US army set for “hopping rotochut” that hops to avoid rubble trouble

London, September 19 (ANI): The U.S. army’s fleet of robots will soon be enhanced with the addition of forthcoming reconnaissance craft called the ‘hopping rotochute’, which will be capable of travelling deep into obstacle-ridden spaces like caves and rubble-laden buildings to video what it finds.

The self-righting probe is being developed for the Army Research Lab in Aberdeen, Maryland, by Eric Beyer and Mark Costello, a pair of robotics engineers at Georgia Institute of Technology in Atlanta.

The project attains significance because present-day military robots, which run on small tank-style tracks, cannot cope with irregular surfaces and obstacles such as rubble or boulders.

“They usually have trouble and get stuck with even low obstacles and walls a couple of feet high,” says Costello.

Although small helicopters are one alternative, continuous flying drains the batteries fast.

Thus, Costello stresses the need for a rotor-powered, bottom-heavy, self-righting vehicle that spends most of its time on the ground, conserving battery power.

AS to whether repeated hopping might harm the craft, a spokesman for the Impact Centre at Cranfield University in Bedfordshire, UK, said: “From a crashworthiness point of view this concept looks perfectly feasible. There should be no problem with the vehicle surviving hundreds of impacts, which is roughly equivalent to dropping a mobile phone from waist height.” (ANI)

Terrorism a by-product of Pak’s past mistakes: Zardari

London, Sep. 19 (ANI): President Asif Ali Zardari has revealed that extremism was a by-product of Pakistan’s past mistakes and was deliberately created during the 1980s.

He said the employment of a liberal policy encouraged religious fanaticism and achieved of certain strategic objectives of terror perpetrators.

“What we are witnessing today is the outcome of that policy of the 80′s and even earlier.The policy of using religious extremism as an instrument of war. We in Pakistan have paid a very heavy price for this policy,” The News quoted Zardari, as saying.

Addressing a gathering at London’s International Institute of Strategic Studies (IISS), Zardari pointed out that militants and militancy were not created in a vacuum; they have been the product of a deliberate policy to fight the rival ideology.

The free world adopted a novel strategy that was based on the exploitation of religion to motivate Muslims around the world to wage jehad, he added.

Furthermore, Zardari pointed out that the strategy may have worked well but some serious mistakes were also made as the world abandoned Afghanistan in a hurry and no thought was given to its stability after the withdrawal of foreign forces.

“After the retreat of foreign forces, Afghanistan was abandoned and left at the mercy of the warlords and the jehadis…Pakistan has suffered more than others. For decades we had to host and continue to host millions of Afghan refugees,” he said. (ANI)

Natural hydrogel may boost spinal cord healing

Washington, Sep 18 (ANI): A jab of biomaterial gel into a spinal cord injury site may significantly improve healing, according to researchers at the Barrow Neurological Institute at St. Joseph’s Hospital and Medical Center.

Dr. Mark Preul and Dr. Alyssa Panitch have found in a study that injection of an engineered hydrogel made up mainly of hyaluronic acid (a naturally-occurring body substance) into the spinal cord injury site decreases scarring, and promotes a realignment of the spinal cord fibres around the injury site.

The hyaluronic acid, which forms a scaffold-like configuration may help to structurally stabilize the spinal cord injury site.

The researchers traced cells in the brain stem after injury, and found much higher levels in the hydrogel treated animals as compared to animals that did not receive the treatment, and approached nearly normal levels.

Treated animals had higher functional scores than their non-treated counterparts.

“Spinal cord injury is devastating to civilian and military populations – especially to the young. There has been little progress toward paradigms of regeneration and few results that show real, sustained functional recovery. We’ve been so pre-occupied with regeneration, but that is a highly complicated and difficult to define goal. This project is a synergy of neurosurgeons and bioengineers that attempts repair of the SCI lesion cavity using a tissue-engineering biomaterials approach,” says Preul.

He added that the team aimed at finding ways to structurally allow the body to better heal itself.

“In this project we did not add anything to the hyaluronic acid. It may be that adding growth factors or cells into the gel matrix may allow even better results,” he said.

Preul said that the results show “we may be on a practical path that can give hope to the many people who suffer this sort of injury.”

The work was presented at the Annual Meeting of the American Association of Neurological Surgeons in San Diego where it won the Synthes Prize for Spine Research. (ANI)

Mystery of odd rotating stars solved by scientists

Washington, September 18 (ANI): A team of scientists has solved a longstanding mystery about a pair of stars called DI Herculis whose peculiar rotation had remained a mystery for three decades.

