Pediatricians tend to miss elevated BP in kids

Washington, May 3 (ANI): Researchers at Johns Hopkins Children”s Center say that pediatricians and nurses may be missing the development of hypertension and its serious consequences even when they read a child’s blood pressure.

The American Academy of Pediatrics (AAP) guidelines call for regular BP checks in children three years and older to screen for elevated BP.

They say elevated BP on three consecutive medical visits qualifies as hypertension.

Even a single episode of high BP can indicate hypertension and should trigger repeat measurements during the visit and subsequent doctor visits, the AAP says.

The problem is that measuring a child’s BP is far more complicated than it is in adults and requires interpreting each individual measure against a reference table for age, gender and height, says lead author Tammy Brady, nephrologist at Hopkins Children’s Hospital in the US.

Researchers at Hopkins analysed 2,500 records of visits to the pediatrician’s office. Medical staff did not check BP in 500 cases.

Elevated BP scores were recorded in 726 cases of the 2,000 measurements taken, but the implications went unrecognized and unremarked upon in 87 percent of them, the study found.

The findings underscore the need for better recognition and aggressive monitoring of all children to prevent both the short-term and long-term complications of hypertension, the investigators say.

The study found that medical staff were more likely to miss elevated BP in children of normal weight and in those without a family history of cardiovascular disease.

The same was true for those children whose blood pressure was at or below 120/80, a score considered ideal in adults, but one that may portend trouble in a child, depending on height, gender and age, said a Johns Hopkins release.

Hypertension, defined as persistently elevated BP, can cause kidney, eye and heart damage. While some complications take years and decades to develop, certain ones evolve quickly, the researchers say.

The results of the study were published in Pediatrics. (ANI)

Weight loss can prevent kidney disease progression in obese patients

Washington, Sept 18 (ANI): Shedding extra pounds can preserve kidney function in obese people with kidney disease, according to a new study led by Indian origin scientist from Cleveland Clinic.

Weight loss can improve a number of health problems, like it can improve control of diabetes, lower blood pressure and cholesterol levels, and reduce the effects of heart disease.

During the study, Dr Sankar Navaneethan, and his colleagues analysed the studies that examined the effects of weight loss interventions in obese kidney disease patients.

It showed that weight loss attained through diet and exercise reduces proteinuria (excess excretion of protein in the urine-a hallmark of kidney damage) and may prevent additional decline in kidney function in obese patients with kidney disease.

Studies also showed that surgical interventions normalize the filtration rate of the kidneys in obese patients with high filtration rates (a risk factor for the development of kidney disease).

While the findings imply that weight reduction may prevent the progression of kidney disease in obese kidney disease patients, the authors noted that there were only a small number of studies available for analysis and additional high-quality long-term studies on this topic are needed.

The study appears in Clinical Journal of the American Society Nephrology. (ANI)

Stem cell transplantation may correct rare genetic disorder in kids

Washington, Sep 18 (ANI): Scripps Research Institute scientists have offered new hope for parents whose children suffer from the rare genetic disorder ‘cystinosis’ by showing through an experiment on mice that stem cell transplantation can successfully correct the defect.

“After meeting the children who suffer from this disease, like an 18-year-old who has already had three kidney transplants, and the families who are desperately searching for help, our team is committed to moving toward a cure for cystinosis, a lysosomal storage disorder. This study is an important step toward that goal,” said principal investigator Stephanie Cherqui.

In the study, the researchers used bone marrow stem cell transplantation to address symptoms of cystinosis in a mouse model.

The procedure virtually halted the cystine accumulation responsible for the disease, and the cascade of cell death that follows.

Cystine is a by-product of the break down of cellular components the body no longer needs in the cell’s “housekeeping” organelles, called lysosomes.

Normally, cystine is shunted out of cells, but in cystinosis a gene defect of the lysosomal cystine transporter causes it to build up, forming crystals that are especially damaging to the kidneys and eyes.

Cystinosis is a rare but devastating disease affecting children as young as six months, who begin to suffer renal dysfunction, which grows progressively worse with time. Other symptoms include diabetes, muscular disease, neurological dysfunction, and retinopathy.

The only available drug to treat cystinosis, cysteamine, while slowing the progression of kidney degradation, does not prevent it, and end-stage kidney failure is inevitable.

In the new study, the researchers found that transplanted bone marrow stem cells carrying the normal lysosomal cystine transporter gene abundantly engrafted into every tissue of the experimental mice.

