CNS Welcomes Go Markets to San Diego Datacenter

July 26, 2010 By Leave a Comment

SAN DIEGO, CA, Jul 25 (MARKET WIRE) —
Commercial Network Services is pleased to announce the arrival of
Australia’s leading FOREX broker to the CNS San Diego datacenter. Go
Markets has added a new server in the CNS San Diego datacenter to their
global MT4 network. The new server will result in better performance for
traders all over North America and most especially those hosted on a
Trader’s VPS in the CNS-SDCA datacenter, who will enjoy < 1ms latency to
the new server from their MT4 client terminals. The new server is the
latest addition to the growing Go Markets global presence, which now
includes servers in Singapore, Melbourne, Sydney, Perth and San Diego.

Commercial Network Services is the leading provider of VPS services
designed especially for FOREX traders and operates out of datacenters in
San Diego, New York City and London.

Contact:
Commercial Network Services
www.CommercialNetworkServices.com

Go Markets
www.gomarketsaus.com

Copyright 2010, Market Wire, All rights reserved.

Filed Under: International News Tagged With: , , , , , , , , , , , , , , , , , , ,

Airvana and KDDI R&D Laboratories Achieve Voice Call Routing Optimization and IP Data Local Breakout Milestones Using Femtocells

June 16, 2010 By Leave a Comment

Ability to route media path between femtocells, home network and Internet
demonstrates potential to improve network efficiency and enable new applications
CHELMSFORD, Mass. & TOKYO–(Business Wire)–
Airvana, and the Mobile Network Laboratory of KDDI R&D Laboratories, Inc.
(hereinafter “KDDI R&D Labs”), the research and development arm of KDDI Group,
today announced the achievement of an important milestone in their joint
research on CDMA2000 1x voice call routing optimization for sessions between
subscribers using femtocells, and on femtocell local breakout for data sessions.
Airvana and KDDI R&D Labs have successfully prototyped two capabilities. The
first, Voice Call Routing Optimization, separates voice call signaling and media
paths and routes the media path, carrying the call`s content directly between
two subscribers` HubBub femtocells. The call signaling path, which contains the
signaling messages required to establish and maintain a call, remains routed
through the operator`s core network. The second, IP Data Local Breakout, enables
mobile handsets to connect directly to other devices in the home network and to
the Internet, without going through the operator`s core network.

These advances have the potential to benefit operators through reduced traffic
burden on the core network and the ability to offer new femtocell applications
as well as to benefit subscribers through improved voice call quality, better
user experience with reduced latency and direct access to devices and content on
the home network.

In the case of Voice Call Routing Optimization (illustrated in Figure 1), the
subscribers` femtocells are used to establish a direct link for the media path
between mobile devices attached to different femtocells for a standard CDMA2000
1x mobile voice call.

In the case of IP Data Local Breakout (illustrated in Figure 2), the femtocells
are used to create a direct connection between the subscriber`s mobile handset
and home network devices such as PCs, printers and digital video recorders. IP
Data Local Breakout will enable new services by making the mobile device
simultaneously part of both home and mobile networks, while also reducing
traffic load on the core network.

“The achievement between our two companies illustrates how femtocells, when
deployed in large numbers, will have the potential to enhance mobile networks
for the benefit of both the operator and the subscriber,” explained. Dr. Akiba,
President and CEO at KDDI R&D Labs. “We`ve effectively shown that operators will
be able to use femtocells in a variety of ways to deliver new services and
optimize performance of their mobile networks.”

“This work highlights the `intelligent network edge` that femtocells will create
for mobile networks, not only for optimizing network capacity and performance,
but also for delivering innovative applications,” said Vedat Eyuboglu, CTO,
Airvana. “Through prototyping of advanced technologies with KDDI R&D Labs we are
working to maximize the full potential of femtocells.”

About Airvana

Airvana helps operators transform the mobile experience for users worldwide. The
company`s high-performance technology and products, from comprehensive femtocell
solutions to core mobile network infrastructure, enable operators to deliver
compelling and consistent broadband services to mobile subscribers, wherever
they are. Airvana`s products are deployed in 70 commercial networks on all six
continents. The company is headquartered in Chelmsford, Mass., USA, with offices
worldwide. For more information, please visit www.airvana.com.

