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Broccoli may help fight breast cancer

May 4, 2010 By vani Leave a Comment

Washington, May 4 (ANI): A broccoli compound may help prevent or treat breast cancer by targeting cancer stem cells, according to a new study.

Stem cells are the small number of cells that fuel a tumor”s growth.

The study from researchers at the University of Michigan Comprehensive Cancer Center tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures.

Researchers found sulforaphane targeted and killed the cancer stem cells and prevented new tumors from growing.

“Sulforaphane has been studied previously for its effects on cancer, but this study shows that its benefit is in inhibiting the breast cancer stem cells. This new insight suggests the potential of sulforaphane or broccoli extract to prevent or treat cancer by targeting the critical cancer stem cells,” says study author Duxin Sun, Ph.D., associate professor of pharmaceutical sciences at the U-M College of Pharmacy and a researcher with the U-M Comprehensive Cancer Center.

Results of the study appear in the May 1 issue of Clinical Cancer Research. (ANI)

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Popular diabetes drug may help fight breast cancer

September 15, 2009 By admin Leave a Comment

Washington, Sept 15 (ANI): A popular diabetes drug called metformin has been found to be effective in fighting breast cancer.

The findings of the study from Harvard Medical School showed that metformin, along with conventional chemotherapy, shows promise for treating and delaying recurrence of breast cancer.

“We have found a compound selective for cancer stem cells,” said senior author Kevin Struhl, the David Wesley Gaiser professor of biological chemistry and molecular pharmacology at HMS.

“What’s different is that ours is a first-line diabetes drug,” he added.

The drug seemed to work independently of its ability to improve insulin sensitivity and lower blood sugar and insulin levels, all of which are also associated with better breast cancer outcomes.

“There is a big desire to find drugs specific to cancer stem cells,” said Struhl.

“The cancer stem cell hypothesis says you cannot cure cancer unless you also get rid of the cancer stem cells. From a purely practical point of view, this could be tested in humans. It’s already used as a first-line diabetes drug,” he added.

Lead researchers Heather Hirsch and Dimitrios Iliopoulos found that the combination of metformin and the cancer drug doxorubicin killed human cancer stem cells and non-stem cancer cells in culture.

In mice, pre-treatment with the diabetes drug prevented the otherwise dramatic ability of human breast cancer stem cells to form tumours.

In cases where tumours were allowed to take hold for 10 days, the dual therapy also reduced tumour mass more quickly and prevented relapse for longer than doxorubicin alone.

“This is an exciting study,” said Jennifer Ligibel, a medical oncologist at Dana-Farber Cancer Institute and an HMS instructor in medicine, who was not involved in the study.

“There is a lot of interest in studying metformin in breast cancer, but so far we do not have direct evidence that metformin will improve outcomes in patients,” Ligibel said. “That’s what this trial is for.”

The findings appear online in the journal Cancer Research. (ANI)

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Extra virgin olive oil ‘helps combat breast cancer’

February 7, 2009 By admin Leave a Comment

Washington, Feb 6 (ANI): Spanish researchers have found that extra virgin olive oil can help fight breast cancer.

Researchers of the Catalonian Institute of Oncology (ICO) and the University of Granada (Spain) have verified the bioactivity of the polyphenols present in extra virgin olive oil in breast cancer cell lines.

The work, carried out by Javier A. Menndez, of the Catalonian Institute of Oncology (ICO), in collaboration with Professors Alberto Fern ndez Gutirrez and Antonio Segura Carretero, of the University of Granada, has been published in the journal ‘BMC Cancer’.

The study has proved the anti-HER2 effect of fractions of phenolic compounds directly extracted of extra virgin olive oil in breast cancer cell lines. They have used solid-phase extraction methods of semi-preparative liquid chromatography to isolate fractions of commercial oils and, later, separation techniques (capillary electrophoresis and liquid chromatography connected to mass spectrometry) to check the purity and composition of the fractions.

Such fractions were tested in their anti-cancer capacity both against positive HER2 and negative HER2 breast cancers, using in Vitro models and evaluating the effect of polyphenolic fractions in the expression and activation of HER2 oncoprotein through ELISA specific methods for HER2.

Fractions containing polyphonels such as hydroxitirosol, tirosol, elenolic acid, lignans, pinoresinol and acetopinoresinol, and secoiridoids, diacetox oleuropein aglycone, ligustrosid aglycone and oleuropein aglycone were able to induce important tumoricid effects in a range of micromolar and in a selective way against HER2 oncogene.

Therefore, the study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation. (ANI)

Filed Under: Health News Tagged With: aglycone, antonio segura, breast cancer, breast cancer researchers, breast cancers, cancer cell, capillary electrophoresis, combat breast cancer, commercial oils, elenolic acid, extra virgin olive oil, fight breast cancer, granada spain, oleuropein, phenolic compounds, preparative liquid chromatography, solid phase extraction, spanish researchers, university of granada, virgin olive oil

Broccoli may help fight breast cancer

Popular diabetes drug may help fight breast cancer

Extra virgin olive oil ‘helps combat breast cancer’

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