This led to an average drop in cystine levels of about 80 percent in every organ.

Not only it prevented kidney dysfunction, there was less deposition of cystine crystals in the cornea, less bone demineralization, and an improvement in motor function.

“The results really surprised and encouraged us. Because the defect is present in every cell of the body, we did not expect a bone marrow stem cell transplant to be so widespread and effective,” says Cherqui.

Cherqui said that adult bone marrow stem cell therapy is particularly well suited as a potential treatment for cystinosis because these cells target all types of tissues.

In addition, stem cells reside in the bone marrow for the duration of a patient’s life, becoming active as needed, a particular benefit for a progressive disease like cystinosis.

The study has been published in the journal Blood. (ANI)

Natalie Cole makes comeback after kidney transplant op

Washington, September 11 (ANI): R andB singer Natalie Cole made a comeback to the stage and performed at a concert in Hollywood after fighting severe health conditions for almost a year.

“I really do have to say … it really is a miracle time. It’s a miracle night for me. I never thought I’d be standing here healthy and whole and 100 percent,” People magazine quoted her as telling the crowd present.

The singer was diagnosed with Hepatitis C in April last year.

Apart from treating the liver disease with chemotherapy, she also battled kidney problems later that year.

However, she was back with a bang at the Hollywood Bowl belting out hits like ‘This Will Be,’ ‘Our Love,’ and ‘Unforgettable’

She said: “My heart is very full tonight, and I know a lot of you know why. It’s just good to be back. You know what I’m saying?

“You know, things don’t always go the way we want it to. Things happen unexpectedly. You got to take the good with the bad.”

Cole also brought the attention of the audience to health problems.

She said: “One in eight people has kidney failure. That’s a lot of people and I never thought it would happen to me, but here we are.”

She described the phase she was ill as “a real tough journey.” (ANI)

Bariatric surgery can eliminate diabetes symptoms

London, Aug 28 (ANI): Weight-loss surgery can help eliminate the symptoms of type 2 diabetes in nearly 80 percent patients, an international study has found.

The research team led by Professor Henry Buchwald of the Department of Surgery at the University of Minnesota, Minneapolis, observed almost 135,000 patients for the study.

The findings concluded that 78 per cent patients had a “complete resolution” of diabetes for up to two years post-surgery, while 87 either saw resolution or noted an improvement in their condition, reports Timesonline.

Type 2 diabetes is common to obese people and occurs when the body stops producing or using insulin, the hormone that maintains the sugar level in blood.

Losing weight can help the body to efficiently use available insulin, and thus prevent kidney failure, nerve damage and eye problems.

The weight-loss surgery, medically known as the bariatric surgery, or the gastric-band operation, fits a band around the upper part of the stomach, restricting the amount people can eat before feeling full. Though the operation can benefit diabetes patients, it is advised only for the very obese, who’ve failed to lose weight otherwise.

But charity Diabetes UK is a little sceptical about the findings of the research.

Zoë Harrison, care adviser for the charity, said: “Although the data shows good results from bariatric surgery, it must be remembered that any surgery carries serious risks.

“Bariatric surgery should be considered only as a last resort. It can lead to dramatic weight loss, which in turn may result in a reduction in people taking their type 2 diabetes medication, and even in some people needing no medication at all. This does not mean type 2 diabetes has been cured.

“These people will still need to eat a healthy, balanced diet and be physically active to manage their diabetes.” (ANI)

Metal catalysts in carbon nanotubes block critical signalling pathway in neurons

Washington, August 28 (ANI): In what may prove very useful in improving treatments for human neurological disorders, Brown University scientists have found out why carbon nanotubes tend to block a critical signalling pathway in neurons.

Writing about their findings in the journal Biomaterials, the researchers have revealed that it is not the tubes, but the metal catalysts used to form them, that are to blame.

They say that minute amounts of a metal called ‘yttrium’ may impede neuronal activity.

They add that the findings mean that carbon nanotubes without metal catalysts may be able to treat human neurological disorders, although other possible biological effects still need to be studied.

“It’s a problem we can fix. We can purify the nanotubes by removing the metals, so it’s a problem we can fix,” said Lorin Jakubek, a Ph.D. candidate in biomedical engineering and lead author of the paper.

Taking single-walled carbon nanotubes to the laboratory of Brown neuroscientist Diane Lipscombe, the research team zeroed in on ion channels located at the end of neurons’ axons.

