‘More support needed’ for breastfeeding mothers

The Australian Breastfeeding Association says the culture of breastfeeding in Australia needs to change if health benefits, such as the prevention of metabolic disease in mothers, are to be fully felt.

A study of more than 50,000 women published in US journal Diabetes Care has found women who have children are more likely to develop type 2 diabetes than those who never give birth.

But it found breastfeeding for three months per child can offset that risk.

The manager of the association’s lactation resource centre, Kate Mortensen, says while this is good news, more needs to be done for breastfeeding babies and mothers.

She says when babies reach three months of age, only about 65 per cent of Australian mothers are still breastfeeding, and by six months that figure drops to about 40 per cent.

“That’s been the state of play now for quite a number of years,” she said.

“Mothers still choose to breastfeed, it’s just that they are not seemingly able to keep it going, and so we need skilled lactation support for problems that they face.

“They need good maternity leave so they know they do have a period where they can be at home with their babies and establish lactation. They need good community support and we need more knowledge about breastfeeding out there.”

Ms Mortensen says one of the most common reasons why mothers start supplementing with formula is because of perceived low supply.

“Overall, from my 20 years of counselling mothers, it seems that mothers don’t realise there is not this deep community understanding that a breastfed baby needs to be fed anywhere between eight and 12 times in 24 hours – so that means you are feeding a baby quite often, ” she said.

“There is still this old-fashioned idea that a mother should feed a baby three to four hourly at evenly spaced times throughout the day, which is totally unrealistic. The normal baby will have lots of frequent feeds and their feeding patterns change as they get older.”

Australia’s most recent dietary guidelines, published in 2003, suggest 80 per cent of mothers breastfeeding at six months is an achievable goal.

“But we haven’t even reached 80 per cent at three months,” Ms Mortensen said.

Ms Mortensen says the health benefits associated with breastfeeding are well-known and the recent Australian study backs up previous research in the US, which found the longer the duration of breastfeeding, the lower the risk of diabetes for the mother.

“There is research around lactation helping to reduce the weight that you keep from pregnancy. It also affects where your weight is lost from,” she said.

“You’re in a different metabolic state while you’re breastfeeding. You have a reduced reaction to stress and you have a lowered blood pressure.

“The research on weight loss because of lactation is quite mixed but overall it does seem to have a beneficial effect on mothers’ weight loss – breastfeeding does use calories, but it also affects your metabolism. You require less insulin while you’re breastfeeding, so it affects your metabolism at a quite a deep level.”

Last year the Federal Government put forward a National Breastfeeding Strategy for 2010 to 2015.

The association says this strategy must be supported and implemented if the health benefits of breastfeeding are to be maximised.

Genes controlling insulin ‘alter’ body clock

Washington, Sept 18 (ANI): Scientists at University of California, San Diego have identified certain insulin-regulating genes that can also alter the timing of the body clock.

They said that the findings can lead to new approaches to treating disorders such as metabolic syndrome that can result, at least in part, from chronic disruption of the sleep-wake cycle.

“People knew that the clock regulates many different processes, but what they didn’t realize what that when you tweak those processes, it feeds back and alters the clock,” said Steve Kay, Dean of the Division of Biological Sciences at the University of California, San Diego, who led the study along with John Hogenesch of the University of Pennsylvania.

A molecular clock controls daily physiological rhythms in many types of cells, even cells grown in culture.

By engineering cultured cells to glow yellow when a particular clock gene switched on, the team made the cycle visible. They then interfered with every human gene to see which would shift the clock. They found that hundreds altered the timing.

“We just suddenly discovered 350 new genes that affect the clock that weren’t known before,” Kay said.

However, subsequent screening to confirm the genes’ effect on a second clock gene narrowed the list to 200.

Seven genes involved in insulin control also influenced the rhythms of the clock.

“What came out very strongly was this close relationship between circadian regulation and insulin signalling. There’s a reciprocal relationship between circadian dysfunction and metabolic dysfunction,” said Kay.

The researchers suggest that genetically altered mice with malfunctioning clocks become obese and develop diet-induced diabetes.Understanding this close relationship between circadian regulation and metabolic homeostasis should provide novel ways of identifying new therapies for metabolic disease,” Kay added.

The study appears in journal Cell. (ANI)

Biocon limited, Amylin pharmaceuticals enter global development agreement

Bangalore/ California Sep 11(ANI/Business Wire India): Biocon, Limited (NSE: BIOCON) and Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN) announced today that they have entered into an exclusive agreement to jointly develop, commercialize and manufacture a novel peptide therapeutic for the potential treatment of diabetes.

Amylin and Biocon will collaborate to develop the therapeutic potential of the compound and share development costs. Research will center on Amylin’s “phybrid” technology. A phybrid is a peptide hybrid molecule that combines the pharmacological effects of two peptide hormones into a single molecular entity.

