Immunocellular brain cancer vaccine shows promise

June 2 (Reuters) – A small, early-stage trial of a therapeutic brain cancer vaccine developed by ImmunoCellular Therapeutics Ltd (IMUC.OB) showed that nearly half the patients were alive without their cancer worsening 18 months after diagnosis, the company said on Wednesday.

The Phase 1 trial from ImmunoCellular, which trades in the over-the-counter market, involved 16 patients diagnosed with glioblastoma multiforme, the most common and deadly form of brain cancer.

They were treated with ICT-107, an experimental dendritic cell based cancer vaccine, following the standard care of surgery, radiation and chemotherapy.

“We are targeting specific antigens that are on cancer stem cells … the only population of cells that can really propagate a tumor,” said Dr. John Yu, director of surgical neuro-oncology at Cedars-Sinai Medical Center in Los Angeles and ImmunoCellular’s chief scientific officer.

A year after diagnosis, all of the patients were alive. After two years, 80 percent of them were alive.

Historically, after a year with standard treatment, 61 percent of glioblastoma patients are alive, and 26.5 are alive after two years, according to the company.

In the ImmunoCellular trial, median overall survival had not yet been reached at the 26.4 months analysis point, with 12 out of 16 patients alive. Seven patients continued to live with no disease progression.

Side effects seen in the trial included fatigue and skin rash.

Yu said ImmunCellular is planning a mid-stage trial of the vaccine that would include between 30 and 50 patients. (Reporting by Deena Beasley; Editing by Steve Orlofsky)

Witness admits Dr “Death” Patel’s procedure value judgment not incompetence

Melbourne, May 19 (ANI): An expert witness in Bundaberg Hospital surgeon Dr Jayant “Death” Patel’s case has denied claims that he unjustly criticized him for failing to insert a fluid monitoring line into a patient after Patel’s lawyer acquainted him with the fact that there were a number of perfectly reasonable explanations for him not having done so.

The witness, Dr John Allsop had claimed on Tuesday that it would be “bread and butter” for a competent surgeon to insert the line.

Patel’s lawyer Michael Byrne said Patel”s decision to send the patient, James Phillips, to intensive care without a central venous line was a value judgment not incompetence, The Courier-Mail reports.

In a hasty retraction from his previous stand, Allsop said: “As I said in one of my reports it is difficult to make equivocal judgment unless you are hovering over one”s shoulder.”

Patel is not charged with any criminal offence regarding his oesophagectomy on Grave but prosecutors led evidence about it because they claimed it should have been a warning to Patel, the paper said.

Byrne also asked Allsop about reports he had compiled for the Health Rights Commission in 2005, which did not contain some of the evidence Dr Allsop had given at the trial.

Allsop conceded that there were things he may not have fully considered in his original report. (ANI)

Police investigate hep C infections

Victorian police are trying to find out whether a doctor deliberately infected 12 women with hepatitis C.

The women were all patients at a Melbourne abortion clinic between June 2008 and December 2009.

The state’s health department went public with its suspicions on Friday, but the department and the Victorian health minister are defending the decision to keep the matter quiet until now.

Suspicions were raised when the Victorian Department of Health noticed in December that three women diagnosed with hepatitis C had all been patients of the same clinic.

When a further nine cases were linked to the clinic early this year the department decided the police needed to be notified.

Victoria’s chief health officer, Dr John Carnie, says he cannot explain how 12 people could be infected by accident.

“I find it difficult to imagine how an accidental transmission could affect 12 patients and because of that difficulty we have tried to involve the police and the medical board in this investigation,” Dr Carnie said.

Dr Carnie would not say what sort of procedures the women had undergone, but it was confirmed today that the doctor is an anaesthetist.

He had been working at the clinic at Croydon in Melbourne’s outer-east.

The Victorian Health Department started testing the clinic’s staff in January, but at that time the doctor was overseas. He was tested on his return to Melbourne in early February.

Dr Carnie says it was confirmed the doctor had hepatitis C. Further testing, which Dr Carnie likens to testing fingerprints, showed that three of the women had the same strain of hepatitis C as the doctor.

It is known as genotype 1B and is a relatively rare form of the virus in Australia.

The Medical Practitioners Board declined to say if the doctor is from overseas.

