Waking up ”sleeping” eggs may boost fertility

London, May 18 (ANI): Scientists in the US say that aging women or women who froze ovaries prior to cancer treatments may have a chance to have babies based on a novel method that can bring dormant reproductive cells into an active state.

Female mammals are born with millions of dormant eggs, but only a small fraction ever mature into cells with reproductive potential.

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

As part of the study, Aaron Hsueh at Stanford University Medical School in California and his colleagues exposed mouse ovaries to a PTEN inhibitor and a molecule that stimulates the signalling pathway that PTEN inhibits, reports New Scientist.

Control ovaries remained untreated. The ovaries were then transplanted back into the mice, and they received a hormone to stimulate egg development.

Two weeks later, the treated ovaries contained two to six times as many mature follicles – which have the potential to release mature eggs – as the untreated ones.

Twenty healthy mouse pups were born after fertilised eggs from the treated ovaries were implanted into surrogate mothers.

Hsueh”s team has used a similar approach to stimulate fragments of human ovarian tissue. When these were implanted into mice, four times as many mature follicles were produced as in controls. But for ethical reasons, the eggs could not be fertilised.

The study has been published in the Journal Proceedings of the National Academy of Sciences. (ANI)

Mum”s phone call as comforting as a hug during stressful times

Washington, May 12 (ANI): A simple phone call from your mum or a warm hug has often brightened your gloomy moments, and now this has been scientifically proven by a new American research.

The findings of the study, conducted by researchers at the University of Wisconsin-Madison, have appeared in the journal Proceedings of the Royal Society B.

Biological anthropologist Leslie Seltzer tested a group of seven- to 12-year-old girls with an impromptu speech and series of math problems in front of a panel of strangers, sending their hearts racing and levels of cortisol – a hormone associated with stress – soaring.

Seth Pollak, psychology professor and director of UW-Madison”s Child Emotion Lab, said: “Facing a challenge like that, being evaluated, raises stress levels for a lot of people.”

Once stressed, one-third of the girls were comforted in person by their mothers – specifically with hugs, an arm around the shoulders and the like.

One-third were left watch an emotion-neutral 75-minute video. The rest were handed a telephone. It was mom on the line, and the effect was dramatic.

Seltzer said: “The children who got to interact with their mothers had virtually the same hormonal response, whether they interacted in person or over the phone.”

The girls” levels of oxytocin, often called the “love hormone” and strongly associated with emotional bonding, rose significantly and the stress-marking cortisol washed away.

Seltzer said: “It was understood that oxytocin release in the context of social bonding usually required physical contact.

“But it”s clear from these results that a mother”s voice can have the same effect as a hug, even if they”re not standing there.”

And the reprieve from stress or anxiety is a lasting one.

Pollak said: “It stays well beyond that stressful task.

“By the time the children go home, they”re still enjoying the benefits of this relief and their cortisol levels are still low.”

The findings square with a “tend and befriend” theory explaining how stress regulation may differ between males and females.

Confronted with a threat, males may be more likely to choose between fight and flight.

A female with offspring in tow or slowed by pregnancy, however, may have to make different choices.

Seltzer said: “You might not be able to run with a child or defend yourself without endangering both of you.”

Instead, Seltzer explained, it might make more sense for a female to create or use a social bond to deal with a stressor – either through touch or soothing vocal communication.

Seltzer said: “Apparently this hormone, oxytocin, reduces stress in females after both types of contact, and in doing so may strengthen bonds between individuals.”

Pollak said: “For years I”ve seen students leaving exams and the first thing they do is pull out their cell phone and make a call.

“I used to think, ”How could those over-attentive, helicopter parents encourage that?” But now? Maybe it”s a quick and dirty way to feel better. It”s not pop psychology or psychobabble.”

He added: “It”s hard to get cortisol up. It”s hard to get oxytocin up.

“That a simple telephone call could have this physiological effect on oxytocin is really exciting.” (ANI)

Witness brain scan doesn’t help

London, May 12 (ANI): Monitoring brain activity of witnesses reveals no more than what they say they remember, a study has shown.

The study by Jesse Rissman and his team at Stanford University in California comes amid controversy over whether to admit functional MRI scans as evidence in US courts.

As part of their research, the team asked 16 volunteers to view 200 mugshots, reports New Scientist.