The shift in the orbit of DI Herculis was a mystery till now.

Now, MIT (Massachusetts Institute Of Technology) researchers and colleagues have determined that the stars are rotating tipped over on their sides, relative to their orbits around each other.

This produces tidal effects that counteract the expected rate for the orbits to shift orientation over time (called precession), finally explaining the mysterious anomaly.

The discrepancy in the rate of precession had been seen as a possible refutation of Einstein’s theory of relativity, so finding a conventional explanation means that relativity has withstood another possible challenge.

This discovery could also help to shed light on how binary stars (about half of all known stars) are formed and how their rotation and orbits evolve over time.

The mystery was solved by postdoctoral researcher Simon Albrecht and assistant professor of physics Joshua Winn and others, who used a high-resolution spectrograph called Sophie on a 1.93-meter telescope at the Observatoire de Haute-Provence in France to make highly detailed observations that revealed the unexpected tilt – one of more than 70 degrees from vertical, the other more than 80 degrees – of the stars’ rotation axes.

The team now hopes to study other unusual binary stars to try to determine how unusual this tipped-over configuration is. (ANI)

Malaysia gives RM1 million grant for Malay Indian tuition centre

Kuala Lumpur, Sep 18 (ANI): The Malaysian Government has allocated RM1 million to the Sri Murugan Centre to help poor and deserving Indian students excel in their education.

The centre’s director and founder, M. Thambirajah, informed about the grant after receiving the cheque from Prime Minister Najib Tun Razak in Putrajaya on Wednesday.

The centre was established in 1982 to focus on education. It provides tuition for UPSR, PMR, SPM and STPM students. It has 103 branches throughout the country, The Star reports.

Thambirajah said that over the years the centre had produced 16,000 graduates, and added that the funds would be used to open new centres with better facilities.

Youth and Sports Minister Ahmad Shabery Cheek said the National Youth Skill Training Institute’s courses would be revised to be more relevant to the job market.

He said his ministry was seeking the assistance of the private sector to identify the areas of demand so that courses could be tailored accordingly. (ANI)

Stem cell transplantation may correct rare genetic disorder in kids

Washington, Sep 18 (ANI): Scripps Research Institute scientists have offered new hope for parents whose children suffer from the rare genetic disorder ‘cystinosis’ by showing through an experiment on mice that stem cell transplantation can successfully correct the defect.

“After meeting the children who suffer from this disease, like an 18-year-old who has already had three kidney transplants, and the families who are desperately searching for help, our team is committed to moving toward a cure for cystinosis, a lysosomal storage disorder. This study is an important step toward that goal,” said principal investigator Stephanie Cherqui.

In the study, the researchers used bone marrow stem cell transplantation to address symptoms of cystinosis in a mouse model.

The procedure virtually halted the cystine accumulation responsible for the disease, and the cascade of cell death that follows.

Cystine is a by-product of the break down of cellular components the body no longer needs in the cell’s “housekeeping” organelles, called lysosomes.

Normally, cystine is shunted out of cells, but in cystinosis a gene defect of the lysosomal cystine transporter causes it to build up, forming crystals that are especially damaging to the kidneys and eyes.

Cystinosis is a rare but devastating disease affecting children as young as six months, who begin to suffer renal dysfunction, which grows progressively worse with time. Other symptoms include diabetes, muscular disease, neurological dysfunction, and retinopathy.

The only available drug to treat cystinosis, cysteamine, while slowing the progression of kidney degradation, does not prevent it, and end-stage kidney failure is inevitable.

In the new study, the researchers found that transplanted bone marrow stem cells carrying the normal lysosomal cystine transporter gene abundantly engrafted into every tissue of the experimental mice.

This led to an average drop in cystine levels of about 80 percent in every organ.

Not only it prevented kidney dysfunction, there was less deposition of cystine crystals in the cornea, less bone demineralization, and an improvement in motor function.

“The results really surprised and encouraged us. Because the defect is present in every cell of the body, we did not expect a bone marrow stem cell transplant to be so widespread and effective,” says Cherqui.

Cherqui said that adult bone marrow stem cell therapy is particularly well suited as a potential treatment for cystinosis because these cells target all types of tissues.