Dr Carnie says the Victorian Health Department did a great job in identifying the hepatitis C cluster.

“We get over 2,000 cases of hepatitis C being notified to the Department. Out of those 2,000-odd cases in total, being able to find this very small number of cases that have this link to the clinic has been the result of very detailed and painstaking work on the part of the communicable disease area,” he said.

People who underwent surgery at the clinic between June 2008 and December 2009 are being contacted by the Department of Health.

But Dr Carnie will not speculate on the number of people that may have been infected.

“This whole episode is going to clearly cause distress in the community. I don’t want to add to that concern by starting to speculate on total numbers,” he said.

Of the 12 women who tested positive to hepatitis C, two have now cleared the virus from their bloodstreams, which Dr Carnie says is not unusual.

The other 10 women are at risk of developing cirrhosis of the liver or liver cancer.

But Dr Carnie says that anti-viral treatment can cure some cases.

Notification process

The doctor in question was suspended in mid-February after already giving the Victorian Department of Health an undertaking not to practice while the matter was being investigated.

Dr Carnie has defended the amount of time it took to suspend the doctor.

“From the time the clinic reopened after the holidays there was no ongoing risk to anyone and this person has not worked at that clinic since his return from overseas,” he said.

The President of the Victorian Medical Practitioners Board, Robert Adler, says doctors who have Hepatitis C are allowed to practice, but only if they follow infection control procedures and don’t do what are known as “exposure prone surgical procedures” like those in internal cavities or those with a higher risk of needle stick injury.

“Normal anaesthesia that follows infection control guidelines carries an extremely low or non-existent risk of transmission of Hepatitis C provided the doctor follows infection control guidelines,” he said.

The hepatitis C cluster was revealed in Melbourne’s Herald Sun newspaper this morning. Dr Carnie says it was not necessary to notify the public earlier.

“We are in the process of starting to call people back, other people who may have had procedures at this clinic and we didn’t want them to be alarmed by a call from the Department,” he said.

“We we wanted them to be aware of the issue that we’re dealing with and that was the reason for making this public.”

Victorian Health Minister, Daniel Andrews, says he was notified of the initial cluster of three cases of Hepatitis C on the December 22 last year.

He does not believe the public should have been notified earlier.

“I am confident that the chief health officer and my department, more broadly, have made appropriate contacts with Victoria Police and I’m confident that my department and the chief health officer have at all times, and at all stages, acted appropriately in relation to these issues,” Mr Andrews said.

Elephants’ legs work like four-wheel drive in a car!

London, Mar 30 (ANI): Elephants move like a 4×4 vehicle with all four legs used to accelerate and brake, boffins have found.

In their research, scientists discovered that elephants eliminate the separation of functions of the front and back legs despite having an anatomy very similar to other four-legged animals.

Power is applied independently to each limb, reports The Daily Express.

Other animals that walk on all fours use the hind limbs for power and their forelegs for braking.

“Elephant legs function in very strange and probably unique ways,” said Dr John Hutchinson, of the Royal Veterinary College, London.

Earlier it was thought that elephants needed rigid pillar-like legs to support their weight but in fact they flex like humans. (ANI)

Chinese factories supplying new ”legal highs” to Brit dealers

London, Mar 29 (ANI): A new probe into “legal highs” has found that Chinese chemical factories are supplying drugs like mephedrone and methylone to British dealers.

The investigation also uncovered plans to outsmart the British authorities if they ban the drug mephedrone.

Shot with a hidden camera, the investigation was conducted by Sky News’ film crew, who posed as customers and managed to buy legal highs in shops, markets and from online dealers.

Media attention has focused on mephedrone after the drug was linked to several deaths in recent weeks.

However, Sky”s investigation discovered an entire new generation of chemical highs including substances such as methylone, butylone and MDPV.

All these drugs mimic the effects of other, better known drugs such as cocaine and ecstasy.

They are freely available with no legal consequences, though to avoid prosecution most dealers describe them as “plant food” or label them “not for human consumption.”

Toxicologist Dr John Ramsey said that we are witnessing a revolution in the drug trade.

“We”re seeing 10 or 11 new compounds every year coming out now,” Sky News quoted him as saying.

“While they”re legal they”re really quite attractive for young people. They can experiment without the risk of getting a criminal record. The problem is, we don”t know what the risks are. They”ve never been tested anywhere for safety,” he added.

