Five-minute screening test could cut risk of developing bowel cancer

London, Apr 28 (ANI): A five-minute screening test has been developed, which researchers say, could cut the risk of developing bowel cancer by a third.

The research led by Imperial College London has been published in the Lancet.

According to the 16-year study, funded by the Medical Research Council, the National Institute for Health Research, and Cancer Research UK, a single flexible sigmoidoscopy examination in men and women aged between 55 and 64 reduced the incidence of bowel cancer by a third, compared with a control group who had usual care.

Screening with flexible sigmoidoscopy (named the ”Flexi-Scope test” by the research team) was particularly effective in the lower bowel, where it halved incidence of the disease.

Over the course of the study, bowel cancer mortality was reduced by 43 percent in the group that had the Flexi-Scope test compared with the control group.

The randomised trial followed 170,432 people over an average period of 11 years, of whom 40,674 underwent a single Flexi-Scope exam.

Professor Wendy Atkin from the Department of Surgery and Cancer at Imperial College London, who led the research, said: “Our study shows for the first time that we could dramatically reduce the incidence of bowel cancer, and the number of people dying from the disease, by using this one-off test. No other bowel cancer screening technique has ever been shown to prevent the disease. Our results suggest that screening with Flexi-Scope could save thousands of lives.”

The Flexi-Scope test works by detecting and removing growths on the bowel wall, known as polyps, which can become cancerous if they are left untreated. Flexi-Scope is able to prevent cancer from developing by removing polyps before they become cancerous. (ANI)

Antibiotic treatment could act as ‘lifeline’ for HIV patients

London, Mar 29 (ANI): Providing antibiotics to some newly diagnosed HIV patients could save tens of thousands of patients, but researchers are missing this opportunity, say researchers.

According to a major study in The Lancet, the simple, cheap, drug treatment halved mortality.

The World Health Organization already endorses the treatment, but specialists say many people are not given the drug.

In the battle against HIV, the researchers have long been focussing on antiretroviral drugs, which can greatly extend life.

However, many patients are at greatest risk in the first weeks after diagnosis, with a variety of infections ready to take advantage of their weakened immune systems.

Studies have estimated that as many as a quarter of people who enter antiretroviral drug treatment programmes in sub-Saharan Africa will die in the first year.

But the addition of co-trimoxazole, an inexpensive antibiotic, to the long-term treatment plan of those with the worst affected immune systems appears to prevent many of such deaths.

The Lancet study, carried out among 3,179 Ugandan patients, suggested a fall of 59 percent over the first 12 weeks, and 44 percent between 12 and 72 weeks.

Its authors, from the Medical Research Council Clinical Trials Unit and Imperial College in London, and centres in Uganda and Zimbabwe, have said that the antibiotic is not available in many places.

They say their findings reinforce the need for swifter action by those responsible for drug treatment programmes.

According to professor Charles Gilks, who led the study, any arguments over the effectiveness of the antibiotics were now “well and truly answered”.

“Tens of thousands of lives can be saved by more universal use of the drug, costing just a few pence a day,” the BBC quoted him as saying.

In addition to preventing bacterial infections in HIV patients, the drug had a welcome benefit – it cut the incidence of malaria by a quarter. (ANI)

Indians, Bangladeshis less prone to asthma than White children

Washington, Mar 25 (ANI): Indians, Bangladeshis and Black Africans have a similar or lower prevalence of asthma than White children, while Black Caribbean and Mixed Black Caribbean/White boys are more likely to have asthma, according to a study of UK schoolchildren.

In the study, the researchers examined the occurrence of asthma, and probed ethnic differences in risk factors.

Melissa Whitrow and Seeromanie Harding from the Social and Public Health Sciences Unit of the Medical Research Council, UK, used data taken from 51 London schools to investigate a random selection of 11-13 year old pupils.

In the final sample for analysis, there were 1219 children who identified themselves as ”White UK”, 933 ”Black Caribbean”, 1095 ”Black African”, 459 ”Indian”, 215 ”Pakistani”, 392 ”Bangladeshi” and 299 ”Mixed White UK and Black Caribbean”.

“Social and environmental factors may influence risk of asthma through early life exposures regulating the allergic inflammatory response and/or later life exposures to allergens. A positive association between body mass index (BMI) and asthma has also been reported. We aimed to investigate the influence of these factors on ethnic differences in asthma prevalence,” said Whitrow and Harding.

The researchers found that a family history of asthma and psychological well being were consistent correlates for asthma regardless of ethnicity.