An hour later, they were again shown pictures of faces, some of which they had seen before and others that were new.

The researchers recorded fMRI scans of the volunteers” brains as they reported which faces they recognised.

While the brain scans matched the volunteers” decisions on whether the faces were familiar, they could not predict if the recollection was accurate.

The team also don”t know how easily a witness could cheat the system: remembering a recent event or fabricating a lie may look the same to the scanner.

The study has been published in the Journal Proceedings of the National Academy of Sciences. (ANI)

Chemicals from seaweeds damage coral on contact

Washington, May 11 (ANI): Researchers have offered first proof that several common species of seaweeds in both the Pacific and Caribbean Oceans can kill corals upon contact using chemical means.

While competition between seaweed and coral is just one of many factors affecting the decline of coral reefs worldwide, this chemical threat may provide a serious setback to efforts aimed at repopulating damaged reefs. Seaweeds are normally kept in check by herbivorous fish, but in many areas overfishing has reduced the populations of these plant-consumers, allowing seaweeds to overpopulate coral reefs.

A study documenting the chemical effects of seaweeds on corals was scheduled to be published May 10, 2010 in the early edition of the journal Proceedings of the National Academy of Sciences (PNAS).

“Between 40 and 70 percent of the seaweeds we studied killed corals,” said Mark Hay, a professor in the School of Biology at Georgia Tech. “We don”t know how significant this is compared to other problems affecting coral, but we know this is a growing problem. For reefs that have been battered by human use or overfishing, the presence of seaweeds may prevent natural recovery from happening at all.”

Coral reefs are declining worldwide, and scientists studying the problem had suspected that proliferation of seaweed was part of the cause – perhaps by crowding out the coral or by damaging it physically.

Using racks of coral being transplanted as part of repopulation efforts, Hay and graduate student Douglas Rasher compared the fate of corals from two different species when they were placed next to different types of seaweed common around Fijian reefs in the Pacific – and Panamanian reefs in Caribbean. They planted the seaweeds next to coral being transplanted – and also placed plastic plants next to some of the coral to simulate the effects of shading and mechanical damage. Other coral in the racks had neither seaweeds nor plastic plants near them.

The researchers revisited the coral two days, 10 days and 20 days later. In as little as two days, corals in contact with some seaweed species bleached and died in areas of direct contact. In other cases, the effects took a full 20 days to appear – or for some seaweed species, no damaging effects were noted during the 20-day period. Ultimately, as much as 70 percent of the seaweed species studied turned out to have harmful effects – but only when they were in direct contact with the coral.

To confirm that chemical factors were responsible, Hay and Rasher extracted chemicals from the seaweeds – and from only the surfaces of the seaweeds. They then applied both types of chemicals to corals by placing the chemicals into gel matrix bound to a strip of window screen, forming something similar to a gauze bandage and applying that directly to the corals. To a control group of corals, they applied the gel and screen without the seaweed chemicals.

The effects confirmed that chemicals from both the surface of certain seaweeds and extracts from those entire plants killed corals.

“In all cases where the coral had been harmed, the chemistry appeared to be responsible for it,” said Hay. “The evolutionary reasons why the seaweeds have these compounds are not known. It may be that these compounds protect the seaweeds against microbial infection, or that they help compete with other seaweeds. But it”s clear now that they also harm the corals, either by killing them or suppressing their growth.” (ANI)

How the human brain learns language

Washington, Apr 30 (ANI): There is no single advanced area of the human brain that gives it language capabilities above and beyond those of any other animal species, says a new study from the University of Rochester.

Instead, humans rely on several regions of the brain, each designed to accomplish different primitive tasks, in order to make sense of a sentence.

Depending on the type of grammar used in forming a given sentence, the brain will activate a certain set of regions to process it, like a carpenter digging through a toolbox to pick a group of tools to accomplish the various basic components that comprise a complex task.

“We”re using and adapting the machinery we already have in our brains,” said study coauthor Aaron Newman. “Obviously we”re doing something different [from other animals], because we”re able to learn language unlike any other species. But it”s not because some little black box evolved specially in our brain that does only language, and nothing else.”