It is understood that Chinese chemical companies are supplying most dealers, said Ramsey.

“The Chinese chemical industry seems to provide anything at a price. So if somebody here orders something they”ll either synthesize it or have it in stock, and they”ll send it regardless of what it”s to be used for,” he said.

A quick search online reveals dozens of Chinese companies ready to sell mephedrone, methylone, MDPV and other drugs in bulk, which can even be ordered at the click of a mouse and sent by courier to Britain. (ANI)

Patel trial hears about Bundaberg hospital’s procedures

The Supreme Court trial of former Bundaberg surgeon Jayant Patel has heard more details about Patel’s patients and the workings of the Bundaberg Base Hospital.

Patel is accused of unlawfully killing Mervyn John Morris, James Edward Phillips and “Gerry” Kemps and causing grievous bodily harm to Ian Vowles.

The 59-year-old former head of surgery at Bundaberg has pleaded not guilty.

Today, his trial heard from Bundaberg’s surgery coordinator Karen Smith.

She told the Court about a formula for funding elective surgery at the Hospital.

She said the Hospital bid for funding and if it didn’t reach its financial year quotas the funding was cut.

The Court also heard from Bundaberg urologist Dr Richard Marsden and radiation oncology specialist at the Royal Brisbane Hospital Dr Gary Pratt, as well as Mervyn Morris’s GP Dr Marthinus Nel and radiologist Dr John Branson about the treatment of Patel’s patients.

The trial continues.

Zach Braff declares Scrubs dead

Is Scrubs finally a goner? According to star Zach Braff, the long-running comedy is finished.

After nine seasons and two networks, Braff says the series will not return next year.

Posting on Facebook, Braff wrote: “Many of you have asked, so here it is: It appears that ‘New Scrubs’, ‘Scrubs 2.0′, ‘Scrubs With New Kids’, ‘Scrubbier’, ‘Scrubs Without JD’ is no more. It was worth a try, but alas … it didn’t work. zb”

Braff, who played Dr John “JD” Dorian on the medical series, starred in only a handful of episodes this season, which attempted to reboot the show by adding younger cast members.

An ABC America representative said the network has not made an official decision. But given the program’s weak ratings this year, a return does seem unlikely.

- Reuters

Inquest told NT croc population has exploded

An inquest into the crocodile death of an 11-year-old girl has heard that crocodile populations in the Northern Territory have exploded to reach pre-European settlement levels.

Briony Goodsell was taken by a crocodile in a creek near her home in Darwin’s rural area last March.

Today, a coronial inquest into her death heard that crocodile populations in the Territory could be up to 150,000.

The Territory’s director of biodiversity conservation, Dr John Woinarski, says crocodile populations in the NT have reached levels not seen since before European settlement.

He said the numbers are very close to reaching a plateau.

Dr Woinarski said crocodiles are now in areas they had never been before.

When crocodile hunting was banned in 1971 the animals numbered less than 10,000.

Another crocodile expert has told the inquest that partial culling of the reptiles may make it more dangerous.

Crocodile researcher, Grahame Webb, told the inquest that eradication is the only way to guarantee public safety.

He said if only the less wary crocodiles are culled, it may become more dangerous because other crocodiles will be hidden.

Mr Webb said a crocodile management program should aim to eradicate crocodiles in urban areas.

He raised concerns that any public safety plan would need to be approved by the Commonwealth which insists on the humane treatment of crocodiles.

Rudd plan to ‘significantly’ improve GP shortage

A group that trains GPs in central and northern Victoria says an industry shortage will be addressed by a Federal Government push to train more doctors.

Yesterday, Prime Minister Kevin Rudd announced a $632 million plan to boost GP numbers over the next decade.

But training group Beyond Medical Education says the effects of the plan will not be felt for up to seven years.

Chief executive Dr John Togno says it will be worthwhile in the long-term.

“It’s not going to cut in immediately but I think within a five year time frame it will significantly correct any shortages in general practice,” he said.

Key predictor of mortality in heart disease patients identified

Washington, March 16 (ANI): A team of Vancouver-based researchers has identified a key predictor of mortality in coronary artery disease (CAD) patients.

According to researchers, the finding means that specialists can better determine how to treat and improve outcomes for patients with CAD.

