FACTBOX – Why is the West sceptical about Iran’s fuel offer?

Iran has outlined a plan to the U.N. atomic watchdog under which it would give up some of its nuclear material but diplomats say the gesture would have no effect on a push to widen sanctions against Tehran.

Under the plan agreed with Brazil and Turkey last week, Iran would transfer 1,200 kg (2,646 lb) of its low-enriched uranium — enough for an atomic bomb if enriched to higher levels — to Turkey within a month.

A year later the Islamic Republic would get special nuclear fuel rods for a medical research reactor which makes isotopes to help treat cancer patients.

Why is the West cautious about this proposal?

TIME LAPSE

Western officials say the landscape has changed in the seven months since they brokered a similar plan with Iran and the International Atomic Energy Agency (IAEA) as a way to ease tensions over Tehran’s atomic work.

Iran has continued enriching uranium and taking away 1,200 kg now would still leave Iran with enough for a bomb if it wanted to build one. Tehran says it has no intention of doing this and says its work is for peaceful purposes only.

Some observers say the swap is still worth it because it would remove half the material. Others say the deal has now lost its value because the bomb risk would remain and it fails to build confidence.

HIGHER ENRICHMENT

Iran also started enriching uranium to higher levels in February, saying it wanted to make fuel for the reactor itself, but the move unsettled Western powers because it takes the material closer to the grade needed for atomic weapons.

Tehran said it took the step because it said it was tired of waiting for the original deal to be agreed. Western officials say it was Iran which stalled progress, with a series of new conditions for the swap which it knew would not be accepted.

Iran has vowed that it will not stop its higher enrichment, even if the fuel supply agreement goes through and has started setting up more equipment for it.

Western diplomats have described this refusal to halt higher enrichment as a likely deal-breaker. They also question why Iran would still need to continue this process — which like its lower-grade enrichment violates U.N. sanctions — when countries are prepared to give it the fuel rods it says it needs.

They say Iran lacks the capability to make the specialized fuel assemblies in the short-term, so it makes no sense to produce more highly enriched uranium for a reactor that Tehran says will run out of fuel by the end of the year.

LACK OF DETAILS

Unlike the IAEA plan, brokered by former IAEA-chief Mohamed ElBaradei, the new proposal does not included detail on who would make the fuel rods, who will pay for the process and what will happen to the low-enriched uranium stored in Turkey after the swap has been completed, Western officials say.

Without this sort of information, they say they cannot begin serious negotiations on Iran’s offer, which many of them see as an attempt to stall sanctions negotiations.

Some Western officials say the Iranian move fits into a familiar pattern of Tehran offering concessions when punitive measures loom.

THE BIGGER PICTURE

Diplomats also say that with its promotion of the new proposal, Iran is trying to give the impression that it was the fuel deal which was at the centre of problems with the West, rather than its nuclear ambitions as a whole.

They acknowledge that the original IAEA-plan was always intended as a first step towards resolving the nuclear issue, not a solution.

But they say Iran’s lack of cooperation with the agency on questions about its atomic programme and its delay in engaging on the fuel deal, have left negotiators feeling wary.

They also fear that Iran may go back on its word.

Talks over the original deal suffered from internal Iranian disputes. Iranian President Mahmoud Ahmadinejad first appeared to favour the U.N. deal as a way to shore up his own power.

But he faced stiff opposition from rivals who did not want to see him reap credit for a breakthrough. Some voiced misgivings about parting with the nuclear material, which is seen as a strategic asset.

But analysts in Iran believe Ahmadinejad wouldn’t have agreed on this deal without the blessing of the supreme leader.

Ahmadinejad urges Obama to accept nuke swap deal

Iran’s president Wednesday urged Barack Obama to accept a nuclear fuel swap deal, warning the US leader will miss a historic opportunity for improved cooperation from Tehran if the offer is rejected.

