Aniston flaunts sexy legs and sexier pooch at Love Happens LA premiere

Washington, Sept 18 (ANI): Jennifer Aniston is known for her super svelte body in Hollywood and world over. However, she made heads turn at Los Angeles premiere of “Love Happens” by sporting a bit of a pooch.

The 40-year-old, who was wearing a sequined mini on the Tuesday event, also drew attention because of her sexy toned legs.

“It’s a team of people! I really am physical everyday, it keeps all of the pistons firing,” Aniston recently told FOX News’ Pop Tarts.

“Being physically in shape is important, especially when you have to sometimes work 13-16 hour days,” she added.

Love Happens is a romantic drama that places Aniston opposite “The Dark Knight” hunk Aaron Eckhart. (ANI)

Ang Lee ‘working on film version of Life of Pi’

Nevada (US), Sept 9 (ANI): Oscar winner Ang Lee is working with a writer on film adaptation of Yann Martel’s fantasy “Life of Pi” about a boy from Pondicherry, India, who survives 227 days after shipwreck, according to reports.

Lee is quoted as saying: “It’s a very strong story, but it’s hard to crack.”

Acclaimed Indo-American statesman Rajan Zed, welcoming the film adaptation of this India influenced story, urged Lee to handle the Pi’s spirituality exploration and holistic edge with cultural sensitivity.

Expected to be released in 2011, Canadian Martel’s (Manners of Dying) Man Booker Prize and other awards winning novel is an adventure tale about 16-years old Pi Patel stranded on a lifeboat with a hyena, orangutan, an injured zebra, and a hungry Bengal tiger in Pacific Ocean on his voyage from India to Canada.

It has sold well over one million copies and was a global publishing phenomenon. Keith Robinson adapted it into a play and toured England.

Oscar nominated M. Night Shyamalan (The Sixth Sense), Alfonso Cuarón (Children of Men), and Jean-Pierre Jeunet (Delicatessen); and Dean Georgaris (What Happens in Vegas) have already dropped this project after preliminary exploration.

The Fox 2000 high profile film adaptation will be produced by Gil Netter (Personal Effects). (ANI)

Ashton Kutcher says he’s piling his millions due to career fears

Washington, August 13 (ANI): Ashton Kutcher has revealed that he has barely spent his millions earned from movies, fearing his career may come to an end any time.

The “What Happens in Vegas” star confessed that he does not splurge big bucks on extravagant purchases because he is worried his Hollywood days maybe numbered.

“You never know what happens in this business,” Contactmusic quoted him as telling the New York Post.

“What we do for a living is nonsense. It’s entertainment… I still haven’t bought myself anything special with my earnings. I can’t even think what I’ve treated myself to.

“Actually, I haven’t spent anything. I’ve kept it all. Except I gave some to my stepdad, who drives needy kids wherever they have to go,” he added. (ANI)

Is it splitsville for Cameron Diaz and Paul Sculfor?

New Delhi, May 06 (ANI): Cameron Diaz has reportedly dumped her boyfriend Paul Sculfor.

The ‘What Happens In Vegas’ star has been dating the British model since last summer (08) but the pair has now ended its romance, according to British magazine Grazia, with sources blaming the couple’s hectic schedules for the break-up, reports the China daily.

“They have fallen out of love. They didn’t seem to find time for each other anymore,” a source said.

“Paul is not too enamoured by Los Angeles and wants to be where his friends are. Cameron thought she could settle in England but missed her old life too much. The romance just died,” the source added.

And it looks like they are dealing well with the split.

The 36-year-old actress was recently seen in Los Angeles’ Chateau Marmont hotel flirting with several men.

“She looked hot and every guy in the place noticed. She was laughing so loudly you could hear her in the lobby,” the source said.

“When a friend asked after Paul she just rolled her eyes and dismissed it with a wave of her hand. It was obvious from the way she referred to him that he’s no longer her boyfriend.”

Meanwhile, Paul, 38, was spotted at West Hollywood bar Swingers enjoying a night out with pals.

