Mayawati slams Congress party’s austerity drive

Lucknow, Sep 18 (ANI): Uttar Pradesh Chief Minister Mayawati has ridiculed Congress party’s austerity drive, terming it as a ploy to steer attention away from the steep price rise.

Addressing a mass rally here on Thursday, Mayawati hit out at the Congress party, calling its austerity drive “a drama.”

“Because of the wrong doings by the Congress government at the centre, the prices are rising due to which poor people across the country are suffering. And now to cover up its weaknesses, they have cut down on its travelling expenses by flying economy class and travelling by train. All this is just a drama,” Mayawati said.

“With a drought looming and elections in some states approaching, the Congress-led government has embarked on a much-publicised austerity drive,” she added.

In a country where the hierarchy of politicians is determined by the size of their bungalows and their convoys, Congress Party President Sonia Gandhi has asked party leaders to give up a fifth of their salaries for drought-relief work, and she flew economy class on a commercial flight to Mumbai to launch the poll campaign.

The finance ministry has appealed for fewer overseas trips with smaller entourages, and a ban on conferences in luxury hotels.

Bharatiya Janata Party and other political parties have criticised the austerity measures in view of the economic downturn and drought-like situation prevailing in the country as a case of ‘tokenism’. (ANI)

How some people maintain weight loss, others don’t

Washington, Sep 16 (ANI): Ever wondered how some people successfully maintain a significant weight loss, while others tend to regain the weight? Well, researchers at The Miriam Hospital attribute such tendencies to a difference in brain activity patterns.

The researchers showed that when individuals who had kept the weight off for several years were shown pictures of food, they were more likely to engage the areas of the brain associated with behavioural control and visual attention, as compared to obese and normal weight participants.

The findings of the study suggest that successful weight loss maintainers may learn to respond differently to food cues.

“Our findings shed some light on the biological factors that may contribute to weight loss maintenance. They also provide an intriguing complement to previous behavioral studies that suggest people who have maintained a long-term weight loss monitor their food intake closely and exhibit restraint in their food choices,” said lead author Dr. Jeanne McCaffery.

Long-term weight loss maintenance continues to be a major problem in obesity treatment.

Participants in behavioural weight loss programs lose an average of 8 to 10 percent of their weight during the first six months of treatment, and will maintain approximately two-thirds of their weight loss after one year.

However, despite intensive efforts, weight regain appears to continue for the next several years, with most patients returning to their baseline weight after five years.

The researchers used functional magnetic resource imaging (fMRI) to study the brain activity of three groups- 18 individuals of normal weight, 16 obese individuals (defined as a body mass index of at least 30), and 17 participants who have lost at least 30 lbs and have successfully maintained that weight loss for a minimum of three years.

When the participants were shown pictures of food items after a four-hour fast, it was found that those in the successful weight loss maintenance group responded differently to these pictures compared to the other groups.

Specifically, researchers observed strong signals in the left superior frontal region and right middle temporal region of the brain – a pattern consistent with greater inhibitory control in response to food images and greater visual attention to food cues.

“It is possible that these brain responses may lead to preventive or corrective behaviors – particularly greater regulation of eating – that promote long-term weight control. However, future research is needed to determine whether these responses are inherent within an individual or if they can be changed,” said McCaffery.

The study has been published in the American Journal of Clinical Nutrition. (ANI)

Popular diabetes drug may help fight breast cancer

Washington, Sept 15 (ANI): A popular diabetes drug called metformin has been found to be effective in fighting breast cancer.

The findings of the study from Harvard Medical School showed that metformin, along with conventional chemotherapy, shows promise for treating and delaying recurrence of breast cancer.

“We have found a compound selective for cancer stem cells,” said senior author Kevin Struhl, the David Wesley Gaiser professor of biological chemistry and molecular pharmacology at HMS.

“What’s different is that ours is a first-line diabetes drug,” he added.

The drug seemed to work independently of its ability to improve insulin sensitivity and lower blood sugar and insulin levels, all of which are also associated with better breast cancer outcomes.

“There is a big desire to find drugs specific to cancer stem cells,” said Struhl.

“The cancer stem cell hypothesis says you cannot cure cancer unless you also get rid of the cancer stem cells. From a purely practical point of view, this could be tested in humans. It’s already used as a first-line diabetes drug,” he added.