They observed that less than six years of residence in the UK had an independent protective effect for Black Caribbeans and Black Africans, possibly reflecting continuing protection from early life exposures in their home countries.

A gender difference was observed for Indians and Bangladeshis, with less asthma in girls than boys.

“These findings point to early protective influences which are not properly understood. International comparisons could provide useful insights into prevention of asthma, for ethnic minority children and for all children,” said the authors, speaking about these results.

The study has been published in the open access journal BMC Pediatrics. (ANI)

Bone Stem Cells can be used to mend damaged hips

London, Mar.20 (ANI): Bone stem cells could in future be used instead of bone from donors as part of an innovative new hip replacement treatment, according to scientists at the University of Southampton.

A team from the University’s School of Medicine believe that introducing a patient’s own skeletal stem cells into the hip joint during bone grafting would encourage more successful regrowth and repair.

The grafting technique is used to repair the thigh bone and joint during replacement (known as ”revision”) hip replacement therapy, a procedure in which surgeons introduce donor bone to the damaged area to provide support for the new hip stem.

In this collaborative study between the University of Southampton and The University of Nottingham, researchers will use adult stem cells from bone marrow in combination with an innovative impaction process and polymer scaffolds.

In a two-year study, funded by the Medical Research Council (MRC), researchers aim to improve the outcomes of this high impact procedure.

“Surgeons currently use bone from donors during bone grafting, so introducing a patient’s own stem cells to create a living cell or material composite would be a totally new approach,” comments Professor Richard Oreffo, an expert in musculoskeletal science at the University of Southampton, who is leading the project.

“This is very much the beginning of a project to investigate the potential for this new technique, but our preliminary work suggests this may have significant therapeutic implications.”

When a hip joint is damaged, part of the thigh bone or femur, including the ball, can be removed and a new, artificial joint fixed to the remaining thigh bone. Revision hip replacement occurs when that artificial joint needs to be changed.

Professor Oreffo will introduce the stem cells to the hip joint using a scaffold, or support structure, which is designed to protect them, and a new impaction process. The polymer scaffolds will be developed by Professors Steve Howdle and Kevin Shakesheff, experts in chemistry and tissue engineering at the University of Nottingham.

Professor Howdle explains: “Building upon strong collaborations with tissue engineering experts, this new grant will allow researchers at Nottingham to take their materials nearer to the clinic.

“This could have great benefits for patients, and also offer a significant cost saving for healthcare authorities; but first we need to verify and build upon our preliminary data.”

“A major part of the work at Nottingham will involve scaling up the supercritical fluid processing apparatus to create larger and more uniform batches of polymer scaffolds for testing.”

Dr Chris Watkins, MRC’s Translation Theme Leader, says: “Resilience, repair and replacement is a priority research area in the MRC’s strategic plan, ‘Research Changes Lives’. This study highlights how a regenerative approach can offer real hope in addressing a significant problem for an ageing population.”

This funding will allow the groups to build on initial studies that show that degradable polymer scaffolds prepared using supercritical carbon dioxide technology can have a dramatic effect on surgical procedures, such as inserting a hip implant in revision hip surgery.

The provisional studies carried out in Southampton show that the polymers can aid bone formation through the creation of a living cell/material composite and aid attachment of the hip implant.

Roxon ‘uncomfortable’ over parents picking children’s sex

The Federal Health Minister Nicola Roxon says she would be very uncomfortable about allowing parents to choose their children’s sex.

The Health and Medical Research Council is reviewing whether to allow any parents who use IVF to select their baby’s gender.

The practice is currently only allowed when there is a risk that parents will pass on genetic diseases.

The Federal Health Minister Nicola Roxon says the Government has no plans to overturn the ban.

“I must say on a personal level I am very apprehensive about such a change,” she said.

“I’m happy to see any review of the science and the arguments that people might want to make for and against the case.

“But I need to flag that the governments had not set down the path because we want to make any changes, and at a personal level I’m very uncomfortable about the suggestions that a change might be made.”

Leading IVF specialist Professor Gab Kovacs says that is ridiculous and not allowing parents to choose the sex of their child could have negative results.

“If a couple are determined enough to go through IVF rather than natural pregnancy to have a child of one particular sex, then it’s possible that if they have a child of the opposite sex, that child may not be as appreciated and well looked after,” he said.

Professor Kovacs says parents can already travel to countries like the US and Thailand to choose their child’s gender.

He says if parents are willing to pay up to $15,000 for the technique, then they should be allowed.