The team of brain and cognitive scientists – comprised of Newman (now at Dalhousie University after beginning the work as a postdoctoral fellow at the University of Rochester), Elissa Newport (University of Rochester), Ted Supalla (University of Rochester), Daphne Bavelier (University of Rochester), and Peter Hauser (Rochester Institute of Technology) – published their findings in the latest edition of the journal Proceedings of the National Academies of Science. (ANI)

Our bodies make their own morphine

Washington, Apr 27 (ANI): Human bodies may possess the biochemical machinery to produce a small but steady amount of natural morphine, according to a new study.

In the study, it was shown that mice produce the “incredible painkiller”, and that humans and other mammals possess the same chemical road map for making it, said study co-author Meinhart Zenk, who studies plant-based pharmaceuticals at the Donald Danforth Plant Science Center in St. Louis, Missouri.

To come up with finding, boffins injected mice with an extra dose of a natural brain chemical called tetrahydropapaveroline (THP), which humans and mice are known to produce, reports The National Geographic News.

And then, by using a tool called a mass spectrometer to analyze the mouse urine, the team was able to tell that THP underwent chemical changes in the body that created morphine.

The study has been published in the journal Proceedings of the National Academy of Sciences. (ANI)

30-million-years-old worms munched on whale bones

Washington, April 21 (ANI): Palaeontologists have discovered the first fossil boreholes of the worm Osedax that consumes whale bones on the deep-sea floor.

The international team of scientists led by the paleontologist Steffen Kiel at the University of Kiel, Germany, concludes that ‘boneworms’ are at least 30 million years old.

Six years ago, Osedax was first described based on specimens living on a whale carcass in 2891 m depth off California. Since then, paleontologists have been searching for fossil evidence to pin down its geologic age.

Now, scientists have found 30-million-year-old whalebones with holes and excavations matching those of living Osedax in size and shape.

The evidence of the boreholes and cavities made by the living worms was provided by Greg Rouse (Scripps Institution of Oceanography), one of the original discoverers of Osedax.

To produce accurate images of the fossil boreholes, the bones were CT-scanned by the scientists. The fossil bones belong to ancestors of our modern baleen whales and their age was determined using so-called co-occurring index fossils.

“The age of our fossils coincides with the time when whales began to inhabit the open ocean,” said Steffen Kiel.

Only from the open ocean dead whales could sink to the deep-sea floor where they served as food for the boneworms.

“Food is extremely rare on the vast deep-sea floor and the concurrent appearance of these whales and Osedax shows that even hard whale bones were quickly utilized as food source,” said Steffen Kiel.

The ancient bones were found by the American fossil collector Jim Goedert.

The findings have been published in the current issue of the scientific journal Proceedings of the National Academy of Sciences of the USA. (ANI)

World”s strongest insect revealed

Washington, March 24 (ANI): Scientists have finally achieved success in finding the world”s strongest insect, a species of dung beetle called Onthophagus taurus.

Dr Rob Knell from Queen Mary, University of London and Professor Leigh Simmons from the University of Western Australia discovered the strongest beetle could pull an astonishing 1,141 times its own body weight – the equivalent of a 70kg person lifting 80 tonnes (almost six full double-decker buses).

The researchers also found these insect athletes have to take care of their diet as much as human athletes. Even the strongest beetles were reduced to feeble weaklings when put on a poor diet for a few days.

Dr Knell from Queen Mary”s School of Biological and Chemical Sciences said: “Insects are well known for being able to perform amazing feats of strength…and it”s all on account of their curious sex lives. Female beetles of this species dig tunnels under a dung pat, where males mate with them. If a male enters a tunnel that is already occupied by a rival, they fight by locking horns and try to push each other out.”

Knell and Simmons tested the beetles” ability to resist a rival by measuring how much weight was needed to pull him out of his hole.

Dr Knell said: “Interestingly, some male dung beetles don”t fight over females.

“They are smaller, weaker and don”t have horns like the larger males. Even when we fed them up they didn”t grow stronger, so we know it”s not because they have a poorer diet.

“They did, however, develop substantially bigger testicles for their body size. This suggests they sneak behind the back of the other male, waiting until he”s looking the other way for a chance to mate with the female. Instead of growing super strength to fight for a female, they grow lots more sperm to increase their chances of fertilising her eggs and fathering the next generation.”

The research has appeared in the journal Proceedings of the Royal Society B. (ANI)

Babies are born to dance

Washington, Mar 16 (ANI): Infants respond to the rhythm and tempo of music and find it more engaging than speech, boffins have found.

