Binge drinking ‘can increase pancreatic cancer risk’

Washington, May 20 (ANI): A new research from UT Southwestern Medical Center suggests that heavy alcohol use and binge drinking can increase the risk of pancreatic cancer in men.

Researchers found that men who consumed alcohol increased their risk of pancreatic cancer by 1.5 to 6 times compared with those who didn”t consume alcohol or who had less than one drink per month.

Also, men who engaged in binge drinking had a 3.5 times greater likelihood of developing pancreatic cancer.

“If this relationship continues to be confirmed, reducing heavy and binge drinking may be more important than we already know,” said Dr. Samir Gupta, assistant professor of internal medicine at UT Southwestern and lead author of the study, which was conducted at the University of California, San Francisco.

Researchers defined one drink as a can, bottle or 12 ounces of beer; a 4-ounce glass of wine; or one shot of liquor – each serving contains about 14 grams of alcohol.

The heaviest drinkers consumed 21 to 35 drinks per week. Binge drinking was defined as consuming five or more drinks during one drinking session.

However, because women don’t consume as much alcohol as men, researchers did not find the same association amongst them.

This study about the relation between pancreatic cancer and alcohol is different and more detailed because the researchers considered other multiple factors which weren’t taken into account earlier.

In the current study, researchers used structured questionnaires to interview pancreatic cancer patients in the San Francisco area diagnosed between 1995 and 1999 and compared those results with those of control participants matched by sex, age and county of residence.

The 532 cancer patients ranged in age from 21 to 85, with the majority between 60 and 80 years of age. Fifty-five percent of study participants were men; 83 percent of them were Caucasian; and most of them were of normal weight with some college education. The 1,701 control participants were of similar demographics.

Cancer of the pancreas, an organ important for digestion and production of hormones, has the lowest overall five-year survival rate of all specific cancers. Early signs of pancreatic cancer are difficult to diagnose, partly because the organ is located deep in the upper abdomen. Mortality rates have changed little in the past three decades, according to the National Cancer Institute.

This study is available online in Cancer Causes and Control. (ANI)

Why men store fat in their bellies, women in their hips

Washington, May 15 (ANI): Researchers claim to have answered the age-old question of why men store fat in their bellies and women store it in their hips – the fat tissue is almost completely different, genetically speaking that is.

“We found that out of about 40,000 mouse genes, only 138 are commonly found in both male and female fat cells,” said Dr. Deborah Clegg, assistant professor of internal medicine at UT Southwestern Medical Center and senior author of the study appearing in the International Journal of Obesity. “This was completely unexpected. We expected the exact opposite – that 138 would be different and the rest would be the same between the sexes.”

The study involved mice, which distribute their fat in a sexually dimorphic pattern similar to humans.

“Given the difference in gene expression profiles, a female fat tissue won”t behave anything like a male fat tissue and vice versa,” Dr. Clegg said. “The notion that fat cells between males and females are alike is inconsistent with our findings.”

In humans, men are more likely to carry extra weight around their guts while pre-menopausal women store it in their butts, thighs and hips.

The bad news for men is that belly, or visceral, fat has been associated with numerous obesity-related diseases including diabetes and heart disease. Women, on the other hand, are generally protected from these obesity-related disorders until menopause, when their ovarian hormone levels drop and fat storage tends to shift from their rear ends to their waists.

“Although our new findings don”t explain why women begin storing fat in their bellies after menopause, the results do bring us a step closer to understanding the mechanisms behind the unwanted shift,” Dr. Clegg said.

For the study, researchers used a microarray analysis to determine whether male fat cells and female fat cells were different between the waist and hips and if they were different based on gender at a genetic level.

Because the fat distribution patterns of male and female mice are similar to those of humans, the researchers used the animals to compare genes from the belly and hip fat pads of male mice, female mice and female mice whose ovaries had been removed – a condition that closely mimics human menopause. Waist and hip fat (subcutaneous fat) generally accumulates outside the muscle wall, whereas belly fat (visceral fat), a major health concern in men and postmenopausal women, develops around the internal organs.

In addition to the genetic differences among fat tissues, the researchers found that male mice that consumed a high-fat diet for 12 weeks gained more weight than female mice on the same diet. The males” fat tissue, particularly their belly fat, became highly inflamed, while the females had lower levels of genes associated with inflammation. The female mice whose ovaries had been removed, however, gained weight on the high-fat diet more like the males and deposited this fat in their bellies, also like the males.

“The fat of the female mice whose ovaries had been removed was inflamed and was starting to look like the unhealthy male fat,” Dr. Clegg said. “However, estrogen replacement therapy in the mice reduced the inflammation and returned their fat distribution to that of mice with their ovaries intact.”

