Mystery of odd rotating stars solved by scientists

Washington, September 18 (ANI): A team of scientists has solved a longstanding mystery about a pair of stars called DI Herculis whose peculiar rotation had remained a mystery for three decades.

The shift in the orbit of DI Herculis was a mystery till now.

Now, MIT (Massachusetts Institute Of Technology) researchers and colleagues have determined that the stars are rotating tipped over on their sides, relative to their orbits around each other.

This produces tidal effects that counteract the expected rate for the orbits to shift orientation over time (called precession), finally explaining the mysterious anomaly.

The discrepancy in the rate of precession had been seen as a possible refutation of Einstein’s theory of relativity, so finding a conventional explanation means that relativity has withstood another possible challenge.

This discovery could also help to shed light on how binary stars (about half of all known stars) are formed and how their rotation and orbits evolve over time.

The mystery was solved by postdoctoral researcher Simon Albrecht and assistant professor of physics Joshua Winn and others, who used a high-resolution spectrograph called Sophie on a 1.93-meter telescope at the Observatoire de Haute-Provence in France to make highly detailed observations that revealed the unexpected tilt – one of more than 70 degrees from vertical, the other more than 80 degrees – of the stars’ rotation axes.

The team now hopes to study other unusual binary stars to try to determine how unusual this tipped-over configuration is. (ANI)

Robot taught to smile and frown through self-guided learning

Washington, July 9 (ANI): Scientists at the University of California, San Diego, have revealed that a hyper-realistic Einstein robot has learnt to smile and make facial expressions through a process of self-guided learning.

The researchers say that they took the aid of machine learning to “empower” their robot to learn to make realistic facial expressions.

“As far as we know, no other research group has used machine learning to teach a robot to make realistic facial expressions,” said Tingfan Wu, the computer science Ph.D. student from the UC San Diego Jacobs School of Engineering who presented this advance on June 6 at the IEEE International Conference on Development and Learning.

The researchers have even uploaded a video showing the Einstein robot head performing asymmetric random facial movements as a part of the expression learning process on the website YouTube.

The faces of robots are increasingly realistic, and the number of artificial muscles that controls them is rising.

It was in light of this trend that the researchers from the Machine Perception Laboratory are studying the face and head of their robotic Einstein, hoping that their work may help them find ways to automate the process of teaching robots to make lifelike facial expressions.

According to them, the Einstein robot they worked on has about 30 facial muscles, each moved by a tiny servo motor connected to the muscle by a string.

The researchers point out that developmental psychologists speculate that infants learn to control their bodies through systematic exploratory movements, including babbling to learn to speak.

Initially, these movements appear to be executed in a random manner as infants learn to control their bodies and reach for objects.

“We applied this same idea to the problem of a robot learning to make realistic facial expressions,” said Javier Movellan, the senior author on the paper presented at ICDL 2009 and the director of UCSD’s Machine Perception Laboratory, housed in Calit2, the California Institute for Telecommunications and Information Technology.

The research team may have achieved promising results, but they admit that some of the learned facial expressions are still awkward. One potential explanation is that their model may be too simple to describe the coupled interactions between facial muscles and skin.

To begin the learning process, the UC San Diego researchers directed the Einstein robot head to twist and turn its face in all directions, a process called “body babbling”.

During that period, the robot could see itself on a mirror and analyse its own expression using facial expression detection software created at UC San Diego called CERT (Computer Expression Recognition Toolbox).

That provided the data necessary for machine learning algorithms to learn a mapping between facial expressions and the movements of the muscle motors.

After the robot had learnt the relationship between facial expressions and the muscle movements required to make them, the researchers made it learn to make facial expressions it had never encountered.

For example, the robot learned eyebrow narrowing, which requires the inner eyebrows to move together and the upper eyelids to close a bit to narrow the eye aperture.

“During the experiment, one of the servos burned out due to misconfiguration. We therefore ran the experiment without that servo. We discovered that the model learned to automatically compensate for the missing servo by activating a combination of nearby servos,” the authors wrote in the paper presented at the 2009 IEEE International Conference on Development and Learning.

“Currently, we are working on a more accurate facial expression generation model as well as systematic way to explore the model space efficiently,” said Wu, the computer science PhD student.

Wu concedes that his team’s “body babbling” approach may not be the most efficient way to explore the model of the face.