Lead researchers Heather Hirsch and Dimitrios Iliopoulos found that the combination of metformin and the cancer drug doxorubicin killed human cancer stem cells and non-stem cancer cells in culture.

In mice, pre-treatment with the diabetes drug prevented the otherwise dramatic ability of human breast cancer stem cells to form tumours.

In cases where tumours were allowed to take hold for 10 days, the dual therapy also reduced tumour mass more quickly and prevented relapse for longer than doxorubicin alone.

“This is an exciting study,” said Jennifer Ligibel, a medical oncologist at Dana-Farber Cancer Institute and an HMS instructor in medicine, who was not involved in the study.

“There is a lot of interest in studying metformin in breast cancer, but so far we do not have direct evidence that metformin will improve outcomes in patients,” Ligibel said. “That’s what this trial is for.”

The findings appear online in the journal Cancer Research. (ANI)

Chidambaram discusses counter-terrorism, 26/11 update with US officials

Washington, Sept 10 (ANI): Indian Home Minister P. Chidambaram held meetings here with senior Obama administration officials, including National Security Advisor Lt. Gen. (retired) James Jones, Homeland Security Secretary Janet Napolitano and the U.S. Attorney General Eric H Holder Jr. on Wednesday.

Enhanced co-operation between India and US on tackling terrorism particularly in South Asia dominated the discussions, sources said.

Pakistan’s inaction in dealing with the perpetrators of 26/11 was also raised.

Chidambaram also met Senator Dianne Feinstein, the Chairwoman of Senate Select Committee on Intelligence.

Chidambaram is scheduled to meet the Secretary of State Hillary Clinton on Thursday.

On Tuesday, officials from FBI, intelligence and security agencies and the New York Police briefed Chidambaram about the measures being taken by them to prevent a Mumbai-type terrorist attack.

From walking at the Penn Station, to a briefing by the New York Police, which had made several changes in its counter-terrorism measures post the 26/11 attacks, Chidambaram and his team of officials got to know what a mega city like New York can do to protect itself from terrorists without inconveniencing its residents.

Chidambaram was also informed about the coast guard facility at Staten Island. It was an important aspect of his trip given that the terrorists who attacked Mumbai on November 26 last year entered Mumbai through the sea route.

Within hours of his landing in New York, Chidambaram visited the Joint Terror Task Force Centre of the FBI where he was given an exclusive briefing by the New York Police Department.

Before leaving New York City for Washington by train, Chidambaram was briefed about security of the Mass Transport System at the Penn station.

The Home Minister is also scheduled to meet the top US intelligence and security officials, including FBI Director Robert Mueller and Director of National Intelligence Dennis C Blair; besides meeting National Security Adviser, Gen (Retd) James Jones at the White House. A tour of the National Counter-terrorism Centre in Virginia is also on his itinerary.

Besides meeting experts and think-tanks” members, Chidambaram is expected to hold talks with key US lawmakers, including Senator Joe Lieberman, Chairman, Senate Homeland Security and Governmental Affairs Committee; and Congressman Sylvester Reyes, Chairman, House Select Committee on Intelligence. (ANI)

Syringe attacks continue in Urumqi despite death penalty warning

Urumqi (China), Sep. 9 (ANI): Despite a death penalty warning, 77 cases of needle attack were reported between Sunday and Monday evenings in Urumqi, the capital of Xinjiang Uygur autonomous region, police say.

So far, police have caught 45 suspects during the syringe scare, of whom 12 remain in police custody.

The procuratorate has approved the arrests of four. Eight people have been sent to drug rehab, according to Urumqi police authorities.

Despite signs of recovery in the city after assaults caused fear among residents and triggered mass protests, the Urumqi municipal government implemented traffic control Monday night on the city’s main streets.

Shops and businesses in the city center were ordered to close early. The control lasted from 9 pm Monday to 9 am Tuesday.

The Public Security Department of the Xinjiang Uygur autonomous region reiterated syringe attackers must be given punishment in order to protect residents and maintain social order.

The pledge followed a joint notice on Sunday of the court, the prosecutor’s office and the police bureau of Urumqi, which said an attacker may face a life sentence or even the death penalty.he department emphasized that those who stab others, no matter what means they use, are considered to have committed crimes and must be punished according to law.