Mahmoud Ahamdinejad also issued a stern warning to Russia, saying Moscow’s support for the US-led push for a new round of UN sanctions against Iran was contrary to the two countries’ neighbourly and friendly relations.

Washington has denounced the Iranian offer, brokered last week by Brazil and Turkey, as a ploy by Tehran to avoid a new round of UN sanctions over its controversial nuclear program, which the West fears is geared toward nuclear weapons.

“There are people in the world who want to pit Mr Obama against the Iranian nation and bring him to the point of no return, where the path to his friendship with Iran will be blocked forever,” Ahmadinejad said during a rally in the southern town of Kerman.

Iran proposed last week to ship much of its low-enriched uranium to Turkey in return for nuclear fuel rods needed for a Tehran medical research reactor.

The fuel swap would diminish Iran’s stockpile of low-enriched uranium that can possibly be used in making atomic bombs, if the uranium is enriched to a higher, weapons-grade level.

Iran says to reconsider fuel swap if sanctions imposed

Iran will reconsider a nuclear fuel swap deal if world powers agree to impose further sanctions on the Islamic Republic, Interfax news agency quoted Tehran’s ambassador to Moscow as saying on Tuesday.

“If there are new sanctions, it will become obvious to the Iranian public that the “5 + 1″ group is hiding evil intentions and pursuing political objectives. This would force us to revise the Tehran accords,” Mahmoud Reza Sadjadi was quoted as saying.

Under the deal, agreed with Turkey and Brazil, Iran would send 1,200 kg of its low-enriched uranium (LEU) to Turkey in return for fuel rods to keep a Tehran medical research reactor running.

Western critics say the deal would still leave Iran with enough uranium for one bomb, as it has stockpiled more LEU since the idea was first proposed last year.

“We believe that by this (deal) Iran has demonstrated its goodwill,” Sadjadi said. “After all that lobbying by Brazil, Turkey and other countries, we believe that it makes no sense to talk about new sanctions.”

(Writing by Dmitry Solovyov, editing by Guy Faulconbridge)

Iran starts meeting with IAEA on nuclear fuel deal

Iranian officials met the U.N. nuclear watchdog chief for talks on Monday at which they were expected to hand over a letter outlining a deal to send some of Tehran’s enriched uranium abroad.

The deal to swap low-enriched uranium for fuel to run an Iranian medical research reactor, aimed at allaying fears Iran is trying to amass enough fissile material for nuclear weapons, was agreed last week by Tehran with Turkey and Brazil.

Under the plan, Iran would transfer 1,200 kg (2,646 lb) of its low-enriched uranium (LEU) — enough for an atom bomb if enriched to high purity — to Turkey in return for special fuel rods to replenish the stocks of its medical isotope reactor.

World powers have voiced doubt about the value of this offer — based on a seven-month-old, IAEA-backed proposal — since Iran’s LEU stockpile has grown significantly since then, meaning it could still be left with enough for a nuclear warhead.

Iran has also started refining uranium to a higher level.

(Reporting by Sylvia Westall; Editing by Mark Heinrich)

Seaweed may halt swine flu spread

Tasmanian scientists have discovered a compound occuring naturally in seaweed which could help provide the key to beating swine flu.

The Japanese seaweed Undaria arrived in Tasmania in ballast water more than 20 years ago.

A compound in the seaweed acts as a natural defence against marine viruses and toxins.

Scientists at a private laboratory near Hobart are convinced it is just as effective on humans.

They have tested the compound against several viruses and say it profoundly inhibits the H1N1 virus.

Researcher Dr Helen Fitton says viruses use receptors to get into cells, but this process is stopped in the presence of the seaweed compound.

“The virus is unable to use its receptor to get into the cell,” she said.

Marinova Laboratories CEO Paul Garrott says he is anticipating immediate commercial interest and expects the compound will be used in nasal sprays, hand washes and tablets.