While the primary goal of this work was to solve the engineering problem of how to approximate the appearance of human facial muscle movements with motors, the researchers say this kind of work could also lead to insights into how humans learn and develop facial expressions. (ANI)

Low thyroid activity may actually be a sign of longevity

New Delhi, June 19 (ANI): Gaining weight and losing hair? Well, chances are that you will live longer, say researchers.

According to Dr Martin Surks and colleagues at the Montefiore Medical Center and the Albert Einstein College of Medicine in New York, low thyroid activity may hold the key to a long life.

Located in the neck, thyroid is a kind of master gland, secreting hormones that affect metabolism. Its activity is usually checked by an indirect measure – looking at levels of TSH, or thyroid stimulating hormone.

High TSH levels suggest the thyroid is underactive, a condition known as hypothyroidism. Low levels suggest it is overactive, known as hyperthyroidism.

People with low thyroid function may lose hair, gain weight and feel sluggish, while those with overactive thyroids may lose weight, feel their hearts race and have trembling hands.

To reach the conclusion, researchers studied hundreds of people who had lived to be 100, and found evidence that people with low thyroid activity were more likely to be in that group, reports The China Daily.

“We studied a large group of Ashkenazi Jews with exceptional longevity,” Surks told a news conference at a meeting of the Endocrine Society, specialists in human hormones.

Surks and colleagues found 15 to 20 percent of people over the age of 60 had TSH levels that suggest an underactive thyroid gland. (ANI)

Eating meat does not increase breast cancer risk in postmenopausal women

Washington, May 29 (ANI): Consuming red or white meat does not raise the risk of breast cancer in postmenopausal women, says a new study.

The large study, conducted by researchers at Albert Einstein College of Medicine of Yeshiva University, has been published in the International Journal of Cancer.

A number of previous studies have found that eating red meat or meat cooked at high temperatures increases the risk of breast cancer. (High temperatures -caused by grilling, barbecuing or pan-frying – produce high amounts of heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) in meat; HCAs and PAHs are mutagens (chemicals capable of causing mutations in DNA) that can cause breast tumors in laboratory animals.)

But a link between meat in the diet and breast cancer in women hasn’t been established.

“Previous epidemiologic studies in humans looking at the amount of meat in the diet and estimated intakes of HCAs and PAHs in relation to breast cancer risk have yielded inconsistent results,” says lead author Geoffrey C. Kabat, Ph.D., M.S., senior epidemiologist in the department of epidemiology and population health at Einstein.

To reach the conclusion, Kabat and his colleagues analyzed data on 120,755 postmenopausal women who participated in the NIH-AARP Diet and Health Study, a collaboration between the National Institutes of Health and American Association of Retired Persons. When the women enrolled in the study (between 1995 and 1996), they gave detailed information on what types of food they ate and how often they ate certain foods. In addition, they provided information on meat-preparation methods.

Over the next eight years, approximately three percent, or 3,818, of the women developed breast cancer. The researchers found no evidence that the amount of meat consumed, meat-cooking methods used, or meat-mutagen intake was associated with an increased risk for breast cancer.

Reported meat intake included steak, hamburger, chicken, pork, processed meat and meat cooked at high temperatures.

The study, “Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study,” also found that consumption of meat or meat cooked at high temperatures, through grilling and oven-broiling, did not increase breast cancer rates in subgroups including obese women, those who did not have children, who were consumers of alcohol, who were smokers, who used menopausal hormone therapy, who had low levels of physical activity, or had a low intake of fruits or vegetables.

Neither the current study nor earlier studies assessed the diets of younger women.

“So we haven’t ruled out the possibility that eating meat and exposure to meat mutagens at a younger age – particularly during adolescence when the breasts are developing – may increase one’s risk of breast cancer,” says Kabat. (ANI)

‘Creativity chemical’ in the brain biased towards smarter people

London, May 21 (ANI): High levels of a so-called “creativity chemical” in a certain part of the brain is what boosts creativity in smart people, revealed a study.

People with average intelligence, on the other hand, are less ingenious because of low levels of the same chemical.

N-acetyl-aspartate, which is found in neurons, is apparently linked with neural health and metabolism.

Already, Rex Jung at the University of New Mexico in Albuquerque and his colleagues knew that high levels of NAA in the left parieto-occipital lobe, which coordinates sensory and visual information, were linked with intelligence.

In order to know whether NAA also plays a role in creativity, the researchers recruited 56 men and women aged 18 to 39, and measured the NAA levels in various regions of their brains.