Coronary artery disease is the most frequent cause of heart disease and occurs when important blood vessels become narrow or blocked and can no longer give enough blood to meet the heart”s demand.

The researchers said that high levels of an enzyme, myeloperoxidase, in the blood of CAD patients more than doubles the risk for death over a 13 year period. Myeloperoxidase is an enzyme associated with oxidative stress, which damages arterial tissue.

The research team looked at blood samples and records from a group of patients admitted to hospital in the early 1990s with symptoms of heart disease.

Over a 13-year period, mortality was more than double for patients with high blood levels of myeloperoxidase than for those with lower levels.

Based on this work, the researchers were able to develop a new classification of risk for CAD patients based on their levels of myeloperoxidase.

Measurement of the enzyme provides added predictive value for cardiovascular death when compared to traditional risk factors such as smoking and diabetes.

“We hope that the discovery of new markers of cardiovascular risk will help identify specific patients who could benefit from more aggressive treatment strategies,” said lead investigator, Dr. John Hill.

The study has been published in the prestigious Journal of the American College of Cardiology. (ANI)

Nicotine plays “tricks” on the brain

Washington, Sept 10 (ANI): Nicotine, the addictive component in cigarettes, “tricks” the brain into creating memory associations between environmental cues and smoking behavior, say researchers at Baylor College of Medicine.

The study has been published in the journal Neuron.

“Our brains normally make these associations between things that support our existence and environmental cues so that we conduct behaviors leading to successful lives. The brain sends a reward signal when we act in a way that contributes to our well being,” said Dr. John A. Dani, professor of neuroscience at BCM and co-author of the study.

“However, nicotine commandeers this subconscious learning process in the brain so we begin to behave as though smoking is a positive action,” the expert added.

Dani said that environmental events linked with smoking can become cues that prompt the smoking urge. Those cues could include alcohol, a meal with friends, or even the drive home from work.

To understand why the associations are so strong, Dani and Dr. Jianrong Tang, instructor of neuroscience at BCM and co-author of the report, decided to record brain activity of mice as they were exposed to nicotine, the addictive component of tobacco.

The mice were allowed to roam through an apparatus with two separate compartments. In one compartment, they received nicotine. In the other, they got a benign saline solution. Later, the researchers recorded how long the mice spent in each compartment. They also recorded brain activity within the hippocampus, an area of the brain that creates new memories.

“The brain activity change was just amazing. Compared to injections of saline, nicotine strengthened neuronal connections – sometimes up to 200 percent. This strengthening of connections underlies new memory formation,” Dani said.

Consequently, mice learned to spent more time in the compartment where the nicotine was administered compared to the one where saline was given to them.

“We found that nicotine could strengthen neuronal synaptic connections only when the so called reward centers sent a dopamine signal. That was a critical process in creating the memory associations even with bad behavior like smoking,” the expert said. (ANI)

How addictive drugs influence learning and memory

Washington, Sep 10 (ANI): In a new study on mice, researchers have found why and how the use of addictive drugs take control of reward signals and influence neural processes associated with learning and memory.

The study could help explain how drug-associated memories, such as the place of drug use, drive and perpetuate the addiction.

It is known that the neurochemical dopamine, a key player in the brain’s reward system, is involved in the process of addiction.

Research has indicated that dopamine participates in neural processes associated with learning, such as the strengthening of neuronal connections, called synaptic potentiation.

Evidence has also implicated the hippocampus, a deep-brain structure that is critical for formation of new memories, in the development of drug addiction.

“Although addictive drugs like nicotine have been shown to influence the induction of synaptic potentiation, there has been little or no research in freely moving animals that monitors ongoing induction of synaptic potentiation by a biologically relevant drug dose,” explains senior author Dr. John Dani from the Department of Neuroscience at the Baylor College of Medicine in Houston, Texas.

The researchers recorded from the brains of freely moving mice while applying physiologically relevant concentrations of nicotine, the addictive component in tobacco.

The researchers found that nicotine induced synaptic potentiation correlated with the mice learning to prefer a place associated with the nicotine dose.

Importantly, these effects required a local dopamine signal within the hippocampus.

The finding reinforces the view that dopamine enables memory for specific events.

Overall, the results point to some intriguing possibilities about how drug-associated memories might contribute to behaviors associated with addiction.

