AllCells LLC Announces Facilities Expansion

EMERYVILLE, Calif.–(Business Wire)–
AllCells LLC (the “Company”), a leading supplier of primary cell types, today
announced it has completed its expansion into 10,000 additional square feet of
office and laboratory production space located in Emeryville, California.

The newly leased space, adjacent to AllCells` headquarters, will be used to meet
the rapidly growing demand for the Company`s hematopoietic stem/progenitor and
other primary cell products used for drug discovery, regenerative medicine,
cell-based assay development, and other research applications. Jay Tong M.D.,
the Company`s President & CEO, commented, “The facilities expansion is an
important step towards executing our strategic growth plan, enabling AllCells to
increase production capacity and continue providing the best possible service to
our customers.” Dr. Tong added, “We have experienced dramatic growth over the
past few years; in a recent market survey, >90% of AllCells` customers reported
being very satisfied with our products & service, with more than one third
expecting to increase their business.”

The Company has simultaneously expanded staff in several areas. Wayne Vaz
recently joined the Company as VP, Corporate & Business Development, previously
serving with Millipore Corp. and Serologicals Corp. in the areas of Technology &
Alliance and Corporate Business Development & Strategic Planning. Headcount has
also been expanded within the areas of Sales & Marketing, Laboratory Operations,
and Accounting. Dr. Tong further commented, “We are pleased to have talented
individuals joining us from some of the industry`s top life science companies.
We are focused on strengthening our core competencies to build AllCells`
business going forward.”

About AllCells LLC

AllCells (www.AllCells.com) is a global biotechnology company founded in 1998 to
provide researchers with a reliable supply of biologically relevant, consistent
quality primary cells that enable the advancement of scientific research in the
areas of cell biology, oncology, virology, hematology, infectious disease and
stem cell research. Unlike cell lines, which are typically mutated, transformed
or immortalized, primary cells retain their original phenotypes hence better
reflect in vivo morphology, metabolism and growth characteristics. These
attributes are especially important for in vitro research applications where in
vivo-like models are critically important. By partnering with AllCells,
investigators can dramatically reduce time needed to isolate cells with
guaranteed consistency thereby improving the efficiency, accuracy and relevance
of their research studies. AllCells is fully certified in accordance with local,
state and federal requirements.

AllCells LLC
John Y. Chang, 510-450-3900 ext. 117
Marketing

Copyright Business Wire 2010

Genes controlling insulin ‘alter’ body clock

Washington, Sept 18 (ANI): Scientists at University of California, San Diego have identified certain insulin-regulating genes that can also alter the timing of the body clock.

They said that the findings can lead to new approaches to treating disorders such as metabolic syndrome that can result, at least in part, from chronic disruption of the sleep-wake cycle.

“People knew that the clock regulates many different processes, but what they didn’t realize what that when you tweak those processes, it feeds back and alters the clock,” said Steve Kay, Dean of the Division of Biological Sciences at the University of California, San Diego, who led the study along with John Hogenesch of the University of Pennsylvania.

A molecular clock controls daily physiological rhythms in many types of cells, even cells grown in culture.

By engineering cultured cells to glow yellow when a particular clock gene switched on, the team made the cycle visible. They then interfered with every human gene to see which would shift the clock. They found that hundreds altered the timing.

“We just suddenly discovered 350 new genes that affect the clock that weren’t known before,” Kay said.

However, subsequent screening to confirm the genes’ effect on a second clock gene narrowed the list to 200.

Seven genes involved in insulin control also influenced the rhythms of the clock.

“What came out very strongly was this close relationship between circadian regulation and insulin signalling. There’s a reciprocal relationship between circadian dysfunction and metabolic dysfunction,” said Kay.

The researchers suggest that genetically altered mice with malfunctioning clocks become obese and develop diet-induced diabetes.Understanding this close relationship between circadian regulation and metabolic homeostasis should provide novel ways of identifying new therapies for metabolic disease,” Kay added.