The researchers also tested the volunteers’ general intelligence and, more specifically, their capacity for divergent thinking-a factor in creativity that includes coming up with novel ideas, such as new uses for everyday objects.

On the whole, volunteers’ creativity scores were concurrent with levels of NAA in a brain region called the anterior cingulate gyrus (ACG), which regulates the activity of the frontal cortex – implicated in higher mental functions.

However, while low levels of NAA in the ACG correlated with high creativity in people of average intelligence, the reverse was found to be true in people with IQs of above 120.

Jung predicted that if there is less NAA to regulate frontal cortex activity in “average” brains, they are freer to roam and find new ideas.

However, in highly intelligent people, tighter control over the frontal cortex could apparently enhance creativity.

This could be because they are more likely to come up with new ideas anyway, and the tighter control allows them to “fine-tune” that ability.

“People say you have to let your mind wonder freely to be creative. For people of average intelligence, perhaps it’s true that you need to utilise more areas of your [frontal cortex] for something truly novel and creative to emerge, but in more intelligent folks, there’s something different going on,” New Scientist magazine quoted Jung as saying.

In his opinion, the findings could shed new light on what made the brains of creative geniuses like Einstein tick. (ANI)

Probe to look out for gravity waves emitted 14 billion years ago

Washington, May 16 (ANI): A new probe is going to look for the cosmic microwave background (CMB) radiation, which is the afterglow of the Big Bang, that may still carry a faint signature of gravitational waves, which rippled through the very fabric of space-time nearly 14 billion years ago.

A tiny fraction of a second following the Big Bang, the universe allegedly experienced the most inflationary period it has ever known.

“During this inflationary era, space expanded faster than the speed of light. It sounds crazy, but it fits a variety of cosmological observations made in recent years,” said University of Chicago physicist Bruce Winstein.

“Theorists take it to be true, but we have to prove it,” said Winstein, the Samuel K. Allison Distinguished Service Professor in Physics at the University of Chicago. “It needs a real test, and that test is whether or not gravity waves were created,” he added.

“The CMB is probably our best handle on the overall structure of the universe and how it was born,” he further added.

Winstein and his Chicago associates are part of the international QUIET (Q/U Imaging ExperimenT; the Q and U stand for radiation parameters called Stokes parameters) collaboration that has devised such a test.

QUIET’s goal is to detect remnants of the radiation emitted at the earliest moments of the universe, when gravity waves rippled through the very fabric of space-time itself.

The intensive gravitational fields that existed at these earliest moments, according to Einstein, produced gravity waves that alternatively compressed and expanded space, first in one direction, then another.

The QUIET experiment began operating last October with an antenna array that contains 19 detectors.

Since then, QUIET collaborators at the Jet Propulsion Laboratory in California have produced 91 detectors sensitive to the radiation at a higher frequency.

Over the past several months, the Chicago collaboration has assembled and calibrated these 91 detectors in the basement of the Laboratory for Astrophysics and Space Research.

Winstein’s team has tested each detector, adjusting 10 critical voltages for each to yield the best performance.

According to Winstein, correctly optimized voltages can improve detector performance by a large factor, making it possible to observe in one day what would have otherwise required a week.

This newer, more sensitive array will begin operating in June. (ANI)

Gene in breast cancer pathway identified

Washington, May 13 (ANI): In a new study, scientists at Albert Einstein College of Medicine of Yeshiva University have unravelled a mechanism responsible for turning on and off a gene crucial to breast cancer spread.

Einstein scientists had previously discovered a gene called ZBP1 (zipcode binding protein 1), which helps cells to move, grow and organize spatially.

“ZBP1 is very active in the developing embryo but largely silent in adult tissues,” said Dr Robert H. Singer, professor and co-chair of anatomy and structural biology and co-director of the Gruss-Lipper Biophotonics Center at Einstein.

This gene has been found active in several types of cancer, including breast, colorectal, and non-small cell lung cancers; but the gene is silenced in metastasizing cancer cells.

In the new study, Singer and another Einstein scientist, Dr John Condeelis sought to determine how ZBP1 gene is activated and silenced and how it influences the spread of breast cancer.

The find may offer potential drug targets for preventing metastasis.

After examining mouse, rat, and human breast cancer cells, they found that ZBP1 silencing occurs when a methyl group (CH3) attaches to ZBP1′s promoter region (the segment of a gene where gene expression is initiated).

The attachment of CH3 prevents the promoter from binding to a protein called beta-catenin. And without beta-catenin, the ZBP1 gene is effectively silenced.

