Viracor-IBT Laboratories Expands Fungal Testing Services With Launch of Aspergillus PCR Panel

LEE’S SUMMIT, MO, Jun 09 (MARKET WIRE) —
Viracor-IBT Laboratories today announced the launch of the Aspergillus
PCR Panel, a collection of three new tests that will assist in detecting
and measuring Infiltrative Pulmonary Aspergillosis. The new testing
service offers 24-hour turnaround of results and unparalleled
sensitivity. It also expands Viracor-IBT’s comprehensive suite of fungal
testing services which includes Platelia(TM) Aspergillus Galactomannan
EIA and Fungitell(R) β-D Glucan.

Infiltrative Pulmonary Aspergillosis (IPA) is caused by Aspergillus, a
common fungus with more than 100 species. The infection occurs when
Aspergillus spores are inhaled and colonize in a person’s airways. The
disease primarily affects those with compromised immune systems,
including solid organ transplant, hematopoietic stem cell
transplantation, pelvic inflammatory disease and AIDS patients. It
typically progresses to pneumonia, but can also cause complications in
the central nervous system, kidneys, liver, and heart.

Fast diagnosis of IPA is critical. For patients who are diagnosed within
10 days of the onset of an infection, the disease is treatable and has a
mortality rate of 41 percent. For patients who are not diagnosed within
the first 10 days, the mortality rate climbs to 90 percent.

“Traditional diagnostic tools for IPA can be too slow or not sensitive
enough to help establish an accurate diagnosis,” said Steve Kleiboeker,
chief scientific officer for Viracor-IBT. “In many cases, doctors are
forced to treat patients based on incomplete information and can have to
administer toxic anti-fungal drug therapies as a preventative measure.
When used in conjunction with other diagnostic procedures, Viracor-IBT’s
Aspergillus PCR Panel can be useful in helping to diagnose IPA and
monitor patients with the infection. It has the potential to help improve
patient outcomes and reduce healthcare costs.”

Viracor-IBT’s Aspergillus PCR Panel includes three assays:
Pan-Aspergillus PCR, A. Fumigatus PCR and A. Terrus PCR. The
Pan-Aspergillus assay detects the presence of all Aspergillus species.
The A. Fumigatus and A. Terrus assays detect the species of Aspergillus
that cause most IPA infections. A. Fumigatus is the source of 50-80
percent of all IPA infections. A. Terrus causes 15 percent of infections.
A. Terrus is important to detect because the fungus is resistant to
Amphotericin B (AmB), a common anti-fungal drug therapy.

Viracor-IBT’s Aspergillus PCR Panel can be employed as a diagnostic aid
for IPA as well as used to monitor a patient’s response to therapy and
serve as a surveillance tool to determine illness before symptoms. The
extraction method used in the Aspergillus PCR Panel makes a distinction
between colonizing Aspergillus, which does not cause infection, and
invasive Aspergillus, which does. Past diagnostic options have not been
able to make this distinction, leading to some misdiagnosis and overuse
of anti-fungal therapies.

Viracor-IBT’s Aspergillus PCR Panel was created with seven years of
research and development. To verify the new panel of tests, Viracor-IBT
worked in partnership with collaborators including University of
Pittsburgh Medical Center, Duke University, University of Arkansas,
University of Texas Health Sciences, and the National Cancer Institute’s
Pediatric Oncology Group.

For more information about Viracor-IBT, the Aspergillus PCR Panel and
other tests available through the company, please visit
www.ViracorIBT.com.

About Viracor-IBT Laboratories

ViraCor Laboratories and IBT Laboratories merged in June 2009 to form a
unique specialty diagnostics laboratory. The combined company specializes
in cellular, immunology, and allergy testing services as well as
molecular assays that detect and monitor microbial pathogens. The company
serves more than 4,000 physicians, hospitals, commercial laboratories and
biopharmaceutical companies nationwide. www.ViracorIBT.com

Media Contact:
Amy D. Asper
615-327-7999
aasper@seigenthaler.com

Copyright 2010, Market Wire, All rights reserved.

Marrying a younger man increases a woman”s mortality rate

Washington, May 13 (ANI): The greater the age difference from the husband, the lower the wife’s life expectancy is.

And this is the case irrespective of whether the woman is younger or older than her spouse.

That’s the conclusion of a new study published in the journal Demography.

Previous studies have shown that men with younger wives live longer. While it had long been assumed that women with younger husbands also live longer, in the new study Sven Drefahl from the Max Planck Institute for Demographic Research (MPIDR) in Rostock, Germany, has shown that this is not the case.

Related to life expectancy choosing a wife is easy for men – the younger the better. The mortality risk of a husband who is seven to nine years older than his wife is reduced by eleven percent compared to couples where both partners are the same age. Conversely, a man dies earlier when he is younger than his spouse.

For years, researchers have thought that this data holds true for both sexes. They assumed an effect called “health selection” was in play; those who select younger partners are able to do so because they are healthier and thus already have a higher life expectancy. It was also thought that a younger spouse has a positive psychological and social effect on an older partner and can be a better caretaker in old age, thereby helping to extend the partner’s life.

“These theories now have to be reconsidered”, says Drefahl from MPIDR. “It appears that the reasons for mortality differences due to the age gap of the spouses remain unclear.”