“There are a small number of couples who are so determined they want a child of a particular sex, they’re prepared to go for the cost and the difficulty of IVF to get pregnant, rather than just do it naturally,” he said.

“I can’t see any reason why it should be forbidden. I’ve seen a number of couples who have maybe three or four children of one particular sex and they’re very keen on family balancing. That’s the type of couple that most often ask about sex selection.”

Dr Sandra Hacker, chair of the council’s Australian Health Ethics Committee, says the review will consider all sides of the controversial and emotive issue.

She says previous consultations have found the majority of Australians are opposed to the practice being widely available.

“There is considerable interest from the general public about this,” she said.

“But on the other hand, the idea that gender selection should be available for reasons other than genetic abnormalities seems to be one that has a general disaffection within the general population.”

Boy or girl? Push for parents to choose

Couples in Australia having fertility treatment could soon be able to choose their babies’ sex.

Sex selection is only allowed in Australia when there is a risk that parents will pass on genetic diseases.

The five-year moratorium on the practice expires this year and the National Health and Medical Research Council is reviewing whether to continue the general ban.

But the Government is yet to be convinced it is the right move.

Dr Sandra Hacker, chair of the council’s Australian Health Ethics Committee, says the review will consider all sides of the controversial and emotive issue.

She says previous consultations have found the majority of Australians are opposed to the practice being widely available.

“There is considerable interest from the general public about this,” she said.

“But on the other hand, the idea that gender selection should be available for reasons other than genetic abnormalities seems to be one that has a general disaffection within the general population.”

Professor Gab Kovacs, the international medical director of Monash IVF, says if parents are willing to pay up to $15,000 for the technique, then they should be allowed.

“There are a small number of couples who are so determined they want a child of a particular sex, they’re prepared to go for the cost and the difficulty of IVF to get pregnant, rather than just do it naturally,” he said.

“I can’t see any reason why it should be forbidden. I’ve seen a number of couples who have maybe three or four children of one particular sex and they’re very keen on family balancing. That’s the type of couple that most often ask about sex selection.”

Professor Kovacs says some parents already travel to countries like the United States and Thailand to choose the sex of their children.

He says it is ridiculous the practice is not available here in Australia.

“If a couple are determined enough to want to go through IVF rather than natural pregnancy to have a child of one particular sex, then it’s possible that if they have a child of the opposite sex, that child may not be as appreciated and well looked after, as if they were able to choose the sex they wanted,” he said.

“So in fact it may have been in the best interests of the child to allow this to happen.”

Federal Health Minister Nicola Roxon says the Government has no plans to overturn the ban.

“I’m happy to see any review of the science and the arguments that people might want to make for and against the case,” she said,

“But I need to flag that the governments had not set down the path because we want to make any changes, and at a personal level I’m very uncomfortable about the suggestions that a change might be made.”

Master gene that switches on disease-fighting cells identified

London, Sep 14 (ANI): British scientists have identified the master gene, called E4bp4, that causes blood stem cells to turn into disease-fighting ‘Natural Killer’ (NK) immune cells.

The discovery, by researchers at Imperial College London, UCL and the Medical Research Council’s National Institute for Medical Research, could one day help scientists boost the body’s production of these frontline tumour-killing cells, creating new ways to treat cancer.

By ‘knocking out’ E4bp4 in a mouse model, the researchers created the world’s first animal model entirely lacking NK cells, but with all other blood cells and immune cells intact.

The breakthrough model should help solve the mystery of the role that Natural Killer cells play in autoimmune diseases, such as diabetes and multiple sclerosis.

According to many scientists, these diseases are a result of malfunctioning NK cells that turn on the body and attack healthy cells, which cause disease instead of fighting it.

They believe that clarifying NK cells’ role could lead to new ways of treating these conditions.

Natural Killer cells – a type of white blood cell – are a major component of the human body’s innate, quick-response immune system, providing a fast frontline defence against tumours, viruses and bacterial infections.

The gene E4bp4 is the ‘master gene’ for NK cell production, which means it is the primary driver that causes blood stem cells in the bone marrow to differentiate into NK cells.

Led by Dr Hugh Brady, the researchers are hoping to progress with a drug treatment for cancer patients which reacts with the protein expressed by their E4bp4 gene, causing their bodies to produce a higher number of NK cells than normal, to increase the chances of successfully destroying tumours.

“If increased numbers of the patient’s own blood stem cells could be coerced into differentiating into NK cells, via drug treatment, we would be able to bolster the body’s cancer-fighting force, without having to deal with the problems of donor incompatibility,” Nature quoted Brady as saying.