The study showed that the silencing of ZBP1 increases cancer cells’ ability to migrate and promotes the proliferation of metastatic cells.

The researchers claim that the study has important implications for forecasting breast cancer outcomes.

They said that signs of ZBP1 silencing in breast cancer cells would indicate that a breast tumour is likely to spread information that would help in choosing a treatment strategy.

“If you could turn on this protein in cancer cells, or prevent it from being turned off, you could seriously reduce the ability of the cells to metastasize,” said Singer.

The study appears in the Journal of Cell Science. (ANI)

Camphor-containing products may cause seizures in kids

Washington, May 7 (ANI): Improper use of camphor-containing products may lead to seizures in young children, according to a study.

Conducted by researchers at Albert Einstein College of Medicine of Yeshiva University, the study calls for efforts to educate communities about the hazards of camphor, and to crack down on illegally marketed camphor products.amphor is a naturally occurring waxy substance with a strong, aromatic odour and is found in many consumer products.

For a long time, scientists have known that camphor can cause serious health problems, including seizures and children are particularly prone to the toxic effects of camphor, which is easily absorbed through the skin and mucous membranes.

It is because of this reason that government agencies have limited the camphor content of common cold preparations, and asked for proper labelling of camphor-containing products.

Still, camphor products without proper or complete labelling are widely available and commonly used for medicinal, spiritual and aromatic purposes and for pest control, especially in the Hispanic community.

The Einstein researchers report on three cases of camphor-associated seizures in children seen in the emergency department of a single New York City hospital-Children’s Hospital at Montefiore in the Bronx-over a two-week period.

In the first case, a 15-month-old Hispanic boy accidentally ingested camphor cubes that his parents were using to ward off evil spirits. In the second case, a 22-month-old Hispanic boy ate a camphor-containing product that was placed around his apartment to control roaches.

In the third case, a three-year-old Hispanic girl had been heavily exposed to numerous camphor-containing products, including crushed tablets spread around the house to control roaches and an ointment that her mother had rubbed on her skin hourly for 10 hours before her seizures began.

All three children received drug treatment to terminate their seizures, and their parents were advised to stop using all camphor-containing products.

The children were found to be seizure-free when followed up 10 weeks later.

“With the exception of the first case, the information about camphor exposure became apparent only after we directly questioned the parents,” said study leader Hnin Khine.

Khine said that the above cases highlight the toxicity associated with camphor usage in the community, and indicate that inappropriate use of illegally sold camphor products is an important public health issue.

The study has been published in the journal Pediatrics. (ANI)

Fortis Healthcare To Set Up Separate Cancer Block At Noida

Fortis Healthcare has made announcement about the establishment of a separate block for the treating of cancer patients at its Noida Hospital.

The hospital said that it will make an investment of Rs 30 crore to set up this block.

Mr. Shivinder Mohan Singh, Fortis Healthcare Managing Director, said, “Fortis Noida is constructing a separate block for Oncology covering an area of 30,000 sq ft. This block is expected to be operational in third quarter of fiscal 2010.”

Mr. Singh also said that after setting up this separate block, the hospital would get the status of complete care centre for treatment of cancer.

Moreover, Fortis Hospital also inaugurated its ‘Fortis International Oncology Centre’ in Noida, Uttar Pradesh.

It is the most innovative and complete centre for Cancer in Uttar Pradesh.

With the intention to bring quality oncology services to the people of NCR and UP, the hospital has also entered into an exclusive deal with International Oncology Services Private Limited (IOSPL).

International Oncology Services is a cancer care and research services company run by well-known American Board Certified Doctors.

IOSPL, in turn, has a strategic partnership with Albert Einstein Cancer Centre, New York, for research and treatment, technology transfer, current training of doctors and employees from India, clinical examinations and physicist services, radiation planing services.

“Noise” from space may help reveal mass of near-Earth asteroids

Washington, April 4 (ANI): Planetary scientists are all set to turn “noise” from the data obtained by NASA/ESA LISA satellites’ mission into useful information about the mass of near-Earth asteroids.

LISA is on a mission to detect gravitational waves – a warping of the space/time continuum that scientists hope to see directly for the first time.

Slated for launch no earlier than 2018, LISA will include three satellites connected by laser beams. The distance between the satellites should change as a gravitational wave passes.

