one percent patients were under 19 while 5.67 percent are older than 65.

While three-quarters of people in the study were women, most of them were Caucasian.

African Americans comprised 10 percent of the patient population; Hispanics, Asians and Native Americans make up the rest.

Over half of the procedures performed are gastric bypass, followed by gastric banding.

The data collection effort is significant because “it will help us understand how to better care for bariatric surgery patients now and in the future,” said DeMaria.

The findings were presented at the annual meeting of the American Society for Metabolic and Bariatric Surgery in Grapevine, TX. (ANI)

Key pathways in Ebola infection identified

Washington, June 24 (ANI): Scientists have identified two biochemical pathways-PI3 kinase pathway and the CAMK2 pathway-that are vital for Ebola virus infection.

For the study, the researchers the University of Texas Medical Branch at Galveston used substances that block the activation of those pathways, and prevented Ebola infection in cell culture experiments.

In this way they potentially offered a critical early step in developing the first successful therapy for the deadly virus.

Ebola inflicts severe and often fatal hemorrhagic fever on its victims, producing 90 percent mortality rates in some outbreaks, but to date no vaccine exists for the virus, and it is considered a high-risk agent for bioterrorism.

Robert Davey, lead author of the study, said that they took a new approach to stopping viral infection, using powerful new computational and analytical techniques to focus more on the host cell than the virus.

“The premise for this work is that the virus is essentially nothing without a cell. It needs to rely on many cell proteins and factors for it to replicate. The idea is that if we can suppress the expression of those cell proteins for just a short time, we can then stop the disease in its tracks,” he said.

For spotting the critical proteins, the researchers first conducted large-scale screening experiments using sets of cells treated with small interfering RNA (siRNA) to block 735 different genes that might produce proteins important to Ebola infection.

Later, they added Ebola “pseudotype” viruses-artificially created virus particles made by wrapping Ebola envelope proteins around a core of genetic material from another virus.

“We got a number of hits, quite a lot of places where the virus wasn’t infecting the cells. The problem was then to understand what those hits meant,” said Davey.

To reach a conclusion, the researchers turned to a newly developed statistical algorithm designed especially to prioritise the results of siRNA screens.

After subjecting that output to further computational analysis, they found that two networks of biochemical reactions seemed particularly important to Ebola’s entry into cells: The PI3 kinase pathway and the CAMK2 pathway.

The above accomplishment could lead to first therapy for deadly isease. (ANI)

Heart attack patients should be treated ‘as soon as possible’ to avoid death

London, May 20 (ANI): More heart attack patients could be saved if treated as soon as possible after admission to hospital, a new research has suggested.

Researchers base in the U.S. have called for an ‘as soon as possible’ treatment standard to be implemented after their study indicated that mortality rates could be significantly reduced by treating heart attack patients ‘as soon as possible’.

Following a heart attack, patients often undergo a procedure using a balloon-tipped catheter that is inserted into a main artery, pushed into the narrowed coronary artery, and inflated to clear the blockage.

The time elapsed between a patient’s arrival at hospital and first balloon inflation is known as the “door-to-balloon time” with the current target set at 90 minutes.

But after analysing the data of 43,801 patients from the American College of Cardiology’s national cardiovascular data registry who underwent balloon angioplasty within 12 hours of a heart attack between 2005 and 2006, researchers found a delay in “door-to-balloon time” is associated with a higher mortality rate.

Some three per cent of patients with door-to-balloon times of 30 minutes died in hospital, while 4.3 per cent of patients with door-to-balloon times of 90 minutes died. The highest mortality rate (10.3 per cent) was found in patients with door-to-balloon times of 270 minutes.

The average door-to-balloon time was found to 83 minutes, with over half of patients (58 per cent) treated within 90 minutes of admission.

“Rather than accepting the 90 minute door-to-balloon time benchmark, our data support calls for an ‘as soon as possible’ standard for patients undergoing primary percutaneous coronary intervention,” the authors said.

“Such an approach, using necessary safeguards against inappropriate treatment, offers the potential for notable mortality reduction,” they added.

The study appears on bmj.com. (ANI)

Nomad tribals in Uttrakhand lament politicians’ apathy

Timli (Uttrakhand), Apr 30 (ANI): Gujjar-Bakarwals, cattle rearing tribe in Uttarakhand, lamented that they have for years lived on empty promises of the politicians before every elections.

The tribals said they have for long-lived in jungles without any social security for their children and the politicians only remember them before polls to give them empty promises.

“We face a lot of problem here. We stay in jungles. We have no houses, no land of our own. We have to travel with our buffaloes. There is no security for our children and no arrangement for their education.

We do not have facilities of electricity and water. At the time of elections, politicians walk to us and say they will ensure them their rights,” said Zamila, a tribal woman.

The experts aggress that the tribals are neglected.

“They write in their manifesto that they will ensure them their rights. They only remember them during elections and forget them after that,” said Avdesh Kaushal, an expert on tribal affairs.

The Central Government granted the community Scheduled Tribe status in 1991.The move aimed at prioritizing their socio economic upliftment.

But Bakarwals complain that their living conditions continue to be pitiable. The community’s literacy rate continues to be quite low while mortality rates are high due to disease and poverty. They blame government apathy for their condition.

Still living in centuries old traditions of nomadic life, many of them want to come to terms with modernization. They want to shift to a settled life and want the government to help them in this regard.