“This whole class of fucoidan compounds have been shown to have very profound antiviral activities against a range of influenza strains, against a range of other viruses and coated viruses – we mentioned HIV, we mentioned the herpes simplex virus.”

Genes associated with osteoporosis identified

London, May 4 (ANI): Researchers at Jewish General Hospital in Montreal have identified 20 genes associated with osteoporosis and bone weakness, including 13 genes never previously associated with the disease.

Osteoporosis is a highly heritable trait, but this marks the largest international effort to conclusively identify genes linked to the often-devastating bone disorder.

The study”s co-first author is Dr. J. Brent Richards of the Lady Davis Institute for Medical Research at the Jewish General Hospital in Montreal, who collaborated with more than 30 co-authors worldwide.

The results were published recently in the journal Nature Genetics.

The researchers reviewed data collected from nearly 20,000 individuals in five recent international genetic studies. (ANI)

Multitasking splits the brain into two parts

London, Apr 16 (ANI): People who think they can juggle more than a few tasks at once with ease, here’s a research: “multi-tasking” skills are limited by the physical division of the brain into two hemispheres.

In a new study, boffins found that when individuals carry out two tasks simultaneously their brains divide each job up so that one is performed largely by the left side of the brain and the other is carried out mainly on the right.

The study’s finding may explain why humans tend to prefer a simple choice between two options rather than three or more, reports The Independent.

To reach the conclusion, Sylvain Charron and Etienne Koechlin of France”s National Institute of Health and Medical Research in Paris asked 32 volunteers to carry out two different mental puzzles while their brains were being scanned by an MRI machine.

“Each subject was performing two tasks concurrently. One task was to pair upper case letters and the other task was to pair lower case letters together. It was a very simple task and the subjects had to switch back and forth between them,” Dr Koechlin said.

“We motivated them with a reward if they made no errors between trials. It was a monetary reward actually, so when the subject made an error on one of the tasks, their reward was less. We rewarded brain activity and at the same time we monitored the subjects” errors, reaction time and so on. So we could measure performance and we found that a larger reward was associated with a better performance,” he said.

The study, published in the journal Science, focused on the medial frontal cortex. It is this part of the brain that is thought to drive the pursuit of rewards associated with carrying out a task.

“We found that brain activity increased with rewards and expectations in the medial frontal cortex. We found in the left hemisphere that the activity increased as the reward value of one task increased, but not the other task, whereas in the right hemisphere the brain activation was related to the reward value of the other task,” Professor Koechlin said.

“The two hemispheres co-operated when there was only one task. But in two tasks, one hemisphere covers the reward of one task and the other hemisphere covers the reward of the other.”

“The human prefrontal function seems to be built to control two tasks simultaneously. It means in everyday behaviour we can readily switch between two tasks but not between three. With three tasks the division is limited to only two hemispheres, so there is a problem,” he said. (ANI)

Parkinson’s patients have pedal power

Medical scientists are baffled by a phenomenon in which sufferers of Parkinson’s disease who cannot walk are able to ride bikes and ice skate.

A doctor in the Netherlands who specialises in Parkinson’s disease has written a case study on one of his patients who is unable to walk but rides kilometres on his bike every day.

The study, published in the New England Journal of Medicine, has attracted similar stories from around the world.

Doctors suspect it may have something to do with the way humans store special memories.

Neurologist Bas Bloem from the Radboud University Nijmegen Medical Centre in the Netherlands thought he had seen it all in his years of caring for Parkinson’s patients, that is until he met a 58-year-old man who could not walk.

“He had freezing of gait – the mysterious phenomenon where the people really feel as if their feet are glued to the floor,” he said.

Video footage of the man shows him taking a tentative shuffle, his hands shaking by his sides, then he freezes and falls to the ground.

“This man told me he’d been on his bicycle for like 50 miles just the other day and that he was doing this on a regular basis and I said, ‘you know that is impossible, you can’t possibly ride a bike’,” Professor Bloem said.

“And he said, ‘Yeah, yeah I can ride a bike’.”