Using data from almost two million Danish couples, Drefahl was able to eliminate the statistical shortcomings of earlier research, and showed that the best choice for a woman is to marry a man of exactly the same age; an older husband shortens her life, and a younger one even more so. (ANI)

Mass vaccinations an overreaction to flu epidemic

A leading health expert has called for a rethink on mass immunisations against influenza.

Professor Peter Collignon, an expert in infectious diseases from the Australian National University, says the handling of the swine flu response last year is an example of how not to handle an outbreak.

He says the swine flu response last year need not have included mass vaccinations or pandemic plans as the mortality rate was quite low.

He says mass vaccination programs often mean people who do not really need the drugs get them before people in more dire need.

“Because there was a general panic in society, the wrong people got the drugs at the wrong time,” he said.

“We ran the risk of paralysing our health system with people, 99 per cent of whom would have got better by themselves anyway by just being at home, taking fluids, taking panadol … and keeping away from people so they didn’t spread the infection.”

Professor Collignon says attempting to vaccinate everyone, as happened with the swine flu outbreak in Australia last year, overwhelms the health system.

“We don’t want to necessarily immunise the whole population with a vaccine,” he said.

“We want to target our response to those who are at risk and I think we need to learn from this so that we do this better in the future.

“This has been a problem where there’s been resources allocated for swine flu which probably could have been better, in retrospect, allocated elsewhere.”

20 minutes of brisk walking can halve death risk for elderly men

London, Aug 31 (ANI): Just 20 to 40 minutes of brisk walking can reduce the risk of death in elderly men by 50pct, according to a US study.

By comparing the death rates in men aged between 70 and 92 who were sedentary with those of varying levels of fitness, the researchers found that for every two minutes of exercise the mortality rate dropped by 10 per cent.

The exercise tests showed that for every 100 men who died in the very low fitness group, 74 died in the next group up, 54 in the moderately fit group, and 46 in the high fit category.

“The overall message is that although ageing and death are inevitable, the rate for both can be modulated by simply maintaining a physically active lifestyle at any age,” the Telegraph quoted Dr. Peter Kokkinos, from the Veterans Affairs Medical Centres in Washington and Palo Alto in California, as saying.

“Although I cannot guarantee that regular exercise will add years to your life, I am quite certain that it will add life to your years. It is important nevertheless to emphasise moderation,” he added.

Kokkinos advised that exercise should be started slowly and gradually.

The findings were presented at the European Society of Cardiology Congress in Barcelona. (ANI)

Heart attack death rates fall in US following hospitalization

Washington, Aug 19 (ANI): There has been a significant reduction in the death rates of heart attack patients over a decade in the US following efforts to improve care.

According to researchers, from 1995 to 2006, hospital 30-day death rates decreased significantly for patients hospitalized for a heart attack, as did the variation in the rate between hospitals.

“Over the last 2 decades, health care professional, consumer, and payer organizations have sought to improve outcomes for patients hospitalized with acute myocardial infarction [AMI; heart attack],” wrote the authors.

Lead researcher Dr Harlan M. Krumholz, S.M., of Yale University School of Medicine, New Haven, Conn. and colleagues examined 30-day mortality among patients, aged 65 years or older (average age, 78 years) who were hospitalized with an AMI.

They found that the all-cause and in-hospital death rates decreased over the study period.

“The 30-day mortality rate decreased from 18.9 percent in 1995 to 16.1 percent in 2006, and in-hospital mortality decreased from 14.6 percent to 10.1 percent,” said the authors.

“In contrast, the 30-day mortality rate for all other conditions was 9.0 percent in 1995 and 8.6 percent in 2006,” they added.

The 30-day risk-standardized mortality rates (RSMRs) decreased from 18.8 percent in 1995 to 15.8 percent in 2006.

“Between 1995 and 2006, the RSMR for patients admitted with AMI showed a marked and significant decrease, as did between-hospital variation,” said the authors.

“Although the cause of the reduction cannot be determined with certainty, this finding may reflect the success of the many individuals and organizations dedicated to improving care during this period,” they added.

The study is published in The Journal of the American Medical Association (JAMA). (ANI)

Personality traits associated with chronic worrying can lead to early death

Washington, Aug 19 (ANI): Too much worry and stress can lead to early death, at least in part, as people are more likely to engage in unhealthy behaviours, such as smoking, say researchers.

In this study, the researchers from Purdue University looked at how smoking and heavy drinking are associated with the trait.

“Research shows that higher levels of neuroticism can lead to earlier mortality, and we wanted to know why,” said Daniel K. Mroczek, a professor of child development and family studies.

“We found that having worrying tendencies or being the kind of person who stresses easily is likely to lead to bad behaviours like smoking and, therefore, raise the mortality rate.

“This work is a reminder that high levels of some personality traits can be hazardous to one’s physical health,” he added.

Researchers suggest that a person with high neuroticism is likely to experience anxiety or depression and may self-medicate with tobacco, alcohol or drugs as a coping mechanism.

The study showed that smoking accounted for about 25 percent to 40 percent of the association between high neuroticism and mortality.

The other 60 percent is unexplained, however, it is possibly attributed to biological factors or other environmental issues that neurotic individuals experience, Mroczek added.

Mroczek said that a better understanding of the bridge between personality traits and physical health can perhaps help clinicians improve intervention and prevention programs.

“For example, programs that target people high in neuroticism may get bigger bang for the buck than more widespread outreach efforts,” he said.