In addition, stem cells reside in the bone marrow for the duration of a patient’s life, becoming active as needed, a particular benefit for a progressive disease like cystinosis.

The study has been published in the journal Blood. (ANI)

Karzai unlikely to claim Afghan election victory soon

Washington, Sep.17 (ANI): With accusations of vote fraud piling up around Afghanistan’s presidential election, incumbent Hamid Karzai is unlikely to claim victory any time soon.

At the very least, a national electoral complaints commission investigating fraudulent voting will take weeks to determine how much of Karzai’s officially declared 54.6 percent of the vote will be tossed out, reports the Christian Science Monitor.

At the other extreme, a potential need for a runoff vote could end up stretching Afghanistan’s political turmoil into next spring – presenting President Obama and other NATO leaders with an unsettled and deteriorating climate just as crucial policy decisions are under review.

Marvin Weinbaum, a former State Department intelligence specialist in Asian affairs now at the Middle East Institute in Washington, said:. “We face a possible constitutional crisis that, if not resolved, becomes a disaster for us, and a partner [Karzai] acting in ways that in effect raise questions as to whether he should be in there or not.”

Aside from a runoff vote, which could be declared if investigations show Karzai’s total falling below 50 percent, some parties are calling for a coalition government, while others support the idea of a nonpolitical transitional government.

That debate has crystallized in a row between foreign officials over the best way to address Afghanistan’s political predicament. Peter Galbraith, a senior US official working in Kabul as the deputy special UN representative for Afghanistan, abruptly left the country after clashing with his boss, Kai Eide, over what path forward to advocate.

Galbraith favors a larger recount of votes, even if it leads to a runoff between Karzai and his main political rival, Abdullah Abdullah, and an extended period of political uncertainty. (ANI)

Scientists map melting history of Greenland’s ice sheet

Washington, September 17 (ANI): Researchers from the Niels Bohr Institute at the University of Copenhagen have mapped the history of the melting of the Greenland ice sheet.

Numerous drillings have been made through both Greenland’s ice sheet and small ice caps near the coast.

By analyzing every single annual layer in the kilometres long ice cores, researchers can get detailed information about the climate of the past.

But now, the Danish researcher Bo Vinther and colleagues from the Centre for Ice and Climate at the Niels Bohr Institute, University of Copenhagen, in collaboration with researchers from Canada, France and Russia, have found an entirely new way of interpreting the information from the ice core drillings.

“Ice cores from different drillings show different climate histories. This could be because they were drilled at very different places on and near Greenland, but it could also be due to changes in the elevation of the ice sheet, because the elevation itself causes different temperatures,” explained Bo Vinther about the theory.

Today, the ice sheet is more than three kilometres thick at its highest point and thinning out towards the coast.

Four of the drillings analyzed are from the central ice sheet, while two of the drillings are from small ice caps outside of the ice sheet itself.

By comparing the Oxygen-18 content in all of the annual layers from the four drillings through the ice sheet with the Oxygen-18 content of the same annual layers in the small ice caps, Bo Vinther has calculated the elevation course through 11,700 years.

Just after the ice age the elevation of the ice sheet rose slightly because when the climate transitions from ice age to warm age, there is a rapid increase in precipitation.

But at the same time, the areas lying near the coast begin to decrease in size, because the ice is melting at the edge.

When the ice melts at the edge, it slowly causes the entire ice sheet to ‘collapse’ and become lower.

The calculations show that in the course of about 3,000 years, the elevation changed and became up to 600 meters lower in the coastal areas.

But in the middle, it was a slow process, where the elevation decreased around 150 meters in the course of around 6,000 years.

It then stabilized.

The new results show the evolution of elevation of the ice sheet throughout 11,700 years and they show that the ice sheet is very sensitive to the temperature.

The results can be used to make new calculations for models predicting future consequences of climate changes. (ANI)

WII to host global deer conservation meet in Srinagar next month

Srinagar, Sep 16 (ANI): The Wildlife Institute of India (WII) is hosting a five day global meeting of the deer experts here-from October 9 to discuss conservation plans for the Hangul, which is also known as Kashmir Stag.

The meeting is also expected to chalk out a long-term effective management plan for the conservation of Hangul habitat.

Hangul is one of the endangered species of the world and has been listed in the Red Data Book of International Union of Conservation of Nature (IUCN).

According to WII Director P.R. Sharma the experts would share their knowledge in the management and conservation of endangered deer species in general and Red deer and its subspecies such as Hangul in particular in the meeting.