Einstein’s General Theory of Relativity predicts that gravitational waves from exploding stars or colliding black holes ripple across the universe, causing other bodies to wobble like driftwood in a motorboat’s wake.

In 2006, planetary scientists realized that Near Earth Asteroids (NEAs) also would make the spacecraft wobble as they passed nearby, creating a distinct signature in the data being collected.

Pasquale Tricarico, a scientist at the Tucson-based Planetary Science Institute, expanded on that work to predict the number of asteroid encounters LISA can expect and how those encounters can be used to determine the mass of passing asteroids.

According to Tricarico, LISA can expect to see one or two known near-Earth asteroids a year, and a total of around ten during the expected mission lifetime.

When an encounter with a known asteroid shows up in the data, scientists will already know its trajectory.

“So from the signal, we can indirectly measure the asteroid’s mass because that’s the only uncertainty in the equation,” Tricarico said.

“These mass measurements are important because we only know the mass of asteroids that have been visited by spacecraft or the mass of a few binary asteroids observed from Earth,” he added.

“We always wonder about the porosity, the density, and this will give us measurements from additional asteroids,” he explained.

If a known asteroid passes one of the satellites and doesn’t leave a signature, “that allows us to put an upper limit on the mass of that asteroid,” Tricarico added.

Tricarico also has predicted the number of potential encounters with smaller, unknown NEAs.

If LISA starts detecting five asteroids a year instead of two or three, this could modify theories concerning the distribution of sizes in the NEA population. (ANI)

World’s oldest person, 130, credits cottage cheese, sense of humour for longevity!

London, Mar 25 (ANI): A Kazakhstan lady, who mothered ten children, will be celebrating her 130th birthday this week, making her the world’s oldest person by 16 years.

Sakhan Dosova’s age was discovered during a census in Karaganda in northern Kazakhstan, when the date of birth on her passport showed as 1879, which was the same year Edison invented the light bulb and Stalin and Einstein were born.

Dosova’s age surprised demographers when they found that she had been on Stalin’s first census of the former Soviet region in 1926, when her age was given as 47, and they are now trying to confirm the record.

For the 129-year-old lady, she puts her longevity down to her love for cottage cheese and her sense of humour, and never visiting a doctor or eating sweets.

“I don’t have any special secret. I’ve never taken pills and if I was ill I took grannies’ remedies,” the Sun quoted her as saying.

“I’ve never eaten sweets. But I love kurt – a salty dried cottage cheese – and talkan, a ground wheat,” she stated.

Dosova lives in poor conditions in an overcrowded flat with a granddaughter, Gaukhar Kanieva, 42, and apart from hearing problems she is in good health.

“She is a very cheerful woman. We think laughter and her good mood help her live so long,” Kanieva said of her grandma.

The aged lady has been congratulated by the local mayor, and as of now, she is the oldest living person in the world followed by American Edna Parker who is 114.

Dosova was born on March 27, 1879, when Queen Victoria had 22 years left to rule, Benjamin Disraeli was Prime Minister and Sherlock Holmes creator Sir Arthur Conan Doyle published his first story. (ANI)

Black hole duo could be creating “ripples” in fabric of space-time

Washington, March 5 (ANI): Astronomers have suggested that two newfound black holes on the verge of crashing into each other could be creating “ripples” in the fabric of space-time.

According to a report in National Geographic News, the two supermassive black holes orbit each other about once a century, separated by just a third of a light-year, and they seem to be getting closer.

Such systems should be relatively common, but so far they have proven elusive, said study co-author Todd Boroson of the National Optical Astronomy Observatory in Tucson, Arizona.

“We believe that galaxies grow primarily by merging with other galaxies,” he explained. “If you have a black hole in the center of each, you’d expect to find systems where you have two black holes that gradually merge,” he added.

If confirmed, scientists will likely want to study this system intensely to figure out why they haven’t seen others like it.

The binary black holes also could provide a unique environment to test aspects of Einstein’s theory of general relativity, astronomers note.

The theory predicts that compact, massive bodies, such as black holes orbiting one another, should produce ripples in space-time that move at the speed of light.

Boroson and colleague Tod Lauer spotted the newfound binary black holes by examining data on more than 17,000 quasars from the Sloan Digital Sky Survey, a major mapping project that has so far imaged more than a quarter of the cosmos.

Each quasar is thought to represent a supermassive black hole at the center of a distant galaxy. Quasars are extremely bright because matter gets superheated as it falls into a black hole, sending out huge amounts of energy.