These channels are gateways of sorts, driven by changes in the voltage across neurons’ membranes. When an electrical signal, known as an action potential, is triggered in neurons, these ion channels “open”, each designed to take in a certain ion.

One such ion channel passes only calcium, a protein that is critical for transmitter release and thus for neurons to communicate with each other.

In experiments using cloned calcium ion channels in embryonic kidney cells, the researchers found that nickel and yttrium, two metal catalysts used to form the single-walled carbon nanotubes, were interfering with the ion channel’s ability to absorb the calcium.

Lipscombe, who specializes in neuronal ion channels and is a corresponding author on the paper, pointed out that yttrium’s ionic radius is nearly identical to calcium’s, which is why it “gets stuck and prevents calcium from entering and passing through. It’s an ion pore blocker.”

The experiments showed that yttrium in trace amounts – less than 1 microgram per milliliter of water – may disrupt normal calcium signalling in neurons and other electrically active cells, an amount far lower than what had been thought to be safe levels.

With nickel, the amount needed to impede calcium signalling was 300 times higher.

“Yttrium is so potent that … a very low nanotube dose” would be needed to affect neuronal activity, said Robert Hurt, professor of engineering and a corresponding author on the paper.

Jakubek said she was surprised that the metals turned out to be the cause.

“Based on the literature, I thought it would be the nanotubes themselves,” she said. (ANI)

Bariatric surgery can eliminate diabetes symptoms

London, Aug 28 (ANI): Weight-loss surgery can help eliminate the symptoms of type 2 diabetes in nearly 80 percent patients, an international study has found.

The research team led by Professor Henry Buchwald of the Department of Surgery at the University of Minnesota, Minneapolis, observed almost 135,000 patients for the study.

The findings concluded that 78 per cent patients had a “complete resolution” of diabetes for up to two years post-surgery, while 87 either saw resolution or noted an improvement in their condition, reports Timesonline.

Type 2 diabetes is common to obese people and occurs when the body stops producing or using insulin, the hormone that maintains the sugar level in blood.

Losing weight can help the body to efficiently use available insulin, and thus prevent kidney failure, nerve damage and eye problems.

The weight-loss surgery, medically known as the bariatric surgery, or the gastric-band operation, fits a band around the upper part of the stomach, restricting the amount people can eat before feeling full. Though the operation can benefit diabetes patients, it is advised only for the very obese, who’ve failed to lose weight otherwise.

But charity Diabetes UK is a little sceptical about the findings of the research.

Zoë Harrison, care adviser for the charity, said: “Although the data shows good results from bariatric surgery, it must be remembered that any surgery carries serious risks.

“Bariatric surgery should be considered only as a last resort. It can lead to dramatic weight loss, which in turn may result in a reduction in people taking their type 2 diabetes medication, and even in some people needing no medication at all. This does not mean type 2 diabetes has been cured.

“These people will still need to eat a healthy, balanced diet and be physically active to manage their diabetes.” (ANI)

Clues to gigantism provided by family in Borneo Mountains

Washington, August 22 (ANI): An indigenous family living in a mountainous area of Malaysian Borneo has helped Van Andel Research Institute (VARI) scientists to discover information about genetic mutations associated with acromegaly, a form of gigantism that often results in enlarged hands, feet, and facial features.

The information could lead to better screening for the disease, which most often results from a benign pituitary gland tumor that can be deadly if left untreated, but which is difficult to detect until later stages when features become pronounced.

Researchers located a 31-member aboriginal family that included individuals with acromegaly living in a mountainous region of Borneo, Malaysia, when the effects of the family patriarch’s growing pituitary tumor necessitated medical treatment.

A medical team including VARI Distinguished Scientific Investigator Bin Tean Teh, and staff from the Department of Medicine at the University of Malaya Medical Centre and the Department of Medicine at the Queen Elizabeth Hospital in Malaysia subsequently traveled to the family’s village several times to collect blood samples for testing.

“Researchers had recently found a mutation in the AIP gene associated with acromegaly, but we found that several family members who didn’t have visible symptoms of acromegaly had this mutation as well,” said Dr. The.

“This increases the importance of screening for families with cases of acromegaly since anyone could be a carrier. On one side of the family, at least two generations carried the gene before someone showed any symptoms,” he added.

The later stages of acromegaly often produce enlarged hands and feet, protruding brows and lower jaws, thick voice and slowed speech from swelling of vocal cords, and other symptoms.