Those who pretend to suffer syringe attacks and cause fear among the public will also face punishment, according to the public notice. (ANI)

Chidambaram meets FBI, New York Police officials, gets anti-terrorism tips

New York/Washington, Sep.9 (ANI): India’s Home Minister P. Chidambaram on Tuesday, was briefed by officials from FBI, intelligence and security agencies and the New York Police about the measures being taken by them to prevent a Mumbai-type terrorist attack.

From walking at the Penn Station, to a briefing by the New York Police, which had made several changes in its counter-terrorism measures post the 26/11 attacks, Chidambaram and his team of officials got to know what a mega city like New York can do to protect itself from terrorists without inconveniencing its residents.

Chidambaram was also informed about the coast guard facility at Staten Island. It was an important aspect of his trip given that the terrorists who attacked Mumbai on November 26 last year entered Mumbai through the sea route.

Within hours of his landing in New York, Chidambaram visited the Joint Terror Task Force Centre of the FBI where he was given an exclusive briefing by the New York Police Department.

Before leaving New York City for Washington by train, Chidambaram was briefed about security of the Mass Transport System at the Penn station.

In Washington, Chidambaram will meet with top Obama Administration officials, heads of intelligence and security agencies and influential lawmakers over the next three days.

Apart from discussing the 26/11 dossiers that India has submitted to Pakistan,Chidambaram will also discuss issues related to combating financing of terrorism and steps which will need to be taken in this regard as well as with regard to prevention of money laundering.

Ways to strengthen Indo-US anti-terrorism cooperation are among the issues likely to figure prominently in the talks on Wednesday and Thursday.

Chidambaram will meet his counterpart Janet Napolitano; Secretary of State Hillary Clinton, Treasury Secretary Timothy Geithner and Attorney General Eric H Holder.

The Home Minister is also scheduled to meet the top US intelligence and security officials, including FBI Director Robert Mueller and Director of National Intelligence Dennis C Blair; besides meeting National Security Adviser, Gen (Retd) James Jones at the White House. A tour of the National Counter-terrorism Centre in Virginia is also on his itinerary.

Besides meeting experts and think-tanks’ members, Chidambaram is expected to hold talks with key US lawmakers, including Senator Joe Lieberman, Chairman, Senate Homeland Security and Governmental Affairs Committee; and Congressman Sylvester Reyes, Chairman, House Select Committee on Intelligence. (ANI)

Jet Airways sacks three pilot, calls strike illegal

New Delhi, Sep. 8 (ANI): Jet Airways, which had to cancel 190 flights by 2 p.m. on Tuesday due to mass sick leave taken by its pilots, has sacked three pilots.

The airliner has called the agitation illegal, and has secured a restraint order from Bombay High Court against any strike.

“The Bombay High Court has passed an order restraining any kind of strike,” Jet CEO Wolfgang Prock-Schauer was quoted as saying.

“We were assured by the National Aviators Guild last night that there would be no strike and we went by this assurance. But we were shocked by the mass sick leave by about 360 pilots… it is nothing but a simulated strike,” he added.

The Jet pilots have been protesting the sacking of two of their colleagues by the management for reportedly joining the guild.

Asked what action the management would take against the striking pilots and if the two-sacked pilots could be reinstated, Prock-Shauer declined to comment.

Prock-Schauer also said that he was confident about normal services by Wednesday.

“The matter is on in the Labour Commission and we would not like to comment,” he said.

Jet Airways had earlier sought the Directorate General of Civil Aviation”s (DGCA) intervention to resolve the crisis.

Last month, Jet Airways had terminated the services of two of its senior most pilots, saying their services were not required after both formed a trade union body within the company.

A conciliatory meeting was called on August 31 between the Jet Airways management and the union, which claims to have representation of over 650 pilots.

Jet Airways has 1000 pilots on its rolls.

Although the National Aviators Guild (NAG) has decided not to go on the proposed strike, its members have decided on an alternate course of protest like going on mass casual leave to hamper operations of the private carrier. (ANI)

Jet Airways pilots defiant, flights cancelled

New Delhi, Sep 8 (ANI): At least ten Jet Airways flights and its subsidiary out of Delhi were cancelled on Tuesday after a large number of pilots did not report to work in protest against the sacking of two of their colleagues.

According to airport sources, at least 10 early morning flights of Jet Airways and JetLite were cancelled, as the pilots failed to report for duty.