Conservationists from Russia, East Tibet, Middle East, Afghanistan and China will deliberate on issues threatening the existence of the species and formulate strategies, take effective relocation and recovery plan at the meet.

The conference would help the Indian conservationists to enhance and updating scientific knowledge on globally successful species recovery, conservation programmes and aspects of deer ecology, Sinha said.

That the meet is being held in Srinagar itself mirrors the government’s concern to urgently save the Hangul, one of the four easternmost subspecies of Red deer that is endemic to Kashmir mountains in Jammu and Kashmir.

The population the Hangul, which is one of the four easternmost subspecies of Red deer, has declined from an estimated 2000 individuals in 1947 to about 170-200 individuals in recent years, due to poaching, excessive grazing of livestock, forest fires.

Deer are important part of woodland ecosystems and their effects are vital to the survival of plants and animals that depend on open woodlands. Their low numbers and restricted range is of great ecological concern amongst the conservationists throughout the world. (ANI)

Scientists unravel chemistry of Titan’s hazy atmosphere

Washington, September 16 (ANI): In a new research, a team of scientists has unraveled the chemical evolution of the orange-brownish colored atmosphere of Saturn’s moon Titan, the only solar system body besides Venus and Earth with a solid surface and thick atmosphere.

Scientists at University of Hawai’i at Manoa carried out the research.

The UH Manoa team, including Xibin Gu and Seol Kim, conducted simulation experiments mimicking the chemical reactions in Titan’s atmosphere utilizing crossed molecular beams in which the consequence of a single collision between molecules can be followed.

The team’s experiments indicate that triacetylene can be formed by a single collision of a “radical” ethynyl molecule and a diacetylene molecule.

An ethynyl radical is produced in Titan’s atmosphere by the photodissociation of acetylene by ultraviolet light.

Photodissociation is a process in which a chemical compound is broken down by photons.

“Surprisingly, the photochemical models show inconsistent mechanisms for the production of polyynes,” said Kaiser, who is the principal investigator of this study.

The mechanism involved in the formation of triacetylene, was also confirmed by accompanying theoretical calculations by Alexander Mebel, a theoretical chemist at Florida International University.

These theoretical computations also provide the 3D distribution of electrons in atoms and thus the overall energy level of a molecule.

To apply these findings to the real atmosphere of Titan, Danie Liang and Yuk Yung, planetary scientists at Taiwan’s Academia Sinica and California Institute of Technology (Caltech), respectively, performed photochemical modeling studies of Titan’s atmosphere.

All data together suggest that triacetylene may serve as a building block to form more complex and longer polyynes and produce potential precursors for the aerosol-based layers of haze surrounding Titan.

The study demonstrated for the first time that a sensible combination of laboratory simulation experiments with theory and modeling studies can shed light on decade old unsolved problems crucial to understand the origin and chemical evolution of the solar system.

The researchers hope to unravel next the mystery of the missing ethane lakes on Titan – postulated to exist for half a century, but not detected conclusively within the framework of the Cassini-Huygens mission.

In the future, the UH Manoa team will combine the research results with terrestrial-based observations of Titan’s atmosphere. (ANI)

British troops far from defeating Taliban, says Brit Defence Secretary

London, Sep.16 (ANI): British troops are a long way from winning the battle against a resilient Taliban in Afghanistan, and the conflict in the country could lead to “major shifts” in military spending, said British Defence Secretary Bob Ainsworth.

“We are facing a resilient enemy which we are far from succeeding against yet,” he told an audience of defence experts at King’s College London.

“I reject the proposition we are not making progress. I also reject the proposition a reduced military presence will lead to less Taliban success,” The Telegraph quoted Ainsworth, as saying further.

A leading thinktank warned earlier that the presence of large numbers of foreign troops in Afghanistan made it harder to achieve a political settlement to the conflict.

The International Institute for Strategic Studies said western forces in Afghanistan needed a “more cunning” strategy if they were to achieve their aims.

Ainsworth said a military failure in Afghanistan would have “profound consequences for our national security” and “undermine the Nato alliance”.

He also called for an open debate about future defence policy and how money for the military should be spent before the government publishes a defence review green paper in advance of next year’s general election. (ANI)

Cracks on Mars a result of evaporating lakes in ancient times

Washington, September 16 (ANI): Networks of giant polygonal troughs etched across crater basins on Mars have been identified as desiccation cracks caused by evaporating lakes, providing further evidence of a warmer, wetter Martian past.