When diagnosed, the tumor and entire pituitary gland are usually removed, followed by hormone therapy for the rest of the patient’s life. owever, because the progression of the disease is so gradual, it is difficult to detect. If left unchecked, patients can die from complications such as heart or kidney failure.

Sok Kean Khoo, VARI Research Scientist and lead author of the study, led researchers in scanning DNA in the family’s blood to find other factors that might explain why only some family members with the genetic mutation had visible symptoms of the disease.

They found regions on a few chromosomes that might lead to further insight.The sooner we know how and why people are affected differently by this disease, the sooner we can help families who have it,” said Dr. Teh. (ANI)

Natural organic matter plays key role in making mercury toxic to living creatures

Washington, August 19 (ANI): Scientists have found that naturally occurring organic matter in water and sediment appears to play a key role in helping microbes convert tiny particles of mercury in the environment into a form that is toxic to most living creatures.

According to Duke University environmental engineers, this finding is important because it could change the way mercury in the environment is measured and therefore regulated.

This particularly harmful form of the element, known as methylmercury, is a potent toxin for nerve cells. When ingested by organisms, it is not excreted and builds up in tissues or organs.

In a series of laboratory experiments, Amrika Deonarine, a graduate student in civil and environmental engineering at Duke’s Pratt School of Engineering, found that organic matter and chemical compounds containing sulfur – known as sulfides – can readily bind to form mercury sulfide nanoparticles.

Since they are more soluble than larger particles, these nanoparticles may be the precursors to a process known as methylation.

“When the organic material combines with the mercury, it prevents the particle from accumulating with other mercury particles and growing larger,” said Deonarine.

“Since the mercury remains in a nanoparticle size, it can easily collect on the surface of microbes where any mercury that dissolves can be taken in by the microbes,” she said.

“Without the organic matter, the mercury sulfide nanoparticles would grow too large and become insoluble, thus reducing the availability of mercury for microbial methylation,” she added.

It is while inside the microbe that the mercury is converted into the harmful methylmercury form, according to the researchers.

These reactions can only take place in cold water environments with little to no oxygen, such as the zone of sediment just below the bottom of a body of water.

Other such anaerobic environments can also be found in waste water and sewage treatment systems, the researchers said.

Mercury is extremely toxic and can lead to kidney dysfunctions, neurological disorders and even death. In particular, fetuses exposed to methylmercury can suffer from these same disorders as well as impaired learning abilities.

There are many ways mercury gets into the environment, with the primary sources being the combustion of coal, the refining of such metals as gold and other non-ferrous metals, and in the gases released during volcanic eruptions. (ANI)

Negativity ‘ups mortality risk in peripheral arterial disease patients’

Washington, Aug 18 (ANI): Peripheral arterial disease patients with negative, inhibited personality type are at an increased risk of dying within four years, say researchers.

Peripheral arterial disease (PAD) occurs when plaque builds up in arteries that supply blood to body areas other than the heart and brain, such as the extremities.

However, patients with PAD also have an increased risk of secondary events such as stroke, heart attack and death, according to background information in the article.

According to the authors, preliminary evidence has suggested that personality traits such as hostility may also be associated with the severity and progression of atherosclerosis [plaque buildup] in patients with PAD.

However, another potential individual risk factor in this context is the distressed personality type (type D).

Type D refers to the joint tendency to experience negative emotions and to inhibit self-expression in social interaction.

In the study, Dr Annelies E. Aquarius, of Tilburg University, Tilburg, the Netherlands looked at 184 patients (average age 64.8) with peripheral arterial disease.

During four years of follow-up, 16 patients (8.7 percent) died, including seven who died of cancer and six of cardiovascular disease.

But after adjusting for age, sex, diabetes and kidney disease, patients with type D personality had an increased odds of death.

The personality type has been associated with increased activation of the immune system and changes in the body’s stress response system.

In addition, “inadequate self-management of chronic disease is a potential behavioral mechanism that may explain the relation between type D personality and poor prognosis in cardiovascular disease,” the authors said.

The study appears in Archives of Surgery, one of the JAMA/Archives journals. (ANI)

Reducing BP below standard target may not offer any benefits

Washington, July 8 (ANI): A new study has revealed that reducing blood pressure below the standard target may not offer any benefits.

Researchers at the University of Costa Rica have found that using antihypertensive drugs to reduce blood pressure below the 140/90 mm Hg does not really reduce death rates or serious morbidity.