“He was checking out an attractive brunette and whispered to his friend, ‘She’s beautiful’ and they both just stared at her for ages. He wasn’t acting like a guy with a girlfriend,” one fellow reveller said. (ANI)

Cameron Diaz may star in ‘Swingles’

Washington, Mar 24 (ANI): Cameron Diaz is in talks to star in the romantic comedy ‘Swingles’ at Paramount Pictures.

The story revolves around a bachelor who is dumped by his wingman and teams up with a sharp-tongued woman he can’t stand in order to meet singles.

The screenplay has been written by Duncan Birmingham and Jeff Roda.

Kevin Misher is the producer of the film, reports Variety.

Meanwhile, Diaz, who is dating British model Paul Sculfor, is reportedly planning a big wedding in the English countryside.

The ‘What Happens In Vegas’ star and her beau have reportedly been hunting Britain for a perfect place to tie the knot. (ANI)

Kutcher to star in football-themed comedy film ‘Traded’

Washington, Feb 18 (ANI): Actor Ashton Kutcher is in final negotiations to star in football-themed film Traded.

The plot of the comedy film revolves around a superstar NFL quarterback and a 12-year-old middle school geek who magically trade bodies, and then quickly learn valuable lessons about humility and courage, reports the Variety.

The script has been written by David Stem and David Weiss of “They Came From Upstairs,” fame.

Kutcher, who recently starred in “What Happens in Vegas,” has two films in his kitty: the indies “Personal Effects” and “Spread.”

Meanwhile, the Punk’d star is plotting to re-stage Michael Jackson’s infamous baby-dangling incident after finding out that he was staying in the same hotel room as the singer.

He revealed on his online Twitter.com post that he was planning to repeat the blunder by wrapping up a doll and hanging it over the heads of the paparazzi outside from the balcony of his room at Berlin’s Hotel Adlon. (ANI)

Zoya Akhtar’s ‘Luck by Chance’ to star Juhi Chawla and Farhan Akhtar

Zoya Akhtar’s ‘Luck by Chance’ to star Juhi Chawla and Farhan Akhtar The vibrant and talented Juhi Chawla, who is also known for her extraordinary performance and unique roles, has undergone a makeover. She would be seen with blonde hair to fit in the role of Minty Rolly, the producer wife of Rishi Kapoor in Zoya Akhtar’s film Luck By Chance.

Since the role required the veteran actress to do something different, she went for blonde look, a thing she has never done before.

A bubbly Juhi said, “When Zoya offered me the role, I was thrilled, even though I was told it was not a big one. I didn’t mind. It was different from the other characters I have played till now, and that was the most exciting part. Playing Minty was so much fun.”

The movie, which would release on 30th January, will finally tell the response of the public.

It should also be noted here that “Luck by Chance” is also starring the new-eye candy Farhan Akhtar, who also happens to be the brother of Zoya Akhtar. Zoya could not think of anyone else for the lead role except for her brother, since she thinks he is perfect for it.

Zoya said, “Farhan was the perfect choice for the role in ‘Luck By Chance’ because he knows the industry in and out. He is smart and bright and both of us have been working together for years.”

The ultimate pair of this brother and sister has earlier worked in several films like “Lakshya” and “Dil Chahta Hai” and both share a comfortable working equation.

Federer: I’ve become more human

Federer: I've become more human Melbourne – Even ice-calm Roger Federer admits that his stress levels have eased in recent months as he slipped from tennis’ top ranking.

Still ranked second, the Swiss star said that he feels an eerie calm as he pursues a fourth title in six years at the Australian Open.

“Maybe I’m a bit more relaxed,” he said after passing the first round against Italy’s Andreas Seppi. “When you’re number one you put your head down, you try to win as many tournaments as possible.”

He admitted: “Maybe sometimes you forget to enjoy it as much as you can, because everything happens so quickly.”

While he’s not about to give up his quest to replace Rafael Nadal atop the ATP rankings, Federer said he has come to appreciate the slight dialing down of the tension level at his current position.

“It’s nice time to be number one, having everybody talking about you. But I’m getting older. I’m enjoying myself more. I still love the traveling. I love competing out on centre court. Those are good feelings,” he said.