“It also may be possible to use personality traits to identify people who, because of their predispositions, are at risk for engaging in poor health behaviors such as smoking or excessive drinking,” he added.

The findings are published in Journal of Research in Personality. (ANI)

Bariatric surgery relatively safe, claims study

Washington, June 25 (ANI): After a large-scale analysis, a Duke University Medical Center researcher has said that advances in weight-loss surgery, also called bariatric surgery, have made it as safe as any routine surgical procedure.

Dr. Eric J. DeMaria, vice chair of the department of surgery at Duke, reviewed data from nearly 60,000 patients and found it resulted in low complication and mortality rates.

Compiled from the largest repository of bariatric surgery patients ever recorded, the analysis indicates complication rates hover around 10 percent – with the most common complaint being nausea/vomiting.

Total mortality rate was under one percent with 78 deaths reported among 57,918 patients.

“The complication and mortality rates are even lower than have been reported in the past,” said DeMaria.

The researchers collected the data from participants in the ASMBS Bariatric Surgery Centers of Excellence program. All follow identical guidelines.

“We believe the Bariatric Surgery Centers of Excellence program is one reason why there is an even further reduction in mortality being observed,” said DeMaria.

In this first analysis of bariatric surgery patients, the report found that almost all patients are between the ages of 19-65.

Less than one percent patients were under 19 while 5.67 percent are older than 65.

While three-quarters of people in the study were women, most of them were Caucasian.

African Americans comprised 10 percent of the patient population; Hispanics, Asians and Native Americans make up the rest.

Over half of the procedures performed are gastric bypass, followed by gastric banding.

The data collection effort is significant because “it will help us understand how to better care for bariatric surgery patients now and in the future,” said DeMaria.

The findings were presented at the annual meeting of the American Society for Metabolic and Bariatric Surgery in Grapevine, TX. (ANI)

Babies delivered before 39 weeks in womb have lower IQs

Toronto, June 24 (ANI): While babies born at 37 or 38 weeks are though to be full term, scientists have now found that such tots have slightly lower IQs, and a modestly higher risk of death in early infancy, as compared to those born after closer to 40 weeks in the womb.

Michael Kramer, a McGill University epidemiologist, says that the finding attains significance as births these days are increasingly induced after 37 or 38 weeks of pregnancy.

He points out that it has been assumed for years that a few weeks in the final month of pregnancy do not matter much to babies, his team have now found evidence that those extra weeks can make a difference.

While making a presentation at a conference in California this week, Dr. Kramer’s research associate Seungmi Yang revealed that the IQs of babies born at 37 weeks had been found to be 1.7 points lower than those of infants born at 39 or 40 weeks during their study.

Those seeing the presentation heard that the study involved 18,000 children who underwent cognitive testing at the age of six and a half.

“There was an increase in IQ from 37 to 40 weeks. The IQ score was highest at 40 weeks of gestational age,” the Globe and Mail quoted Dr. Yang, who works at the Research Institute of Montreal Children’s Hospital and McGill University Health Centre, as saying.

He further revealed that a similar finding surfaced when he and his colleague Xun Zhang examined the mortality rate of more 12 million babies born in the US, with those delivered at 37 and 38 weeks having a small, but significantly higher chance of dying as newborns.

The researcher revealed that infant mortality rates were highest for babies born at 37 weeks – 0.66 per 1,000 in the neonatal period and 1.68 per 1,000 in the post-neonatal period.

The rates decreased between 37 and 39 weeks, and remained stable for babies born at 40 weeks, at 0.34 per 1,000 for newborns and 1.03 per 1,000 later.

They also had an increased chance of neonatal seizures or other problems shortly after birth.

“Despite a low absolute risk of infant death at these gestational ages, the risks were more than 50 per cent higher at 37 weeks than at 40 weeks,” the researchers say in a research article, published in the Journal of Pediatrics.

Dr. Kramer conceded that those differences were relatively small, but insisted that they raised serious questions about whether inducing births at 37 and 38 weeks does more harm than good.

He stressed the need for a large clinical trial that would compare the outcomes of term births induced at different gestational ages for a variety of reasons and births that weren’t induced in similar circumstances. (ANI)

Older population may be less prone to swine flu after past exposures to H1N1 strains

Washington, June 19 (ANI): A Rhode Island Hospital expert believes the swine flu virus may have enough similarity to the previously circulated H1N1 strains or those used in past vaccines, and thus it may lead to protection of older individuals.

Leonard Mermel, an infectious diseases specialist at the hospital, has identified characteristics of the outbreak of H1N1 in 1977 and speculated its impact on the current pandemic in a letter to the editor, published in the journal the Lancet.

Mermel notes that in the late 1970s, an influenza H1N1 reappeared in humans. It had a pandemic-like spread that began in younger aged individuals.

He points out that the strain, known as the “Russian flu” H1N1, was similar to H1N1 strains that circulated internationally between 1946 and 1957.

The expert further writes in the letter that the Russian flu spread rapidly across the former Soviet Union, initially affecting individuals between the ages of 14 and 20 in schools, as well as young military personnel, and later spread to preschool children.

Individuals older than age 30, however, had dramatically lower attack rates and the overall mortality was low. The epidemic peaked rapidly, with a relatively short duration.

According to the letter, the first outbreak of the Russian flu in the US occurred in a Wyoming high school. The attack rate there was over 70 percent, but it affected students only and no faculty were reported to have the illness.