In a press statement Jet Airways said some pilots have resorted to a simulated strike by reporting sick.

Jet Airways had last month terminated the services of two of its senior most pilots, saying their services were not required after both formed a trade union body within the company.

A conciliatory meeting was called on August 31 between the Jet Airways management and the union, which claims to have a representation of over 650 pilots. Jet Airways has 1000 pilots on its rolls.

While the National Aviators Guild (NAG) has decided not to go on the proposed strike, its members have decided on an alternate course of protest like going on mass casual leave to hamper operations of the private carrier. (ANI)

Brit, Scot MPs to probe ex-PM Blair’s role in Lockerbie bomber’s release

London, Sep.6 (ANI): British and Scottish Members of Parliament are keen to know whether former Prime Minister Tony Blair played a role in a deal between Britain and Libya to secure the release of the Lockerbie bomber Abdel Baset Ali al-Megrahi at a meeting in a London club in 2003, long before either the Scottish government or Gordon Brown was involved.

According to The Independent, questions are being raised in Parliament over the meeting that Blair orchestrated that brought Libya in from the cold.

MPs are set to demand the minutes of an extraordinary cloak-and-dagger summit in London between British, American and Libyan spies held three days before Blair announced that Colonel Muammar Gaddafi was surrendering his weapons of mass destruction programme.

At the time of the secret meeting in December 2003 at the private Travellers Club in Pall Mall, London – for decades the favourite haunt of spies – Libyan officials were pressing for negotiations on the status of Megrahi, who was nearly three years into his life sentence at a Scottish jail.

Whitehall sources said the issue of Megrahi’s imprisonment was raised as part of the discussions, although it is not clear whether Britain or America agreed to a specific deal over his imprisonment, or a more general indication that it would be reviewed.

MPs are to investigate what was promised by Britain at the talks on December 16, 2003 and the role that Blair played in the affair.

Until now, the controversy over Megrahi’s release last month has centred on discussions between Gordon Brown’s government and the Scottish executive and Libya since 2007, with Blair apparently not involved in any way.

It has also focused on claims that the deal was related to oil deals, with Jack Straw admitting yesterday that BP’s interests in Libya played a “big part”.

But authoritative sources said the seeds for Megrahi’s release were sown in 2003, when Libya made the historic agreement to end its status as a pariah, and that the focus on oil and trade was a “red herring”.

Last night, a spokesman for Blair could not be drawn on the December 2003 meeting. (ANI)

American glaciers shrinking dramatically in response to global warming

Washington, September 6 (ANI): Reports indicate that most glaciers in Washington and Alaska in the US are dramatically shrinking in response to a warming climate.

During the past 50 years, USGS (US Geological Survey) scientists have measured changes in the mass (length and thickness) of three glaciers: Alaska’s Gulkana and Wolverine Glaciers and Washington’s South Cascade Glacier.

These are the longest such records in North America and among the longest in the world.

These three glaciers are known as benchmark glaciers because they are widely spaced, represent different climate regimes, and can be used to understand the thousands of other glaciers in nearby regions.

In addition to these three glaciers, more than 99 percent of America’s thousands of large glaciers have long documented records that show an overall shrinkage as climate warms. (ANI)

Assam football club creates swine flu awareness

Guwahati, Sep 5(ANI): With numerous cases of swine flu being detected in different parts of northeast, a local football club in Assam’s Guwahati city has taken up an initiative to create mass awareness about the deadly H1N1 virus through a football tournament.

In a tournament sponsored by Udyan Kristi Sangha, the Rainbow XI Club played the game wearing facemasks with an aim to create awareness about Swine Flu among the villagers, who have little knowledge about the disease.

“We are wearing mask and playing football to create awareness about swine flu among the villagers, so that they can be vigil and take necessary precautionary measures,” said Monoj Basumatary, a Rainbow Club player.

While, T. Medhi, a member of the organising committee, said: “Swine Flu is spreading and in this regard, the club from Odalbakra has done a fine job in creating awareness about the swine flu.”

In the first case of swine flu reported from the northeastern states, a 19-year-old Manipuri woman fencer who returned from a competition in Singapore tested positive for the disease.

While in Meghalaya, five persons have already tested positive for the H1N1 virus and in Assam, a law student who recently came to Guwahati also tested positive.