The findings were presented at the European Planetary Science Congress by PhD student M. Ramy El Maarry of the Max Planck Institute for Solar System Research.

The polygons are formed when long cracks in the surface of the Martian soil intersect.

El Maarry investigated networks of cracks inside 266 impact basins across the surface of Mars and observed polygons reaching up to 250 meters in diameter.

Polygonal troughs have been imaged by several recent missions but, until now, they have been attributed to thermal contractions in the Martian permafrost.

El Maarry created an analytical model to determine the depth and spacing of cracks caused by stresses building up through cooling in the Martian soil.

He found that polygons caused by thermal contraction could have a maximum diameter of only about 65 meters, much smaller than the troughs he was seeing in the craters.

“I got excited when I saw that the crater floor polygons seemed to be too large to be caused by thermal processes. I also saw that they resembled the desiccation cracks that we see on Earth in dried up lakes,” said El Maarry.

“The stresses that build up when liquids evaporate can cause deep cracks and polygons on the scale I was seeing in the craters,” he added.

El Maarry identified the crater floor polygons using images taken by the MOC camera on Mars Global Surveyor and the HiRISE and Context cameras on Mars Reconnaissance Orbiter.

The polygons in El Maarry’s survey had an average diameter of between 70 and 140 kilometers, with the width of the actual cracks ranging between 1 and 10 meters.

Evidence suggests that between 4.6 and 3.8 billion years ago, Mars was covered in significant amounts of water.

Rain and river water would have collected inside impact crater basins, creating lakes that may have existed for several thousand years before drying out.

However, according to El Maarry, in the northern hemisphere, some of the crater floor polygons could have been formed much more recently.

“When a meteorite impacts with the Martian surface, the heat can melt ice trapped beneath the Martian crust and create what we call a hydrothermal system. Liquid water can fill the crater to form a lake, covered in a thick layer of ice. Even under current climatic conditions, this may take many thousands of years to disappear, finally resulting in the desiccation patterns,” said El Maarry. (ANI)

Popular diabetes drug may help fight breast cancer

Washington, Sept 15 (ANI): A popular diabetes drug called metformin has been found to be effective in fighting breast cancer.

The findings of the study from Harvard Medical School showed that metformin, along with conventional chemotherapy, shows promise for treating and delaying recurrence of breast cancer.

“We have found a compound selective for cancer stem cells,” said senior author Kevin Struhl, the David Wesley Gaiser professor of biological chemistry and molecular pharmacology at HMS.

“What’s different is that ours is a first-line diabetes drug,” he added.

The drug seemed to work independently of its ability to improve insulin sensitivity and lower blood sugar and insulin levels, all of which are also associated with better breast cancer outcomes.

“There is a big desire to find drugs specific to cancer stem cells,” said Struhl.

“The cancer stem cell hypothesis says you cannot cure cancer unless you also get rid of the cancer stem cells. From a purely practical point of view, this could be tested in humans. It’s already used as a first-line diabetes drug,” he added.

Lead researchers Heather Hirsch and Dimitrios Iliopoulos found that the combination of metformin and the cancer drug doxorubicin killed human cancer stem cells and non-stem cancer cells in culture.

In mice, pre-treatment with the diabetes drug prevented the otherwise dramatic ability of human breast cancer stem cells to form tumours.

In cases where tumours were allowed to take hold for 10 days, the dual therapy also reduced tumour mass more quickly and prevented relapse for longer than doxorubicin alone.

“This is an exciting study,” said Jennifer Ligibel, a medical oncologist at Dana-Farber Cancer Institute and an HMS instructor in medicine, who was not involved in the study.

“There is a lot of interest in studying metformin in breast cancer, but so far we do not have direct evidence that metformin will improve outcomes in patients,” Ligibel said. “That’s what this trial is for.”

The findings appear online in the journal Cancer Research. (ANI)

Scientists make first high-resolution 3D images of a polymer solar cell’s insides

Washington, September 14 (ANI): Researchers from the Eindhoven University of Technology and the University of Ulm in Germany have made the first high-resolution 3D images of the inside of a polymer solar cell.

This gives them important new insights in the nanoscale structure of polymer solar cells and its effect on the performance.

The investigations shed new light on the operational principles of polymer solar cells.