High attack rates were seen in schools as well as military bases throughout the US, similar to the outbreak in Russia. There were few reports of the H1N1 strain in individuals older than age 26, and again, the mortality rate was low.

In his commentary, Mermel hypothesizes that older population may have had enough exposure to past H1N1 flu strains to avoid infection. (ANI)

Anaemia increases death risk in heart disease patients

Washington, May 29 (ANI): Scientists at Charles Sturt University in Australia have found that the presence of anaemia in patients with chronic heart failure is associated with a significantly increased risk of death.

The researchers say that their findings also show that anaemia is associated with a poorer degree of left ventricular function and a lower left ventricular ejection fraction, an objective measure of cardiac function.

They revealed that they undertook this study to assess the impact of anaemia on the clinical outcomes of chronic heart failure (CHF) by a meta-analysis and systemic review of published literature.

The researchers identified 97,699 patients with CHF from the published studies.

Conducting a collective analysis, the researchers found that when anaemia occurs, it worsens patient prognosis, making them more likely to be hospitalised or die from heart failure.

“Health professionals may need to improve current practices to better treat anemia in patients with chronic heart failure,” says Dr. Lexin Wang, Head of the Cardiovascular Group at Charles Sturt University and co-author of the study.

Even with contemporary medical treatment, the mortality rate from chronic heart failure is still very high, reaching 40 percent in very sick patients.

Considering the clear association between anaemia and the mortality rate and hospitalisation rate, the researchers believe that optimal treatment of anaemia, in addition to other heart-failure-specific therapies, may reduce the rate of mortality and further improve patient’s prognosis.

A research article on the study’s findings has been published in the journal Congestive Heart Failure. (ANI)

Heart attack patients should be treated ‘as soon as possible’ to avoid death

London, May 20 (ANI): More heart attack patients could be saved if treated as soon as possible after admission to hospital, a new research has suggested.

Researchers base in the U.S. have called for an ‘as soon as possible’ treatment standard to be implemented after their study indicated that mortality rates could be significantly reduced by treating heart attack patients ‘as soon as possible’.

Following a heart attack, patients often undergo a procedure using a balloon-tipped catheter that is inserted into a main artery, pushed into the narrowed coronary artery, and inflated to clear the blockage.

The time elapsed between a patient’s arrival at hospital and first balloon inflation is known as the “door-to-balloon time” with the current target set at 90 minutes.

But after analysing the data of 43,801 patients from the American College of Cardiology’s national cardiovascular data registry who underwent balloon angioplasty within 12 hours of a heart attack between 2005 and 2006, researchers found a delay in “door-to-balloon time” is associated with a higher mortality rate.

Some three per cent of patients with door-to-balloon times of 30 minutes died in hospital, while 4.3 per cent of patients with door-to-balloon times of 90 minutes died. The highest mortality rate (10.3 per cent) was found in patients with door-to-balloon times of 270 minutes.

The average door-to-balloon time was found to 83 minutes, with over half of patients (58 per cent) treated within 90 minutes of admission.

“Rather than accepting the 90 minute door-to-balloon time benchmark, our data support calls for an ‘as soon as possible’ standard for patients undergoing primary percutaneous coronary intervention,” the authors said.

“Such an approach, using necessary safeguards against inappropriate treatment, offers the potential for notable mortality reduction,” they added.

The study appears on bmj.com. (ANI)

50 percent of Zimbabwe prisoners died of hunger, disease in last 1 year

Harare, May 19 (ANI): At least 700 out of the 1300 inmates in Zimbabwe’s maximum security jail have died of starvation or disease in the last year.
Due to its death rate, Chikurubi prison, located on the outskirts of Harare, has been touted as one of the worst jails in history.

On Sunday alone, six prisoners were found dead in their filthy cell, while the same number died last weekend due to revolting conditions.

Some 100 bodies, many of them mutilated by rats, are stacked up in the prison mortuary. If they are unclaimed, they will be buried as paupers in the prison grounds, The Telegraph reports.

The collapse of Zimbabwe’s economy has crippled the prison system, leaving thousands of inmates with scarcely any food. The provision of medical care has also collapsed, leaving prisoners to die of starvation and disease.

Chikurubi packs about 30 inmates into cells designed for only 10, the paper reported.

A jail warder revealed that the mortality rate in other prisons of the country was almost the same.

“It’s the same at all the rest of the prisons around the country. We often find six died at a time. A lot have AIDS, but die quickly because they don’t have enough food,” he said.

Between November and January, 327 deaths were recorded at Chikurubi – almost a quarter of all the inmates.

The commissioner in charge of jails, Major-General Paradzai Zimondi (a close aide of President Robert Mugabe), is blamed for not doing his job properly.

“He has never been to see what is going on in Chikurubi. He doesn’t care,” the paper quoted the warder, as saying. (ANI)

|Pak Govt. in talks with Taliban for return of Sikhs evicted from Orakzai|World[Kohat{Kohat, May 19 (ANI): The Pakistan Government has started discreet negotiations through religious clerics with the deputy chief of Tehrik-i-Taliban Pakistan for the rehabilitation of Sikh families, evicted from Orakzai Agency.

A high placed source said on Monday, that the tribal administration on the directives of the federal government had assigned the task of holding peace talks with the deputy chief of TTP, Hakeemullah Mehsud.