The study appears in journal Cell. (ANI)

Weight loss can prevent kidney disease progression in obese patients

Washington, Sept 18 (ANI): Shedding extra pounds can preserve kidney function in obese people with kidney disease, according to a new study led by Indian origin scientist from Cleveland Clinic.

Weight loss can improve a number of health problems, like it can improve control of diabetes, lower blood pressure and cholesterol levels, and reduce the effects of heart disease.

During the study, Dr Sankar Navaneethan, and his colleagues analysed the studies that examined the effects of weight loss interventions in obese kidney disease patients.

It showed that weight loss attained through diet and exercise reduces proteinuria (excess excretion of protein in the urine-a hallmark of kidney damage) and may prevent additional decline in kidney function in obese patients with kidney disease.

Studies also showed that surgical interventions normalize the filtration rate of the kidneys in obese patients with high filtration rates (a risk factor for the development of kidney disease).

While the findings imply that weight reduction may prevent the progression of kidney disease in obese kidney disease patients, the authors noted that there were only a small number of studies available for analysis and additional high-quality long-term studies on this topic are needed.

The study appears in Clinical Journal of the American Society Nephrology. (ANI)

Stem cell transplantation may correct rare genetic disorder in kids

Washington, Sep 18 (ANI): Scripps Research Institute scientists have offered new hope for parents whose children suffer from the rare genetic disorder ‘cystinosis’ by showing through an experiment on mice that stem cell transplantation can successfully correct the defect.

“After meeting the children who suffer from this disease, like an 18-year-old who has already had three kidney transplants, and the families who are desperately searching for help, our team is committed to moving toward a cure for cystinosis, a lysosomal storage disorder. This study is an important step toward that goal,” said principal investigator Stephanie Cherqui.

In the study, the researchers used bone marrow stem cell transplantation to address symptoms of cystinosis in a mouse model.

The procedure virtually halted the cystine accumulation responsible for the disease, and the cascade of cell death that follows.

Cystine is a by-product of the break down of cellular components the body no longer needs in the cell’s “housekeeping” organelles, called lysosomes.

Normally, cystine is shunted out of cells, but in cystinosis a gene defect of the lysosomal cystine transporter causes it to build up, forming crystals that are especially damaging to the kidneys and eyes.

Cystinosis is a rare but devastating disease affecting children as young as six months, who begin to suffer renal dysfunction, which grows progressively worse with time. Other symptoms include diabetes, muscular disease, neurological dysfunction, and retinopathy.

The only available drug to treat cystinosis, cysteamine, while slowing the progression of kidney degradation, does not prevent it, and end-stage kidney failure is inevitable.

In the new study, the researchers found that transplanted bone marrow stem cells carrying the normal lysosomal cystine transporter gene abundantly engrafted into every tissue of the experimental mice.

This led to an average drop in cystine levels of about 80 percent in every organ.

Not only it prevented kidney dysfunction, there was less deposition of cystine crystals in the cornea, less bone demineralization, and an improvement in motor function.

“The results really surprised and encouraged us. Because the defect is present in every cell of the body, we did not expect a bone marrow stem cell transplant to be so widespread and effective,” says Cherqui.

Cherqui said that adult bone marrow stem cell therapy is particularly well suited as a potential treatment for cystinosis because these cells target all types of tissues.

In addition, stem cells reside in the bone marrow for the duration of a patient’s life, becoming active as needed, a particular benefit for a progressive disease like cystinosis.

The study has been published in the journal Blood. (ANI)

Green tea may help improve bone health

Washington, Sept 17 (ANI): Green tea may help improve bone health, researchers in Hong Kong have reported.

The boffins found that the tea contains a group of chemicals that can stimulate bone formation and help slow its breakdown.

The study has been published in ACS’ Journal of Agricultural and Food Chemistry, a bi-weekly publication.

In the study, Ping Chung Leung and colleagues noted that many scientific studies have linked tea to beneficial effects in preventing cancer, heart disease, and other conditions.

To reach the conclusion, scientists exposed a group of cultured bone-forming cells (osteoblasts) to three major green tea components – epigallocatechin (EGC), gallocatechin (GC), and gallocatechin gallate (GCG) – for several days. They found that one in particular, EGC, boosted the activity of a key enzyme that promotes bone growth by up to 79 percent. EGC also significantly boosted levels of bone mineralization in the cells, which strengthens bones.