About KDDI R&D Laboratories, Inc.

KDDI R&D Labs is helping to usher in the FMBC age, which will bring the
convergence of fixed communications, mobile communications and broadcasting.
KDDI R&D Labs is developing the entire array of the communications systems and
infrastructure needed to support this age. In the meantime, KDDI R&D Labs is
also researching and developing world-leading telecommunications technologies
while pursuing extensive initiatives, including next-generation networking and
super high-speed wireless transmission technology, security technology, the
development of revolutionary applications and pioneering technology to support
basic technological infrastructure.

Photos/Multimedia Gallery Available:

http://www.businesswire.com/cgi-bin/mmg.cgi?eid=6326760〈=en

Davies Murphy Group
Robert Morton, 781-418-2400
airvana@daviesmurphy.com

Copyright Business Wire 2010

Filed Under: International News Tagged With: , , , , , , , , , , , , , , , , , , ,

Source of ‘noise’ in HIV identified

April 21, 2010 By Leave a Comment

Washington, April 21 (ANI): Scientists in the U.S. have discovered a molecular mechanism that the human immunodeficiency virus (HIV) seems to utilize for generating random fluctuations called ‘noise’ in its gene expression.

The research has identified the likely source of HIV gene-expression noise and offers intriguing insight into the role of this noise in driving HIV”s fate decision between active replication and latency.

After infecting a human cell, HIV integrates into the genome and typically begins to actively replicate. However, the virus can also enter a long-lived latent state, which remains the greatest barrier to eradicating virus from the patient.

Senior study author, Dr. Leor S. Weinberger, a molecular virologist and systems biologist from the Department of Chemistry and Biochemistry at the University of California, San Diego, recently showed that noise in HIV gene-expression critically influences the viral decision to enter either active replication or latency. However, the source of the noise was not clear.

To probe the source of this inherent noise in HIV gene expression, Dr. Weinberger and colleagues exploited a technique from electrical engineering that analyzes how noise changes across different levels of expression.

The researchers examined cells carrying a single integrated copy of HIV engineered to produce a quantifiable protein, and measured HIV-1 expression noise at dozens of different viral integration sites which act as distinct genetic environments for viral gene expression.

The researchers found that HIV noise levels are substantially higher than measured in other organisms, and that HIV gene expression occurs in randomly timed bursts.

During these expression bursts, multiple copies of HIV gene products are produced that leads to the high noise levels in HIV gene expression.

The bursting model argues that during active expression HIV cycles between periods of silence and bursting and provides insight into how HIV may be activated by host signaling molecules.

“We know that noise in gene-expression can critically influence HIV”s entry to proviral latency. These new results point to transcriptional bursting as a major source of the noise,” Dr. Weinberger said

“This finding that transcriptional bursting generates an exceptionally noisy HIV promoter, noisier than almost all other measured promoters, supports the theory that latency may be fundamental to the HIV life cycle and that HIV evolved for probabilistic entry into latency,” Dr. Weinberger added.

The study has been published in the April 20th issue of the Biophysical Journal. (ANI)

Filed Under: International News Tagged With: , , , , , , , , , , , , , , , , , , ,

GigaSpaces Launches Version 7.1 of eXtreme Application Platform (XAP), Making Dynamic Scaling Simpler Than Ever

April 16, 2010 By Leave a Comment

NEW YORK CITY, NEW YORK, Apr 14 (MARKET WIRE) —
GigaSpaces announces the release of eXtreme Application Platform (XAP),
version 7.1, which automatically implements dynamic scalability and
multi-tenancy, based on an organization’s individual business
requirements. This significantly simplifies development, deployment and
operations while enabling enterprises to maximize utilization of modern
IT resources with no change to the way they do business.

“We have always delivered reliable technology that guarantees dynamic
scalability and high availability with millisecond latency,” says Nati
Shalom, GigaSpaces CTO. “Now we are simplifying operations for developers
and administrators. With each new generation, we focus on features that
most benefit the enterprise’s bottom line.”

Simplified API Streamlines Development & Operations

XAP eases development, deployment, and operations with its new API for
the Elastic Data Grid. Users input their business requirements, and XAP
deploys and configures the data grid cluster automatically, saving
substantial effort and cost involved in sizing, hardware provisioning,
and configuring distributed middleware.