They would make efforts to pave the way for rehabilitation of Sikh families in the area where they had been living for centuries. The source declined to disclose the names of clerics involved in the talks, and said that meetings were going on peacefully.

He said that the displaced Sikh families were willing to come back. After getting orders for payment of Jazia, the Sikhs had already raised Rs12 million and just requested for one more day to collect the amount.

About 35 Sikh families were forced to leave their permanent abodes in Feroze Khel area of Orakzai Agency after Taliban burnt their houses and looted their shops.

Taliban had imposed Jazia (religious tax) on Sikh community for being non-Muslims living in an Islamic state for the protection of their lives and property.

The community failed to raise Rs15 million by April 29 after which their houses were attacked. But they had left the area before the attack, The Dawn reported.

Thirteen Sikh families were still living in Merozai area of lower Orakzai Agency on the land possessed by Shia community where the TTP had no control.

To a question about the collateral damage caused by the shelling and bombardment on militant hideouts in the area, he said that so far dozens of men, women and children had been killed in such attacks. (ANI)

WHO official says swine flu has not spread beyond North America

London, May 3 (ANI): A top World Health Organization official has said that the health watchdog has no evidence of sustained community spread outside North America.

Dr Michael Ryan, WHO Director of Global Alert and Response, also praised European nations’ handling of cases and said events did not seem out of control.

Mexico has cut its suspected death toll by 75 to 101, indicating the outbreak may not be as bad as initially feared.

The country has ordered a five-day shutdown in a bid to contain the virus.

Mexican Health Minister Jose Angel Cordova told the BBC that, based on samples tested, the mortality rate was comparable with that of seasonal flu.

“I think it would be, at this stage, unwise to suggest that, in any way, those events are out of control or spreading in an uncontrolled fashion,” the BBC quoted Ryan, as saying.

“At the present time I would still propose that a pandemic is imminent because we see the disease spread,” Dr Ryan added.

The WHO is sending 2.4 million courses of antiviral treatment to 72 nations around the world, Dr Ryan said, among them many developing countries.

But in cases of the virus outside Mexico, the effects do not appear to be severe.

Italy and the Irish Republic reported their first cases on Saturday, bringing the number of countries affected to 18.

Canada has announced that a herd of pigs has tested positive for swine flu.

A senior agriculture official told a news conference that a farm worker who fell ill after returning from Mexico last month might have infected the pigs.

In Egypt, authorities have begun in earnest the slaughter of more than 300,000 pigs, in what was originally described as a precaution against swine flu.

Officials now say the move is a general health measure aimed at restoring order to Egypt’s pig-rearing industry.

International experts say there is no scientific rationale for Egypt’s pig cull

Experts say the virus cannot be caught from eating pork and there is no scientific rationale for the cull.

Five countries outside Mexico have confirmed person-to-person transmission.

China is trying to stop the spread of the virus, after getting its first case on Friday.

It says it will quarantine all those who travelled on a flight from Mexico with a man suffering from swine flu.

Flights from Mexico have been suspended, and fellow guests and staff at the Hong Kong hotel where he was staying have been quarantined.

On Saturday, Mexico’s foreign minister advised citizens not to travel to China to avoid the health measures being taken there against

The US has now confirmed 160 cases of swine flu across 21 states but has seen only one death, of a Mexican toddler in Texas.

President Barack Obama said in his weekly radio address that the US was taking “all necessary precautions” to ensure it was prepared if the virus developed into “something worse”. (ANI)

NEWSWEEK Cover: The Mystery of Epilepsy

Why We Must Find a Cure for Epilepsy

The Toll of Epilepsy Has Been Overlooked – and the Research Underfunded -For
Too Long

NEW YORK, April 12 /PRNewswire/ — “Put harshly, we need more of a cancerlike
sensibility around epilepsy,” Newsweek Editor Jon Meachamwrites in the April
20 cover, “The Mystery of Epilepsy” (on newsstands Monday, April 13). “We
cannot usually see our friends’ cancer, but we do not hesitate to invest the
search for a cure for different cancers with the utmost cultural and political
importance. We must now do the same with epilepsy.” Meacham writes that the
toll of epilepsy has been overlooked — and the research underfunded — for
too long. Public and private funding for research lag far behind other
neurological afflictions. “It is time to remedy that gap, and to raise
epilepsy to the front ranks of public and medical concern,” he writes.

(Photo: http://www.newscom.com/cgi-bin/prnh/20090412/NY97676 )

“Epilepsy in America is as common as breast cancer, and takes as many lives,”
Meacham writes. A mysterious and widely misunderstood affliction, epilepsy is
a disorder in which the brain produces sudden bursts of electrical energy that
can interfere with a person’s consciousness, movements or sensations. By some
estimates, the mortality rate for people with epilepsy is two to three times
higher — and the risk of sudden death is 24 times greater — than that of the
general population. Yet epilepsy still receives too little attention, either
from the medical community or the public at large. “One reason is that
advances in drug treatments have created the popular impression that epilepsy
is now an essentially manageable condition,” Meacham writes. “Most people
with epilepsy are not in a constant state of seizure — they are, rather, in
perpetual but quiet danger — their condition can appear less serious than it
truly is. It is all too human, but all too true, that a problem, including the
problem of a serious medical affliction, stays out of mind when it is out of
sight.”