Dr. Clegg said the results suggest that hormones made by the ovaries may be critical in determining where fat is deposited. (ANI)

Indian doctor”s simple checklist for health at every age

Washington, May 7 (ANI): An Indian doctor has organised a simple checklist for health at every age, by collecting some of the “generally accepted truths” on how to prevent disease.

Shantanu Nundy, MD, a second-year resident in internal medicine at the University of Chicago Medical Center, was driven by his mother”s health questions and the difficulty of providing simple, reliable answers.

After making the checklist, Nundy persuaded the Johns Hopkins University Press to publish them as Stay Healthy at Every Age: What Your Doctor Wants you to Know.

“We all know it is far better to prevent an illness than to treat it,” he said.

“Yet because millions of Americans don”t know these things, and doctors don”t take the time to tell or remind them, thousands die each year from preventable disease,” he explained.

Five well-established but little-used measures, he argues, could save 100,000 lives a year, things as simple as taking a daily aspirin or getting a flu shot.

Yet, misled by a system designed to treat the sick rather than preserve health, fewer than half of those who could benefit know about and bother to take those simple steps.

This guide gives readers the tools to understand and acquire the preventive services they need.

Checklists, the simpler the better, have recently gained status in the world of medicine.

First employed in intensive care units, where complexity is vast, stakes are high and errors can be lethal, they have helped caregivers establish a higher standard of performance.

Checklists serve to “make explicit the minimum, expected steps in complex processes,” according to Atul Gawande, MD, a surgeon who has written a book about their value in medicine.

They can lower infection rates, prevent complications and reduce time in the hospital.

Nundy has adopted the checklist approach but shifted it from the complex world of the ICU to primary care, and from the doctor to the patient.

The idea came from his mother. She struggles with type-2 diabetes. As a medical student, eager to help, he combed through his texts and patient encounters looking for ways to keep her healthy.

He found quite a few-nothing new or surprising, but a long list of established, verified recommendations.

He was surprised to learn, however, that although his mother saw a physician regularly, much of the standard advice was new to her.

“She has a doctor. She has insurance. She has a college education and worked for the World Bank. But she didn”t know a lot of the basic steps,” he said.

So he stepped in, with constant advice on medicines and tests, diet and exercise. Over time, thanks to his diligence, the suggestions piled up. They soon became overwhelming.

So Nundy began searching the medical literature for simple comprehensive lists of which steps to take, which tests to consider at each age and which ones to avoid.

He found pieces of what his mother needed, but they were spread over many sources, primarily guidelines from the United States Preventive Services Task Force and the Centers for Disease Control and Prevention.

He could not, however find all the preferred advice in one place, so he set out to compile it himself. That led to the book.

The core of the 366-page book is 18 pages of lists, the current state of the art of preventive health through each phase of life.

There is a one-page checklist for early childhood and two pages for adolescents or those in their 20s.

With age comes extra pages: three each for the 30s, 40s, 50 to 64, and 65 and over. Some advice is for everyone, some just for women or men, with additional measures for people at greater risk for specific ailments.

Early childhood is mostly about screening and vaccinations. Sexually transmitted disease become a prominent health issue during adolescence and never quite goes away.

Diet and exercise, and alcohol and tobacco use, come to the fore in the 20s and 30s.

Cardiovascular issues gain prominence in the 40s, especially for men, and breast cancer prevention and detection for women. Colon cancer screening tops the list for the 50s.

After 65, vaccinations re-emerge as a crucial prevention tool. At age 80, those who started taking aspirin in their 40s or 50s can stop.

Some widely promoted health measures, on the other hand, don”t make the list. Despite nationwide campaigns for prostate cancer screening, the benefits remain uncertain, so no recommendation.

Nor do vitamin supplements help those who eat a healthy diet.

“They aren”t cheap. They aren”t covered by insurance. It”s just an extra pill,” Nundy said. (ANI)

Boffins come closer to understanding how cystic fibrosis causes lung disease

Washington, April 29 (ANI): A new American research has made an advance in scientists” understanding of how cystic fibrosis (CF) causes lung disease in people with the condition.

The study by a University of Iowa research team and colleagues at University of Missouri has appeared in the journal Science Translational Medicine.

Lead author David Stoltz, UI assistant professor of internal medicine, said: “Using our model we are beginning to answer that question, and it looks like infection does precede inflammation.

“The importance of that finding is that it could dictate what types of therapy we might use. Knowing that infection is first suggests that if we can prevent or fight infection, then that might delay or prevent the lung disease in people with CF.”