The finding suggests that babies may be born with a predisposition to move rhythmically in response to music.

The research was conducted by Dr Marcel Zentner, from the University of York”s Department of Psychology, and Dr Tuomas Eerola, from the Finnish Centre of Excellence in Interdisciplinary Music Research at the University of Jyvaskyla.

Dr Zentner said: “Our research suggests that it is the beat rather than other features of the music, such as the melody, that produces the response in infants.

“We also found that the better the children were able to synchronize their movements with the music the more they smiled.

“It remains to be understood why humans have developed this particular predisposition. One possibility is that it was a target of natural selection for music or that it has evolved for some other function that just happens to be relevant for music processing.”

In the study, Infants listened to a variety of audio stimuli including classical music, rhythmic beats and speech. Their spontaneous movements were recorded by video and 3D motion-capture technology and compared across the different stimuli.

Professional ballet dancers were also used to analyse the extent to which the babies matched their movement to the music.

The study has been published in the journal Proceedings of the National Academy of Sciences Online Early Edition. (ANI)

Scientists extract DNA of extinct giant bird from fossil eggs

London, March 10 (ANI): Experts have successfully managed to extract DNA from a 19,000-year-old emu eggshell.

Charlotte Oskam and Michael Bunce, Murdoch University in Perth, Western Australia, were able to isolate mitochondrial DNA from the eggshells of several extinct megafauna, including the giant moa of New Zealand and a 19,000-year-old emu from Australia.

The researchers’ breakthrough also included recovery of DNA from the egg of the elephant bird of Madagascar, New Scientist reported.

The findings will help understand better how ancient bird and reptilian species lived and died, Bunce explained.

Bunce further elaborated how eggshell was the best substance for radiocarbon dating and isotope analysis, which gives information about the environment in which the egg was laid.

Jaime Gongora, an expert in avian genetics, the University of Sydney, said: “It”s a breakthrough. Extracting even a little more DNA is really important with ancient samples.”

Matt Phillips at Australian National University, Canberra, nodded: “Better access to the genetic information of the nuclear genome promises far richer reconstructions of evolutionary history than is currently possible.”

The study has been published in the journal Proceedings of the Royal Society B. (ANI)

Now, a ‘patch’ to mend broken hearts

London, Aug 25 (ANI): Scientists in Israel have developed a ‘patch’ from heart muscle that can be used to fix scarring left over from a heart attack.

The researchers showed that the technique strengthened the hearts of rats that had suffered heart attacks, reports the BBC.

The ‘patch’ was grown in abdominal tissue first, then transplanted to damaged areas of the heart.

This is the first experiment to show that such patches can actually improve the health of a heart after it has been damaged.

The researchers measured an increase in the size of the muscle in damaged areas, and improved conduction of the electrical impulses needed for the heart to pump normally.

Heart attacks usually cause irreversible damage to heart muscle. If people survive, then the damaged muscle can cause another serious condition called heart failure.

The researchers, led by Tal Dvir from Ben-Gurion University of the Negev in Beer-Sheva, hope that the procedure may eventually lead to treatments in humans because of its “simplicity and safety”.

However, they added “because most patients with heart attacks are old, and multiple surgery can pose a large risk to them, our strategy is not currently an option”.

The study has been described in the journal Proceedings of the National Academy of Sciences (PNAS). (ANI)

Bird flu virus ‘linked’ to Parkinson’s, Alzheimer’s

London, Aug 13 (ANI): Some kinds of influenza viruses may set up people infected with them to be at higher risk of developing chronic neurodegenerative diseases like Parkinson’s and Alzheimer’s later in life, according to a new study.

Researchers from St. Jude Children’s Research Hospital in Memphis examined the impact of the H5N1 avian flu virus in the brains of mice.

During the study, Richard Smeyne and colleagues sprayed a solution containing a highly pathogenic subtype of H5N1 avian flu into the noses of 225 mice.

They found that the virus infected nerves in the gut, then entered the brain stem and finally reached the brain.

In the brain, it led to chronic activation of the immune system, even long after the viral infection had been cleared.

This immune system activity later led to protein aggregation and neuron loss in the brain, and to symptoms like tremor and loss of coordination – the hallmarks of Parkinson’s and Alzheimer’s.

“Infection with influenza virus might leave the brain vulnerable to damage from future infections with new influenza strains,” New Scientist quoted Smeyne as saying.