“But maybe today, after a tough year, sometimes you can show more because you’ve been through a tough time. I show maybe a bit more emotions, a bit more happiness, which maybe people didn’t see before.”(dpa)

Aussies work longest hours in developed world

Sydney, Jan 9 (ANI): Australians work the longest hours in the developed world, according to a new study.

One third of full-time workers won’t take any annual leave this year, according the country”s largest ever study into annual leave accrual by Tourism Australia.

Almost 60 per cent of full-timers don”t use their four weeks holidays each year and have at least eight weeks of leave up their sleeve, the figures show.

Corporate men aged between 35 and 49 are the worst offenders, comprising the largest group with accrued leave – and half of them have children under the age of 12.

Australians have 121 million days of accrued annual leave, worth 31 billion dollar in holiday pay.

Geoff Buckley, Tourism Australia managing director, said there had been a shift in Australia”s traditionally laid-back psyche to one where diligent workers were too busy to look at a holiday brochure.

“You”ve got younger people who are driving to create a career and don”t take the leave that they”re owed,” the Sydney Morning Herald quoted Buckley, as saying.

“Or there is the other end of the market where they”re worried about taking leave and maybe not having a job at the end of it.

“And then there is a whole group who are keeping that leave up their sleeve in case something happens.

“That”s a big risk strategy for people with families or who are struggling to pay the mortgage. It”s almost like a forced savings,” Buckley

And when people do take time off, they”re opting for short, weekend escapes over the traditional month-long coast holiday, popular 20 years ago.

Buckley said many people felt a short break was enough, while others had too much trouble finding a long stretch when both partners could get time off work. (ANI)

Quantum lubricant could be used to keep nanomachines rolling

London, Jan 8 (ANI): A team of scientists has observed a quantum effect that causes objects to repel one another, which could be used to lubricate future nanomachines.

According to a report in New Scientist, the team detected the weak repulsive force when they brought together a thin sheet of silica and a small gold-plated bead, about half the diameter of a human hair.

The force is an example of the Casimir effect, generated by all-pervasive quantum fluctuations.

The simplest way to imagine the Casimir force in action is to place two parallel metal plates in a vacuum. Thanks to the odd quantum phenomenon, these become attracted to one another.

It happens because even a vacuum is actually fizzing with a quantum field of particles, constantly popping in and out of existence. They can even fleetingly interact with and push on the plates.

However, the small space between the two plates restricts the kind of particles that can appear, so the pressure from behind the plates overwhelms that from between them.

The result is an attractive force that gums up nanoscale machines.

Harvard physicist Federico Capasso, a member of the group who measured the effect, said that that the Casimir force needn’t be an enemy.

“Micromechanics at some point will have to contend with these forces – or make use of them,” he said.

In 1961, Russian theorists calculated that in certain circumstances, the Casimir effect could cause objects to repel one another – a scenario Capasso’s team have finally created experimentally.

The team achieved this by adding a fluid, bromobenzene, to the setup.

The Casimir attraction between the liquid and the silica plate is stronger than that between the gold bead and the silica, so the fluid forces its way around the bead, pushing it away from the plate.

The effect is akin to the buoyancy experienced in the macro world, where objects less dense than water are held up by the liquid around them. But, in this case, the bromobenzene is less dense than the solid bead.

“You could call it quantum buoyancy,” Capasso told New Scientist.

The force he measured was feeble – amounting to just a few tens of piconewtons – but that is still enough to buoy up nanoscale objects.

“Harnessing the repulsive Casimir force could provide a kind of lubrication to solve the problem of nanomachines becoming gummed up by the better-known attractive version,” said Capasso. (ANI)

It”s most difficult to restore trust if broken early in relationship

Washington, Jan 8 (ANI): Trust, they say, once broken can never be built again, but researchers have now said that if the breach of trust happens in the beginning of a relationship, it is more difficult to overcome than a betrayal that occurs after ties are established.

According to the results, early violations can be particularly devastating, and plant seeds of doubt that may never go away

“First impressions matter when you want to build a lasting trust. If you get off on the wrong foot, the relationship may never be completely right again. It”s easier to rebuild trust after a breach if you already have a strong relationship,” said Robert Lount, co-author of the study and assistant professor of management and human resources at Ohio State University”s Fisher College of Business.