Authorities in the northeastern region have taken precautionary measures against the spread of swine flu. By Peter Alex Todd(ANI)

Immersion of Ganesha idols poses threat to aquatic life in Surat

Surat, Sep 5 (ANI): The immersion of thousands of idols during the recently concluded Ganesha festival in the waters of Ukai dam near Surat poses a pollution threat.

Most of the elaborately painted and decorated idols are worshipped before being taken in mass processions for immersion into nearby rivers, lakes and sea.

Environmentalists said the idols are mostly made of non-biodegradable material such as plastic, cement and plaster of Paris and painted using toxic dyes, which are harmful for mud, water and micro-organisms living in water.

“Idols immersed in water have polluted water in a big way. Chemicals and colours are used in making idols. All these are very harmful for mud, water and micro-organisms living in water both for short-term and long-term,” said Mohini Gadia, Professor, Aquatic Biology Department, Vir Namard University.

Devotees said that parts of the idols could seen floating in water, which was an insult to lord Ganpati.

“Due to lack of water, the idols could not be properly immersed in water. The remains of idols are lying all around. It is very unfortunate. This is an insult to lord Ganpati. The authorities concerned should think about this,” said Dhananjay Purohit, a devotee. (ANI)

High earners munch frequently at work, stay healthier

Washington, Sep 5 (ANI): People who earn more money are more likely to munch on muffins or chocolate bars while working, according to researchers at University of Texas at Austin.

What’s more, such people boost their chances of staying healthy – thanks to the regular munching.

Economist Daniel Hamermesh and his colleagues used data from the American Time Use Survey from the U.S. Bureau of Labor Statistics to reach the conclusion.

And they examined how much time Americans spend eating meals each day and how much time they spend “grazing” – snacking or drinking while working, watching TV or doing some other activity.

“When their time becomes more valuable, people substitute grazing for eating, essentially switching to multi-tasking. Overall, better health is associated with more time spent eating, but especially with spreading that time over more meals per day,” said Hamermesh.

It was found that over fifty percent of all adults graze each day, with their grazing time almost equalling the time they spend eating meals.

The average American adult spends about two-and-a-half hours eating or grazing every day.

The study also revealed that men graze less but spend more time eating meals than women. Overall, men spend about three-and-a-half more minutes a day eating meals than women.

It was also found that better-educated people eat more frequently, spend more total time eating, graze more frequently and spend more total time grazing than those with less education.

Higher earners also spend more time eating individual meals, graze more frequently and spend more time during each individual grazing episode.

Those who spend more time eating have a lower body mass index (BMI), on average, and view themselves as healthier than those who spend less time eating.

The National Bureau of Economic Research released the study recently. (ANI)

Further unrest in west China’s Urumqi region following syringe attacks

Urumqi (China), Sep 3(ANI): Following a spate of ethnically motivated syringe attacks in China’s Xinjiang province, renewed mass demonstrations and violence was reported in the region on Thursday.

Thousands of people gathered at the residential quarter of Xiaoximen, at Renmin Cinema and Beiyuanchun farmers’ produce wholesale market and demanded security assurance from authorities, Xinhua reports.

Local Police had detained 15 people and arrested four in connection with the attacks, but it did not say what ethnic group they belonged to.

In recent weeks, ethnic-fueled violence has plagued the city, following the riots that occurred between Uyghurs, who are predominantly Muslim, and ethnic Han Chinese, the majority group in China.

Unconfirmed reports of deaths in those riots range from 200 to many more. (ANI)

Marxist-Leninst activists stage protest against spiralling prices in West Bengal

Kolkata, Sep 3 (ANI): Members of the West Bengal state unit of the Communist Party of India (Marxist-Leninist)-Liberation, staged a mass protest against the risen prices of essential commodities here.

Over 500 protestors took out a procession holding banners and raising slogans against the State government.

They alleged that the Communist state government has created artificial shortage of essential commodities at the behest of hoarders and black-marketing traders.

“The callous government of West Bengal has failed to reduce the prices of essential commodities and failure to supply essential commodities to the PDS (Public Distribution System). They are supporting and patronising hoarders so that the artificial crisis increases,” said Partha Ghosh, Secretary, West Bengal State unit of Communist Party of India (Marxist-Leninist)-Liberation.

The Kolkata Police arrested some of the party supporters when they tried to violate the prohibitory orders in force.