The researchers proved the pivotal role E4bp4 plays in NK production when they knocked the gene out in a mouse model.

Without E4bp4 the mouse produced no NK cells whatsoever but other types of blood cell were unaffected.

“Now finally, with our discovery of the NK cell master gene and subsequent creation of our mouse model, we will be able to find out if the progression of these diseases is impeded or aided by the removal of NK cells from the equation. This will solve the often-debated question of whether NK cells are always the ‘good guys’, or if in certain circumstances they cause more harm than good,” said Brady.

The study has been published in Nature Immunology. (ANI)

Lower IQ ‘a risk factor for heart disease’

Washington, July 15 (ANI): A new study, conducted by researchers in the UK, has shown that having a lower than average IQ is in itself a risk factor for heart disease.

In the study of over 4,000 people, Dr David Batty and his colleagues at the University of Glasgow and the University of Edinburgh found that IQ alone explained more than 20 percent of the difference in mortality between high and low socio-economic groups.

The researchers found that the results were the same even when known heart disease risk factors were taken into account.

“We already know that socio-economically disadvantaged people have worse health and tend to die earlier from conditions such as heart disease, cancer and accidents,” the BBC quoted Dr David Batty, who led the research for the Wellcome Trust and the Medical Research Council, a saying.

“Environmental exposures and health-related behaviours, such as smoking, diet and physical activity, can explain some of this difference, but not all of it,” he added.

The research team studied a group of 4,289 former US soldiers from all walks of life.

As expected from past trends, those on low incomes and with less education had a higher risk of dying from cardiovascular disease.

However, when the researchers took into account intelligence or cognitive function, commonly referred to as IQ, and controlled for nine other known heart disease risk factors, IQ alone explained 23 percent of the differences in mortality between the highest and lowest socio-economic groups in the study.

They offer several possible explanations for this – low IQ scores might simply be a marker of underlying poor health or intelligence might lead to greater knowledge about how to keep healthy.

Batty said, whatever the explanation, the findings imply the IQ of the public should be considered more carefully when preparing health promotion campaigns.

“I think the public health messages on things like diet, exercise and smoking could be simplified,” Batty said.

“For instance, we often read about how some types of alcohol are good for you while others, or even the same ones, are not. The messages can be difficult to interpret, even by knowledgeable people,” he added.

The study has been published in the European Heart Journal. (ANI)

Scientists find way to stop cancers seed in brain

LONDON: British scientists may have found a way to stop cancers spreading to the brain. The research team discovered that cancer cells hijack the brain’s blood vessels to get all the nourishment they need to seed themselves there.

Boffins believe that the key to this is a protein on the surface of cancer cells called integrin that allows them to stick to the vessels, PLoS ONE journal reports.

Researchers at Oxford University, with funding from Cancer Research UK, the Medical Research Council and the US National Institutes of Health, wanted to investigate exactly how cancers spread.

After analyses, Dr Shawn Carbonell and his team found that the metastatic cancer cells start to grow on the walls of blood vessels in the brain in over 95 percent of cases, and not on the nerve cells.

“We have identified the protein that cancer cells use to anchor themselves to blood vessels in the brain. Now we can try to come up with drugs to target this protein and stop metastatic cancer cells from taking hold in the brain,” The BBC quoted Carbonell, as saying.

Brain area that makes person sociable identified

Washington, May 20 (ANI): Whether someone is a ‘people-person’ may depend on their brain’s structure, say researchers.

The greater the concentration of brain tissue in certain parts of the brain, the more likely they are to be a warm, sentimental person, Cambridge University researchers added.

To reach the conclusion, Maël Lebreton and colleagues from the Cambridge Department of Psychiatry, in collaboration with Oulu University, Finland, examined the relationship between personality and brain structure in 41 male volunteers.

The volunteers underwent a brain scan using Magnetic Resonance Imaging (MRI). They also completed a questionnaire that asked them to rate themselves on items such as ‘I make a warm personal connection with most people’, or ‘I like to please other people as much as I can’. The answers to the questionnaire provide an overall measure of emotional warmth and sociability called social reward dependence.

The researchers then analysed the relationship between social reward dependence and the concentration of grey matter (brain-cell containing tissue) in different brain regions. They found that the greater the concentration of tissue in the orbitofrontal cortex (the outer strip of the brain just above the eyes), and in the ventral striatum (a deep structure in the centre of the brain), the higher they tended to score on the social reward dependence measure.