These solar cells do not have the high efficiencies of their silicon counterparts yet. Polymer cells, however, can be printed in roll-to-roll processes, at very high speeds, which makes the technology potentially very cost-effective.

Added to that, polymer cells are flexible and lightweight, and therefore suitable to be used on vehicles or clothing or to be incorporated in the design of objects.

In these hybrid solar cells, a mixture of two different materials, a polymer and a metal oxide are used to create charges at their interface when the mixture is illuminated by the sun.

The degree of mixing of the two materials is essential for its efficiency.

Intimate mixing enhances the area of the interface where charges are formed but at the same time obstructs charge transport because it leads to long and winding roads for the charges to travel.

Larger domains do exactly the opposite.

The vastly different chemical nature of polymers and metal oxides generally makes it very difficult to control the nanoscale structure.

The Eindhoven researchers have been able to largely circumvent this problem by using a precursor compound that mixes with the polymer and is only converted into the metal oxide after it is incorporated in the photoactive layer.

This allows better mixing and enables extracting up to 50 percent of the absorbed photons as charges in an external circuit.

The importance of the degree of mixing was clearly demonstrated by visualization of the structure of these blends in three dimensions.

Traditionally such visualization has been extremely challenging, but by using 3D electron tomography, the team has been able to resolve the mixing with unprecedented detail on a nanoscale.

From these images, the researchers at the Institute of Stochastics in Ulm have been able to extract typical distances between the two components, relating to the efficiency of charge generation, and analyze the percolation pathways, that is, how much of each component is connected to the electrode.

These quantitative analyses of the structure matched perfectly with the observed performance of the solar cells in sunlight. (ANI)

Master gene that switches on disease-fighting cells identified

London, Sep 14 (ANI): British scientists have identified the master gene, called E4bp4, that causes blood stem cells to turn into disease-fighting ‘Natural Killer’ (NK) immune cells.

The discovery, by researchers at Imperial College London, UCL and the Medical Research Council’s National Institute for Medical Research, could one day help scientists boost the body’s production of these frontline tumour-killing cells, creating new ways to treat cancer.

By ‘knocking out’ E4bp4 in a mouse model, the researchers created the world’s first animal model entirely lacking NK cells, but with all other blood cells and immune cells intact.

The breakthrough model should help solve the mystery of the role that Natural Killer cells play in autoimmune diseases, such as diabetes and multiple sclerosis.

According to many scientists, these diseases are a result of malfunctioning NK cells that turn on the body and attack healthy cells, which cause disease instead of fighting it.

They believe that clarifying NK cells’ role could lead to new ways of treating these conditions.

Natural Killer cells – a type of white blood cell – are a major component of the human body’s innate, quick-response immune system, providing a fast frontline defence against tumours, viruses and bacterial infections.

The gene E4bp4 is the ‘master gene’ for NK cell production, which means it is the primary driver that causes blood stem cells in the bone marrow to differentiate into NK cells.

Led by Dr Hugh Brady, the researchers are hoping to progress with a drug treatment for cancer patients which reacts with the protein expressed by their E4bp4 gene, causing their bodies to produce a higher number of NK cells than normal, to increase the chances of successfully destroying tumours.

“If increased numbers of the patient’s own blood stem cells could be coerced into differentiating into NK cells, via drug treatment, we would be able to bolster the body’s cancer-fighting force, without having to deal with the problems of donor incompatibility,” Nature quoted Brady as saying.

The researchers proved the pivotal role E4bp4 plays in NK production when they knocked the gene out in a mouse model.

Without E4bp4 the mouse produced no NK cells whatsoever but other types of blood cell were unaffected.

“Now finally, with our discovery of the NK cell master gene and subsequent creation of our mouse model, we will be able to find out if the progression of these diseases is impeded or aided by the removal of NK cells from the equation. This will solve the often-debated question of whether NK cells are always the ‘good guys’, or if in certain circumstances they cause more harm than good,” said Brady.

The study has been published in Nature Immunology. (ANI)

Scientists develop ‘electronic nose’ that can sniff out toxins by changing colors

Washington, September 14 (ANI): A team of scientists has developed a sensor that works as an ‘electronic nose’ in sniffing out some known poisonous gases and toxins, simply by changing colors.

Support for the development and application of this electronic nose comes from the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

Once fully developed, the sensor could be useful in detecting high exposures to toxic industrial chemicals that pose serious health risks in the workplace or through accidental exposure.