But, one quasar in the survey displayed two distinct sets of energy emissions moving at different speeds.

The astronomers interpreted this to be two black holes spinning around each other.

According to Einstein’s theory, such a system might be producing an effect called gravitational radiation, noted Jon Miller of the University of Michigan in Ann Arbor.
lthough cosmologists have yet to see the effect directly, they think gravitational radiation propagates across the universe like waves on the surface of a puddle and remains unchanged as it travels.

Because the ripples reach us in an unaltered state, their strength, direction, and frequency could tell us more about the distant, dramatic events that created them, such as supernovae and black hole mergers.

Boroson said that the “endgame story” of black hole pairs like this ne is to merge into a single massive object. (ANI)

Black hole duo could be creating “ripples” in fabric of space-time

Washington, March 5 (ANI): Astronomers have suggested that two newfound black holes on the verge of crashing into each other could be creating “ripples” in the fabric of space-time.

According to a report in National Geographic News, the two supermassive black holes orbit each other about once a century, separated by just a third of a light-year, and they seem to be getting closer.

Such systems should be relatively common, but so far they have proven elusive, said study co-author Todd Boroson of the National Optical Astronomy Observatory in Tucson, Arizona.

“We believe that galaxies grow primarily by merging with other galaxies,” he explained. “If you have a black hole in the center of each, you’d expect to find systems where you have two black holes that gradually merge,” he added.

If confirmed, scientists will likely want to study this system intensely to figure out why they haven’t seen others like it.

The binary black holes also could provide a unique environment to test aspects of Einstein’s theory of general relativity, astronomers note.

The theory predicts that compact, massive bodies, such as black holes orbiting one another, should produce ripples in space-time that move at the speed of light.

Boroson and colleague Tod Lauer spotted the newfound binary black holes by examining data on more than 17,000 quasars from the Sloan Digital Sky Survey, a major mapping project that has so far imaged more than a quarter of the cosmos.

Each quasar is thought to represent a supermassive black hole at the center of a distant galaxy. Quasars are extremely bright because matter gets superheated as it falls into a black hole, sending out huge amounts of energy.

But, one quasar in the survey displayed two distinct sets of energy emissions moving at different speeds.

The astronomers interpreted this to be two black holes spinning around each other.

According to Einstein’s theory, such a system might be producing an effect called gravitational radiation, noted Jon Miller of the University of Michigan in Ann Arbor.
lthough cosmologists have yet to see the effect directly, they think gravitational radiation propagates across the universe like waves on the surface of a puddle and remains unchanged as it travels.

Because the ripples reach us in an unaltered state, their strength, direction, and frequency could tell us more about the distant, dramatic events that created them, such as supernovae and black hole mergers.

Boroson said that the “endgame story” of black hole pairs like this ne is to merge into a single massive object. (ANI)

Women’s long-term fertility linked to reduced Parkinson’s risk

Washington, Feb 26 (ANI): Women who are fertile for more than 39 years and have natural menopause are at a lower risk of contracting Parkinson’s disease, says a new study.

The study, which will be presented at the American Academy of Neurology’s 61st Annual Meeting in Seattle, April 25 to May 2, 2009, provides evidence that longer exposure to the body’s own hormones may protect women from the disease.

According to the study’s results, women who have more years of fertile lifespan (number of years from first menstruation to menopause) had a lower risk of developing the disease than women with fewer years of fertile lifespan.

The fertile lifespan is a marker for the body’s own sex hormone levels.

In addition, women with four or more pregnancies were at greater risk of developing the disease than women with fewer pregnancies.

Separately, the risk of Parkinson’s disease was increased in women who had hysterectomies and had also previously taken hormone replacement therapy compared to those who never took hormone therapy, but it was not increased in women who took the hormones but had not had hysterectomies.

“This study does not support a role for treatment with hormone therapy in Parkinson’s, but there are still many unanswered questions,” said study author Rachel Saunders-Pullman, MD, MPH, MS, of Albert Einstein College of Medicine in Bronx, NY, and Beth Israel Medical Center in New York, NY, and a member of the American Academy of Neurology.

For the study, researchers analyzed the records of the Women’s Health Initiative Observational Study to determine who developed Parkinson’s disease. The study involved about 74,000 women who underwent natural menopause and about 7,800 women who underwent surgical menopause. (ANI)

Multivitamin may not cut postmenopausal women’s cancer risk

Washington, Feb 10 (ANI): Multivitamins may offer no benefit in reducing the risk of common cancers, cardiovascular disease or overall mortality in postmenopausal women, according to a new study.