The research is published in the European Journal of Neuroscience.

Dr Graham Murray, who is funded by the Medical Research Council and who led the research, said: “Sociability and emotional warmth are very complex features of our personality. This research helps us understand at a biological level why people differ in the degrees to which we express those traits.”

But he cautioned, “As this research is only correlational and cross-sectional, it cannot prove that brain structure determines personality. It could even be that your personality, through experience, helps in part to determine your brain structure.” (ANI)

Chemical cocktail ‘puts baby boys at cancer, infertility risk’

London, May 14 (ANI): Gender-bending chemicals found in many food, cosmetic and cleaning products put unborn baby boys at greater risk of developing cancer and infertility later in life, a leading scientist has warned.

According to Professor Richard Sharpe, of the Medical Research Council, the hormone-disrupting chemicals are “feminising” boys in the womb.

While explaining the harmful effects, the expert linked the chemicals to raising rates of birth defects and testicular cancer and falling sperm counts.

Sharpe, one of Britain’s leading reproductive biologists, added that the chemicals block the action of the male sex hormone testosterone, or mimic the female sex hormone oestrogen, reports The BBC.

Chemicals in consumer products and food that have been reported to disrupt the sex hormones include:

Phthalates: Found in vinyl flooring, plastics, soaps, toothpaste

Pesticides: Including pyrethroids, linuron, vinclozolin and fenitrothion

The report by Sharpe was commissioned by the CHEM Trust, a charity which works to protect humans and wildlife from harmful chemicals.

Sharpe said: “Because it is the summation of effect of hormone-disrupting chemicals that is critical, and the number of such chemicals that humans are exposed to is considerable, this provides the strongest possible incentive to minimise human exposure to all relevant hormone disruptors, especially women planning pregnancy, as it is obvious that the higher the exposure the greater the risk.” (ANI)

Scary anti-drinking ads don’t work, says leading expert

Melbourne, Apr 28 (ANI): Advertising campaigns designed to tackle problems such as alcohol among youngsters fail to work, says a prominent communications expert.

Noel Turnbull, adjunct professor in the School of Applied Communications at RMIT University, who is now a director of DrinkWise Australia, said that young people “think they’re immortal”.

“They simply don’t believe the risks are as great as other people say,” News.com.au quoted him as saying.

Pushing for a longer-term approach to tackling alcohol abuse, Turnbull has warned against approaches that “generate widespread community hostility and seek to control the bulk of moderate consumers of alcohol as if they were people with significant alcohol problems”.

While ridiculing on draft guidelines the National Health and Medical Research Council issued last year, he said that the Australian politicians might have been misled by their own campaign advertisements.

He said: “One of the reasons why governments like fear is that is the sort of advertising they do in a political context.

“They’ve demonstrated that negative advertising works when it comes to elections and assume that it also works when it comes to other forms of behavioural change, but the evidence for that is not quite so strong.”

On the other hand, Turnbull insisted that using social marketing to change behaviour would be a better approach.

He said: “We’re not going to solve social problems purely and simply by regulating them out of existence. We have to actually build social capital.

“It’s no good telling people this is the wrong thing to do. Long-term solutions are about building social capital and people’s own capacity to change.”

Turnbull will present his ideas at the forum of DrinkWise- an education body funded by the federal Government and the liquor industry. (ANI)

Statins have no role in preventing Alzheimer’s disease

Washington, Apr 15 (ANI): Statins, the most successful class of cholesterol-lowering medicines, have no role in preventing Alzheimer’s Disease (AD), according to a new review of studies.

Statins includes medications like atorvastatin (Lipitor) and pravastatin (Pravachol), which are some of the best-selling drugs in the world.

The drugs lower cholesterol by inhibiting a key enzyme used by the body to make it, which decreases cholesterol formation and helps reduce the amount of low-density lipoprotein (LDL or “bad” cholesterol).

“From these trials, which contained very large numbers and were the gold standard … it appears that statins given in late life to individuals at risk of vascular disease do not prevent against dementia. I feel the follow-up time was sufficient to allow for an effect to appear,” said lead study author Bernadette McGuinness, a senior clinical research fellow in geriatric medicine at Queen’s University in Belfast, Ireland.

Many studies have shown that elevated serum cholesterol levels may lead to AD, and thus lowering them could prevent the neurological disorder.

The review comprised 26,340 participants in two major studies.

One study, the Medical Research Council/British Heart Foundation Heart Protection Study (HPS), looked at simvastatin (Zocor) use in 20,536 patients and followed them for five years.