The soaring prices of food grains, sugar and other items of daily needs because of weak monsoon and drought like situation, have created an explosive situation in India because of weak monsoon and drought like situation. (ANI)

Popular Arab TV Program exposes real Al Qaeda

Dubai, Sep.2 (ANI): The Al Arabiya satellite television channel has come up with a popular program titled “Death Making,” that exposes another side of Al Qaeda.

Hosted by female correspondent Rima Salha, the Dubai-based show is heading into its third year on Al Arabiya and aims to influence how the Arab world views Al Qaeda, reports Fox News.

It is a unique program that lets jihadists tell their stories, and then shows the results of their actions.

“It’s not enough to tell you that Al Qaeda is a terrorist organization. You have to understand why, what it means, how everything works, and what the end goal is for them,” Al Arabia’s general manager Abdul Rahman al-Rashed explains.

For her work, Salha, who is Lebanese, gets death threats, including when Osama bin Laden’s number two, Ayman al Zawahiri, singled the show and Al Arabiya out, by weaving video of both into one of his multi-media diatribes against mass media.

Despite the threats, Salah is undeterred. She goes to the jihadists, wherever they are: in refugee camps off limits even to security forces and to Iraq. She and her team convince subjects to talk to them. It’s not easy, but some of these militants apparently think they stand to benefit from a bit of publicity.

The topic of terrorism is so hot that Salha gets attacked from all sides. (ANI)

Smoking, overweighing up breast cancer risk

Washington, September 2 (ANI): A study conducted in Canada has reinforced the correlation between being overweight, smoking and breast cancer.

Published in the Journal of Cancer Epidemiology, the study is unique because it did not include subjects who were diagnosed for BRCA1 and BRCA2 gene mutations, which predispose women to breast cancer.

The study entirely focused on lifestyle factors like smoking, exercise, nutrition and weight.

All women analysed in the study were direct ancestors of the first French colonists.

“To our knowledge, this is the first study conducted on a sample of women without BRCA1 and BRCA2 gene mutations, which are often found in French-Canadian women,” said lead researcher Vishnee Bissonauth, a graduate of the Universite de Montreal’s Department of Nutrition, and a researcher at the Sainte-Justine University Hospital Research Center.

The study found that weight gains after the age of 20 increased the risk of breast cancer.

Where the weight gain was more than 15.5 kilos, the risk was found to increase by an average of 68 percent.

Risk increases depending on how late in life the weight gain occurs, according to the study.

Women who gained more than 10 kilos after age 30, or more than 5.5 kilos after age 40, were found to be almost twice as likely to suffer from breast cancer as a those whose weight was stable.

The study showed that the risk tripled if the body mass index was at its maximum after age 50.

Smoking a pack a day for nine years was also found to increase breast cancer risks by 59 percent.

Though the impact of smoking seemed to decrease for menopausal women, it remained at 50 percent.

Bissonauth stressed the need for more research into the correlation between smoking and breast cancer.

The researchers revealed that moderate physical activity appeared to decrease cancer risks by 52 percent for pre-menopausal and post-menopausal women.

The correlation was also observed for women who did intense physical activity, but the difference was not significant, said the lead researcher.

That finding, said Bissonauth, may be down to the fact that women who did moderate physical activity were more likely to do it regularly, while those who did intense physical activity were likely to quit after a few weeks.

“Cancer is a complex disease and can be latent for several years. Therefore, it is important to work on the factors we can control and to lead a healthy lifestyle, which means watching one’s weight, avoid smoking and doing regular exercise,” said Bissonauth. (ANI)

New ultrasensitive electronic sensor to speed up DNA testing (corrected)

Washington, Sept 1 (ANI): Singapore scientists have developed a new ultrasensitive electronic sensor that would speed up DNA testing for disease diagnosis and biological research.

The novel electronic sensor array would be rapid, accurate and cost-efficient.

According to lead researcher Dr Zhiqiang Gao, from Singapore’s Institute of Bioengineering and Nanotechnology (IBN), the Nanogap Sensor Array has shown “excellent” sensitivity at detecting trace amounts of DNA.

“By saving time and lowering expenses, our newly developed Nanogap Sensor Array offers a scalable and viable alternative for DNA testing,” said Gao.

The biosensor translates the presence of DNA into an electrical signal for computer analysis.

The distinctively designed sensor chip has the ability to detect DNA more efficiently by “sandwiching” the DNA strands between the two different surfaces.