He said that this is more likely to happen in young children or during an flu pandemic.

Smeyne suspects that all flu viruses, including the current H1N1 swine flu pandemic, could cause symptoms of encephalitis, or inflammation of the brain.

However, he insists that there is currently no proof that flu viruses other than the H5N1 he worked with can enter the central nervous system.

The study has been described in the Journal Proceedings of the National Academy of Sciences. (ANI)

Brain scans can tell ‘honest’ person from ‘dishonest’ one even when both tell the truth

Washington, July 14 (ANI): Researching into the cognitive process involved with honesty, Harvard University psychologists have come to the conclusion that truthfulness depends more on absence of temptation than active resistance to temptation.

Assistant Professor Joshua Greene and graduate student Joe Paxton, the duo that led the study, have revealed that they used neuroimaging to look at the brain activity of people given the chance to gain money dishonestly by lying, and found that honest people showed no additional neural activity when telling the truth.

The researchers say that that observation implied that extra cognitive processes were not necessary to choose honesty.

However, the researchers also found that individuals who behaved dishonestly, even when telling the truth, showed additional activity in brain regions that involve control and attention.

“Being honest is not so much a matter of exercising willpower as it is being disposed to behave honestly in a more effortless kind of way. This may not be true for all situations, but it seems to be true for at least this situation,” says Greene.

The researchers say that they carried out the study to test two theories about the nature of honesty – the “Will” theory, in which honesty results from the active resistance of temptation, and the “Grace” theory in which honesty is a product of lack of temptation.

Writing about their findings in the journal Proceedings of the National Academy of Sciences, they have suggested that the “Grace” theory is true, because the honest participants did not show any additional neural activity when telling the truth.

To prompt participants to lie, the researchers created a cover story about the focus of their study. The research was presented as a study of paranormal ability to predict the future.

The researchers asked those participating in the study to predict the outcomes of a series of coin tosses.

The subjects were told that the research team believed predicting the future was more likely when given a monetary incentive, and when the prediction was not shared in advance of the outcome. That gave the participants the opportunity to lie and say that they had correctly predicted the coin toss to win the money.

The subjects’ honesty was assessed based on whether their number of correct responses was statistically feasible.

According to the researchers, the participants who reported improbably high levels of accuracy were classified as dishonest, and those reporting statistically feasible levels of accuracy were classified as honest.

With the aid of fMRI technique, Greene found that the honest individuals displayed little to no additional brain activity when reporting their prediction of the coin toss. However, the dishonest participants’ brains were most active in control-related brain regions when they chose not to lie.

Greene notes that there was an important distinction between the brain activity when the honest participants told the truth, and when the dishonest participants told the truth.

“When the honest people leave money on the table, you don’t see anything special or extra going on in their brains at all. Whereas, when the dishonest people leave money on the table, that’s when you saw the most robust control network activation,” says the researcher.

The researchers hope that their findings may pave the way for a technique to detect lies by looking at someone’s brain activity, but they also concede that a lot more work must be done before this becomes possible. (ANI)

New discovery to pave way for novel treatments of alcohol dependence

Washington, July 1 (ANI): Scientists have identified a brain mechanism linked with alcohol addiction that involves the stomach hormone ghrelin, a discovery that may lead to new therapies for addictions like alcohol dependence.

The researchers at the Sahlgrenska Academy, Gothenburg, have observed that blocking ghrelin’s actions in the brain can reduce alcohol’s effects on the reward system.

Ghrelin is a hormone produced by the stomach and, by signalling in the brain, it increases hunger.

Its involvement in alcohol addiction highlights the reward system of the brain as a key target for ghrelin’s effects.

“Ghrelin’s actions in the brain may be of importance for all kinds of addictions, including chemical drugs such as alcohol and even food,” said Suzanne Dickson, Professor of Physiology, a leading expert in appetite regulation.

The researchers showed that mice treated with ghrelin increase their alcohol consumption.

When ghrelin’s actions are blocked, for example, by administering ghrelin receptor antagonists, mice no longer show preference for an alcohol-associated environment.

This means that alcohol is no longer able to produce its addictive effects that include reward-searching behaviour (similar to craving in alcoholic patients).

“If we can develop drugs that block the receptors for ghrelin, we could have a new effective treatment for alcohol dependence. It may however take several years until such a pharmacological treatment will reach the patient”, said a co-author of the study.