The other study, the PROSPER trial, looked at pravastatin use in 5,804 patients, with an average follow-up of 3.2 years.

Both studies were double-blind randomised, placebo-controlled studies of statin medications in individuals at risk for dementia and Alzheimer disease and had participants between the ages of 40 and 82 in total.

The review showed no evidence that statin medications were harmful to cognition.

Also the review authors found no difference between patients receiving the medications and patients receiving placebo medications, when it came to incidence of dementia, cognitive function or performance on specific neuropsychological tests, such as a picture word-learning test.

Dr. Beatrice Golomb, of the department of family and preventive medicine at the University of California, San Diego, said that some randomised trials had shown that the net effect of statin medications was significantly adverse and others had shown it was neutral.

However, she claimed that none had shown that using statin could be favourable for cognition.

The new review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. (ANI)

Male circumcision cuts HIV risk

Washington, Apr 15 (ANI): Male circumcision reduces the risk of contracting HIV in heterosexual men, concludes a new study.

“Research on the effectiveness of male circumcision for preventing HIV in heterosexual men is conclusive. No further trials are required to establish that HIV infection rates are reduced in heterosexual men for at least the first two years after circumcision,” says lead researcher Nandi Siegfried, Co-director of the South African Cochrane Centre at the South African Medical Research Council.

“Policy makers can consider implementing circumcision as an additional measure into HIV prevention programmes,” Nandi added.

Circumcision may help to protect against HIV by removing cells in the foreskin to which the virus is specifically attracted. Called Langerhans cells, they display receptors that enable HIV entry. Previous non-randomised studies investigated the association between circumcision and HIV, but until now, Cochrane researchers have been unable to make strong recommendations for the intervention due to a lack of high quality evidence gained from randomised clinical trials.

The clinical trials included in the review took place in South Africa, Uganda, and Kenya between 2002 and 2006, and included a total of 11,054 men. The results show that circumcision in heterosexual men significantly reduces their risk of acquiring HIV by 54 percent over a two year period, compared with uncircumcised men. This reduced risk is the best estimate of the average effect and the researchers report that the true risk will be reduced by between 38 to 66 percent.

Further research, however, is required to establish whether male circumcision offers any benefit to women partners of circumcised men and homosexual men.

The researchers warn that policy makers also need to think about the culture and environment in which circumcision is carried out.

“In many countries, male circumcision is practiced as part of the rites of initiation by traditional healers who are not trained in aseptic surgical techniques. So adverse events following traditional circumcisions can be high,” says Nandi. (ANI)

There’s ‘no safe amount’ of alcohol for teens, say researchers

Melbourne, Apr 13 (ANI): Researchers from Murdoch Children’s Research Institute in Melbourne have revealed that there is no safe level of drinking for teenagers, as even moderate amounts could lead to alcohol abuse or promote risky sexual behaviour.

According to the Fairfax newspapers, the new study casts doubt on national guidelines that suggest there is a “low risk” level of drinking for under-18s.

Experts have urged to move away from “harm minimisation” approach to teenage drinking, and appeal to initiate a campaign to raise the legal drinking age, reports News.com.au

The research involving 1520 young people’s drinking habits from the mid-teens, showed no “safe” or “sensible” level of drinking for adolescents.

The official guidelines from the National Health and Medical Research Council define a “low risk” level of drinking for adults as fewer than three standard drinks a day.

However, the new study has shown that even at this level, teenagers increased their chances of alcohol abuse, social or legal problems, or alcohol-related high-risk sexual behaviours 10 years later. (ANI)

Two drinks a day can raise death risk

Melbourne, Mar 7 (ANI): Australia’s new guideline on alcohol consumption has stated that two alcoholic drinks a day can put people at a greater risk of dying.

The guidelines, which were released on March 6 by Australia’s top health advice body, warn that the health benefits of alcohol have been overstated.

It said that someone consuming two drinks a day has nearly one chance in 100 of dying from alcohol-induced injury or illness, than they do from drowning, being in a pedestrian accident or an accidental fall.

That compares with a one-in-683 lifetime risk of drowning, a one-in-403 risk of being in a pedestrian accident and a one-in-125 risk of a fatal fall, the Weekend Australian reports.

World-first modelling of the health risks of alcohol shows that above two drinks a day, the dangers escalate quickly – taking drinkers closer to better-recognised dangers such as car crashes (one in 54), cancer (one in four) and heart disease (one in four).

The guidelines, published by the National Health and Medical Research Council, also recommend that adults drink no more than four drinks on any one occasion.