For example, the finding would seem to support early and aggressive treatment of lung infections in children with CF, added Stoltz, who also is assistant director of the Adult Cystic Fibrosis Center at UI Hospitals and Clinics.

The new experimental model that Stoltz and his colleagues used were pigs with a CF-causing gene mutation.

The team generated the pig model in the hope that it would more closely mimic the human disease than mouse models do.

By studying the CF pigs through their first six months of life, the team has shown that these animals do develop lung disease typical of what is seen in humans, including infection in the lungs, inflammation, and accumulation of mucus in the airways, which is a significant problem for patients with CF.

Randall Prather, distinguished professor of reproductive biotechnology at the University of Missouri, said: “This is a really great example where the pig serves as a model for what happens in the human, and the pig reacts to this disease in nearly the same way.

“In contrast, when you use mice, they don”t get the lung disease that is common in patients with cystic fibrosis.”

The team also found that the lungs of newborn CF pigs tended to be infected with more bacteria than lungs of control pigs.

Furthermore, within a few hours of birth, the CF pigs showed signs that their lungs are less able to get rid of bacteria from their lungs.

This problem might represent an initial step in the disease process that results in chronic lung infection in CF.

Stoltz said: “Our new model will help us understand the mechanisms of lung disease in humans with CF.

“It also provides a unique opportunity to test different therapies starting at a very early stage of the disease — much earlier than we can in humans with CF — and maybe to target preventive therapies that might help delay or even prevent the type of lung disease that affects people with CF.” (ANI)

Stomach pacemaker can help treat stomach disorders, chronic vomiting

Washington, Mar 30 (ANI): Individuals suffering from acute stomach disorders can occasionally suffer from chronic vomiting. According to a study from the Sahlgrenska Academy at the University of Gothenburg, Sweden, this symptom can be treated with electrical impulses from a pacemaker in the stomach.

A new method enables patients who could benefit from this treatment to be identified, and electrical stimulation leads to reduced nausea and fewer days in hospital, shows the study.

Gastric electrical stimulation has previously been shown to be effective in most diabetics who suffer from severe vomiting due to the disease. New research shows that people with other severe stomach disorders could also benefit from this treatment.

27 patients were included in a study testing electrical stimulation of the stomach. 22 had fewer symptoms as a result of initial temporary stimulation, and 20 of these then had a permanent pacemaker surgically inserted into the stomach. Of the patients who responded well to temporary stimulation, 90 percent also had good results in a long-term follow-up of the surgically inserted pacemaker.

The treatment led to reduced nausea and vomiting. In another study of 16 patients, electrical stimulation led to fewer days in hospital in the year following treatment. Simple temporary stimulation through the skin can be used to identify the patients who could benefit from the treatment.

“We insert gastric electrodes into the patient under local anaesthesia through a small incision in the skin, and these are then connected to an external pacemaker,” explains junior doctor Stina Andersson, a doctoral student at the Department of Internal Medicine. “If the results are positive, we can be relatively certain that treatment with a surgically inserted pacemaker will work for that patient. The next step is to insert a pacemaker using keyhole surgery.” (ANI)

Shift workers at increased irritable bowel syndrome risk

Washington, Mar 19 (ANI): Shift workers face a significantly increased risk of developing Irritable Bowel Syndrome (IBS) and abdominal pain compared to those working a standard day-time schedule, says a new study.

The study has been published in the American Journal of Gastroenterology.

“We know that people participating in shift work often complain of gastrointestinal symptoms such as abdominal pain, constipation and diarrhea,” says Sandra Hoogerwerf, M.D., assistant professor of internal medicine at the University of Michigan Medical School. “These are the same symptoms of IBS.”

IBS is the most common functional bowel disorder and is difficult to identify because it is diagnosed by clinical symptoms rather than tests, says Hoogerwerf, lead author of the study. IBS symptoms include recurrent episodes of abdominal pain or cramping in connection with altered bowel habits.

Hoogerwerf and her colleagues evaluated nurses classified into three groups—214 working permanent day shifts, 110 working permanent night shifts and 75 working rotating shifts between day and night—based on self-reported abdominal symptoms and sleep quality. More than 85 percent were women.

“Our findings suggest that nurses participating in shift work, particularly those who participate in rotating shift work, have a higher prevalence of IBS and abdominal pain. This association is independent of sleep quality,” the authors write.

“We know the colon has its own biological clock and that”s what increases the likelihood of having a bowel movement in the first six hours of the day,” Hoogerwerf says.

“Shift work can cause chronic disruption of that biological rhythm, resulting in that clock to constantly be thrown off and needing to adjust, creating symptoms of diarrhea, boating, constipation and abdominal pain and discomfort.”