He said that the results defy the popular notion that suggests many great relationships start off on a bad note.

“Our results fly in the face of this Hollywood notion of hating someone at first sight but then developing a wonderful, passionate relationship. The likelihood of that happening in real life is pretty low,” he said.

For the study, the researcher conducted two related experiments, where college students participated in a game in which their partners violated their trust either right at the beginning of the game or somewhere in the middle.

Using a famous game in psychology called the prisoner”s dilemma, the researchers aimed at determining how much the students were willing to cooperate with the partner after trust was breached.

In the first experiment, 138 students played multiple rounds of the game on a computer, which they thought they were playing with a student via a computer in another room. However, they were actually playing with a computer that was programmed to defect at specific points during the more than 30 rounds of the game.

The results indicated that participants who experienced the immediate breaches of trust had the most negative evaluations of their partners.

It was found that participants who experienced a breach of trust during the first two trials of the game were also the least likely to cooperate at the end of the game, suggesting they had the least trust in their partners.

On the other hand, participants who experienced a trust breach latest in the game showed the most cooperation at the end of the game.

Lount pointed out that in all cases, the computer defected against the participants the same number of times, but the timing of the breaches was key.

“An immediate breach of trust is particularly difficult to overcome, and later breaches are considerably less harmful,” he said.

After the experiment, the participants filled a questionnaire and it was found that those who experienced the immediate breach rated their partners as less trustworthy than did those whose partner defected later in the game.

In a second experiment, the researchers essentially repeated the first experiment with 108 students, but this time the students answered a short set of questions concerning their perceptions and feelings about their partner immediately following a breach and every 10 trials thereafter.

“Our results suggest that immediate breaches are especially costly because they seriously damage the impressions people have about their partner, and that”s hard to repair,” he said.

The study has been published in a recent issue of the journal Personality and Social Psychology Bulletin. (ANI)

Now US porn industry wants $5B Govt. bailout

London, January 8 (ANI): Porn baron Larry Flynt says that the US Government should help rejuvenate the industry, which has been bearing the brunt of the ongoing global economic crisis, with a financial assistance of five billion dollars.

The Hustler magazine founder has even joined forces with ‘Girls Gone Wild’ video series’ creator Joe Francis to approach Congress so as to sustain the same kind of financial aid as was recently approved for automakers.

“Congress seems willing to help shore up our nation”s most important businesses, (and) we feel we deserve the same consideration. In difficult economic times, Americans turn to entertainment for relief. More and more, the kind of entertainment they turn to is adult entertainment,” the Telegraph quoted Francis as saying in a statement

“The take here is that everyone and their mother want to be bailed out from the banks to the big three. The porn industry has been hurt by the downturn like everyone else and they are going to ask for the $5 billion. Is it the most serious thing in the world? Is it going to make the lives of Americans better if it happens? It is not for them to determine,” the paper quoted Owen Moogan, a spokesman for Flynt, as telling CNN.

Francis is also said to have admitted during an interview with the website TMZ that the move is more of a “precautionary measure” than an emergency rescue.

He, however, insisted that “as long as the government is handing out money, we want to be there to take it.”

The pair admit that though DVD sales and rentals have dropped 22 per cent over the past year, online traffic has continued to grow.

“The 13-billion-dollar industry is in no fear of collapse. But why take chances?” they say.

Flynt insists that Americans can do without cars but not without sex, and the only way Congress could “rejuvenate” the country’s sexual appetite was “by supporting the adult industry and doing it quickly.”

There was no response from Congress to the request. (ANI)

Metropolitan Police being sued for £1M over alleged sex pest cops

London, January 7 (ANI): The Metropolitan Police in the UK is being sued for one million pounds by two serving WPCs, alleging that they have been pestered by sex-obsessed cops.

While one of them claims that her groin was repeatedly groped when she was at a police station, the other says that a male officer pulled down his trousers and asked her to perform a sex act on him as he drove on patrol.

WPCs Julie Facey, 33, and Paula Church, 35, are bringing the law suit over the alleged actions of three PCs based in Essex.

While Facey said that the first officer pestered her for sex, Church said that he sexually assaulted her repeatedly.

