Nano to go hybrid way, get facelift: Tata

Less than a year after the launch of the Nano comes news that the car is going to have a hybrid and is even getting an exterior facelift. Talks of an electric version of the Nano have been in the air for a while now, but reports on Monday said Ratan Tata, chairman of Tata Motors (TATAMOTORS.BO : 660.9 +31.4), told a South Korean newspaper about his interest to make his dream project join the environmental-friendly trend. However, the chairman did not elaborate on the possible timeline for the launch of the cheap hybrid versions.

Tata Motors shares closed at Rs 660.90, up 4.99%, on Monday on 30-11-2009 the BSE (^BSESN : 17198.27 +272.05).

At the 63rd annual general meeting of the company in Mumbai, the chairman had hinted at the subject and talked about the progressing work at the company on alternate fuel technology, including hybrids. He had said, “We are working on an eco-car in Thailand, electric vehicles and hybrids.”

The company also talks about use of bio-diesel and ethanol across Tata companies. Tata had also talked about a car project the company is working on with a France company, which will run on compressed air. He, however, expressed doubt about the project, saying “it may or may not happen”. Till October, the company has delivered 10,518 units. The Nano delivery had started in July this year.

Further, the newspaper quoted the company considering exporting Tata Motors’ light truck, Ace, to South Korea, and also assembling or manufacturing the model in its South Korean plant. Further, Tata was quoted saying that the group is interested in Vietnam and evaluating the US market, in which it is yet to make active investments.

The Indian conglomerate is also studying investments in automobiles, software and hotel businesses, as well as biofuel in South American markets such as Brazil and Argentina.

Song birds have to deal with cover artists too

Washington, Sep 9 (ANI): Just like great singers among humans, birds too have to deal with cover artists who copy songs.

A new research has revealed that some bird species have evolved to sing the same tune as their rivals, in order to compete effectively.

Led by Dr. Joseph Tobias and Dr Nathalie Seddon from the Edward Grey Institute, University of Oxford, the research team analysed the calls and songs of two antbird species that were living side-by-side in the Amazon rainforest- the Peruvian warbling-antbird and the yellow-breasted warbling-antbird.

The study was aimed at investigating their similar songs, and, in particular, at testing the theory that the birds’ songs could become increasingly similar to enable effective communication between competing species.

The above notion has attracted controversy as many scientists have argued that convergence in territorial or mating signals results in needless confrontation or crossbreeding and the creation of hybrids.

“Biologists have long been fascinated by convergence in ecological traits as it offers tangible evidence of evolution and the forces of selection by which it operates, but until now there is no clear evidence that social competition between animal species can produce convergent signals. We examined this idea by analysing the structure and function of songs in two birds which we knew to be strong social competitors,” said Tobias.

The researchers studied the species in Peru and Bolivia at one site where they lived together, and two sites where they lived in isolation.

Firstly, they recorded three sets of signals-songs, calls, and plumage colour of both species (including a total of 504 songs from 150 individuals).

Later, they played them back to individuals of each species to test the significance of songs of both types.

The results showed that territorial songs of both species were extremely similar particularly where they lived together, such that territorial birds treated songs of both species as equally threatening.

In the meantime, they discovered that non-territorial signals like calls and plumage were highly divergent.

“In effect, the territorial songs of these birds are more or less interchangeable in design and function. Given that they last shared a common ancestor more than 3 million years ago, it is almost equivalent to humans and chimpanzees – which diverged around 5 million years ago – using the same language to settle disputes over resources” said Tobias.

“Our results provide the first compelling evidence that social interaction can cause convergent evolution in species competing for space and resources.

They also suggest that while competition drives convergence in territorial songs, this is offset by divergence in non-competitive signals such as plumage colour to promote species recognition and reduce the chance of interbreeding,” he added.

The study has been published in Evolution.(ANI)

Nobel laureate Richard Roberts calls for more research in personalized medicine

Bangalore, June 19 (ANI/Business Wire India): Starting as a small company without taking the help of any investor but still doing focused research to generate revenue is a good approach for start-ups in Biotechnology, according to Nobel Laureate Dr. Richard.

J. Roberts. Delivering the highlight lecture on the second day of the ninth edition of Bangalore Bio, India’s premier Biotechnology event organized by the Department of Information Technology, Biotechnology and Science and Technology, Government of Karnataka, Vision Group on Biotechnology and MM Activ Sci-Tech Communications Co., he shared the experience of his own company New England Biolabs, which started as a small research firm in a basement and today has become the world’s largest source for recombinant and native enzymes for DNA technology.

Dr. Robert’s discovery, that we can split genes revolutionized the thinking and led to therapies with recombinant drugs. Dr. Roberts precisely discussed on topics within the broad purview of Biotechnology.