The researchers say their study suggests that sleep disturbances do not completely explain the existence of IBS or abdominal pain associated with shift work.

“The question now for further research is if IBS and abdominal pain is an underlying manifestation of a circadian rhythm disorder,” Hoogerwerf says. (ANI)

Erectile dysfunction plus heart disease ups death risk

Washington, Mar 16 (ANI): Men with cardiovascular disease and erectile dysfunction (ED) are at an increased risk of death, according to a new study.

Reporting in Circulation: Journal of the American Heart Association, German researchers stated that erectile dysfunction (ED) is a strong predictor of death from all causes and of heart attack, stroke and heart failure in men with cardiovascular disease (CVD).

In the first study to show that ED is predictive of death and cardiovascular outcomes, researchers found that men with CVD and ED (compared to those without ED) were twice as likely to suffer death from all causes and 1.6 times more likely to suffer the composite of cardiovascular death, heart attack, stroke and heart failure hospitalization.

“Erectile dysfunction is something that regularly should be addressed in the medical history of patients; it might be a symptom of early atherosclerosis,” said Michael Böhm, M.D., lead author of the study and chairman of internal medicine in the Department of Cardiology and Intensive Care at the University of Saarland, Germany.

The worldwide study included 1,519 men from 13 countries in a substudy of the ONTARGET and TRANSCEND trials of cardiovascular patients. The men answered a questionnaire to determine whether they had ED. Men with ED were then categorized as having mild, mild-to-moderate, moderate or severe ED. The questionnaires were given at the initial visit, after two years or at the final visit after an average follow-up of five years. (ANI)

Blame the brain for overeating

Washington, Sept 14 (ANI): The next time you sabotage your efforts to get back on track after bingeing on an extra scoop of ice cream blame the brain, says a new study.

A new study, from UT Southwestern Medical Center, has suggested that fat from certain foods we eat makes its way to the brain. Once there, the fat molecules cause the brain to send messages to the body’s cells, warning them to ignore the appetite-suppressing signals from leptin and insulin, hormones involved in weight regulation.

The researchers also found that one particular type of fat – palmitic acid – is particularly effective at instigating this mechanism.

“Normally, our body is primed to say when we’ve had enough, but that doesn’t always happen when we’re eating something good,” said Dr. Deborah Clegg, assistant professor of internal medicine at UT Southwestern and senior author of the rodent study appearing in the September issue of The Journal of Clinical Investigation.

“What we’ve shown in this study is that someone’s entire brain chemistry can change in a very short period of time. Our findings suggest that when you eat something high in fat, your brain gets ‘hit’ with the fatty acids, and you become resistant to insulin and leptin,” Dr. Clegg said.

“Since you’re not being told by the brain to stop eating, you overeat,” the expert added.

Although it is known that eating a high-fat diet can cause insulin resistance, little has been known about the mechanism that triggers this resistance or whether specific types of fat are more likely to cause increased insulin resistance.

Dr. Clegg said she suspected the brain might play a role because it incorporates some of the fat we eat – whether it is from healthy oils or the not-so-healthy saturated fat found in butter and beef – into its structure.

Based on this suspicion, her team attempted to isolate the effects of fat on the animals’ brains.

To reach the conclusion, researchers exposed the animals to fat in different ways: by injecting various types of fat directly into the brain, infusing fat through the carotid artery or feeding the animals through a stomach tube three times a day. The animals received the same amount of calories and fat; only the type of fat differed. The types included palmitic acid, monounsaturated fatty acid and oleic acid.

Palmitic acid is a common saturated fatty acid occurring in foods such as butter, cheese, milk and beef. Oleic acid, on the other hand, is one of the most common unsaturated fatty acids. Olive and grapeseed oils are rich in oleic acid.

“We found that the palmitic acid specifically reduced the ability of leptin and insulin to activate their intracellular signaling cascades,” Dr. Clegg said.

“The oleic fat did not do this. The action was very specific to palmitic acid, which is very high in foods that are rich in saturated-fat,” the expert added. (ANI)

Family, friends may affect breast cancer surgery decision

Washington, Sept 1 (ANI): A new study from the University of Michigan Comprehensive Cancer Center has found that about 75 percent of women newly diagnosed with breast cancer are accompanied by a friend or family member during their first visit to a surgeon and that person plays a major role in the patient’s decision of what type of surgery to have.

In the study, the researchers looked at factors affecting a woman’s choice between a mastectomy to remove the entire breast or breast-conserving surgery, which involves removing only the tumor and is followed by radiation treatments.

They found that when the patient, rather than the doctor, drives the surgery decision, the patient is more likely to choose a mastectomy. This proved to be the case among all racial and ethnic groups.

