New research paves way for drugs to treat age-related memory loss

Washington, May 19 (ANI): Researchers at Princeton University have shown that two methods of extending life span have very different effects on memory performance and decline with age.

While the nematode C. elegans is already well known for its utility in longevity research, previously it was not known how the memory of C. elegans compares with that of other animals, or whether longevity treatments could improve learning and memory.

To answer these questions, Amanda Kauffman and colleagues, of Coleen Murphy”s lab at Princeton, designed new tests of learning and memory in C. elegans, then used these tests to identify the necessary components of learning, short-term memory, and long-term memory. They found that the molecules required for learning and memory appear to be conserved from C. elegans to mammals, suggesting that the basic mechanisms underlying learning and memory are ancient.

The authors also determined how each of the behaviors declines with age, and tested the effects of two known regulators of longevity — dietary restriction and reduced Insulin/IGF-1 signaling — on these declines. Surprisingly, very different effects on memory were achieved with the two longevity treatments: dietary restriction impaired memory in early adulthood but maintained memory with age, while reduced Insulin/IGF-1 signaling improved early adult memory performance but failed to preserve it with age.

These results suggest not only that longevity treatments could help preserve cognitive function with age, but also that different longevity treatments might have very different effects on such declines.

Murphy said: “Since one of the most devastating age-related declines is the loss of memory, it is exciting that we now can use C. elegans as a model to understand not only longevity but also memory function.

“We hope to use the system now to identify new drugs and treatments for age-related cognitive decline. Maybe targeting more than one longevity pathway would be the right approach.”

The study will publish in the online, open-access journal PLoS Biology. (ANI)

Drugs that could ‘switch on’ memory offer hope to Alzheimer”s sufferers

London, May 7 (ANI): Scientists have identified a genetic switch that causes memory impairment in mice when it goes into ‘off’ mode, raising hopes of powerful new drugs to treat Alzheimer”s and other diseases.

As part of their research, Andre Fischer of the European Neuroscience Institute in Gottingen, Germany, and colleagues forced 3-month-old mice to find their way around a new environment and assessed them on their ability to associate an electric shock with a particular environment.

The result was increased activity of a cluster of over 1500 genes, which are known to make proteins that are needed for the creation of new neurons – a process that is necessary for learning in humans and mice, reports New Scientist.

This boost in gene expression did not occur in 16-month-old mice given the same tasks: the activity of their genes changed only slightly. The mice also did worse than the young ones at spatial learning and memory tasks.

To find out what prevents elderly mice getting this genetic boost, the researchers analysed the DNA found in neurons in the hippocampus of both old and young mice.

They found that when young mice are learning, a molecular fragment known as an acetyl group binds to a particular point on the histone protein that DNA wraps itself around – with the result that the cluster of learning and memory genes on the surrounding DNA ends up close to the acetyl group. This acetyl ‘cap’ was missing in the older mice that had been set the same tasks.

From this, the team concluded that the cap acts as an ‘on’ switch for the cluster of learning and memory genes: removing the cap switches off the genes.

Next, by injecting an enzyme known to encourage caps to bind to any kind of histone molecule, Fischer”s team artificially flipped the switch to the on position in old mice.

The acetyl group returned to the histone molecule and the mice”s learning and memory performance became similar to that of 3-month-old mice.

The study has been published in the journal Science. (ANI)

Inability to ignore distractions behind memory decline in old age

Washington, Mar 26 (ANI): Older adults fail to retain information because they cannot ignore irrelevant information when forming memories, according to a new study at the University of California San Francisco.

Research has shown that in older adults there is an increase in brain activity at the time of suppressing responses to distractions.

In the new study, researchers have shown that even prior knowledge of an impending distraction does not help to improve the working memory performance of older adults.

Drs. Theodore Zanto and Adam Gazzaley studied 21 adults aged between 60 and 80 years while they performed a working memory task in which they were shown random sequences of pictures containing faces and scenes.

From a given sequence, participants were asked to remember either only the faces (ignoring scenes) or only the scenes (ignoring faces). In a second round of testing, the participants were given prior information about which specific pictures in the sequence would be relevant and which to ignore.

The participants” brain activity during the tasks was recorded using electroencephalograms (EEGs).

In earlier study, the researchers have shown that the increase in brain activity in response to distractions occurs very soon (within 200 milliseconds) after the distraction appears.

Since there is only a very short amount of time allotted for the brain to identify an item as irrelevant and suppress any further neural processing, it was suggested that older adults might benefit from prior knowledge of the impending distraction.

However, results from the new study have proved that this is not the case.

Interestingly, the researchers found that later stages of neural processing (500-650 milliseconds after item presentation) do show signs of suppression, confirming that the “suppression deficit” is related to early stages of neural processing.

The findings suggest that a working memory decline in older adults is indeed due to an inability to ignore distracting information, which furthermore cannot be improved with preparedness.