Also in the cover package, SeniorEditor Jerry Adler and Contributor Eliza Gray
profile a doctor on the front lines of the epilepsy wars, Orrin Devinsky of
New York University. Devinsky tries to find the right combinations of drugs
to help his patients. Adler and Gray write, “There are, at this time, only a
few ways to treat epilepsy, and applying them is still an art as much as it is
a science. What works for one patient often has no benefit for another with
identical symptoms.”

Susan Axelrod, who is married to David Axelrod, President Obama’s senior
adviser, and is a founding board member and president of CURE, Citizens United
for Research in Epilepsy, contributes an essay on her family’s experience with
epilepsy — and what it has led her to believe must be done. The Axelrods’
daughter, Lauren, suffered her first seizure when she was just 7 months old.
“Epilepsy entered our lives more than 25 years ago, and yet, far too often, I
have no confidence that outcomes today will be any better than they were for
Lauren,” she writes.

(Read cover at www.Newsweek.com)

Cover: http://www.newsweek.com/id/193586
In the Grip of the Unknown: http://www.newsweek.com/id/193484
Agony, Hope and Resolve: http://www.newsweek.com/id/193587

SOURCE Newsweek

Katherine Barna of Newsweek, +1-212-445-4859

NEWSWEEK: Media Lead Sheet/April 20, 2009 Issue

COVER: “The Mystery of Epilepsy” (p. 38). Newsweek Editor Jon Meacham writes
that we need more of a cancerlike sensibility around epilepsy. We cannot
usually see our friends’ cancer, but we do not hesitate to invest the search
for a cure for different cancers with the utmost cultural and political
importance. We must now do the same with epilepsy. The toll of epilepsy has
been overlooked — and the research underfunded — for too long. Public and
private funding for research lag far behind other neurological afflictions.
Epilepsy in America is as common as breast cancer, and takes as many lives. A
mysterious and widely misunderstood affliction, epilepsy is a disorder in
which the brain produces sudden bursts of electrical energy that can interfere
with a person’s consciousness, movements or sensations. By some estimates,
the mortality rate for people with epilepsy is two to three times higher –
and the risk of sudden death is 24 times greater — than that of the general
population. Yet epilepsy still receives too little attention, either from the
medical community or the public at large.

http://www.newsweek.com/id/193586

(Photo: http://www.newscom.com/cgi-bin/prnh/20090412/NY97676 )

“In The Grip of the Unknown” (p. 43). SeniorEditor Jerry Adler and
Contributor Eliza Gray profile a doctor on the front lines of the epilepsy
wars, Orrin Devinsky of NYU. Adler and Gray write, “There are, at this time,
only a few ways to treat epilepsy, and applying them is still an art as much
as it is a science. What works for one patient often has no benefit for
another with identical symptoms.”

http://www.newsweek.com/id/193484

“Agony, Hope and Resolve” (p. 49). Susan Axelrod, who is married to David
Axelrod, President Obama’s senior adviser, and is a founding board member and
president of CURE, Citizens United for Research in Epilepsy; contributes an
essay on her family’s experience with epilepsy — and what it has led her to
believe must be done. The Axelrods’ daughter, Lauren, had her first seizure
when she was just 7 months old. “Epilepsy entered our lives more than 25
years ago and yet, far too often, I have no confidence that outcomes today
will be any better than they were for Lauren,” she writes.

http://www.newsweek.com/id/193587

“Obama Gets Gun Shy” (p. 20). Investigative Correspondent Michael Isikoff and
National Correspondent Suzanne Smalley write that despite a recent spate of
killings, the president and fellow Democrats choose not to wage war on assault
weapons. Running for president in last year’s Democratic primaries, Barack
Obama promised to restore a federal ban on certain semiautomatic assault guns
– a position that’s still on the White House Web site. The ban was originally
passed by the Democratic-controlled Congress in 1994 and lapsed five years
ago. But Obama and top White House aides have all but abandoned the issue.
Chief of staff Rahm Emanuel and other White House strategists have decided
they can’t afford to tangle with the National Rifle Association at a time when
they’re pushing other priorities, like economic renewal and health-care
reform.

http://www.newsweek.com/id/193589

“Faith, Fear and the Wages of Columbine (p. 24). Contributor Matthew
Phillipsand Religion Editor Lisa Millerwrite about two pastors from the
opposite ends of the theological spectrum who are still haunted by the
Columbine High School massacre. The Rev. Don Marxhausen presided over the
funeral of 17-year-old Dylan Klebold ten years ago after Klebold and Eric
Harris killed 13 people. This decision has haunted him ever since. Two days
later, another Littleton, Colo., pastor presided over another funeral. Cassie
Bernall, a Columbine junior, had been shot in cold blood as she crouched under
a library table, and word was that in her final seconds she answered her
murderer’s question and affirmed her belief in God. During his sermon, George
Kirsten proclaimed Cassie a martyr. Over the next 10 years, Kirsten’s
persistent evangelicalism would make him the target of accusations that he was
exploiting a tragedy.

http://www.newsweek.com/id/193591

“We Are Not in This Together” (p. 30). Zachary Karabell, president of River
Twice Research, writes that young, minority men who didn’t earn much to begin
with are hit the hardest by unemployment. We may feel united by a common
anxiety about losing our jobs, but we are not all in this together. Young,
minority men are suffering more than their white-collar counterparts. The
unemployment rate for those over 25 with a college degree was 4.3 percent –
half the national rate, according to the most recent Bureau of Labor
Statistics report. For those college-educated and white, the number was 2.3
percent at the end of 2008, the most recent available for that demographic. On
the other end of the spectrum, the unemployment rate for African-Americans
over the age of 16 was 13.3 percent, and for Hispanics, 11.4 percent. For
anyone without a high-school diploma, the rate was 13.3 percent. Minorities
and the less educated have always suffered more during downturns, but the
disparity has become more stark.