The complaint against the second officer is that he forcefully kissed one of the women, quizzed her about her underwear, and suggested sexual forfeits as they worked.

He has also been accused of stalking the woman, daubing messages on her car, and bombarding her with text messages.

WPC Facey complained that the third officer, who happens to be a married man, called her a “cute babe”.

“Until I get another fit bird on the team, you’re not going anywhere. I need a reason to come in every day,” the Mirror quoted her as saying, as she revealed what the officer allegedly told her.

The WPCs also claimed that their bosses pressured them not to bring any criminal charges.

The women’s solicitor, Lawrence Davies, of Equal Justice, said: “If what they say is true, it will show that the Met is more interested in protecting its image than tackling serious sexual misconduct.”

The three officers and the Met force are being sued for sex discrimination and harassment at Stratford Employment Tribunal.

The Met and the individual officers deny the claims. Their case is due to be heard later this year. (ANI)

Conventional risk assessment tools do not accurately predict coronary heart disease

Washington, Jan 7 (ANI): Traditional risk assessment tools, like the Framingham and National Cholesterol Education Program tools, NCEP, do not accurately predict coronary heart disease, according to a study by researchers at Yale University School of Medicine in New Haven, CT.

The study was conducted on 1,653 patients who had no history of coronary heart disease, other than 738 patients who were taking statins (cholesterol lowering drugs like Lipitor) because of increased risk of developing coronary heart disease.

All the patients underwent a coronary CT angiogram and doctors compared their risk of coronary heart disease, determined by the Framingham and NCEP risk assessment tools, to the amount of plaque actually found in their arteries as a result of the scan.

According to the results, 21 percent of the patients believed to be in need of statin drugs before the scan (because of the Framingham and NCEP assessment tools) did not require them.

“26percent of the patients who were already taking statins (because of the risk factor assessment tools) had no detectable plaque at all,” said Kevin M. Johnson, MD, lead author of the study.

He added: “Risk assessment tools are used by physicians implicitly. Physicians use them as a way to separate and treat patients accordingly. Ultimately, the Framingham influences what every physician does, but I feel it is not good enough to show what is happening with each individual patient.

“The average person tends to put a lot of weight on family history, but the association between that and coronary heart disease is only modest,” said Dr. Johnson. “We are living in an era where genetic research is in the headlines, but reality is a lot more complicated than that.

“There are still 400,000 people a year who die from heart attacks and have no warning signs at all; doctors want to be able to find those people before that happens and I hope this study gets people interested in finding out better predictors for coronary heart disease.”

This study appears in the January issue of the American Journal of Roentgenology. (ANI)

Army man beats world champion Gagan Narang to win shooting gold

New Delhi, Jan 7 (ANI): Naib Subedar Surendra Singh Rathod of the Army Marksmanship Unit (AMU) bagged the first individual gold medal at the 52nd National Shooting Championship by defeating his nearest rival Gagan Narang, who also happens to be the current 10 Metre Air Rifle world record holder.

Rathod scored a card of 592/600 and scored 102.7/109 in the finals to beat Narang at the championship being held at Thodupuzha Kerala from January 4-17.

Gagan Narang eventually finished with a bronze medal scoring 591 /600 and 100.5/109 in the finals. Joydeep Karmokar of the Railways with a total score of 693.0 won the silver medal.

The AMU Team in the same event also bagged the team gold medal with a collective score 1763/1800. The Team comprised of Rathod (592), Havaldar Sushil Ghaley (586) and Havaldar Hariom Singh (585).

The first event was 50 Metre Free Rifle Prone Posn (Men) wherein two individuals of the Army Marksmanship Unit (AMU) made it to the finals. (ANI)

Alaska authorities accused of delaying arrest of woman connected to Sarah Palin

London, Jan 7 (ANI): A drug investigator has laid claims that Alaskan authorities delayed the arrest of a woman, who was connected to Governor Sarah Palin, until after the November election was over.

According to the Anchorage Daily News, the drug investigator revealed that the arrest of Sherry Johnston, who happens to be the mother of Levi Johnston, who is engaged to Palin’s daughter, Bristol, had been put on hold due to political reasons.

Palin was at that time running for the Republican vice-presidential post.