The study also showed that women who had a friend or family member accompany them to the surgical consultation were more likely to receive a mastectomy, compared to women who attended the appointment alone.

Latinas who speak little English were most influenced by family in their decision-making: 75 percent, compared to 34 percent of white women.

“Family and friends have a potentially important role in treatment discussions. More than 70 percent of women brought someone with them to the appointment, providing a chance for surgeons to convey information to both the patient and her support person. Clearly, others help with and contribute to decision making, and may do so differently for different racial or ethnic groups,” says lead study author Sarah Hawley, Ph.D., M.P.H., research associate professor of internal medicine at the U-M Medical School.

Researchers analyzed survey responses from 1,651 women diagnosed with early stage breast cancer in the Detroit and Los Angeles metropolitan areas.

Patients were asked about their surgical treatment decision, including how involved they were in the decision making, whether a family member or friend accompanied them to the appointment and their attitudes toward surgery. Higher numbers of African Americans and Latinas were included.

The study appears online Aug. 31 in the Journal of the National Cancer Institute. (ANI)

Scientists find novel way to deliver cancer-fighting molecules

London, Aug 28 (ANI): Scientists from University of Iowa have found a novel way to inject cancer-fighting molecules in the bloodstream and inhibit tumour growth.

Small interfering RNA (siRNA), a type of genetic material, are known to block potentially harmful activity in cells, such as tumour cell growth.

But delivering siRNA successfully to specific cells without adversely affecting other cells has been challenging.

In the new study, the researchers have modified siRNA so that it can be injected into the bloodstream and impact targeted cells while producing fewer side effects.

The findings, which were based on animal models of prostate cancer, also could make it easier to create large amounts of targeted therapeutic siRNAs for treating cancer and other diseases.

“Our goal was to make siRNA deliverable through the bloodstream and make it more specific to the genes that are over expressed in cancer,” Nature quoted Dr Paloma Giangrande, assistant professor of internal medicine and a member of Holden Comprehensive Cancer Centre as saying.

Previous studies have shown that a compound called an aptamer can be combined with siRNA to target certain genes.

However, in the new study, the researchers trimmed the size of a prostate cancer-specific aptamer and modified the siRNA to increase its activity.

After injecting it into the bloodstream, the combination triggered tumour regression without affecting normal tissues.

Giangrande said making the aptamer-siRNA combination smaller akes it easier to produce large amounts of it synthetically,

The study results appeared in journal Nature Biotechnology. (ANI)

Potential target to treat patients with deadly lung disease identified

London, Aug 24 (ANI): Researchers at the University of Michigan have discovered a potential target that could help treat patients with idiopathic pulmonary fibrosis, a deadly lung disease.

They found that targeting of a novel gene utilizing genetic and pharmacologic strategies was successful in treating pulmonary fibrosis in mice and will be developed for future testing in humans.

The treatments attack an oxidant-generating enzyme, NOX4, that researchers discovered is involved in the fibrotic process – which involves scar-like tissue formation in an organ such as the lung.

“We’ve identified the target. We know the enemy now. This is the first study that shows pulmonary fibrosis is driven by this NOX4 enzyme,” said Subramaniam Pennathur, M.D., assistant professor of internal medicine/nephrology.

“But what’s really significant is this discovery may have relevance to fibrosis in other organ systems, not just the lung,” Pennathur added.

Pennathur said that those suffering from common cardiac or kidney diseases, which often involve fibrosis, also may benefit from treatments stemming from this research.

The discovery was made in the University of Michigan lab of Victor J. Thannickal, M.D.

Thannickal said the study points to a very viable treatment strategy for idiopathic pulmonary fibrosis, and researchers saw success both in mouse models of lung fibrosis and in fibrogenic cells isolated from lungs of patients with Idiopathic Pulmonary Fibrosis.

“It remains to be seen if fibrosis is reversible. But therapeutic targeting of this pathway this may allow us to halt the progression of fibrosis and preserve lung function,” he said.

The findings will be published in the September issue of the journal Nature Medicine. (ANI)

Mutation in high blood pressure-regulating gene linked to inherited kidney disease

Washington, August 19 (ANI): A collaborative study has shown that a mutation in a gene that helps regulate high blood pressure is a cause of inherited kidney disease.

The discovery made by researchers Wake Forest University School of Medicine, Charles University in Prague, and colleagues provides insight into a protein, renin, that is important in blood pressure regulation, and reveals the cause of one type of inherited kidney disease occurring in adults and children.