“At present there is no evidence from randomized trials to support aiming for a blood pressure target lower than 140/90, in the general population of patients with elevated blood pressure,” said lead researcher Jose Arguedas of the Faculty of Medicine at the University of Costa Rica in Costa Rica.

The Cochrane review has cast doubts on the guidelines recommending for lower targets, based on the assumption that “lower is better” when it comes to blood pressure.

The researchers reviewed seven trials, which together involved 22,089 people.

While patients aiming for targets below 135/85 mmHg did succeed in achieving greater reductions in blood pressure than those in the standard target group, there was no difference between the two groups in terms of the number of patients dying or suffering heart attacks, strokes, heart failure or kidney failure.

“Our research included patients with diabetes or chronic renal disease, and the evidence was slightly less robust for those subgroups of patients,” said Arguedas.

“We intend to carry out separate systematic reviews for those subgroups, especially because guidelines recommend even lower blood pressure targets for them” he added. (ANI)

Microscopic ‘beads’ may revolutionise organ transplantation

Washington, July 7 (ANI): If Medical College of Georgia researchers are to be believed, organ transplantation in future may include microscopic beads that create “designer” immune cells so that patients may tolerate their new organ.

Dr. Anatolij Horuzsko, reproductive immunologist at the MCG Center for Molecular Chaperone/Radiobiology and Cancer Virology, has already used this approach successfully in mice with skin grafts.

“It’s absolutely natural,” says the researcher.

The degradable microparticles deliver the most powerful known form of HLA-G, a natural suppressor of the immune response, straight to dendritic cells, which typically show the immune system what to attack.

The microparticles are given right after a transplant, just as dendritic cells are giving the immune system a heads up to get busy attacking the new organ.

Dr. Horuzsko says that microparticle therapy likely would be needed for just a few weeks, until the dendritic cells have learned instead to ignore it.

“It’s like a calming effect and once tolerance is established, we don’t need it any more,” he says.

His team compared the success of HLA-G microparticles with the dendritic cell marker to those without a marker, those with were much more efficient at getting where needed and acting.

He says that those without direction likely were consumed by garbage eaters called macrophages.

“We want to create in kidney transplant patients, the same tolerance to the new kidney,” says Dr. Horuzsko, who reckons that HLA-G microparticles could be doing just that within five years.

He presented the patented process along with his other latest HLA-G findings during an opening lecture of the 5th International Conference on HLA-G in Paris, July 6-8.

Dr. Horuzsko believes that marked microparticles also have treatment potential in diseases where the immune system attacks normal tissue, such as arthritis, multiple sclerosis and inflammatory bowel disease.

He is currently working in collaboration with Dr. Laura Mulloy, chief of the Section of Nephrology, Hypertension and Transplantation Medicine in the MCG School of Medicine, to find out whether higher natural levels of HLA-G already are giving some transplant patients an edge, by comparing HLA-G expression in those who keep and reject their transplanted kidneys. (ANI)

Expert says swine flu child toll will double in next year

Melbourne, July 2 (ANI): A leading expert on swine flu has warned that twice as many children will die of the disease in the next 12 months compared to the number of deaths from regular influenza.

Professor Robert Booy, however, said the number of deaths would still be fairly small – around 10 or 12 in a year.

Three to six children die every year from regular influenza. It (death from swine flu) can occur in a healthy child although most of them we believe will occur in a child with a problem, say a chronic heart problem, long-standing lung, kidney, liver (problems) or diabetes,” Professor Booy told ABC radio.

“The likelihood is with this virus we’ll see more of the small number of severe (cases) than we do normally.”

Yesterday a three-year-old Victorian boy with swine flu died. The family requested the boy’s medical history not be released.

Prof Booy is the co-director of the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases at The Children’s Hospital at Westmead in Sydney. (ANI)

President Patil condoles passing away of Assam Governor

New Delhi, June 26 (ANI): President Pratibha Patil has condoled the passing away of the Governor of Assam, Shiv Charan Mathur, who died after prolonged illness at a hospital in New Delhi on Thursday evening.

In her message, the President said Mathur was closely associated with developmental activities at various levels in Rajasthan during his long public career.

He was always concerned about the welfare of the people in rural areas. In his passing away the nation has lost a personality who was always in touch with the grassroots of society

The 84 year-old Governor was suffering from acute heart and kidney ailments for the last several months.