Alcohol dependence is a complex and chronic disease that leads to adverse consequences affecting not only the patient but also their immediate family, and it also has a profound economic burden on society.

The results of the study will be published in the renowned American scientific journal Proceedings of the National Academy of Sciences (PNAS). (ANI)

Monkeys exchange grooming as common currency for food and sex

London, July 1 (ANI): A French researcher has found that grooming acts as a common currency among monkeys, and that the non-human primates exchange it for food, greater tolerance from dominant members of the group, and sex.

Ronald Noe, associated with the University of Strasbourg, created an artificial market in groups of vervet monkeys by introducing a plastic box filled with food that only one subordinate female was trained to open. The aim was to see how the exchange system works.

The researcher says that just an hour after the female opened the box, it was observed that she was rewarded by being groomed more often and for longer by other group members, and that she could afford to groom dominant group members less often.

Noe and colleagues later halved the importance of the female’s ability to provide food, by introducing a second lunch box that only a second female could open.

The first female’s grooming “stock value” decreased, while the second monkey’s rose, until both arrived at roughly the same value and were groomed for the same amount of time.

“One can say that the second provider was groomed at a cost of the first provider,” New Scientist magazine quoted Noe as saying.

A research article describing the study has been published in the journal Proceedings of the National Academy of Sciences. (ANI)

Green neighbors unwittingly goad one to go green too

Washington, June 30 (ANI): Individuals are more likely to register for conservation programs if their neighbors do, says a new study.

The research, to be published in the journal Proceedings of the National Academy of Sciences (PNAS) this week, is the first to focus on the phenomenon of social norms in the context of China’s conservation efforts, said scientist Jianguo “Jack” Liu of Michigan State University (MSU).

“Much of the marginal cropland in rural communities has been converted from agriculture to forests through the Grain-to-Green Program, one of the largest ‘payment for ecosystem services’ programs in the world,” said Alan Tessier, program director in the National Science Foundation (NSF)’s Division of Environmental Biology.

“Results of this study show that a community’s social norms have substantial impacts on the sustainability of these conservation investments,” the expert added.

While money is a key factor in whether people sign up for the voluntary program, peer pressure also plays a surprisingly large role, Liu said.

“That’s the power of social norms. It’s like recycling. If you see your neighbors doing it, you’re more likely to do it,” he said.

A representative survey of households in China’s Wolong Nature Reserve for giant pandas found that both government payments and social norms had “significant impacts” on citizens’ intentions of re-enrolling in the Grain to Green program.

“In other words, people’s re-enrollment intentions can be affected by the re-enrollment decisions of their neighbors and tend to conform to the majority,” says Liu. (ANI) and

Homing pigeons’ inbuilt ‘satnav’ that uses Earth’s magnetic field helps them return home

London, June 24 (ANI): Homing pigeons have fascinated humans for many years through their uncanny ability to find their way home from thousands of miles away. Now, researchers claim to have found the reason behind it.

Scientists researchers from the University of Auckland in New Zealand said that the birds have inbuilt ‘satnav’ that uses Earth’s magnetic field to pinpoint position and help them find their way home.

Researchers have discovered that like global positioning technology, they first determine where they are before heading off for home, reports The Telegraph.

In the study, which has been published in the journal Proceedings of the Royal Society B, boffins discovered that the initial flight path involves finding the magnetic waves which can then be used to find their way home.

In order to reach the conclusion, researchers reviewed a number of studies in Germany that saw as many 150 birds returning to three lofts near Frankfurt.

Dr Cordula Mora and her colleagues concluded that “respond to the Earth’s magnetic field at the release site”, calculate their position using the fields and then calculate their way home.

“Our results imply that pigeons use the earth’s magnetic field for determining their position at the release site before laying a course for home,” she said. (ANI)

‘Chemical nose’ can sniff out cancer

Washington. June 23 (ANI): Researchers at the University of Massachusetts Amherst have developed a ‘chemical nose’ that can sniff out cancer.

The revolutionary tool contains an array of nanoparticles and polymers that differentiate not only between healthy and cancerous cells but also between metastatic and non-metastatic cancer cells.

Currently, detecting cancer via cell surface biomarkers has taken what’s known as the “lock and key” approach.

However, this method includes foreknowledge of the biomarker.