Dr. Anthony Bleyer, professor of internal medicine-nephrology at the School of Medicine, points out that a mutation in the gene that encodes renin was first identified as the cause of an hereditary kidney disease by a research group led by Dr. Stanislav Kmoch, at Charles University in Prague.

Working with Kmoch and Dr. Suzanne Hart, at the National Institutes of Health, Bleyer identified the condition among American families in his study group of families with rare, inherited kidney disease.

The researchers revealed that families identified with the specific genetic mutation investigated in this study suffered from anaemia in childhood, and progressive kidney disease resulting in the need for dialysis, a mechanical way to cleanse the blood.

Children typically have relatively low blood pressure. Adults suffer from gout and worsening kidney disease.

“There are many families with inherited kidney disease that do not know the cause and may suffer from this condition. We are interested in helping these families identify the cause of kidney disease that runs in their family,” Bleyer said.

The researcher further revealed that the research team had identified a potential treatment for the disease, and a clinical trial was under way at Wake Forest University School of Medicine.

Understanding how the mutation in the renin gene affects these families also provides insight into how renin works in healthy individuals, for the low levels of renin in children with this condition appear to cause anaemia.

The researchers say that the importance of renin in maintaining a normal blood count, and preventing anaemia in childhood was not previously known.

They plan to continue researching renin with hopes of better understanding how the protein functions in health and disease.

A research articled describing their study has been published in the American Journal of Human Genetics. (ANI)

Chemotherapy, radiation may help preserve voice box even with largest cancers

Washington, June 26 (ANI): Some patients with large tumours on their larynx may preserve their speech by choosing Chemotherapy and radiation, and avoiding surgery to remove the voice box, according to a study.

Conducted by researchers at the University of Michigan Comprehensive Cancer Center, the study has shown that a single round of chemotherapy could identify those patients who are most likely to benefit from this approach.

“Organ preservation studies have excluded these patients because their tumors are so large. We found that if a patient’s tumor does not respond to chemotherapy, the patient can be instantly referred for a laryngectomy, which is the standard of care. But if the tumor responded to the drugs, perhaps some of those people could survive the cancer with their voice box intact,” says lead study author Dr. Francis P. Worden, associate professor of Internal Medicine at the U-M Medical School.

For their study, the research team reviewed data from two U-M studies of advanced laryngeal cancer patients, looking specifically at patients who had the largest tumours, called T4.

The researchers point out that besides being large, T4 tumours often invade the nearby cartilage, making them particularly difficult to treat.

They revealed that those participating in the study were administered one round of induction chemotherapy, an initial dose designed to see if the cancer responds.

If the tumour shrank by more than 50 percent after that first round, say the researchers, the participants were given three more rounds of chemotherapy, combined with daily radiation therapy.

They add that the participants whose tumours did not respond to the induction chemotherapy were referred for surgery.

The researchers revealed that 81 per cent of the 36 T4 disease patients enrolled in the two studies responded to the induction chemotherapy, and many saw their tumours shrink completely.

After three years, 78 percent of the T4 study participants were still alive, and 58 percent still had an intact larynx.

While chemotherapy and radiation come with unpleasant and serious side effects, avoiding surgery allows patients to retain their voice.

The study also showed that people whose larynx were preserved had better quality of life and less depression than those who had undergone surgery. Few people required a feeding tube or tracheostomy.

“If the patient failed chemotherapy up front, he or she could go straight to surgery and avoid the side effects of chemo-radiation. Meanwhile, a large group of patients get to preserve their voice box by avoiding laryngectomy,” Worden says.

“We saw no survival difference between the smallest and the largest tumors, which suggests that organ preservation is a viable alternative to surgery for some of the largest laryngeal cancers,” he adds.

A research article describing the study has appeared online in the journal Laryngoscope. (ANI)

Partner issues significantly influence women’s sexual activity

Washington, June 26 (ANI): It’s not just age, partner’s health and interest in sex too have significant impact on sexual activity among middle-aged and elderly women, say researchers.

During the study, the team from University of California, San Francisco and Kaiser Permanente examined 2,000 women, aged 45 to 80 years old, 43 percent reported at least moderate sexual desire, and 60 percent had been sexually active in the previous three months.

Among sexually inactive women, the most common reason was lack of interest in sex with 39 percent of the respondents saying the same.

Thirty-six pct said lack of a partner, 23 pct agreed to physical problem of partner while 11 pct said lack of interest by partner.

Only nine percent were inactive from personal physical problems.

According to the researchers, sexual activity was defined as any activity that was arousing, including masturbation.

“Our findings indicate that a substantial portion of women are interested and engaged in sexual activity as they age,” said lead author Alison Huang, MD, assistant professor in internal medicine at the University of California, San Francisco.