Video footage of the man cycling around the hospital car park shows his movements as fluid and he looks controlled and happy.

An outsider would be forgiven for thinking it was a different person.

The man leaps off the bike – a more subtle version of jockey Frankie Dettori’s famous flying dismount – then his symptoms return and he forgets how to walk.

A stunned Professor Bloem asked 20 other severely affected patients about riding a bike; it turned out they could all do it.

He suspects the motor program for cycling is stored in a different part of the brain than the one needed for walking.

“Or, perhaps, patients when they cycle are able to explore other areas of the brain that are still healthy in Parkinson’s disease in order to support the rhythmic movements of their feet,” he said.

“We may use this observation to provide a nice way to exercise patients with Parkinson’s disease.

“We know that these patients tend to become immobilised in the course of their disease because of their physical problems, and this is really bad news for them because being immobile deprives you of your social contacts but it also increases the risk of, say, strokes or cardiovascular disease.”

Professor Bloem says his article has attracted similar tales.

“I’ve received a beautiful email from Canada from a daughter of a patient who said, ‘My mother was unable to walk but she could ice skate perfectly well’ and I’ve had numerous more examples of unexpected abilities to move,” he said.

“I think what we as doctors should do much more is listen to our patients and explore the unique opportunities that patients have found themselves in order to make themselves move better and actually build this into our therapeutic arsenal.”

Professor Bloem hopes exercise can be used to slow the progression of Parkinson’s disease, as it does in rats.

He is currently undertaking a $1 million clinical trial. The results are expected towards the end of next year.

Trial of bionic eye within three years

Melbourne researchers have developed a prototype for a bionic eye which they hope to implant in a person within three years.

It has been nearly two years since Prime Minister Kevin Rudd’s 2020 ideas summit, where the prospect of a functioning artificial eye grabbed headlines.

Researchers received a $42 million grant from the Federal Government to develop the prototype.

The consortium behind the device, Bionic Vision Australia, says the eye will help patients suffering from degenerative vision loss to increase their mobility and independence.

Research director Anthony Burkitt unveiled the design this morning.

The prototype consists of a mini camera, mounted on a pair of glasses, that sends information to an image processor which can be kept in the wearer’s pocket.

Professor Burkitt says the processor will then send a signal wirelessly to an electronic unit which is surgically inserted in layers on the outside of the eye.

“The electrode ray is inserted into the back of the eye, which is where – for normal-sighted people – the central part of the visual field would be,” he said.

“This is the part of the retina which has the greatest density of the receptive neurons.

“The electrical impulses that are sent out from the electrode ray are picked up by the neurons in the retina and then sent back through the optic nerve to the vision centres of the brain.”

There are 98 electrodes in the prototype bionic eye and each adds an extra point of reference, showing up as a dot in the visual field.

“It consists of points of light. These are called phosphenes and these are able to provide not an entirely perfect representational image, but enough information for these patients to regain their mobility and their independence,” Professor Burkitt said.

“This is what we call our first generation device – the wide view neuro-stimulator. It will enable patients to be able to navigate in their environment and be able to avoid obstacles.”

Life-changing potential

More than 50,000 Australians are visually impaired because of conditions like retinitis pigmentosa and macular degeneration.

Mr Rudd is still getting his head around the details, but he is excited by the progress that has been made since the summit.

“It’s medical developments like the bionic eye that have the potential to improve the health and quality of life of Australians around this country and, in fact, people around the world,” he said.

The chairman of Vision Australia, Kevin Murfitt, describes the bionic eye as a revolution.

“It will be … the innovation of a lifetime if it comes off, because it helps so many people,” he said.

“Being able to recognise people. Absolutely amazing. And we live in a very beautiful world and … nothing replaces the beauty of your family and world.”

Mr Murfitt says he is optimistic the eye will be available in a few years.

“I think this consortium is doing it in a very staged and planned way,” he said.