While physicists have radiation badges to protect them in the workplace, chemists and workers who handle chemicals do not have equivalent devices to monitor their exposure to potentially toxic chemicals.

The investigators hope to be able to market the wearable sensor within a few years.

“The project fits into the overall goal of a component of the GEI Exposure Biology Program that the NIEHS has the lead on, which is to develop technologies to monitor and better understand how environmental exposures affect disease risk,” said NIEHS Director Linda Birnbaum.

“This paper brings us one step closer to having a small wearable sensor that can detect multiple airborne toxins,” she added.

Kenneth S. Suslick, the M.T. Schmidt Professor of Chemistry at the University of Illinois at Urbana-Champaign, and his colleagues have created what they refer to as an optoelectronic nose, an artificial nose for the detection of toxic industrial chemicals (TICs) that is simple, fast, inexpensive, and works by visualizing colors.

“We have a disposable 36-dye sensor array that changes colors when exposed to different chemicals. The pattern of the color change is a unique molecular fingerprint for any toxic gas and also tells us its concentration,” said Suslick.

“By comparing that pattern to a library of color fingerprints, we can identify and quantify the TICs in a matter of seconds,” he added.

The power of this sensor to identify so many volatile toxins stems from the increased range of interactions that are used to discriminate the response of the array.

To test the application of their color sensor array, the researchers chose 19 representative examples of toxic industrial chemicals.

Chemicals such as ammonia, chlorine, nitric acid and sulfur dioxide at concentrations known to be immediately dangerous to life or health were included.

The arrays were exposed to the chemicals for two minutes.

Most of the chemicals were identified from the array color change in a number of seconds and almost 90 percent of them were detected within two minutes. (ANI)

New method to monitor early sign of oxidative stress that triggers cancer

Washington, Sept 12 (ANI): Scientists from University of Michigan have developed a new method to monitor early sign of oxidative stress that triggers cancer spread.

Lead researcher Kate Carroll suggests that being able to monitor a marker of oxidative stress that is associated with the activation of tumor cell growth pathways, particularly at an early stage, and then tailor treatments accordingly would allow for more targeted studies and might improve the odds of success with antioxidants and pro-oxidants.

The new method detects sulfenic acid in proteins-a tip off to early oxidative stress and to a specific protein modification associated with cell growth pathways.

Sulfenic acid is produced when a particular oxidant, hydrogen peroxide, reacts with the protein building block cysteine. But because the chemical modification involved is so small and transient, it has been difficult to detect.

To get around that problem, Carroll and Seo used a chemical probe that “traps” sulfenic acid and tags it for recognition by an antibody.

The antibody is labeled with a fluorescent dye that glows when observed with a fluorescence microscope.

The researchers then used the method to assess sulfenic acid levels as a marker of oxidative stress in several systems, including a panel of breast cancer cell lines.

“For each line, we saw a very distinct pattern of sulfenic acid modifications,” indicating different oxidative stress levels and hinting at differences in the underlying molecular events associated with tumor growth,” said Carroll, assistant professor of chemistry and a research assistant professor in the Life Sciences Institute.

“Whether the patterns we see will correlate with response to antioxidant treatment or other therapies that modulate oxidative stress level remains to be seen, but now we at least have a way to investigate that question,” the expert added.

The study appears in Proceedings of the National Academy of Sciences. (ANI)

2009 H1N1 influenza vaccines well tolerated, induce strong immune response in adults

Washington, September 12 (ANI): Early results from various clinical trials of 2009 H1N1 influenza vaccines in healthy adults seem to be quite encouraging, say U.S. health experts.

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health in the U.S., has revealed that the early data from these trials suggest that 2009 H1N1 influenza vaccines are well tolerated, and induce a strong immune response in most healthy adults, when administered in a single unadjuvanted 15-microgram dose.

It has even congratulated the companies that have carried out these trials, which it claims are an important part of the ongoing worldwide effort to develop vaccines to protect the public from 2009 H1N1 influenza.

The National Institute of Allergy and Infectious Diseases is also conducting clinical trials of 2009 H1N1 influenza vaccines, produced by Sanofi Pasteur and CSL Limited.

The trials are testing two different dosages-15 micrograms versus 30 micrograms-and evaluating the immune response to one and two doses of these vaccines.

More than 2,800 people are said to be participating in the ongoing NIAID trials of these vaccines.

The institute says that preliminary analyses of early data from its trials align with the recently announced findings, and those to be announced imminently by other companies.