Under the terms of the Development and Commercialization Agreement, Amylin will provide expertise in peptide hormone development, particularly in the area of phybrid technology, as well as metabolic disease therapeutics. Biocon will utilize its expertise in recombinant microbial expression to manufacture the compound and also leverage its experience in pre-clinical and clinical development of diabetes products.

“This agreement fully leverages the synergistic capabilities of the two companies,” said Kiran Mazumdar-Shaw, Chairman and Managing Director, Biocon, Ltd. “Amylin’s knowledge of peptide therapeutics and their leadership in the diabetes market, paired with Biocon’s capabilities in process development, manufacturing and clinical development, provides this global program with the potential to effectively bring a novel therapy to patients living with diabetes.”

“This program could unleash the potential of cutting-edge peptide science to transform the lives of patients with diabetes,” said Daniel M. Bradbury, President and Chief Executive Officer, Amylin Pharmaceuticals. “We are pleased to work with Biocon, a biologics innovator and world-class manufacturing expert, and look forward to collaborating with them on this exciting program.”

Amylin Pharmaceuticals is a biopharmaceutical company committed to improving lives through the discovery, development and commercialization of innovative medicines. (ANI)

Toxic chemical in children’s toys may lead to low birth weight in infants

Washington, June 25 (ANI): Researchers have found that exposure to toxic chemical used as plasticizers in a wide variety of personal care product and children’s toys might contribute to low birth weight in infants.

Phthalate exposure can begin in the womb and has been associated with negative changes in endocrine function.

Low birth weight is the leading cause of death in children under 5 years of age and increases the risk of cardiovascular and metabolic disease in adulthood.

During the study, Dr. Renshan Ge of the Population Council and colleagues from Fudan University and Second Military Medical University in Shanghai examined 201 pairs of newborns and their mothers between 2005 and 2006.

Of the 201 infants studied, 88 were born with low birth weight. The researchers analyzed samples of the infants’ meconium, the first bowel movement that occurs after birth, and cord blood to determine phthalate levels.

They found that Infants with low birth weight had consistently higher levels of phthalates.

“The results showed that phthalate exposure was ubiquitous in these newborns, and that prenatal phthalate exposure might be an environmental risk factor for low birth weight in infants,” said Dr. Ge.

The study appears in the Journal of Pediatrics. (ANI)

The biological basis for the 8-hour work-shift

Washington, April 24 (ANI): Your usual nine to five office shift has a biological reason behind it, and now scientists have found that some genes in the body are switched on once every 12 or 8 hours, which in turn keeps us actively involved in the work, according to a new study.

The findings by researchers at the University of Pennsylvania School of Medicine and the Salk Institute for Biological Studies indicated that shorter cycles of the circadian rhythm are also biologically encoded.

Already, scientists know that some genes are controlled by the clock and are turned on only one time during each 24-hour cycle.

In the new study, researchers looked at gene activity in the mouse liver every hour for 48 hours using a novel time-sampling approach.

They also found 10-fold more genes controlled by the 24-hour clock than previously reported.

This the first report where researchers have found other periodicities than the 24-hour cycle functioning in a live animal.

According to researchers, these findings have implications for better understanding disruptions to normal circadian rhythms that contribute to a host of pathologies such as cardiovascular and metabolic disease, cancer, and aging-related disorders.

“The principal frequency, which is not a surprise, is the 24-hour cycle, and it is the most prevalent. What was a surprise to us – although we set up the experiment to see exactly this – are the 12-hour and the 8-hour cycles,” said senior author John Hogenesch, PhD, Associate Professor of Pharmacology in the Institute for Translational Medicine and Therapeutics at Penn.

To uncover these shorter oscillations, researchers isolated RNA from the livers of mice every hour for 48 hours.

Microarray analysis showed that more than 3,000 genes were expressed on a circadian rhythm – which account for approximately 4 percent of all of the genes expressed in the liver.

In addition, 260 genes were expressed on a 12-hour cycle and 63 genes were expressed on an 8-hour cycle.

The researchers saw similar 12-hour gene expression patterns in five other tissues.

“There is an obvious biological basis to a 12-hour rhythm. The 12-hour genes predicted dusk and dawn. These are two really, really stressful transitions that your body goes through and your mind goes through. Anybody who has young children realizes that they are more likely to cry around those times – and you’re more likely to cry with them,” said Hogenesch.

The shift in gene expression controlled by these harmonics can help an animal prepare for the behavioural and physiological changes that accompany the shift from light to dark and back.

“We have less of a handle on the 8-hour rhythms, but the fact that we can see them reliably means to me there is the possibility that there could be a biological basis to an 8-hour cycle,” he said.

The study appears in the April issue of PLoS Genetics (ANI)