He was first admitted to the Guwahati Medical College and Hospital and later shifted to the Escorts Hospital in New Delhi four days back.

After little recovery the Governor was released from hospital on thursday afternoon and taken to his Vasant Kunj residence in the capital. But he fell sick again and immediately brought to the nearby Fortis Hospital where he breathed his last at around 8.05. p.m.

A veteran Congress leader, two-time Chief Minister of Rajasthan, Shiv Charan Mathur, was sworn- in as the 20th Governor of Assam on the July 4 last year. (ANI)

Natalie Cole ‘discharged from hospital’

Washington, May 26 (ANI): Singer Natalie Cole has reportedly been released from the hospital after undergoing a kidney transplant and is said to be recuperating.

Natalie, who suffered a kidney failure caused by hepatitis C, was discharged five days after her kidney transplant.

“Natalie is continuing to do well under the circumstances,” People quoted Natalie’s representative, as saying.

Sadly for Natalie, who had planned to attend a private family memorial service for her sister Carol “Cookie” Cole, who passed away following a battle with lung cancer, had to undergo the life-saving organ transplant on the very same day.

Meanwhile, Natalie is expected to spend the next three to four months recuperating and will reorganize her tour dates in support of her album Still Unforgettable. (ANI)

Murdered Brit teen Scarlett Keeling’s organs sent back to the UK

London, May 26 (ANI): The mother of murdered British teen Scarlett Keeling has revealed that authorities in Goa have finally released her girl’s remaining bodily organs.

They have been sent to a coroner in the UK. He is reportedly keen to do tests on the uterus and kidneys of the 15-year-old from Bideford, Devonshire, who died on holiday in India.

Scarlett’s mum Fiona MacKeown, 43, said: “I expect the uterus will reveal Scarlett’s sexual activities before she died. And the kidney should reveal details of drinks and drugs that were consumed before she died, although tests on hair have already been done to expose this.”

She said she had received an email from the coroner saying the organs would be picked up from Heathrow.

Scarlett was raped and murdered in Goa on February 19 last year. A post mortem revealed she had taken ecstasy, cocaine and LSD on the night she died. Her body was returned to England last year and later it was found that some organs were missing.

Scarlett’s mum is still not sure when she will be able to bury her daughter. (ANI)

Hypertension doubles already elevated risk of heart disease in diabetics

New Delhi, May 21 (ANI): The presence of hypertension doubles the already elevated risk of heart disease in diabetics, and at the same time, increases the risk for other vascular complications such as strokes, retinal damage and peripheral vascular disease.

Detailing the specifics on the subject, Dr. Vikas Ahluwalia, president of Diabetes Care Foundation of India, says hypertension also greatly accelerates the progression of kidney disease in diabetics.

Both diabetes and hypertension are dangerous because they usually have no symptoms, he adds.

“You can be feeling fine at the same time as damage to internal organs is progressing. It is important to treat diabetes and hypertension early before one feels the symptoms and reaches a stage when things go out of control,” he opines.

There are six facts that need to be highlighted:

1. Hypertension is twice as common in Diabetes Mellitus.

2. New onset Diabetes Mellitus is 2.5 times in hypertension.

3. 20 to 40 percent of IGT patients have hypertension.

4. 40 to 50 percent of Type 2 Diabetes Mellitus have hypertension.

5. Only 1/4 of hypertension in Diabetes Mellitus is controlled.

6. Diabetes Mellitus and hypertension increases cardio-vascular risk three fold.

In Dr. Ahluwalia’s opinion, these problems can be treated at an early stage by following a prescribed diet, exercising, and taking medications as directed.

“At a later stage treatment, it is often more difficult. For example, end-stage kidney disease may require dialysis, or heart disease may require bypass surgery. Therapeutic lifestyle changes (TLC) are very important at all stages / severity and are common for both Diabetes Mellitus and hypertension,” Dr. Ahluwalia adds.

The lifestyle changes should include regular 30 minutes of moderately intense exercise after consulting your physician; No tobacco and minimal intake of alcohol; Salt restriction to less than six grams per day; Avoid high salt foods – pickles, savories; Use of K containing foods – fruits, vegetables; Weight reduction – goal ideal weight and Reduce coffee consumption.

He also says that it is essential to set yourself blood pressure targets.

If you are a diabetic Without proteinuria, Dr. Ahluwalia says the ideal blood pressure would be – 130/80, while with proteinuria it should be 125/75.