Johnston, 42, was arrested on December 18, and on January 5 she pleaded not guilty to six counts of possessing and selling OxyContin, a powerful prescription painkiller.

As per reports, Kyle Young, a drug investigator and state trooper, had written to the Public Safety Employees Association last week to say a search warrant for Johnston”s house had been delayed.

“It was not allowed to progress in a normal fashion, the search warrant WAS delayed because of the pending election and the Mat Su Drug Unit (a regional drug enforcement team) and the case officer were not the ones calling the shots,” the Telegraph quoted Young as having written in the message sent on December 30.

The warrant was delivered on the same day Johnston was arrested, and Joe Masters, the Public Safety Commissioner, insists that the case had been handled fairly.

Masters also said that no one in the Governor”s office had known that troopers were investigating Johnston until after her house was searched, and that it was only then that he called Palin’s chief of staff to warn him of the potential media firestorm the investigation could prompt.

It was only then that Masters called Palin”s chief of staff to warn him of the potential media firestorm the investigation could prompt, he said.

Rob Cox, the union president, said that the allegation stemmed from a misunderstanding between investigators and public safety officials, adding that the warrant against Johnston would never have been ready to serve before the election. (ANI)

Obama, Biden apologise to Feinstein over Panetta snub

Washington, Jan.7 (ANI): U.S. President-elect Barack Obama and Vice President-elect Joe Biden have apologized to Diane Feinstein, the head of the Senate Intelligence Committee, for not consulting her about the nomination of Leon Panetta to head the CIA.

According toa Fox News report, Obama and Biden called Feinstein a day after her spokesman said the California senator did not receive a phone call about Panetta from anyone in the Obama camp and learned about the decision to nominate him from news reports.

Feinstein”s committee would be in charge of holding Panetta”s confirmation hearing.

“I have been contacted by both President-elect Obama and Vice President-elect Biden, and they have explained to me the reasons why they believe Leon Panetta is the best candidate for CIA director,” she said in a written statement.

“I look forward to speaking with Panetta about the critical issues facing the intelligence community and his plans to address them,” she added.

Feinstein told Roll Call, a newspaper on Capitol Hill, that Obama and Biden “apologized profusely” for not calling her and that she has no hard feelings.

“I”ve been around a long time I know this happens,” she said.

Biden, who previously served as chairman of the Senate Foreign Relations Committee, on Tuesday called it a “mistake” to exclude Feinstein in discussions on a CIA pick. (ANI)

Exertion at work and play can trigger deadly asthma attacks

Washington, Jan 6 (ANI): A new study by researchers at Tel Aviv University has revealed that physical exertion, as part of work or play, can trigger a deadly asthma attack.

The study gives doctors a new way of advising those who may be at risk and will also help young asthmatic adults find safer and more suitable employment.

“The diagnosis of asthma is increasing in the western world. Some say it’s because of genetics, pollution, and more accurate diagnostic tools,” said Dr. Shlomo Moshe from Tel Aviv University’s Sackler Faculty of Medicine.

“I tried to tackle what happens from the occupational hazards side. Under what conditions do young adults develop asthmatic attacks? How can doctors better recognize this under-diagnosed disease?” Dr. Moshe added

Dr. Moshe said that doctors should be aware of the risk level for asthma in young adult patients.

“Using our recent research, we have developed a tool that gives both percentages and risks. If you had asthma in childhood, you can certainly develop it again. Family physicians need to know that certain jobs can be risky to their patients. If a patient wants to be a pro-football player, a baker, a carpenter, or a technician in an animal laboratory, his doctor needs to advise him accordingly,” Dr. Moshe said.

Dr. Moshe’s most recent research, which follows upon an earlier study, finds an indisputable connection between asthma and exercise.

“When young adults start their first job, they should be aware of the pulmonary risks,” says Dr. Moshe, whose study covered nearly 800 young recruits to the Israel Defense Forces.

“Exercise and sports like football do cause asthmatic attacks. Logically, that should be considered if someone wants to do a job which includes physical exertion, like being a guard, taking part in competitive sports, or working in a factory on heavy machinery,” Dr. Moshe added.