“Clinicians should consider a woman’s overall health when addressing concerns about sexual inactivity.

However, treatment directed solely at improving women’s sexual functioning, such as medications, may not substantially affect their activity if partner issues also are not addressed,” Huang added.

The study appears in Journal of the American Geriatrics Society. (ANI)

Kids with early attention problems struggle in high school

Washington, May 26 (ANI): A new study by researchers from UC Davis Medical School and Michigan State University has found a link between problems early in school – as early as kindergarten – and lower high school test scores.

“In our study, a child’s inability to pay attention when they start school had the strongest negative effect on how they performed at the end of high school – regardless of their IQ (intelligence quotient),” said lead study author Joshua Breslau, an assistant professor of internal medicine at the UC Davis School of Medicine and a researcher with the UC Davis Center for Reducing Health Disparities.

He suggested that addressing attention problems early in life could keep some children from entering “a downward spiral of failure.”

Breslau and colleagues analysed data on approximately 700 children who were followed from kindergarten (ages 5 through 6) through the end of high school (ages 17 through 18).

It examined the relationship between aggressive, inattentive and depressive behaviours and children’s later performance on standardized high school achievement tests.

The researchers found that inattentiveness in kindergarten was the only behaviour that consistently predicted lower scores on reading and math achievement tests administered more than a decade later.

“Our study shows that early attention problems predict poor performance later in math and reading,” Breslau said.

The study appears online in the June issue of the medical journal Paediatrics. (ANI)

What you need to know about swine flu

Washington, Apr 28 (ANI): While there have been a number of outbreaks of the new strain of swine flu, there also have emerged a whole gamut of misinformation. Now, scientists have elaborated exactly what one needs to know about this new epidemic.

Infectious disease expert Charles Ericsson, M.D., professor of internal medicine and director of Travel Medicine at The University of Texas Medical School at Houston, has answered some questions regarding swine flu, which are as follows:

1. How do symptoms of swine flu differ from other types of flu?

None, really, although this flu might include gastrointestinal symptoms (diarrhea and vomiting), as well as the usual respiratory symptoms. The basic symptoms for swine flu are similar to the seasonal flu we are vaccinated for each year, which may include, fever, sore throat, cough, stuffy nose, chills, headache and body aches, fatigue.

2. Is there medication for this?

Yes, Tamiflu or Relenza have shown to be effective against these recently reported strains of swine flu. Altogether, there are four anti-viral drugs that we commonly use to treat various strains of flu.

3. Is there a vaccine?

Not yet, but the CDC has this current strain of virus and will consider whether to add it to next year’s flu vaccine as time goes on.

4. Can I catch it from pigs?

No. This strain is one that is communicable through human-to-human contact. It is a mutated form of a swine virus.

5. Can I catch it from eating pork?

Absolutely not! Swine flu is not transmitted by food. It is not a so-called foodborne illness. Bacon, ham and other pork products are safe to eat, assuming they are prepared properly. An internal temperature of 160 degrees for cooked meat will kill any bacteria or virus.

Swine flu is transmitted by airborne droplets from an infected person’s sneeze or cough; or from germs on hands, or germ-laden surfaces. Eating pork will not give you swine flu any more than eating chicken will give you bird flu.

6. How does it cross from a pig to a human?

The swine virus mutates so that it can infect humans and be spread by humans.

7. Can it kill me?

Deaths have been reported from the Mexico City outbreak. So far the cases in the US have been mild and there have been no deaths as yet. But, like seasonal flu, there is the potential for serious outcomes.

8. How is it different from avian (bird) flu?

Avian flu so far has had difficulty infecting humans unless they are exposed intensely to birds, because the virus has not mutated in a way that makes it transmissible by humans to other humans. This virus has origins genetically from both pigs and birds, and the big difference from the avian flu is that this swine virus can be transmitted readily from human to human.

9. What if I’m on a plane? Should I wear a mask?

Not necessary. The air on a plane is filtered. Transmission might occur if someone sitting close to you coughs or sneezes on you. The newer designs of aircraft airflow keep the air in a top-down flow, not forced air from front to back. However, if you do have a respiratory illness, it might be best not to travel.

10. Other than hand washing and covering my mouth if I sneeze or cough, what can I do to take care of myself and others?

If you are ill, stay home. Control your sneezes and coughs. If you cough into your hand, remember the virus could be live on your hand at least for a few minutes, so wash your hands before touching anyone else. If you get symptoms suggesting the flu, call your doctor, who can call in a prescription for medication to treat the flu. Resist going to the doctor’s office or a hospital ER for influenza symptoms unless you are seriously ill. You do not want to spread the disease to others.