“Enterprises perpetually need to reduce costs and optimize utilization of
hardware and software resources,” says Massimo Pezzini of Gartner. “They
look for application platform technology providing elasticity,
“continuous” availability as well as automatic deployment and scaling of
applications, while reducing administration burdens.”

XAP automatically maintains SLAs during production, doing everything
necessary to continue meeting the business requirements. When existing
machines exhaust their resources, when a machine fails, when loads
change, or when machines are added, XAP automatically adjusts the cluster
and rebalances the application. Users do not have to manually intervene
to make sure there is enough computing power or memory.

If an organization has special requirements, XAP is flexible enough to
allow for custom deployment behavior via its administration API, which
provides fine-grained control and monitoring over all deployment
parameters.

Built-in Multi-tenancy Eases Resource Sharing

XAP 7.1 is the world’s first middleware platform with built-in
multi-tenancy. Not only does it significantly simplify development, but
it also provides better isolation among multiple users and independent
life cycle management for each tenant. The Elastic Data Grid offers one
simple parameter defining the isolation level, allowing a variety of
configurations such as allocating a dedicated machine per application,
allowing multiple instances of the application to share the same
resources while isolating others, or sharing everything among everyone.

Hardware Efficiency Creates Cost Savings

XAP 7.1 features concurrent transaction management for improved
utilization of multicore processors. This follows previous improvements
in multicore utilization, which resulted in up to 300% performance
improvement on the Intel Nehalem processor.

GigaSpaces XAP 7.1 is certified for use with Cisco UCS, which can form a
cluster that reaches a memory capacity of several terabytes with massive
computing power. This combination offers a full, scalable stack – from
the hardware to the application level – enabling deployment in one API
call for even the largest in-memory operations. New benchmarks will be
released shortly.

Additional Features in XAP 7.1

– Extended in-memory querying capabilities – brings the data grid closer
to the querying capabilities of traditional databases
– Real-time troubleshooting – administrators can automatically gather
dumps and logs from a large number of machines when any suspicious event
occurs or get logs and dumps from an entire distributed system at the
click of a button
– First milestone of web-based dashboard – version 7.1 gets closer to
making XAP’s full management and monitoring GUI accessible using a
regular web browser

Availability

Download the latest XAP 7.1 Product Version

For more information, please visit www.gigaspaces.com/xap7-1. We invite
you to attend the following two webinars related to the 7.1 release:

– April 21: How a Top Financial Firm Uses XAP for Dynamic Scaling and How
7.1 Makes It Simpler than Ever
– April 28: XAP 7.1 Webinar and Live Demo: What’s New in 7.1

About GigaSpaces

GigaSpaces Technologies is a leading provider of a new generation of
application platforms for Java and .Net environments that offers an
alternative to traditional application servers. Its flagship product, XAP
7.1, is an enterprise-grade application server for deploying and
dynamically scaling distributed applications under any requirement.

GigaSpaces customers depending on our reliability and millisecond latency
include dozens of Global Fortune 100/500 companies, including Societe
Generale and British American Tobacco; six of the world’s top 10
investment banks and financial services companies like Dow Jones; leading
telecommunications carriers and eCommerce companies like Nortel and eBay;
and five of the world’s top online gaming companies and Internet media
organizations. GigaSpaces was founded in 2000 and has offices in the
United States, Europe, and Asia.

For more information, please visit http://www.gigaspaces.com, our blog at

http://blog.gigaspaces.com.

Contacts:
K2 Strategic Innovations
Amy Kenigsberg
+972 9 794 1681 (GMT +2)
U.S. +1 913 440 4072 (ET +7)
amy@k2-si.com

Copyright 2010, Market Wire, All rights reserved.

Filed Under: International News Tagged With: , , , , , , , , , , , , , , , , , , ,

New discovery may offer potential strategy for therapies to clear HIV

June 27, 2009 By Leave a Comment

Washington, June 26 (ANI): Gladstone scientists have identified a key that regulates HIV latency – a discovery that may lead to eradication of HIV from infected patients who have been on antiretroviral therapy.

The real cure for HIV has been elusive because the virus can “hide” in a latent form in resting CD4-T cells.