The study also revealed that multivitamins do not increase the risk for these conditions.

The research was conducted as part of the Women’s Health Initiative Clinical Trials and the Women’s Health Initiative (WHI) Observational Study.

Combined, the two studies include data from 161,808 postmenopausal women ages 50 to 79. Of that group, 41.5 percent used multivitamins over 15 study years.

This latest study, led by Marian L. Neuhouser, Ph.D., R.D., of the Fred Hutchinson Cancer Research Center in Seattle, Washington, in collaboration with others from national WHI clinical centers, including Sylvia Wassertheil-Smoller, Ph.D., professor of epidemiology and population health at Albert Einstein College of Medicine of Yeshiva University. Dr. Wassertheil-Smoller is the principal investigator of the WHI study at Einstein, found no overall associations between multivitamin use and breast, colorectal, endometrial, kidney, bladder, stomach, ovary, or lung cancer.

Researchers also found no association between multivitamin use and cardiovascular disease and death.

Researchers collected data for the multivitamin study during participants’ clinic visits.

Clinic staff transcribed the ingredients for each supplement, and then grouped them according to three classifications.

The most common category (35 percent) was multivitamins with minerals, followed by multivitamins alone (3.5 percent) and stress multivitamins (2.3 percent).

“Based on our results, if you fall into the category of the women described here, and you do in fact have an adequate diet, there really is no reason to take a multivitamin,” said Dr. Wassertheil-Smoller.

The authors, however, acknowledge the potential limitations of their study, and caution against extrapolating their results to the general public.

The study is published in Archives of Internal Medicine. (ANI)

Fat cells’ interaction with brain may cast light on weight shedding process

Washington, February 6 (ANI): Georgia State University researchers have discovered that fat cells in the body work in the same fashion as a thermostat regulates temperature inside a house-giving feedback to the brain to regulate the process of fat burning.

C. Kay Song and Tim Bartness, who conducted this study in collaboration with Gary J. Schwartz of the Albert Einstein College of Medicine, say that their work may help advance the scientific understanding of how weight is shed.

The researchers found that during the process of burning fat, known as lipolysis, fat cells use sensory nerves to feed information to the brain.

The team revealed that they used viruses to trace communications in the nerves of Siberian hamsters, and found that the brain uses part of the nervous system used to regulate body functions, called the sympathetic nervous system, to in turn communicate back to the cells to initiate, continue or stop the fat burning depending upon the information the brain receives from the fat.

“The brain can trigger lipid burning by fat cells and through these sensory nerves, the fat cell can give the brain feedback. This is a really important concept in biology, as it can regulate the process of lipolysis much like how a thermostat regulates temperature in your house, using input from the air and output to a furnace or heating unit,” Bartness said.

“The presence and function of the sensory nerves has been completely ignored and the areas in the brain that receive this sensory information were unknown until we did these studies,” he added.

When the body has a low amount of a carbohydrate called glycogen, which acts as fuel for lipolysis, the body starts this process to release energy stored in fats.

Finally, nerves that are part of the sympathetic nervous system, a chemical called norepinephrine is released to trigger the breakdown of fat.

Bartness says that sensory nerves later inform the brain about the status of the lipolysis, communicating whether too much or too little energy has been released – and the activity of the sympathetic nerves can be adjusted accordingly.

“If you’re doing a moderate amount of exercise or even if it has been a fairly long interval since you last ate, you will use up all or most of the available glycogen, necessitating the break down fat to yield sufficient energy. But you don’t want to break down more than you need. So, this would be a way to stop the sympathetic nervous system from triggering the release of too much lipid energy from fat,” he said.

According to the researchers, though this communication process is known to play a role in the short-term burning of fat, it has yet to be determined whether this process is involved with the long-term issues of burning fat – important in understanding obesity and why some people burn fat more readily than others.

“It could be that sensory nerves have a dual function. In addition to the moment-to-moment lipolysis process, they might also have a longer term function. It’s complicated, and it might be a different subset of the sensory nerves performing the long-term monitoring of fat reserves,” he said.

The research appears in the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. (ANI)

Fluorescent proteins are transforming biomedical research

London, January 26 (ANI): Scientists at the Albert Einstein College of Medicine of Yeshiva University say that remarkable new tools, which spotlight individual cellular molecules, are helping advance biomedical research.