“In 2013 they’ll have the first phase, which should give us vision to be able to move around and see obstacles.

“And then in another five or six years, the next phase will actually allow us to recognise faces and read large print.

“So it’s got huge potential. This is truly a revolution and will be the biggest thing in terms of blindness and low vision since Louis Braille invented the Braille alphabet over 200 years ago. This will be the next big remarkable invention.”

Bionic Vision Australia hopes the first bionic eye will be available for human implant by 2013.

It will only have 96 electrodes. A 1,000 electrode eye should be ready for tests by 2014.

Climate change and chronic disease study

Researchers at the University of Tasmania are calling for volunteers to take part in a study into the effects of climate change on people suffering from chronic diseases.

The study will look at how people with conditions such as type 2 diabetes and heart disease cope with extreme changes in temperature.

Sibella King from the University’s School of Human Life Science says if a person’s heart is already weakened from disease, it may have to work harder due to rising global temperatures.

“In the heat we expect people’s blood pressure to fall a little bit, and when that happens the heart rate will rise to compensate for the falling pressure,” she said.

“So you get a higher heart rate and a lower blood pressure, so that’s what we would expect to see.”

New facility to bolster Indigenous health efforts

The Minister for Rural and Indigenous Health says a new facility in Alice Springs will help reduce the rate of chronic illness in Aboriginal communities.

Flinders University and the Baker IDI Heart and Diabetes Institute are sharing the W and E Rubuntja Research and Medical Education building at the Alice Springs Hospital.

The building will house Flinders’ new rural clinical school and Baker’s research into Aboriginal health problems.

Minister Warren Snowdon says it will provide a base for efforts to tackle some of the chronic diseases affecting Aboriginal health.

“Here in central Australia we know the importance of research into cardiovascular disease, diabetes, renal failure,” he said.

“These are the sorts of things that Baker’s crucially engaged with and if we want to improve the outcomes, the health outcomes, we’ve got to be able to enable people to manage the health of their patients better.”

Mr Snowdon says students will gain remote practice experience and there will also be benefits for doctors and nurses working in central Australia.

“As a result of them being here, and as a result of Flinders being here, I think we’re going to attract professionals to come here who might not otherwise have come,” he said.

“I think they’ll be attracted to coming to work at the hospital, for example, because they can see an opportunity to research at the same time as they’re working.”

Adelaide part of golden staph vaccine trial

Adelaide’s Women’s and Children’s Hospital is after volunteers for a trial of a vaccine aimed at preventing potentially-deadly golden staph infection.

The bacteria live on the skin of about 30 per cent of the population and are usually harmless.

But if they enter the bloodstream, it can lead to pneumonia and joint infections.

Hospital patients are susceptible if they are recovering from surgical or other wounds.

Dr Helen Marshall says the hospital wants to recruit about 50 people for the trial.

“We’re hoping to enrol adults particularly for the study, 18 to 25-year-old adults and then 50 to 85 years,” she said.

“The study is being done in many centres around Australia, we’re just one of the study centres participating.”

The hospital can be contacted on 8161 6328.

Report highlights regional cardiovascular woes

A report has revealed people living in regional areas access cardiovascular disease medicines at a higher rate than those living in the city or in remote areas.

The report, released by the Australian Institute of Health and Welfare (AIHW), shows people in regional Australia generally have poorer cardiovascular health than their city counterparts.

John Woodall from AIHW says the reasons for the patterns across the country are too complex to explain.

But he says Indigenous Australians have significantly higher rates of cardiovascular disease deaths than any other Australians.

Air pollution sending children to hospital

Air pollution accounts for at least 4 per cent of hospitalisations of babies and children, a new Australian Institute of Health and Welfare (AIHW) report estimates.

The report’s author, Dr Adrian Webster, says the study examines the extent of the link between air pollution and asthma attacks.

“Four per cent of around 3,500 hospitalisations of [newborns] to 14-year-olds were related to the amount of particulates in the air,” he said.