The maximum blood pressure in the event of anyone having Diabetes Mellitus is 130/80.

He concludes that almost all Diabetes Mellitus patients require 1 drug for Hypertension.

Identify the co-morbidity – CAD, CKD, CVD.

Dr. Ahluwalia can be contacted as follows:

Dr Vikas Ahluwalia

Director- Diabetes Care Foundation Of India

diabetescarefoundation@gmail.com

Address B -4/234, Safdarjung Enclave,

New Delhi- 110029, 9910328390/26167893 (ANI)

Aspirin and anti-clotting drug’s combo reduces dialysis access failure risk

Washington, May 21 (ANI): A combination of aspirin and the anti-platelet drug dipyridamole could significantly reduce blockages and extend the life of new artery-vein access grafts used for hemodialysis, according to study by the Dialysis Access Consortium (DAC).

Very often, artery-vein access grafts, called arteriovenous (AV) grafts, fail due to narrowing of blood vessels (stenosis) at the graft site and subsequent clotting, which block the flow of blood.

And a blocked graft becomes useless for dialysis and is a major cause of worsening health in dialysis patients.

In the DAC trial, the researchers observed that the combination treatment decreased the rate of loss of primary unassisted graft patency by 18 percent and the rate of developing significant stenosis by 28 percent, compared to placebo.

Graft patency is the useful life of a graft before it becomes blocked the first time.

“This drug combination provides a modest but important new therapy to keep AV grafts in good working order so patients can get the dialysis they needBut clearly more research is needed to extend the useful life of AV grafts,” said Dr.Griffin P. Rodgers, Director National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

The researchers enrolled 649 participants with new AV grafts were for the five-year long trial at 13 clinical sites in the United States.

All the participants were randomly assigned to treatment with dipyridamole plus aspirin or to a placebo.
Our trial results show that we now have a drug therapy that significantly prolongs the viability of AV grafts. This is an important step forward as we proceed to develop therapies to improve dialysis patients’ quality of life,” said Dr. Bradley S. Dixon, lead author of the study.

The study has been published in the New England Journal of Medicine. (ANI)

Recession-hit Denise Richards cuts mansion price

Washington, May 18 (ANI): The ongoing economic crisis seems to have taken its toll on Denise Richards also, for the actress has been forced to reduce the selling price of her California mansion.

The former Bond girl has slashed 400,000 dollars off the asking price of her Hidden Hills home after it was first advertised at 4,250,000 dollars.

According to RadarOnline.com, Richards dropped the asking price to 3,999,999 dollars, and has now cut it by a further 200,000 dollars to 3.8 million in a bid to attract potential buyers, reports Contactmusic.

After receiving harsh criticism for her performance of baseball anthem Take Me Out To The Ball Game at Chicago, Illinois” Wrigley Park, Richards has come out to explain her “awful” singing.

She confessed that she agreed to sing the song only because Cubs officials asked her to perform in return for letting her set up an information booth for the Kidney Cancer Association during riday’s game. (ANI)

3-D kidney atlas to help researchers, physicians treat renal diseases

Washington, May 16 (ANI): In a bid to diagnose and treat renal diseases early and more successfully, researchers from nine European countries have spent four-and-a half years to create a three-dimensional virtual “Kidney Atlas”, which incorporates the latest research findings on the development and diseases of the kidney.

The Kidney Atlas was part of the European Renal Genome Project (EuReGene), coordinated by the Max Delbruck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, which the European Union (EU) funded with more than 10 million euros.

Renal disease not only affects the elderly because of hypertension and diabetes, but also targets children, who are often born with congenital renal anomalies.

Particularly, the increase in the incidence of type 2 diabetes has caused a rise in the number of renal patients.

While the primary aim of the Kidney Atlas is to map genes that play a key role in renal diseases, it also contains other data, for example on anatomy.

The Kidney Atlas, primarily directed towards both basic researchers and clinicians, also contains information for the general public.

The Atlas is based upon various Genome Projects, and the scientists involved in its creation were pathologists, developmental and molecular biologists as well as geneticists from 14 research groups from non-university institutions, universities and six university clinics.

Project coordinator, Professor Thomas Willnow (MDC), has said that the Kidney Atlas will also be of great significance for the research of metabolic disorders, which lead to kidney damage such as diabetes.

The Kidney Atlas was presented at MDC during a two-day symposium, which was attended by approximately 100 researchers. (ANI)