http://www.newsweek.com/id/193585

JONATHAN ALTER: “Let’s Get Ready to Reconcile” (p. 33). Senior Editor
Jonathan Alterwrites that we’re going to have to get used to the idea that
transformational change in health, education and energy policy is more
important than whether Republicans cry foul over being railroaded.
Reconciliation on Capitol Hill is the process by which the House and Senate
“reconcile” their differing versions of the federal budget and deal with the
devilish details. Passing budgets requires only 51 votes in the Senate. But
for the last several years, senators in the minority have somehow convinced
themselves that democracy demands that nothing serious passes their chamber
without 60 votes. Because the Democrats have only 58 (59 when Al Franken shows
up) and might face some Democratic defectors, they’re examining their options.

http://www.newsweek.com/id/193590

“A Serious Cup of Joe (Scarborough)” (p. 36). Reporter Seth Colter Walls
writes that for the first time since it launched in 2007, MSNBC’s “Morning
Joe” defeated CNN’s “American Morning” among younger viewers — the
demographic advertisers prize most. That show is hosted by Joe Scarborough, a
former Florida congressman — and a registered Republican. One reason for the
success of “Morning Joe” is that Scarborough and his team generate an
ideologically unpredictable vibe.

http://www.newsweek.com/id/193535

“A Racial Divide” (p. 50). Contributor Jesse Ellison writes that blacks
experience heart failure earlier and at a greater rate than whites. A study
last month in The New England Journal of Medicine found that blacks under age
50 experience heart failure at 20 times the rate of whites. “To see this among
people in their 30s and 40s was really quite striking to us,” says Dr. Kirsten
Bibbins-Domingo, codirector of the UCSF Center for Vulnerable Populations at
San Francisco General Hospital, and the study’s lead author. Because their
weakened heart muscles can’t pump enough blood, people with heart failure are
often too weak to work. Exactly why these rates are so skewed is unclear, but
high rates of hypertension among young African-Americans is a major culprit.
Genetics, higher sensitivity to salty diets and environmental factors are also
believed to play a role.

http://www.newsweek.com/id/193482

/PRNewswire — April 12/

Bypass surgery better than angioplasty for certain heart patients

London, Mar 20 (ANI): Researchers at Stanford University School of Medicine have found that for the treatment of patients suffering from multi-vessel coronary artery disease, who have diabetes, and for patients older than 65, heart bypass surgery is a better option than angioplasty.

For the study, the researchers worked with investigators from 10 different clinical trials around the world for 3 years, and pooled enough individual patient data to compare the effectiveness of coronary artery bypass surgery with the less-invasive angioplasty procedure on specific groups of patients for the first time.

The study looked at raw data from almost 8,000 research subjects.

It showed that for patients suffering from multi-vessel coronary artery disease, who had diabetes, and for patients older than 65, coronary artery bypass graft might be a better treatment choice than percutaneous coronary intervention (commonly known as coronary angioplasty).

PCI is the technique of using balloons or stents to widen narrowed or obstructed blood vessels.

However, in patients 55 years and younger, PCI may be the best choice.

“Whether you have diabetes really makes a big difference. Over several years there’s a much lower rate of death with bypass surgery. The patient’s age was the other major factor that affected outcomes, and this was a bit of a surprise,” Lancet quoted lead investigator Mark Hlatky, MD, professor of health research and policy and of cardiovascular medicine at Stanford as saying.

It was found that for patients with diabetes, the mortality rate after a five-year follow-up was 12 percent for those who had bypass surgery, compared with 20 percent for the angioplasty procedure.

Among patients older than 65, the mortality rate was 11 percent for those who had bypass, compared with 15 percent for those who had angioplasty.

“This is the kind of research we’re hoping to have more of so that clinicians and policymakers and patients can make informed decisions,” said Douglas K. Owens MD, senior investigator at the Veterans Affairs Palo Alto Health Care System and professor of medicine at Stanford.

The study supports previous findings that long-term mortality is similar after bypass or angioplasty for the average patient with multi-vessel coronary artery disease.

However, the new study goes one step further to check whether this overall result is also true in most patient subgroups, such as women, smokers and patients with hypertension.

“We’re not really sure of why surgery was better for these groups of patients. It’s a very important and provocative observation that needs to be investigated further,” said Hlatky.

The study has been published online in The Lancet. (ANI)

Avian flu could lead to 1918-like Spanish flu pandemic

Washington, Feb 11 (ANI): On comparing the recent avian strain with genetic ressortants of the post World War I virus, researchers found that H5N1 could lead to an avian flu pandemic just like the Spanish flu that spread in 1918.

The study was conducted by Carole Baskin, formerly assistant research professor at Arizona’s Biodesign Institute, currently with Science Foundation Arizona, and an interdisciplinary team of collaborators.

H5N1 was found to replicate profusely within the first 24 hours, causing severe damage to respiratory tissues while sending the host’s innate immune response into a lethal overdrive, reminiscent of the trajectory of the original 1918 virus.