The study has been published in the latest issue of Elsevier”s Cortex. (ANI)

New Alzheimer’s-related genes identified

London, Sept 7 (ANI): A group of British scientists have identified two new genes that are linked with Alzheimer’s disease.

After analysing the gene pool of more than 19,000 older European and U.S. residents, researchers from the School of Medicine at Cardiff in the UK and Washington University School of Medicine in St. Louis have discovered the genes APOJ, also known as clustrin, on chromosome 8, and PICALM, on chromosome 11.

A team of French colleagues have also uncovered a third gene called APOE4, the only one previously linked to the more common late-onset form of the disease.

“There’s good evidence that these new genes may be novel risk factors, the first discovered since APOE in 1993,” Nature magazine quoted Washington University researcher and co-author Alison M. Goate as saying.

“So it’s a very important observation because this study is the first to provide such significant evidence of novel genetic risk factors for the most common form of Alzheimer’s disease,” she added.

Co-author Dr. John C. Morris, of Washington University, said: “The power of the new Genome Wide Association Study methods is that with large datasets we can now identify genes that earlier techniques were unable to confirm. These new genes associated with Alzheimer’s disease provide new clues about how the illness develops.”

Prof Julie Williams, Chief Scientific Adviser to the Alzheimer’s Research Trust, said: “Both CLU and PICALM highlight new pathways that lead to Alzheimer’s disease. The CLU gene produces clusterin which normally acts to protect the brain in a variety of ways. Variation in this gene could remove this protection and contribute to Alzheimer’s development.”

She added: “PICALM is important at synapses – connections between brain cells – and is involved in the transport of molecules into and inside of nerve cells, helping form memories and other brain functions.

We know that the health of synapses is closely related to memory performance in Alzheimer’s disease, thus changes in genes which affect synapses are likely to have a direct effect on disease development.”

Goate believes that many more genes may be involved in Alzheimer’s risk.

A research article on the study has been published in the journal Nature Genetics. (ANI)

Fish oil supplements can cut memory loss in the elderly

London, July 13 (ANI): A study carried out by American bioscience company Martek suggests that taking fish oil supplements can reduce memory loss in old age.

Dr Karin Yurko-Mauro, a researcher associated with the company, has revealed that taking a supplement of omega 3 for six months had a beneficial effect on people with age-related forgetfulness and loss of learning ability during the study.

The research team tested the affect of docosahexaenoic acid (DHA), the most commonly found in fish oil, on 485 healthy people with an average age of 70, and found that memory and general brain function increased significantly.

According to the study report, taking 900mg capsules every day was found to be the equivalent of turning back the clock three years.

The researchers hope that future studies will provide promising results suggesting that the fatty acid may help stave off Alzheimer’s disease, if new techniques can be found to diagnose it before it take holds.

Dr Yurko-Mauro said that the participants who took the supplements had “almost double the reduction in errors on a test that measures learning and memory performance.”

“The benefit is roughly equivalent to having the learning and memory skills of someone three years younger,” the Telegraph quoted him as saying.

Dr. William Thies, Chief Medical and Scientific Officer at the Alzheimer’s Association, feels that it is “too early” to make a recommendation about use of DHA supplements to prevent loss of mental function.

“In high doses, DHA does have side effects, so you would want to see a benefit to justify the risk you are taking. We need more work for that,” he said.

A presentation on the study was made at the international Alzheimer’s Association meeting in Vienna, Austria. (ANI)

Menopause transition may cause temporary memory loss,learning trouble

Washington, May 26 (ANI): Women going through the menopause suffer from temporary loss of memory and learning ability, according to a new study.

The largest study of its kind to date has been published in the May 26, 2009, print issue of Neurology, the medical journal of the American Academy of Neurology.

For a four-year period, researchers studied 2,362 women, who were between the ages of 42 and 52 had at least one menstrual period in the three months before the study started.

The women were given three tests: verbal memory, working memory and a test that measured the speed at which they processed information.

Scientists tested the women throughout four stages of the menopause transition: premenopausal (no change in menstrual periods), early perimenopausal (menstrual irregularity but no “gaps” of 3 months), late perimenopausal (having no period for three to 11 months) and postmenopausal (no period for 12 months).

The study found that processing speed improved with repeated testing during premenopause, early perimenopause and postmenopause, but that scores during late perimenopause did not show the same degree of improvement.

Improvements in processing speed during late perimenopause were only 28 percent as large as improvements observed in premenopause. For verbal memory performance, compared to premenopause, improvement was not as strong during early and late perimenopause. Improvements in verbal memory during early perimenopause were 29 percent as large as improvements observed in premenopause. During late perimenopause, verbal memory improvement was seven percent as large as in premenopause.

Combined, these findings suggest that during the early and late perimenopause women do not learn as well as they do during other menopause transition stages.

“These perimenopausal test results concur with prior self-reported memory difficulties–60 percent of women state that they have memory problems during the menopause transition,” said Gail Greendale, MD, with the David Geffen School of Medicine at the University of California, Los Angeles.