“The novel vertical nanostructure design and two different surfaces of the sensor allow ultrasensitive detection of DNA,” said Gao.

“This sensitivity is best-in-class among electrical DNA biosensors. The design of the sensor also took into consideration the feasibility of mass production in a cost-effective way for expanded usage,” the expert added.

Presently, human DNA is detected through the use of polymerase chain reaction (PCR), which while effective, is also expensive, cumbersome and time-consuming for widespread use.

Although effective, tests involving PCR may not be optimal for situations such as a pandemic outbreak.

The biosensor captures DNA strands more effectively. This is possible because the two surfaces of the sensor are coated with a chemically treated “capture probe” solution through an electrochemical technique specially developed by IBN.

This allows DNA strands to “stick” more easily to the sensor, resulting in a faster and more accurate analysis.

“This new biosensor holds significant promise to speed up on-going efforts in the detection and diagnosis of debilitating diseases such as cancer, cardiovascular problems and infectious viruses,” said Dr Jackie Y. Ying, Executive Director of IBN, one of the research institutes of Singapore’s Agency for Science, Technology and Research (A*STAR).

“We aim to make healthcare accessible to the masses with early disease diagnosis as the critical driving force behind the research we undertake here at IBN,” she added.

The study appears in Journal of the American Chemical Society. (ANI)

Gene behind gum disease, osteoporosis, arthritis identified

Washington, Aug 31 (ANI): An international team of researchers have identified a gene that is common in the development of gum disease, rheumatoid arthritis, and osteoporosis.

Experts at Hospital for Special Surgery say that their findings about the gene, called interferon regulator factor-8 (IRF-8), may lead to new treatments in future.

“The study doesn’t have immediate therapeutic applications, but it does open a new avenue of research that could help identify novel therapeutic approaches or interventions to treat diseases such as periodontitis, rheumatoid arthritis or osteoporosis,” said Nature magazine quoted Dr. Baohong Zhao, a research fellow in the Arthritis and Tissue Degeneration Program at Hospital for Special Surgery located in New York City, as saying.

The researchers discovered that downregulation of IRF-8 (meaning that the gene produces less IRF-8 protein) increases the production of cells called osteoclasts that are responsible for breaking down bone.

In humans and animals, bone formation and bone resorption are closely coupled processes involved in the normal remodelling of bone. Enhanced development of osteoclasts, however, can create canals and cavities that are hallmarks of diseases such as periodontitis, osteoporosis and rheumatoid arthritis.

The genome-wide study showed that the expression of IRF-8 was reduced by 75 percent in the initial phases of osteoclast development.

The genetically engineered mice deficient in IRF-8 had decreased bone mass and severe osteoporosis.

The researchers concluded that IRF-8 suppresses the production of osteoclasts.

“This is the first paper to identify that IRF-8 is a novel key inhibitory factor in osteoclastogenesis (production of osteoclasts),” said Zhao.

“We hope that the understanding of this gene can contribute to understanding the regulatory network of osteoclastogenesis and lead to new therapeutic approaches in the future,” Zhao added.

The study has been published in the journal Nature Medicine. (ANI)

US Fritzl linked to prostitute serial killings

London, Aug 31 (ANI): Police suspect that ‘American Fritzl’ Phillip Garrido terrified Jaycee Lee Dugard by taking her to sites where he may have killed 10 prostitutes.

Garrido kept Jaycee as his sex slave for 18 years and fathered two children with her.

It is believed that his horror tour for the three was meant to make them too scared to flee him, reports the Daily Star.

And it left the mother and her two daughters suffering from Stockholm Syndrome where hostages grow emotionally attached to their kidnappers.

Detectives suspect that convicted rapist Garrido, 58, could be one of America’s worst mass murderers.

It is being said that Garrido may be responsible for unsolved killings dating back to 1998.

The bodies of 15-year-old school- girl Lisa Norrell and three strangled and stabbed hookers were dumped on an industrial estate in the nearby town of Pittsburg where he worked at the time.

Call girls Valerie Schultz, 27, Rachael Cruise, 32, and Jessica Frederick, 24, were mutilated and left in ditches.

Seven other prostitutes also went missing but their bodies have never been found.

And police now know that Garrido took Jaycee and her daughters – named as Starlite and Angel – to the same town just a few weeks ago. (ANI)