Health groups greeted the guidelines, which halve limits set in 2001, enthusiastically.

Despite renewed concern from some experts that many Australians might ignore the advice, some organisations called for even tougher steps.

The Victorian Health Promotion Foundation called for mandatory health warnings reflecting the new advice to be put on all alcoholic products, while the Cancer Council Australia said it would have preferred the daily drinking limit for women to be halved again, to one drink.

Jon Currie, chairman of the NHMRC committee that compiled the new advice, said the guidelines were “not telling you what you can and can’t do”, but were instead designed to help Australians make informed choices about health risks.

He said the health benefits of alcohol had been exaggerated and that any positive effect could be achieved by consuming just one drink every two days. In addition, any benefit would affect only middle-aged and elderly people.

“There is no level of drinking alcohol that can be guaranteed by scientific evidence as being completely safe,” News.com.au quoted Currie as saying.

However, the guidelines have already come in for the same criticism they attracted when released in draft form in October 2007, when they were attacked by some experts as too removed from most people’s experience.

Alex Wodak, director of the alcohol and drug service at St Vincent’s Hospital in Sydney, said he feared the gap between the two-drink recommended limit and many people’s habits would not work.

“I fear these recommendations will be dismissed by many people,” he stated. (ANI)

Doodling can help boost brainpower

Washington, Feb 27 (ANI): People who covered their notepads with scribbles may not have had entirely wasted the goal behind attending a dull meeting, suggests a new study, which found that doodling while listening can help with remembering details.

As per the study, which has been published in the journal Applied Cognitive Psychology, subjects given a doodling task while listening to a dull phone message had a 29 percent improved recall compared to their non-doodling counterparts.

To reach the conclusion, forty members of the research panel of the Medical Research Council’s Cognition and Brain Sciences Unit in Cambridge were asked to listen to a two and a half minute tape giving several names of people and places, and were told to write down only the names of people going to a party.

Twenty of the participants were asked to shade in shapes on a piece of paper at the same time, but paying no attention to neatness. Participants were not asked to doodle naturally so that they would not become self-conscious.

None of the participants were told it was a memory test.

After the tape had finished, all participants in the study were asked to recall the eight names of the party-goers which they were asked to write down, as well as eight additional place names which were included as incidental information.

The doodlers recalled on average 7.5 names of people and places compared to only 5.8 by the non-doodlers.

“If someone is doing a boring task, like listening to a dull telephone conversation, they may start to daydream,” said study researcher Professor Jackie Andrade, Ph.D., of the School of Psychology, University of Plymouth.

“Daydreaming distracts them from the task, resulting in poorer performance. A simple task, like doodling, may be sufficient to stop daydreaming without affecting performance on the main task,” the expert added.

“In psychology, tests of memory or attention will often use a second task to selectively block a particular mental process. If that process is important for the main cognitive task then performance will be impaired. My research shows that beneficial effects of secondary tasks, such as doodling, on concentration may offset the effects of selective blockade,” added Andrade.

“This study suggests that in everyday life doodling may be something we do because it helps to keep us on track with a boring task, rather than being an unnecessary distraction that we should try to resist doing,” the expert concluded. (ANI)

Too much coffee ‘triples hallucination risk’

Washington, Jan 14 (ANI): Too much coffee not just makes napping difficult but also dramatically increases the risk of hallucinating, according to a new study.

The research has found that people with a higher caffeine intake, from sources such as coffee, tea and caffeinated energy drinks, are more likely to report hallucinatory experiences such as hearing voices and seeing things that are not there.

‘High caffeine users’ can be defined as those individuals who consume more than the equivalent of seven cups of instant coffee a day.

Such drinkers were three times more likely to have heard a person’s voice when there was no one there compared with ‘low caffeine users’ who consumed less than the equivalent of one cup of instant coffee a day, the study found.

In the study, funded by the Economic and Social Research Council and the Medical Research Council, 200 students were asked about their typical intake of caffeine containing products, such as coffee, tea and energy drinks as well as chocolate bars and caffeine tablets.

Their proneness to hallucinatory experiences, and their stress levels, were also assessed. Seeing things that were not there, hearing voices, and sensing the presence of dead people were amongst the experiences reported by some of the participants.

The researchers, whose paper is published in the academic journal Personality and Individual Differences, say their finding could be down to the fact that caffeine has been found to exacerbate the physiological effects of stress.