Additional data from the NIAID trials are forthcoming.

“However, on the basis of these strong early data, our results are consonant with other reports that a single 15-microgram dose of unadjuvanted 2009 H1N1 influenza vaccine is well tolerated and induces a robust immune response in healthy adults between the ages of 18 and 64. For adults aged 65 and older, the immune response to 2009 H1N1 influenza vaccine is somewhat less robust, as is the case with seasonal influenza vaccines,” the institute said in a press release.

“We note that the slight discrepancies seen in our trials between the Sanofi Pasteur and CSL Limited vaccines may be due to technical differences in the preliminary measurement of the amounts of antigen in the doses used in the clinical trial lots and the relatively limited numbers of samples studied to date, as well as the fact that our data are drawn from a very early time point after immunization,” the institute added. (ANI)

New biomarker can bring rapid relief from major depression

Washington, Sept 11 (ANI): Scientists from University of California have identified a biomarker that can help accurately predict whether a particular drug will be effective in treating major depression.

During the study, the researchers measured changes in brain-wave patterns using quantitative electroencephalography (QEEG), a non-invasive, computerized measurement that recognizes specific alterations in brain-wave activity.

These changes precede improvement in mood by many weeks and appear to serve as a biomarker that accurately predicts how effective a given medication will be.

The new non-invasive test would help predict within a week whether a particular drug will be effective.

The added benefit of the biomarker test is that it ispainless and fast – about 15 minutes – and only involves the placement of six electrodes around the forehead and on the earlobes.

The researchers recruited a total of 375 people who had been diagnosed with major depressive disorder (MDD) and prescribed the antidepressant escitalopram, commonly known as Lexapro.

Then they examined a biomarker called the antidepressant treatment response (ATR) index – a specific change in brain-wave patterns.

The study showed that the ATR predicted both response and remission with an accuracy rate of 74 percent, much higher than any other method available.

The researchers also found that they could predict whether subjects were more likely to respond to a different antidepressant, bupropion, also known as Wellbutrin XL.

“Until now, other than waiting, there has been no reliable method for predicting whether a medication would lead to a good response or remission,” said Dr. Andrew Leuchter, professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA and lead author of the study.

“And that wait can be as long as 14 weeks. So these are very exciting findings for the patient suffering from depression,” said Leuchter.

The study results appear in the journal Psychiatry Research. (ANI)

Oldest-known fiber materials used by humans date back to 34,000 years

Washington, September 11 (ANI): A team of archaeologists and paleobiologists has discovered flax fibers that are more than 34,000 years old, making them the oldest fibers known to have been used by humans.

The fibers were discovered during systematic excavations in a cave in the Republic of Georgia.

The flax, which would have been collected from the wild and not farmed, could have been used to make linen and thread, according to the researchers.

The cloth and thread would then have been used to fashion garments for warmth, sew leather pieces, make cloths, or tie together packs that might have aided the mobility of our ancient ancestors from one camp to another.

“This was a critical invention for early humans. They might have used this fiber to create parts of clothing, ropes, or baskets-for items that were mainly used for domestic activities,” said Ofer Bar-Yosef of the Harvard University, who jointly led the research with George Grant MacCurdy and Janet G. B. MacCurdy.

“We know that this is wild flax that grew in the vicinity of the cave and was exploited intensively or extensively by modern humans,” he added.

The items created with these fibers increased early humans chances of survival and mobility in the harsh conditions of this hilly region.

The flax fibers could have been used to sew hides together for clothing and shoes, to create the warmth necessary to endure cold weather.

They might have also been used to make packs for carrying essentials, which would have increased and eased mobility, offering a great advantage to a hunter-gatherer society.

Some of the fibers were twisted, indicating they were used to make ropes or strings. Others had been dyed.

Early humans used the plants in the area to color the fabric or threads made from the flax.

Today, these fibers are not visible to the eye, because the garments and items sewed together with the flax have long ago disintegrated.

Bar-Yosef, Eliso Kvavadze of the Institute of Paleobiology, and colleagues, discovered the fibers by examining samples of clay retrieved from different layers of the cave under a microscope.

Bar-Yosef and his team used radiocarbon dating to date the layers of the cave as they dug the site, revealing the age of the clay samples in which the fibers were found.

Flax fibers were also found in the layers that dated to about 21,000 and 13,000 years ago. (ANI)