“There is a huge difference between preparedness and paranoia. Although we’re dealing with a new strain of flu, a set of universally applicable preventive measures exist that can be employed right away by everyone to help stop the spread of this disease,” said Dr. Robert Emery, occupational health expert at the UT School of Public Health at Houston. (ANI)

Protein controls ‘bad’ cholesterol levels outside cells

Washington, Apr 17 (ANI): A protein called PCSK9, which regulates ‘bad’ cholesterol in the blood, has been found to work almost exclusively outside cells, according to researchers at UT Southwestern Medical Centre.

The finding could provide clues for the development of therapies to block the protein’s disruptive actions.

“The fact that it works mostly extracellularly provides more opportunities to develop different kinds of therapies,” said Dr. Jay Horton, professor of internal medicine and molecular genetics and co-author of the study.

PCSK9 disrupts the activity of a key molecule called the low-density lipoprotein receptor, or LDLR, which is made and secreted in the liver.

Horton said that the new findings show that PCSK9 principally acts as a secreted protein to cause the degradation of LDL receptors by latching on to it.

“Therefore, approaches to block the protein’s activity in the blood should be successful in reducing plasma cholesterol levels,” he said.

In order to know if PCSK9 works inside or outside the cell, the researchers designed peptides to jam the interaction between PCSK9 and the LDL receptor.

They then added the peptides to a cultured cell medium to see if they could block the activities of PCSK9.

It was found that the peptides prevented the secreted PCSK9 from binding to the surface of the LDL receptors.

Thus Horton said that PCSK9 is likely to perform its destructive duties outside cells, in order to provide more opportunities for drug development.

“It’s much easier to design inhibitors of PCSK9 function to work outside a cell than to develop a small molecule that works inside a cell,” he said.

The study has been published in the online edition of the Journal of Biological Chemistry. (ANI)

Scientists uncover compound that frees trapped cholesterol

Washington, January 27 (ANI): Scientists at UT Southwestern Medical Center have identified a compound that can free cholesterol that has inappropriately accumulated to excessive levels inside cells.

The researchers say that their discovery in mice shed light on how cholesterol is transported through the cells of the body, and suggest a possible therapeutic target for Niemann-Pick type C disease (NP-C), an inherited neurodegenerative disorder characterized by abnormally high cholesterol levels in every organ.

“What we’ve shown is that very quickly after administration of this compound, the huge pool of cholesterol that has just been accumulating in the cells is suddenly released and metabolized normally,” said Dr. John Dietschy, professor of internal medicine at UT Southwestern.

“With just one dose, you excrete a large portion of this pool of cholesterol,” he added.

Cholesterol in the body comes from dietary sources, and is also made by the body itself. It is essential for many biological processes, including the construction and maintenance of cell membranes.

Normally, it is transported through cells, and excreted by the body.

People with Niemann-Pick type C have a genetic mutation that causes excessive amounts of cholesterol to accumulate in compartments within cells called lysosomes.

The vast majority of children diagnosed with NP-C die before they are 20 years old and many before age 10.

This cholesterol accumulation leads to liver disease, neurodegeneration and dementia. There is no specific level at which cholesterol levels become abnormal.

Late onset of neurological symptoms such as clumsiness, mild retardation and delayed development of fine motor skills can lead to longer life spans, but few people diagnosed with NP-C reach age 40.

For the current study, the researchers injected a single dose of a cholesterol-binding agent known as CYCLO into seven-day-old mice with the Niemann-Pick mutation. Shortly afterwards, such mice began to process cholesterol just as their healthy counterparts did.

After 49 days, the mice treated with a single injection continued to show substantially lower tissue cholesterol levels than the untreated mice, as well as improved liver function and decreased neurodegeneration.

Dr. Dietschy cautioned that the findings in no way represent a Niemann-Pick disease cure.

“The key idea is that we appear to have overcome the transport defect in the lysosome that is brought about by the genetic defect or mutation. We do not yet understand what is happening at the molecular level, but it is clear that this compound somehow overcomes the genetic defect that causes individuals to accumulate cholesterol,” Dr. Dietschy said.

The researcher revealed that the next step would be to find out the concentration of CYCLO needed to trigger the cholesterol’s release.

The team also hope to determine in animals the additional lifespan CYCLO administration provides, as well as how long the drug’s affects lasts.

“By treating at seven days, we eliminated approximately one-third of the accumulated cholesterol almost immediately. Now we want to see what happens if we give it every week. Can we maintain low cholesterol levels? That’s what we’re looking at now,” Dr. Dietschy said.

The study has been published in the online edition of the Proceedings of the National Academy of Sciences. (ANI)