“This is an estimate based on the methodology we’ve developed.

“In relation to adults we only looked at nitrogen dioxide [as] unfortunately we couldn’t resource the research required to do it for particulates.

“We found about 3 per cent … [were] hospitalised due to nitrogen dioxide levels in the air.”

The report is based on data from Melbourne in 2006 and is limited to two pollutants.

Dr Webster says there are several other pollutants that exacerbate asthma symptoms, so it is likely the total effect is worse than the report suggests.

“We are breaking air pollution in total down to its component parts, so the overall impact of air pollution is likely to be much greater than that,” he said.

“But unfortunately we weren’t able to look at the total picture because of a lack of research in the area.”

Associate Professor Bin Jalaludin from Liverpool Hospital, who specialises in the effects of air pollution on respiratory illness, says his research has found that young children are especially vulnerable on high pollution days.

“On high pollution days there are more [admittances] in most departments in Sydney [for] children, especially aged one to four,” he said.

“[For] articulate matter we found an increase of about 1.3 per cent, for nitrogen dioxide about 3 per cent and for ozone about 1 per cent.”

Setting the standard

The AIHW report has attempted to devise a standardised method of measuring the effects of pollution on asthma sufferers.

Dr Webster says similar studies have been conducted but the results have not been consistent.

National Asthma Campaign representative and associate professor of the John Hunter Hospital, Peter Walk, says the current system is inadequate.

“There is a lack of standardisation for measuring air quality … the requirements to report the results really don’t exist in Australia and those standards requirements vary enormously,” he said.

“So we really have what could be a potentially very important public health issue, but there isn’t a standardised way of measuring this or looking at the outcomes for individuals.”

Professor Jalaludin agrees, saying a standardised measure would allow policy-makers to better understand the effects of air pollution and come up with ways to improve health and reduce health costs.

“It may tell us the number of deaths … hospitalisation … and emergency department visits we might be able to avoid if we reduce air pollution,” he said.

“We could work out how much money we might be able to save if we are able to avoid some health affects, or if we can avoid deaths due to air pollution.”

India needs a robust and vibrant public health system : Azad

New Delhi, Sep18 (ANI): Union Health and Family Welfare Minister Ghulam Nabi Azad on Friday said that to improve the standard of public health, there is a need for introducing a robust and vibrant public health system in the country.

Speaking after presenting the Indian Council of Medical Research (ICMR) awards here Azad said: “To improve the health of the public, we need a robust and vibrant public health system in the country. This manpower serves dual purpose of service and epidemiological research. As you are aware, there is an acute shortage of trained public health professionals in the country.”

Azad also appreciated the work taken up by the ICMR in the public health sector in association with the country’s major medical institutes.

“The results of the work carried out by ICMR institutes often become the backbone of national programmes for the control and prevention of diseases. Many of the recommendations of ICMR institutes have either been taken up in the National Control Programmes or are in the process of being taken up,” Azad said.

Stressing on the need for public participation in implementing health programmes Azad said: “Participation of community in any control programme goes a long way in the successful completion of any project. This has been shown by the success in the significant reduction in the incidence of lymphatic filaria in Kerala where community played a significant role in achieving the objectives of the project.”

Azad also called on researchers to concentrate on emerging challenges in the health sector.

“We have been observing an increasing trend in the prevalence of life style diseases including diabetes, cardiovascular diseases and cancer. India is being named as the Diabetes capital of the world. I would like the scientists to develop cost-effective technologies for diagnosis and monitoring of rapidly evolving life style diseases particularly Diabetes. These technologies should be easy to use and which can be provided to the peripheral health workers at the community level,” Azad said.

Azad also recalled the contribution made by the Regional Medical Research Centres of ICMR though located in under served and remote areas of country.