“An animal’s memories or feelings about the environment are updated when the dopamine signal labels a particular event as important, new, and salient. Normally these memories help us to perform successful behaviors, but in our study, those memories were linked to the addictive drug.

When specific environmental events occur, such as the place or people associated with drug use, they are capable of cuing drug-associated memories or feelings that motivate continued drug use or relapse,” concluded Dani.

The study has been published in the latest issue of the journal Neuron. (ANI)

Researchers make bacteria to produce useful proteins

Washington, Sep 7 (ANI): Researchers at the University of British Columbia have turned the bacterium Caulobacter crescentus into a protein production factory by adapting a single protein on its surface, thus making useful proteins that can act as vaccines and drugs.

C. crescentus is a harmless bacterium that has a single protein layer on its surface.

Led by Dr. John Smit, the researchers adapted the system that secretes this protein, which self-assembles into a structure called the “S-layer”, to secrete instead many proteins that are useful for vaccines and other therapeutic purposes.

In other words, by keeping the S-layer protein intact and genetically inserting new things inside it, they produce a very dense display of useful proteins on the cell surface.

The researchers are now hoping to use the entire bacterium in a therapeutic application.

Bacteria are commonly used in biotechnology to produce useful protein products.

If the bacteria secrete the protein rather than keep it contained within the cell, purification costs are greatly lowered.

The researchers have developed a commercially available kit based on this technology, which could be especially useful in developing countries as it might be used to manufacture HIV-blocking agents very cheaply and with little specialist expertise.

“This S-layer system is very efficient at producing and secreting proteins – we can make the bacterium into a protein pump, secreting over half of all the protein it makes as engineered S-layer protein,” said Smit.

He added: “Applications of S-layer display that we are currently developing include anti-cancer vaccines, an HIV infection blocker and agents to treat Crohn’s and colitis, and diarrhoea in malnourished populations”.

Smit presented the findings at the Society for General Microbiology’s meeting at Heriot-Watt University, Edinburgh. (ANI)

How monkeys decide to explore new options

Washington, Sep 5 (ANI): Researchers at Duke University Medical Center have used brain scans in monkeys to predict when monkeys decide if they want to switch from exploiting a known resource to exploring newer options.

Such a trade-off is easy for many, but not for those with conditions such as Alzheimer’s disease or obsessive-compulsive disorder who are trapped in simple routines.

“Humans aren’t the only animals who wonder if the grass is greener elsewhere, but it’s hard to abandon what we know in hopes of finding something better,” said Dr. John Pearson.

“Studies like this one help reveal how the brain weighs costs and benefits in making that kind of decision. We suspect that such a fundamental question engages many areas of the brain, but this is one of the first studies to show how individual neurons can carry signals for these kinds of strategic decisions,” he added.

The researchers analysed how nerve cells fired in a part of the brain known as the posterior cingulate cortex as the monkeys were offered a selection of rewards.

Generally, these neurons fired more strongly when monkeys decided to explore new alternatives.

The monkeys started with four rewards to choose from, each a 200 microliter cup of juice.

Later, the four targets began to slowly change in value, becoming larger or smaller. The monkeys were free to explore the other targets or stay with the initial target, whose value they knew for certain.

The animals had to select an option to learn its current value and integrate this information with their knowledge of the chances of getting more juice at a different target.

The researcher studied individual neurons and were able to predict which strategy the monkey would employ.

“These data are interesting from a human health perspective, because the posterior cingulate cortex is the most metabolically active part of the brain when we are daydreaming or thinking to ourselves, and it is also one of the first parts of the brain to show damage in Alzheimer’s disease,” said Dr. Michael Platt.

“People with Alzheimer’s become set in their ways and don’t explore as much, which may be because this part of the brain is damaged. Likewise, in people with obsessive-compulsive disorder, they can become fixed on certain activities or patterns of activity and can’t disengage from them, which may also relate to changes in this part of the brain that renders them mentally unable to switch gears between exploring and exploiting,” he added.

Such brain functions could be crucial to the flexible adaptation of strategy in response to changing environments, said Pearson.

The study has been published in the latest issue of Current Biology. (ANI)

‘Bullet fingerprinting’ technique improves recovery rate of prints

Washington, July 13 (ANI): A team of scientists has developed ‘Bullet fingerprinting’ technology, which is a simple but effective method to visualize fingerprints even after the print itself has been removed.