When under stress, the body releases a stress hormone called cortisol. More of this stress hormone is released in response to stress when people have recently had caffeine. It is this extra boost of cortisol which may link caffeine intake with an increased tendency to hallucinate, say the scientists.

Lead author, Simon Jones, a PhD student at Durham University’s Psychology Department, said: “This is a first step towards looking at the wider factors associated with hallucinations. Previous research has highlighted a number of important factors, such as childhood trauma, which may lead to clinically relevant hallucinations.

“Many such factors are thought to be linked to hallucinations in part because of their impact on the body’s reaction to stress. Given the link between food and mood, and particularly between caffeine and the body’s response to stress, it seems sensible to examine what a nutritional perspective may add.” (ANI)

Too much coffee ‘triples hallucination risk’

Washington, Jan 14 (ANI): Too much coffee not just makes napping difficult but also dramatically increases the risk of hallucinating, according to a new study.

The research has found that people with a higher caffeine intake, from sources such as coffee, tea and caffeinated energy drinks, are more likely to report hallucinatory experiences such as hearing voices and seeing things that are not there.

‘High caffeine users’ can be defined as those individuals who consume more than the equivalent of seven cups of instant coffee a day.

Such drinkers were three times more likely to have heard a person’s voice when there was no one there compared with ‘low caffeine users’ who consumed less than the equivalent of one cup of instant coffee a day, the study found.

In the study, funded by the Economic and Social Research Council and the Medical Research Council, 200 students were asked about their typical intake of caffeine containing products, such as coffee, tea and energy drinks as well as chocolate bars and caffeine tablets.

Their proneness to hallucinatory experiences, and their stress levels, were also assessed. Seeing things that were not there, hearing voices, and sensing the presence of dead people were amongst the experiences reported by some of the participants.

The researchers, whose paper is published in the academic journal Personality and Individual Differences, say their finding could be down to the fact that caffeine has been found to exacerbate the physiological effects of stress.

When under stress, the body releases a stress hormone called cortisol. More of this stress hormone is released in response to stress when people have recently had caffeine. It is this extra boost of cortisol which may link caffeine intake with an increased tendency to hallucinate, say the scientists.

Lead author, Simon Jones, a PhD student at Durham University’s Psychology Department, said: “This is a first step towards looking at the wider factors associated with hallucinations. Previous research has highlighted a number of important factors, such as childhood trauma, which may lead to clinically relevant hallucinations.

“Many such factors are thought to be linked to hallucinations in part because of their impact on the body’s reaction to stress. Given the link between food and mood, and particularly between caffeine and the body’s response to stress, it seems sensible to examine what a nutritional perspective may add.” (ANI)

Vitamin D deficiency linked to multiple sclerosis susceptibility ‘gene’

Washington, February 6 (ANI): A group of scientists have shown that a direct interaction between vitamin D and a common genetic variant alters the risk of developing multiple sclerosis (MS), the most common disabling neurological condition.

Researchers at the University of Oxford and the University of British Columbia also say that their study suggests that vitamin D deficiency during pregnancy, and the early years, may increase the risk of the offspring developing MS later in life.

A research article in the open-access journal PLoS Genetics reveals that the study was funded by the UK’s MS Society, the MS Society of Canada, the Wellcome Trust and the Medical Research Council.

It shows that proteins activated by vitamin D in the body bind to a particular DNA sequence, which lies next to the gene variant known as DRB1*1501, and switch on the gene as a consequence.

“In people with the DRB1 variant associated with MS, it seems that vitamin D may play a critical role. If too little of the vitamin is available, the gene may not function properly,” says co-author Dr Julian Knight.

“We have known for a long time that genes and environment determine MS risk. Here we show that the main environmental risk candidate – vitamin D – and the main gene region are directly linked and interact,” says Professor George Ebers, University of Oxford.

The researchers reckon that vitamin D deficiency in mothers, or even in a previous generation, may lead to altered expression of DRB1*1501 in offspring.

“Our study implies that taking vitamin D supplements during pregnancy and the early years may reduce the risk of a child developing MS in later life,” says lead author Dr Sreeram Ramagopalan.

“Vitamin D is a safe and relatively cheap supplement with substantial potential health benefits. There is accumulating evidence that it can reduce the risk of developing cancer and offer protection from other autoimmune diseases,” he adds.

Welcoming the research, MS Society’s UK Chief Executive Simon Gillespie said: “These remarkable results tie together leading theories about the environment, genes and MS but they are only part of the jigsaw. This discovery opens up new avenues of MS research and future experiments will help put the pieces together.” (ANI)