“Our new method uses an array of sensors to recognize not only known cancer types, but it signals that abnormal cells are present,” said chemist Vincent Rotello, who conducted the research with cancer specialist Joseph Jerry.

“That is, the chemical nose can simply tell us something isn’t right, like a ‘check engine light,’ though it may never have encountered that type before,” he added.

Further, the chemical nose can be designed to alert doctors of the most invasive cancer types, those for which early treatment is crucial.

The study conducted using four human cancer cell lines (cervical, liver, testis and breast), as well as in three metastatic breast cell lines, and in normal cells showed that the new detection technique correctly indicated not only the presence of cancer cells in a sample but also identified primary cancer vs. metastatic disease.

Rotello’s research team, with colleagues at the Georgia Institute of Technology, designed the new detection system by combining three gold nanoparticles that have special affinity for the surface of chemically abnormal cells, plus a polymer known as PPE, or para-phenyleneethynylene.

As the ‘check engine light,’ PPE fluoresces or glows when displaced from the nanoparticle surface.

The study appears in the journal Proceedings of the National Academy of Sciences online. (ANI)

Crows as smart as chimps when it comes to making and using tools

Washington, May 26 (ANI): Rooks, a member of the crow family, are no bird-brained, infact they’re as good with their beaks as chimps are with their hands.esearchers at the Universities of Cambridge and Queen Mary, University of London have found that rooks have the capacity to use and make tools, modifying them to make them work and using two tools in a sequence.

The surprising study has been published in the journal Proceedings of the National Academy of Sciences.

“This finding is remarkable because rooks do not appear to use tools in the wild, yet they rival habitual tools users such as chimpanzees and New Caledonian crows when tested in captivity,” said Chris Bird, the lead author of the study.

In a series of experiments, the rooks quickly learnt to drop a stone to collapse a platform and acquire a piece of food, and subsequently showed the ability to choose the right size and shape of stone without any training.

Not only could they use stones to solve the task, but they were flexible in their tool choice, using and modifying sticks to achieve the same goal. When the correct tool was out of reach, they used another tool to get it, demonstrating the ability to use tools sequentially.

In further tests, the rooks were able to use a hook tool to get food out of a different tube and even creatively bent a straight piece of wire to make the hook to reach the food.

“We suggest that this is the first unambiguous evidence of animal insight because the rooks made a hook tool on their first trial and we know that they had no previous experience of making hook tools from wire because the birds were all hand-raised,” said Dr Nathan Emery, Queen Mary University of London, in whose lab these experiments were performed.

These findings suggest that rooks’ ability to use tools and represent the tools’ useful properties may be a by-product of a sophisticated form of physical intelligence, rather than tool use having evolved as an adaptive specialisation, such as has been proposed for the tool using abilities of New Caledonian crows. (ANI)

Stone Age humans made ‘superglue’ 70,000yrs ago

Washington, May 12 (ANI): Stone Age humans who lived about 70,000 years ago were such good chemists that they made a sophisticated kind of natural glue by tweaking the chemical and physical properties of an iron-containing pigment, known as red ochre, with the gum of acacia trees for their shafted tools, according to a study.

While it has long been believed that the blood-red pigment served a decorative or symbolic purpose, scientists also suspected that the pigment might have been purposely added to improve glue that held the peoples’ tools together.

With a view to testing this idea, researchers at the University of the Witwatersrand in Johannesburg, South Africa, recreated the ancient glue using only Stone Age materials and technologies.

The results showed that glue containing red ochre was less brittle and more shatterproof than glue made from acacia gum alone.

“We discovered that when we used ochre, the glue is much more robust, and the stone tool doesn’t come off the shaft,” National Geographic News quoted study team member Lyn Wadley as saying.

The researchers also believe that making the glue was mentally taxing work that would have needed the ancient people to account for differences in the chemistry of gum harvested from different trees, and in the iron content of ochre from different sites.

“They couldn’t possibly have known about chemical pH or iron content … but they knew that certain combinations of things worked very well,” Wadley said.

She further said that the intelligence of Stone Age humans was more akin to that of modern humans than previously thought.

“Our study shows that there’s a lot of overlap between ourselves and these ancient people. Their technology was a lot more competent than we have given them credit for.”

A research article on this work has been published in the journal Proceedings of the National Academy of Sciences. (ANI)