The technology has been developed by Dr John Bond, from Northamptonshire Police Scientific Support Unit and an Honorary Research Fellow at the University of Leicester’s Forensic Research Centre, in collaboration with University scientists.

Continuing work exploring this forensic technique in the Department of Chemistry at the University of Leicester is uncovering new ways of recovering fingerprints from metal surfaces.

Researcher Alex Goddard has uncovered a natural technique that he believes is so simple, which can explain why it has been overlooked until now.

The technique involves studying the chemical and physical interactions occurring between the metal and the fingerprint sweat deposit.

Using advanced surface imaging techniques, such as an Atomic Force Microscope, nanoscale observations of fingerprinted brass samples can identify optimum conditions to promote the natural enhancement of the fingerprint, vastly improving their recovery rate.

It has also proven that components of the sweat deposit survive washing and wiping of the surface.

According to Goddard, “Once a finger has touched the metal surface, a residue remains behind. This starts to react with the metal and an image of the fingerprint can be developed by use of elevated temperature and humidity, with the resultant image becoming a permanent feature on the surface of the metal.”

“Currently, fingerprint recovery from bullets is very low; less than 1 percent. This uses a natural process and even if it only leads to small increase in success rate, then that would be significant,” he said.

“Previous recovery methods include applying powder to the material which can actually damage the evidence,” said Goddard.

“This new technique promotes a naturally occurring process which does not involve adding anything to, or damaging, the evidence. Instead, it employs heat and humidity to promote the enhancement of the fingerprint image.

There are also indications that it could be used after other techniques have failed, perhaps as a last resort,” he added. (ANI)

New treatment for acute myeloid leukaemia developed

Washington, July 7 (ANI): Australian and Canadian researchers have developed a new therapy that specifically targets cancer stem cells in acute myeloid leukaemia.

The new treatment targets a protein, CD123, on the surface of cancer stem cells that drive acute myeloid leukemia (AML), which is an aggressive disease with a poor outcome.

In the study led by Dr. Richard Lock in Australia, the researchers showed that antibodies targeting cancer stem cells significantly reduced the growth of human AML cells that had been transplanted into immune-deficient mice, mimicking the human disease.

Principle investigator of the study Dr. John Dick, senior scientist at the Ontario Cancer Institute, had previously shown that there is a population of cells within cancer, termed cancer stem cells, which are responsible for sustaining cancer growth.

The antibody targets the CD123 protein (IL-3 receptor a chain) on the cancer stem cells that drive cancer growth.

However, it does not appear to affect normal blood cells. On the basis of this experimental work, a Phase I clinical trial has been initiated to test safety and effectiveness in patients. (ANI)

Autistic kids should be taught in smaller groups, say experts

Washington, July 3 (ANI): A new study suggests that children with autism need to be taught in smaller groups.

“Sensory integration dysfunction has long been speculated to be a core component of autism spectrum disorder (ASD) but there has been precious little hard empirical evidence to support this notion,” said Dr. John J. Foxe, Professor of Neuroscience at CCNY.

“Viewing a speaker’s articulatory movements can greatly improve a listener’s ability to understand spoken words, and this is especially the case under noisy environmental conditions,” he added.

Foxe said that children with autism may become distressed in large classroom settings simply because they are unable to understand basic speech, if the environment is sufficiently noisy.

Multisensory speech system develops relatively slowly across the childhood years, and that considerable tuning of this system continues to occur even into early adolescence.

However, autistic kids lag almost 5 years behind typically developing children in this crucial multisensory ability.

Foxe said that further studies might result in advances in the understanding of ASD, and the communication abilities of individuals with autism by identifying the neural mechanisms that are at the root of these multisensory deficits. (ANI)

Novel vaccine to prevent ear infections on the anvil

Washington, July 1 (ANI): Scientists are working on a novel vaccine that may one day help prevent ear infections.

Presently, ear infections are generally treated through antibiotics or surgery, in case they occur often enough.

“The emergence of antibiotic-resistant microorganisms and the invasive nature of the surgical procedure raise the need to develop different ways to treat or, preferably, prevent ear infections,” said Dr Lauren Bakaletz, director of the Centre for Microbial Pathogenesis in The Research Institute at Nationwide Children’s Hospital.