The nomads have also been easy prey for militants who demand milk, butter and meat from them. On occasions, they are caught in the crossfire between the security forces and the terrorists.

The community leaders have, therefore, demanded proper security along the seven routes to the pastures. By Ashish Goel (ANI)

Novel genetic regulator involved in head, throat cancers discovered

Washington, Apr 29 (ANI): In a major scientific advancement, pharmacy researchers at Oregon State University have discovered a genetic regulator, called CTIP2, which is expressed at higher levels in the most aggressive types of head and neck cancers.

The study might help in the identification of these cancers earlier or even offer a new therapy at some point in the future.

In a recent research, the “transcriptional regulator” CTIP2 was demonstrated to be a master regulator that has important roles in many biological functions, ranging from the proper development of enamel on teeth to skin formation and the possible treatment of eczema or psoriasis.

But, in the latest study, scientists found for the first time that levels of CTIP2 were more than five times higher in the “poorly differentiated” tumour cells that caused the most deadly types of squamous cell carcinomas in the larynx, throat, tongue and other parts of the head.

The researchers even found a high correlation between greater CTIP2 expression and the aggressive nature of the cancer.

They said that head and neck squamous cell cancers are the sixth most common cancers in the world, and a significant cause of mortality. They have been linked to such things as tobacco use and alcohol consumption.

“Serious head and throat cancer is pretty common, and mortality rates from it haven’t improved much in 20 years, despite new types of treatments. With these new findings, we believe it should be possible to create an early screening and diagnostic tool to spot these cancers earlier, tell physicians which ones need the most aggressive treatments and which are most apt to recur,” said Gitali Indra, an assistant professor in the OSU College of Pharmacy.

The scientists hope that the work could lead to new therapeutic approaches.

Also they said that this genetic regulator could be involved in both skin development and these types of cancer makes some sense, as both originate from epithelial cells.

The study speculated that CTIP2 could help regulate the growth of what is believed to be a cancer “stem” or “progenitor” cell, which has a greater potential to generate tumours through the stem cell processes of self-renewal and differentiation into multiple cell types.

Therefore, targeting cancer stem cells holds promise for improvement of survival and quality of life of cancer patients.

The study is published in PLoS ONE a professional journal. (ANI)

Bakarwals of Kashmir lament government apathy

Rajouri, Feb 11 (ANI): Living semi-nomadic life and herding sheep and goats, Bakarwals, the nomadic tribe of Jammu and Kashmir, are demanding better facilities for their upliftment.

For centuries, Bakarwals have been leading a tough life in the high-altitude meadows of the Himalayas and the Pir-Panjal ranges.

Every year, they along with their families migrate from the lowland plains in the winter to the upper reaches of the Himalaya during the summer taking their sheep high into the mountains, above the tree-line to graze in the lush meadows.

Keeping in mind their tribal character, the Central Government after decades-long struggle granted the community scheduled tribe status in 1991. The move aimed at prioritizing their socio economic upliftment.

But Bakarwals complain that their living conditions continue to be pitiable. The community’s literacy rate continues to be quite low while mortality rates are high due to disease and poverty. They allege government apathy for their condition.

“We cast votes, but nobody thinks of us. We are leading our lives with great difficulty, but nobody pays any heed to our plight,” said Jumma Bakarwal, a Bakarwal tribal.

Still living in centuries old traditions of nomadic life, many of them want to come to terms with modernization. They want to shift to a settled life and want the government to help them in this regard.

“The government should provide them with houses. Their children should be educated, so that they could lead their lives in a settled manner. But nothing has been done so far,” said Abdul Quesam, a resident.

With a new government in place in the state, the Bakarwals hope that the administration will take note of their plight and take some concrete steps would be taken for their upliftment.

Bakarwals are a vital community in Jammu and Kashmir and along with Gujjars, another nomadic tribe, constitute about 30 per cent of state’s population. y Tahir Nadeem Khan (ANI)

Less severe first heart attacks linked to decreased mortality rates

Washington, Jan 20 (ANI): A new study has shown that controlling the risk factors for heart disease, such as blood pressure and cholesterol as well as improvements in hospital management, may lessen the severity of first-time heart attack, eventually leading to reductions in mortality rates.

The study led by Columbia University researchers revealed that the severity of first heart attacks has dropped significantly in the United States, propelling a decline in coronary heart disease deaths.

“This landmark study suggests that better prevention and better management in the hospital have contributed to the reduction in deaths,” said Merle Myerson, M.D., Ed.D., lead author of the study, cardiologist and director of the Cardiovascular Disease Prevention Program at St. Luke’s-Roosevelt Hospital of Columbia University in New York City.

“Better control of risk factors for heart disease, such as blood pressure and cholesterol as well as improvements in hospital management may lessen the severity if somebody has a heart attack.

“We also considered whether people had less severity because they got to the hospital sooner, but that was not the case,” Myerson added.

While analysing the data of Atherosclerosis Risk in Communities (ARIC) data gathered from 1987 to 1994 including an extra eight years, the researchers found more consistent picture with a clear decline in severity of heart attacks.

“The reduction in severity of first-time heart attacks, along with other factors, has impacted on the declining number of deaths from coronary heart disease” Myerson said.

“This tells us that better primary prevention as well as better care for those with acute heart attacks is working.

“Attributing the reduction in severity to specific causes will be an important next step so effective strategies can be reinforced and public health policies can be better directed,” Myerson added.

The study appears in Circulation: Journal of the American Heart Association. (ANI)