“In order to come up with vaccines and therapies, you have to understand the disease. That’s why I think this type of pathogenesis study is so important,” stressed Baskin.

The mortality rate for those stricken with highly pathogenic avian influenza (HPAI) H5N1 is 63 percent, and with a series of modifications the virus could pass from person to person, leading to catastrophic consequences for humankind.

In the study, researchers examined the host-pathogen responses to a common influenza virus and two ressortant strains of the 1918 H1N1 virus, each containing HA and NA-key surface antigens closely linked to the 1918 strain’s potent virulence.

The effects of these strains on host tissues and gene expression were compared with those of a 2004 Vietnam isolate of the Highly Pathogenic Avian Influenza (HPAI) H5N1.

In a non-human primate model of the disease, the avian virus was found to significantly outpace not only run-of-the-mill influenza but even the highly virulent 1918 ressortants, in terms of its relentless pathogenicity.

Ressortant viruses occur when different influenza subtypes or strains simultaneously infect the same host.

Under these conditions, a shuffling and exchange of genetic material between two or more such viruses can occur, which could give rise to new viral forms which share genetic characteristics with each parent strain but may also possess novel attributes, including heightened virulence.

In both H5N1 and 1918 H1N1, the highly pathogenic strains replicate rapidly and induce a massive transcription of genes associated with the innate immune response, the body’s first line of defence for combating viral challenges.

The researchers used a systems biology approach to compare the 1918 flu strain with H5N1, and analysed with high-throughput technologies of functional genomics, proteomics and transcriptomics to measure gene expression and regulation in fine-grained detail.

Then they subjected post-infection respiratory tissues to pathological, viral and microarray analysis.

Although the 1918 ressortant strains were found to be highly virulent, they were outmatched by H5N1′s rapid onset, overwhelming transcription induction of cytokine and chemokine genes and headlong, sustained viral replication with wider distribution in the lungs.

While the new study found that the 1918 ressortant strains and H5N1 each attacked specialized respiratory cells called pneumocytes, the 1918 chimaraes showed preference for so-called type I pneumocytes, responsible for air exchange in the lungs.

On the other hand, H5N1 characteristically infects the more numerous type II pneumocytes, a critical distinction. Thus, H5N1 delivers a devastating one-two punch to the host’s ability to recover from the infectious siege.

The researchers observed that within 24 hours, H5N1 had caused severe bronchiolar and alveolar lesions in lung tissue.

Also, Tissue sampling for H5N1 found a notable absence of dendritic cells whose job it is to phagocytize protein components from the virus and present these to T cells, either locally or at the lymph nodes that drain the lungs.

The absence suggested they were destroyed during the infection process, which would point to H5N1′s ability not only to disable the present infection but also to block the body’s ability to build immunity against later infection by the same type of virus.

Continuing studies of host-pathogen responses at the tissue, cellular and molecular level may provide the understanding needed to stave off a viral pandemic, whether from H5N1 or some other emergent strain.

In terms of how many modifications would be required for H5N1 to become a highly contagious human virus, Baskin said: “There have been some estimations and it’s not a lot. That’s the short and simple answer.”

The study appears in the latest issue of the Proceedings of the National Academy of Science. (ANI)

Diabetes ups Alzheimer’s and dementia risk

Washington, January 28 (ANI): An ongoing study on twins appears to show that diabetics have a significantly increased risk of both Alzheimer’s and other forms of dementia.

It also suggests that the risk of dementia is especially strong if the onset of diabetes occurs in middle age.

“Our results . . . highlighted the need to maintain a healthy lifestyle during adulthood in order to reduce the risk of dementia late in life,” said Dr. Margaret Gatz, who directs the Study of Dementia in Swedish Twins.

Gatz and colleagues from Sweden have found that getting diabetes before the age of 65 corresponds to a 125 percent increased risk for Alzheimer’s disease.

Revealing their findings in the journal Diabetes, the researchers said that the risk of Alzheimer’s disease or other dementia was significant for mid-life diabetics – as opposed to those who develop diabetes after 65 – even when controlling for family factors.

Other studies conducted in the past showed genetic factors and childhood poverty to independently contribute to the risk of both diabetes and dementia.

“Twins provide naturally matched pairs, in which confounding factors such as genetics and childhood environment may be removed when comparisons are made between twins,” said Gatz, professor of psychology, gerontology and preventive medicine at the University of Southern California and foreign adjunct professor of medical epidemiology and biostatistics at the Karolinska Institute in Sweden.

In their study report, the researchers write that the chances of a diabetic developing Alzheimer’s disease may be even greater in real life than in the study.

They say that they have identified some factors that might have led them to underestimate the risk of dementia and Alzheimer’s among those who develop diabetes before the age of 65.

Given that diabetes usually appears at a younger age than dementia does, and is also associated with a higher mortality rate, the researchers say that the size of the sample of older adults might have been reduced.

Besides that, add the researchers, about 30 percent of older adults with diabetes have not been diagnosed.

The team say that their findings implicate adult choices such as exercise, diet and smoking, as well as glycemic control in patients with diabetes, in affecting risk for Alzheimer’s disease and diabetes.

The sample for the study was 13,693 Swedish twins aged 65 or older in 1998, the year tracking for dementia began.

Information about diabetes came from prior surveys of twins and linkage to hospital discharge registry data beginning in the 1960s. (ANI)