The new vaccine being developed in collaboration with Dr John Clements, at Tulane University School of Medicine in New Orleans, was recently tested by placing a droplet of formula on the outer ears of chinchillas and then rubbed into the skin.

The vaccine works by activating cells, which can be found just under the surface of the skin.

When the liquid touches the skin the cells deliver the vaccine to the lymphoid organs, where it can generate an immune response rapidly reducing or eliminating NTHI, one of the bacteria commonly responsible for ear infections, from the nose and ears.

Bakaletz said that it was extremely effective, and that her research team was excited about the ability to immunize without needles.

“These studies lay the foundation for an effective, yet simple, inexpensive and potentially transformative way to deliver vaccines,” said Bakaletz.

“It’s our hope the method of applying the vaccine to the skin will allow us to distribute it to some of the poorest children in the world,” she added.

In addition to protecting against ear infections, the research could have important implications for the prevention of other diseases of the respiratory tract caused by NTHI. (ANI)

Why HIV patients are more vulnerable to TB infection

Washington, July 1 (ANI): Ending one of the biggest mysteries, Harvard scientists have found out why HIV patients are more susceptible to tuberculosis (TB) infection.

In their study paper, a team of researchers led by Dr. Naimish Patel have described how HIV switches off the immune response to Mycobacterium tuberculosis.

The researchers have detailed how HIV interferes with the cellular and molecular mechanisms used by the lungs to fight TB infection.

With this discovery, the researchers have taken an important first step toward the development of new treatments to help people with HIV to prevent or recover from TB infection.

“HIV/TB co-infection is a critical global health problem, especially in developing countries. We hope that these findings will lead to further studies and possible new therapies for treating or preventing tuberculosis in HIV disease,” said Patel.

For their study, the researchers extracted immune cells called “alveolar macrophages” from the lungs of otherwise healthy, asymptomatic HIV-positive patients as well as from people who did not have HIV.

In people who are HIV-positive, the macrophages have a decreased response to the TB bacterium when compared to people who did not have HIV.

To know why this happens, the scientists examined lung specimens from the HIV-positive patients, and found increased levels of a molecule called IL-10.

IL-10 elevated the amount of a protein called “BCL-3″ in alveolar macrophages, which in turn reduced their ability to ward off TB infection.

“HIV and TB represent two of the most significant health challenges in human history and the combination of the two infections is particularly devastating because HIV dramatically increases the severity of TB infection,” said Dr. John Wherry, Deputy Editor of the Journal of Leukocyte Biology,

He added: “There are still many unknowns about how HIV reduces the ability of the body to combat other infections. This study sheds light on co-infection with HIV and TB, which up to this point, has perplexed scientists and physicians alike.”

The study has been published in the Journal of Leukocyte Biology. (ANI)

Ballroom dancing ‘improves pupils’ behaviour, motivates them to exercise’

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London, June 22 (ANI): Ballroom dancing not only helps improve children’s behaviour but motivates them to exercise, researchers have found. /pp
An evaluation of a national dancing initiative found that kids’ attitudes to exercise changed because of the introduction of dance to PE lessons./pp
The Essentially Dance project, aimed to improve children’s health and fitness, also builds their confidence and improves their relationship skills./pp
The initiative is backed by professionals Darren Bennett and Lilia Kopylova from the television programme ‘Strictly Come Dancing’./pp
The evaluation, conducted by Dr Jeanne Keay, Dean of Education and Dr John Spence, Head of Physical Education at Roehampton University, saw more than 2,500 students aged five to 18 learn to cha-cha-cha, waltz and jive in 29 primary and secondary schools across England./pp
It found that shy children’s self-esteem was boosted, and they made friends as a result of the classes./pp
It also revealed that less sporty children became more interested in PE and children’s behaviour improved./pp
Teachers credited disciplined and structured nature of ballroom and Latin dancing for the improvements in kids./pp
Dance clearly has the potential to make a huge impact on all children’s learning, helping pupils learn to move and move to learn, the Telegraph quoted Keay as saying./pp
The research also found that the introduction of dance into schools through this type of scheme has the potential to positively affect social interaction within families and in local communities, Keay added. (ANI)/p