On recession in general and research in Biotechnology in particular, Dr. Roberts said, “We still know very little about the biology and how mechanisms of life work. So this provides us a huge opportunity to focus on the areas that humanity needs most. In fact, recession provides an opportunity to plan and consolidate better. But there is a lot to do in the area of personalized medicine.”

Key thrust areas according to the Nobel Laureate are – GM Foods, Bio-energy, Stem Cell Research, Synthetic Biology and Personalized Medicine. He lamented at politics and politicians agitating against GM foods. He questioned the basis of their view. When a plant breeder introduces hundreds of genes, about which we do not know, to produce hybrids, we accept. But when a scientist works with just one gene, about which he knows fully, politicians oppose it. He called for a need to change this attitude.

Commenting on Pharma industry in general, he said, “They are not really interested in curing the diseases, fearing they lose their future income. Instead, they offer only amelioration, in which case the patient needs to keep on buying medicines. Personalized medicine works differently. But he advised Pharma companies to take up specific drugs to phenotypes as this market also are huge and the possibility of making profits is high.”

Dr. Roberts said, “Small is beautiful in the area of Bio-Energy. A small bio-fuel cell can produce electricity enough to charge a laptop, mobile or a light in a remote African hut.”

On stem cell research, he said, “We can cure diabetes, kidney failure, and many lifestyle diseases and can even grow organs using the cells of the patients. In such case there will not be any possibility of rejection.”

Delivering the second Highlight Lecture, Dr. V M Katoch, Secretary, Department of Health Research, Government of India, and Director General, Indian Council for Medical Research, said, “Proactive bureaucracy and committed political will made Bangalore a Bio-tech hub of India. He called upon Bio-tech companies to work on antiviral drugs and accelerate inventing tools to detect viruses and infections. Though there is lot of research going on in inventing and producing drugs, there is lot to do from the patients perspective to know which drug works better for him.”

Dr. Katoch said, “Classification of diagnosis and diseases among Indian population will address this issue. Though this process is very costly today, bio-tech companies should do research to bring this cost down. When this is done, we can move ahead with personalized medicine. Government of India will encourage bio-tech companies to work in this area.”

Chairing the session, Dr. Sharat Chandra, Director, Center for Human Genetics, said, “In India, two types of biomedical research is going on. One is in the pharma industry that leads to produce drugs. The other is by clinicians to know the outcomes and responses to treatments in patients. The second one is too small as on today, a lot more is needed to be done.” (ANI)

Leishmania parasites undergo sexual reproduction in sand flies

London, Apr 10 (ANI): In a landmark discovery, scientists have found that the parasites responsible for leishmaniasis does reproduce sexually, and that they do it inside sand flies – a natural vector of Leishmania.

Leishmania parasites cause widely differing forms of the disease, some of which horrific skin infections, and others affect the internal organs and can cause death.

The new finding may open up new opportunities for fighting the deadly disease.
Although Leishmania parasites reproduce clonally, there has been no proof that they can exchange genes through sex and form hybrids.

“We could say circumstantial evidence is strong because we see apparent hybrids in nature, but that’s not the same as saying one has or can attain a population-genetics proof. Formal experimental proof has been lacking,” Nature magazine quoted Michael Miles, a Leishmania expert at the London School of Hygiene and Tropical Medicine, as saying.

But, a research team led by David Sacks, of the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, have now established that the parasites reproduce in sand flies.

The researchers infected flies with two different strains of Leishmania that are resistant to two different drugs.

Hybrid parasites resistant to both drugs were later isolated from the flies, showing that the parasites had reproduced sexually.

Overall, 18 hybrids were eventually recovered, each showing a full set of chromosomes from each parent plus additional genetic material called kinetoplast DNA from one parent.

And one reason why sexual reproduction in Leishmania parasites has not been before might be due to practical difficulties of studying its sand-fly vector in the lab.

“It is likely [gene exchange] only occurs in the insect vector, and very few researchers have sand-fly colonies. If sex only occurs in the flies, you have to have flies to investigate the problem,” said Sacks.

He added: “We were convinced it had to occur because of all of those examples of hybrid genotypes from field samples.”

However, he said that parasite sex is not the major method by which Leishmania reproduce.

“Sex is rare. When it occurs, if it confers a powerful sexual advantage, then these lines will propagate clonally,” he said.

And as Leishmania hybrids have now been created in the lab, researchers can bring traditional genetic approaches to bear on the parasite and track down the reasons behind some of the differences between strains, improving our understanding of disease virulence and drug resistance.

The study has been published in the journal Science. (ANI)