Dr. Moshe’s new work builds on a 1999 study, which covered 60,000 subjects. The research evaluated the risks of people who had asthma in childhood and the risks for its later re-emergence as these subjects entered the adult workforce.

The study is published in Occupational Medicine. (ANI)

How our body fights infection

Washington, Jan 6 (ANI): It is a well-known fact that our immune system adapts itself to every new microbe it encounters. Now, scientists from Wayne State University in Detroit have shed light on how human’s antibody-forming system makes “evolutionary leap” to stave off infection.

The study shows that a ”cluster mutations” help our antibody formation system adapt to infection.

The process involves altering the genes that code for antibodies to specific viruses or bacteria.

“We”ve known for a long time that our antibody-forming system adapts itself to every microbe we encounter but what we didn”t understand fully is exactly how this happens,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal.

“Now that we know, we can begin to find ways to manipulate this process so illnesses can be prevented or made significantly less dangerous,” he added.

When the body encounters a foreign invader, like a virus or bacterium, it immediately begins to find a way to neutralize it by means of cellular or antibody-mediated defences.

The process involves two types of genetic manipulation. One type changes a single gene at a time, and the other type changes multiple genes at the same time.

Scientists have explained how multiple genes can be modified simultaneously to make the “evolutionary leap” necessary to stave off infection.

During the study, the researchers treated DNA responsible for making antibody molecules with an enzyme, called activation-induced deaminase, while the DNA was being copied by RNA polymerase.

Like a scanner, RNA polymerase moves across the DNA to copy it. When this scanning process moved smoothly, there were either single mutations or no mutations.

When the researchers made the RNA polymerase stall along the DNA (under certain conditions), it caused several mutations at once (cluster mutations) in the DNA, adapting our antibodies for a rapid and effective response to a new microbial invader.

“As the planet warms, infectious diseases may be one the biggest threats to human survival,” Weissmann said.

“Nowadays, mosquitoes, parasites and viruses cause diseases in the United States that were once isolated to warmer parts of the world.

“They evolve, and – a la Darwin – so does our immune system each time we meet a new microbial invader,” he added.

The study appears in the FASEB Journal (ANI)

Scientists develop new technique to fuse cells for stem cell research

London, Jan 5 (ANI): Researchers at Massachusetts Institute of Technology (MIT) have created a new, highly efficient way to pair up cells so that they can be fused together into a hybrid cell.

The technique, which resulted from collaboration between Joel Voldman, associate professor of electrical engineering and computer science, and Rudolf Jaenisch, professor of biology and a member of the Whitehead Institute, might make it a lot easier for scientists to study what happens when two cells are combined.

For instance, fusing an adult cell and an embryonic stem cell may help researchers study the genetic reprogramming that occurs in such hybrids.

The scientists have developed a simple but ingenious sorting method, which can boost the rate of successful cell fusion from around 10 percent to about 50 percent.

The technique also facilitates thousands of cell pairings at once.

Voldman said that despite the presence of cell fusion techniques in research, there were many technical limitations involved in the process.

And one of the biggest hindrances was how to get the right cells to pair up before fusing them, the researcher added.

If scientists are working with a mixture of two cell types, for example A and B, they end up with many AA and BB pairings, as well as the desired AB match. Earlier, the scientists could successfully trap cells in tiny cups as they flowed across a chip. Each cup could hold only two cells, but there was no way to control whether the cups capture an A and a B, two As or two Bs.

On the other hand, the cell-trapping cups on the new sorting device are arranged strategically to capture and pair up cells of different types.

First, type A cells are flowed across the chip in one direction and caught in traps that are large enough to hold only one cell.

After the cells are trapped, liquid is flowed across the chip in the opposite direction, pushing the cells out of the small cups and into larger cups across from the small ones. Once one A cell is in each large cup, type B cells are flowed into the large cups. As each cup can only hold two cells, thus each ends up with one A and one B.

After the cells are paired in the traps, they can be joined together by an electric pulse that fuses the cell membranes.

Besides helping with studies of stem cell reprogramming, the new method could help to study interactions between any types of cells.

“It”s a very general type of device,” Nature magazine quoted Voldman as saying.

The study has been published in the online edition of the journal Nature Methods. (ANI)