By understanding this “latency” effect, researchers can identify ways to reactivate the virus and enable complete clearance by current or future therapies.

The study showed that methylation of cytosine in the DNA of infected cells is associated with HIV latency and inhibition of DNA methylation causes the reactivation of latent HIV.

“While HIV-1 latency is likely to be a multifactorial process, we have shown that inhibiting the methylation of the provirus contributes to an almost complete reactivation of latent HIV-1,” said lead author Steven E. Kauder.

In addition to finding that DNA methylation is a mechanism of latency, the scientists also discovered that a host protein, called methlyl-CpG binding domain protein 2 (MBD2) binds to the methylated HIV DNA and is an important mediator of latency.

“Interfering with methylation greatly potentiates the reactivation of HIV,” said Kauder.

In this study, the researchers found that the drug 5-aza-2′deoxycytidine (aza-CdR) can inhibit HIV methylation and cause the virus to reactivate.

“Combined with other areas of our investigation into HIV latency, this research provides important new knowledge about the process and opens many new pathways for future study,” said GIVI Associate Director Eric Verdin, MD, senior author of the study.

The discovery was reported in the current edition of PloS Pathogens. (ANI)

Filed Under: Science News Tagged With: , , , , , , , , , , , , , , , , , , , ,

Nightly bedtime routine improves maternal mood, kids’sleep

May 3, 2009 By Leave a Comment

Washington, May 1 (ANI): In the journal SLEEP, researchers have demonstrated that the use of a consistent bedtime routine contributes to improvements in multiple aspects of infant and toddler sleep, bedtime behavior and maternal mood.

Results indicate that the establishment of a nightly bedtime routine produced significant reductions in problematic sleep behaviors for infants and toddlers. Improvements were seen in latency and sleep onset and in the number and duration of night wakings.

Toddlers were less likely to call out to their parents or get out of their crib/bed during the night. Sleep continuity increased and there was a significant decrease in the number of mothers who rated their child’s sleep as problematic. Maternal mood also significantly improved.

According to the study, sleep problems are one of the most common concerns of parents of young children; approximately 20 to 30 percent of infants and toddlers experience sleep difficulties. Previous studies have found that successful treatment of children’s sleep problems with behavioral interventions also result in improvements in parental well-being.

According to principal investigator, Jodi Mindell, PhD, professor of psychology at Saint Joseph’s University in Philadelphia, PA., creating a bedtime routine is an easy change that can significantly improve both the child’s sleep and the mother’s quality of life.

“There is no question that maternal mood and children’s sleep impact one another. The better a child sleeps and the easier bedtime is, the better a mother’s mood is going to be,” said Mindell.

“In addition, a mom who is not feeling tense, depressed, and fatigued is going to be calmer at bedtime, which will help a child settle down to sleep,” the expert added.

Data were collected from 405 mothers and their infant or toddler,(206 infants between the ages of 7 and 18 months and 199 toddlers between the ages of 18 and 36 months), who then participated in two age-specific three week studies.

Families were randomly assigned to a routine or control group. The first week of the study served as a baseline, during which the mothers followed their child’s usual bedtime weeks.

During the following two weeks mothers were instructed to conduct a specific bedtime routine, while the control group continued with their child’s normal bedtime procedure.

All children included in the study had a small to severe sleep problem, as identified by the mother. Problems included more than three nightly wakings, awakening for longer than 60 minutes per night, or having a total daily sleep duration of less than nine hours. All mothers completed an expanded version of the Brief Infant Sleep Questionnaire (BRISQ), and provided subjective data concerning their child’s sleep habits.

Parents in the infant routine group were given a three-step bedtime procedure to follow that included a bath, a massage and quiet activities (such as cuddling and singing); lights were to be turned out within 30 minutes of the end of the bath.

Mothers then proceeded to put the child to sleep as they normally did, by either putting the child to bed while awake or rocking them to sleep. Thus, the only instituted change was the routine. The toddler group followed the same routine, except that mothers were instructed to apply lotion rather than give the child a massage.

Research shows that daily routines in general lead to predictable and less stressful environments for young children and are related to parenting competence, improved daytime behaviors and lower maternal mental distress. (ANI)

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