“The regional medical research centres have played a significant role in creating awareness and better understanding in the health problems of the population in these areas. Tribal health research undertaken by ICMR institutes, especially in the area of genetic disorders, leptospirosis, and hepatitis B have been significant and helped the government. to initiate appropriate control measures.”

This year’s ICMR research awards were presented to the works in communicable and non-communicable diseases, including areas of maternal and child health and basic medical sciences. (ANI)

Swine Flu in Assam | First case of Swine Flu in Assam

Swine Flu in Assam | First case of Swine Flu in Assam

An 18 year old boy today tested positive for Swine flu in Assam, is the first such case in the northeast state.

Joint Director of the state’s Health Services Dr G P Sarma said the samples of the person, who was admitted yesterday in the Mahendra Mohan Choudhury Hospital (MMCH) here, was sent to the Indian Council of Medical Research (ICMR) at Lahowal in Dibrugarh.

“We have received the reports today and his samples have tested positive”, he said.

The health official said his residential address was given as Beltola, Guwahati.The patient had been kept in the isolation ward of the MMCH.

This is the first of the 11 suspected cases of swine flu to test positive while the results of three others are awaited.

State Health Minister Himanta Biswa Sarma had said the state was well equipped with medicine backups to combat any emergency.

Chandigarh Research Institute develops medicine for clots busting linked to heart attacks

Chandigarh, Aug.8 (ANI): India has achieved a major breakthrough in medical research with the efforts of a Chandigarh-based Institute of Microbial Technology (IMTECH), a scientific research institute, in developing a medicine which prevents blood clots.

Its seven yeas of research recently led to the commercial launch of genetically modified recombinant streptokinase, a medicine that dissolves heart-attack causing clots inside blood vessels.

The drug is going through regulatory testing and expected to be commercialized by 2011.

Established in 1984, the Chandigarh-based IMTECH is the youngest among the 38 national laboratories functioning under the aegis of Council of Scientific and Industrial Research.

“This is a recombinant streptokinase which is much more economic as a result of the process by which it is made. So that the price of production of product is much lower than what it used to be previously. Therefore, this product has much more sustaining power and staying power in the market. The hope is that by the introduction of this drug the overall price the overall price of the clot buster drugs will go down. The clot buster drugs are extremely vital lifesaver drugs because when somebody gets a heart attack, within a few hours clot buster drug is given and about 30 to 40 lives can be saved. So it is a kind of SOS therapy, which before a patient can be wheeled into the hospital for bypass is done. This can save lives,” said Dr. Girish Sahni, Director, IMTECH in Chandigarh.

IMTECH scientists have also licensed an improved, new clot specific thromblytic to Nostrum Inc, USA and Symmetrics Biotech, India recently.

Another thrombolytic protein, Staphylokinase has been licensed to M/S Strides Arcolab Ltd., Bangalore.

IMTECH’s efforts have given India and the world four molecules that fight clots associated with heart attacks and prove that India does not lag behind in medical research.

“Actually in all research you get different kinds of problems. And if you are doing this work, then the challenge is to make it commercially viable. So you have to develop a system that can be used for marketing a product, so you have to optimize the cost. For example in case of genetic engineering, in case of developing fermentation process, in case of downswing processing. So lot of effort is required,” said Kanak Dikshit, a scientist with IMTECH in Chandigarh.

A study by California-based firm reveals that India has the highest incidence of heart related diseases in the world.

And if no initiative is taken to check the disease, the most predictable and also preventable among all chronic diseases, India will have 62 million patients by 2015, compared to 16 million in the U.S.

The percentage of people suffering from heart disease had increased from 1-2 to 3-5 per cent in rural India and from 2-3 to 10-11 percent in urban India.

IMTECH’s research in clot buster molecules will help provide an affordable treatment to heart patients. By Sunil Sharma(ANI)

Quitting smoking provides immediate benefit to heart

Washington, July 8 (ANI): Smokers can immediately improve their cardiovascular health by kicking the butt, according to a study.