They have revealed that these new tools are photoactivatable fluorescent proteins (PAFPs) and other advanced fluorescent proteins (FPs).

Dr. Vladislav Verkhusha, associate professor of anatomy and structural biology at Einstein, says that PAFPs and FPs help noninvasively visualize the structures and processes in living cells at the molecular level.

The researcher says that it is now possible to follow cancer cells as they seek out blood vessels and spread throughout the body or to watch how cells manage intracellular debris, preventing premature aging.

The significance of this study lies in the fact that the new fluorescent proteins add considerably to the biomedical imaging revolution started by the 1992 discovery that the gene for a green fluorescent protein (GFP) found in a jellyfish could be fused to any gene in a living cell.

When the target gene is expressed, GFP lights up (fluoresces), creating a visual marker of gene expression and protein localization, via light (optical) microscopy.

While earlier technique could capture images only in non-living cells, the addition of PAFPs, more versatile versions of FPs, made it possible to do real-time SR fluorescence microscopy in living cells.

Dr. Verkhusha is said to have developed a variety of PAFPs and FPs for use in imaging mammalian cells, expanding the applications of fluorescence microscopy.

The collection includes PAFPs that can be turned on and off with a pulse of light, FPs that can fluoresce in different colors, and FPs that have better resolution for deep-tissue imaging.

The researcher most recently developed a red PAFP called PAmCherry1, which has faster photoactivation, improved contrast, and better stability compared to other PAFPs of its type.

“PAmCherry1 will allow improvements in several imaging techniques, notably two-color SR fluorescence microscopy, in which two different molecules or two biological processes can be viewed simultaneously in a single cell,” Nature Methods quoted the researcher as saying in its online version.

Dr. Verkhusha’s PAFPs have been used in several studies, providing new insights into a variety of biological processes.

In one of the studies, his PAFPs were used to capture the first nanoscale images of the orientation of molecules within biological structures.

“Such images could be useful in studying protein-protein interactions, the growth and collapse of intracellular structures, and many other biological questions,” says Dr. Verkhusha.

In another study, Dr. Verkhusha contributed a novel PAFP to a new method of viewing individual breast cancer cells for several days at a time, providing new details on how cancer cells invade surrounding tissue and reach blood vessels, a process called metastasis.

“Mapping the fate of tumor cells in different regions of a tumor was not possible before the development of the photoswitching technology,” explains John Condeelis, Ph.D., co-chair and professor of anatomy and structural biology and co-director of the Gruss Lipper Biophotonics Center.

Dr. Verkhusha has also developed new types of fluorescent proteins for use in conventional fluorescent microscopy, called fluorescent timers (FTs), which can change their colour from blue to red over a matter of hours.

“These FTs will enable scientists to study the trafficking of cellular proteins and to provide accurate insight into the timing of intracellular processes, such as activation or inhibition of gene expression or protein synthesis,” he says.

With the use of the FTs, he and his colleagues have shown for the first time how a protein called LAMP-2A, which scavenges cellular debris, is transported to intracellular organelles called lysosomes, where the debris is digested.

The researchers are of the opinion that understanding this process, which maintains the health of cells and organs, may lead to treatments to keep elderly people’s organs in prime condition. (ANI)

Einstein, Churchill were not dyslexic, says expert

Wellington, Jan 8 (ANI): Albert Einstein and Winston Churchill were not dyslexic, according to Massey University College of Education pro-vice chancellor James Chapman.

Professor Chapman, who is also the president of the International Academy for Research in Learning Disabilities insists that if Einstein and Churchill were dyslexic they wouldn’t have produced the scientific, historical or literary works.

According to a scientific view, dyslexia is a persistent literary learning difficulty.

Chapman said that those who believe that dyslexia is a spectrum disorder would certainly consider Churchill and Einstein dyslexic.

He says that like Einstein and Churchill, people were being incorrectly diagnosed with dyslexia because of the varying definitions.

The Dyslexia Foundation of New Zealand takes the spectrum disorder view.

Trustee chairman Guy Pope-Mayell said no-one would know whether the pair were dyslexic, because they were not tested.

He claims that literary deficit focus, which was used to burst the Einstein and Churchill dyslexic myth, is narrow-minded.

“Over the last 25 years, there”s been a great focus on dyslexia in terms of its deficit, particularly literary deficit, but there”s a groundswell now going into researching the talents, which dyslexics have,” the NZPA quoted Pope-Mayell as saying. (ANI)