“The good news is that the effect of perimenopause on learning seems to be temporary. Our study found that the amount of learning improved back to premenopausal levels during the postmenopausal stage,” the expert added.

The study also found that taking estrogen or progesterone hormones before menopause helped verbal memory and processing speed. In contrast, taking these hormones after the final menstrual period had a negative effect: postmenopausal women using hormones showed no improvement in either processing speed scores or verbal memory scores, unlike postmenopausal women not taking hormones.

“Our results suggest that the ‘critical period’ for estrogen or progesterone’s benefits on the brain may be prior to menopause, but the findings should be interpreted with caution,” said Greendale. (ANI)

Keeping mentally fit: the daily crossword is not enough

Bonn, Germany – A man sits on a train solving a crossword puzzle, a woman broods over a Sudoku grid while an ad for an electronic memory game flashes across a television screen. There is no shortage of ways to improve the brain’s memory powers – after all, lots of people want to improve their mental abilities.

But are Sudoku, crosswords and other training games any good at improving memory? Are they really effective in training the mind or just a nice way of passing the time?

“If you train your brain, you can improve your performance,” says Carsten Brandenburg from Germany’s Memory Training Association. But not every exercise can radically change a person’s ability to remember things.

“If you repeat the same kind of exercise, your mind gets into a routine, and there is no challenge anymore,” says Brandenburg.

Sudoku is most effective in the initial stages. “The brain is not used to thinking in that manner and that’s why new connections are made between the individual nerve cells,” explains Brandenburg.

The chairwoman of the Professional Association of German Psychiatrists, Christa Roth-Sackenheim says, “We have recently come to understand that the human brain can make new connections and even new paths.”

That explains why Sudoku and computer memory games can have a positive effect on the brain’s memory performance. “You don’t just improve your concentration, you also practice strategic thinking and how to link different facts,” explains the psychiatrist. That ability can be useful in daily life.

The most effective puzzles are those that test more than your existing knowledge which excludes puzzles such as crosswords.

There are a number of books and games for electronic consoles that go in that direction, according to Brandenburg, who also works as a memory coach at Germany’s Memory Clinic in Essen.

“The best exercises are well designed and gradually become more challenging as they progress,” he says.

But computer games and electronic memory puzzles are not all-purpose weapons against memory loss, says psychiatrist Michael Rapp from Berlin’s Charite University Hospital.

“There is no exercise that can make a person more intelligent overall,” says the head of the clinic’s geriatric psychiatry working group.

You don’t need to buy expensive games to keep your brain fit. If you follow a few pointers every day, you will improve your memory or at the very least, keep it at the present level.

“Communicating is essential,” says Brandenburg, adding, “That’s how you learn to query things, gain new knowledge and grapple with questions.”

Another way of improving memory is to learn a new language, according to Roth-Sackenheim. Listening to music, doing domestic chores alone or pursuing a hobby can also help.

“Engaging in physical exercise is important for all age groups,” says Roth-Sackenheim. “That’s because sport trains the brain because you have to remember certain physical movements and practice your coordination.”

There is another alternative – keeping busy with your grandchildren. When elderly people try to understand young people’s lives, they also exercise their brains. (dpa)

Thinking that memory deteriorates with age may actually damage yours

Washington, April 22 (ANI): Think memory worsens with age? Then yours probably will, says a new study.

The study found that senior citizens who think older people should perform poorly on tests of memory actually score much worse than seniors who don’t buy in to negative stereotypes about aging and memory loss.

Lead author Dr. Tom Hess and his colleagues from North Carolina State University have shown that older adults’ ability to remember suffers when negative stereotypes are ‘activated’ in a given situation.

“For example, older adults will perform more poorly on a memory test if they are told that older folks do poorly on that particular type of memory test,” Hess said.

Memory also suffers if senior citizens believe they are being “stigmatized,” meaning that others are looking down on them because of their age.

“Such situations may be a part of older adults’ everyday experience, such as being concerned about what others think of them at work having a negative effect on their performance – and thus potentially reinforcing the negative stereotypes,” Hess said.

However, Hess added: “The positive flip side of this is that those who do not feel stigmatized, or those in situations where more positive views of aging are activated, exhibit significantly higher levels of memory performance.”

In other words, if you are confident that aging will not ravage your memory, you are more likely to perform well on memory-related tasks.

The study also found a couple of factors that influenced the extent to which negative stereotypes influence older adults.

For example, the researchers found that adults between the ages of 60 and 70 suffered more when these negative stereotypes were activated than seniors who were between the ages of 71 and 82. However, the 71-82 age group performed worse when they felt stigmatized.

Finally, the study found that negative effects were strongest for those older adults with the highest levels of education

“We interpret this as being consistent with the idea that those who value their ability to remember things most are the most likely to be sensitive to the negative implications of stereotypes, and thus are most likely to exhibit the problems associated with the stereotype,” Hess said.

“The take-home message is that social factors may have a negative effect on older adults’ memory performance,” he added.

The study was published online April 1 by Experimental Aging Research. (ANI)