Researchers at the Feinstein Institute for Medical Research in Manhasset, NY, say that smoking cessation provides immediate benefits to patients.

They examined specific inflammatory biomarkers associated with cardiovascular disease (CVD) in “at risk” women during the smoking cessation process.

It was found that smoking cessation resulted in significant reductions in circulating tumour necrosis factor (TNF), soluble TNF receptors I and II, and soluble vascular cell adhesion molecule-1 (VCAM-1).

Thus, the researchers concluded that there are rapid consequences of smoking cessation on inflammatory biomarkers in women at risk for CVD.

The article has been published in Chest, the peer-reviewed journal of the American College of Chest Physicians. (ANI)

Breakthrough in ‘floppy baby’ syndrome

Washington, May 26 (ANI): Australian researchers have successfully treated mice with a devastating muscle disease that causes a Floppy Baby Syndrome.

The breakthrough could ultimately help thousands of families across the globe.

The research, published online today in the Journal of Cell Biology, reveals how a team at the Western Australian Institute for Medical Research (WAIMR) has restored muscle function in mice with one type of Floppy Baby Syndrome – a congenital myopathy disorder that causes babies to be born without the ability to properly use their muscles.

The currently incurable genetic diseases render most of the affected children severely paralysed and take the lives of the majority of these children before the age of one.

Dr Kristen Nowak, lead author on the publication, said the team was extremely encouraged that it had been able to cure a group of mice born with the condition.

“The mice with Floppy Baby Syndrome were only expected to live for about nine days, but we managed to cure them so they were born with normal muscle function, allowing them to live naturally and very actively into old age,” she said.

“This is an important step towards one day hopefully being able to better the lives of human patients – mice who were cured of the disease lived more than two years, which is very old age for a mouse,” the expert added.

Dr Nowak said the team was able to cure the mice with the recessive form of the genetic condition by replacing missing skeletal muscle actin – a protein integral in allowing muscles to contract – with similar actin found in the heart. (ANI)

Bone find in Britain shows evidence of early amputations in 19th century

London, May 2 (ANI): A team of archaeologists has determined that bones found at a former hospital in Worcestershire, UK, show evidence of early amputations and other medical research in the 19th century.

According to a report by BBC News, county council archaeologists were called in after workers building the new city university campus found about 200 bone pieces in a pit at the former Worcester Royal Infirmary site.
The old hospital is being demolished to make way for a new campus.

Many of the 19th Century bones had been deliberately cut and were “evidence of amputations in their infancy”, according to Simon Sworn, archaeologist and project officer.

The British Medical Research Association (BMA) was founded in the hospital in 1832 and Sworn said that the bones from dead prisoners were among those used for research after this became legal practice.

Sworn said the bones were a rare find.

“It’s a very fascinating and important find and appears to show a great deal about early medical practice,” he said.

Sworn said an Act of Parliament in the mid-19th Century permitted research on dead prisoners, so bones of former inmates could be among those found.

“It could be criminals or it could be poor people who could not be identified and had no family,” he said.

According to Sworn, the bones were from many individuals and included arm and leg bones and fragments of skull and vertebrae.

“They do indicate early anatomical investigations, when people were first dissecting human remains,” he said.

“There’s evidence of research into varying diseases, such as syphilis, which was widespread at the time. There are bones that have been cut into where the disease had taken hold,” he added.

Sworn added there were also animal bones, including those of pigs, found in the pit.

“Some have several saw marks, as if the students had practiced amputations on the animals’ bones first,” he said.

The bones include a hip joint punctured by a nail which Sworn said could be evidence of an early hip replacement operation.

Worcestershire County Council said its archaeologists were immediately called in after the discovery to “make sure the remains were treated appropriately”.

The bones, which were removed under a Home Office licence, are being stored and preserved at the council offices and will be sent to a specialist who is expected to report on their significance.

“The remains are likely to be studied by experts in the history of surgery before reburial,” a county council spokeswoman said. (ANI)