The scientists also showed that high concentrations of ECG blocked the activity of a type of cell (osteoclast) that breaks down or weakens bones. The green tea components did not cause any toxic effects to the bone cells, they noted. (ANI)

Action plan to phase out consumption of HCFC is on track: Ramesh

New Delhi, Sep 16 (ANI): Union Environment and Forest Minister Jairam Ramesh said on Wednesday that India has developed a comprehensive Road Map and Action Plan to phase-out of production and consumption of Hydrochlorofluorocarbons (HCFCs) in various sectors.

Addressing the gathering during the 15th International Ozone Day here Ramesh said: “The Government of India has taken a number of policy measures, fiscal and regulatory, to encourage the early adoption of alternative technologies in this area by existing and new enterprises.”

Ramesh hailed the Montreal Protocol as the most successful international treaty to ever achieve universal participation.

“At a time when the world is trying to solve the problem of climate change, the International Ozone Day provided a timely reminder of how international cooperation can help to solve major global environmental problems,” Ramesh added.

India is one of the first developing countries to join the Montreal Protocol and pledge its commitment to protect the Ozone Layer.

As a part of the accelerated phase-out of CFCs, India has completely phased out the production and consumption of CFCs as on 1 August 2008, 17 months prior to the agreed schedule.

Ramesh informed that over 97percent of controlled Ozone Depleting Substances (ODS) have been phased out by the Montreal Protocol.

“The end of 2009 will mark another significant milestone in the history of its implementation, with the use of potent ODSs -CFCs, Carbon Tetra Chloride (CTC) and Halons, except pharmaceutical-grade CFCs used in the manufacture of Metered Dose Inhalers (MDIs) – being ceased completely,” he said

The CFCs required for manufacturing for MDIs used by Asthma and Chronic Obstructive Pulmonary Disease (COPD) patients are still available in India, a national transition strategy to phase them out by 2013 is currently under implementation.

“The Ministry of Environment and Forests (MoEF), with support from the Global Environment Facility (GEF) and the World Bank recently also launched the India: Chiller Energy Efficiency Project to accelerate the conversion of CFC-based chillers using new, more energy efficient technologies,” Ramesh said.

This year’s theme for the ozone day was ‘Universal participation – Ozone protection unifies the World.’ (ANI)

Twitter could help track swine flu spread

London, September 16 (ANI): People’s updates on popular social networking websites such as Twitter about having coughs and colds could help health officials track early warning signs about flu outbreaks.

The Health Protection Agency annual conference at Warwick University, UK, heard that such websites could indicate an outbreak of flu earlier than conventional disease surveillance methods based on doctor visits.

Combing for messages or “tweets” such as ‘I have flu’ or ‘I’ve got swine flu’ may help provide valuable insight into the spread of infectious diseases, research showed.

Ed de Quincey, a computer scientist at City University London conducted the research and developed the system with his team at the City eHealth Research Centre.

“As UK public health agencies and the NHS are preparing for the approaching flu season amid the H1N1 pandemic, new forms of social interaction via web sites such as Twitter and Facebook can expand the sources used in monitoring such outbreaks,” the Telegraph quoted him as saying.

“The flu pandemic was the perfect opportunity to test this idea and we found that at least 4,000 people reported flu symptoms via Twitter since May 2009.

“We are currently analysing over a million ‘tweets’ that we have collected and exploring the potential of incorporating data from other social networking websites. We hope in the future to expand this approach to investigate other health issues such as drug and substance abuse,” he added. (ANI)

Your bathroom showers are hazardous to health

Washington, September 15 (ANI): That invigorating relief and good cleansing from daily bathroom showers may bring along a face full of potentially pathogenic bacteria, warn researchers at the University of Colorado at Boulder.

Using high-tech instruments and lab methods, the researchers analysed roughly 50 showerheads from nine cities in seven states that included New York City, Chicago and Denver.

CU-Boulder Distinguished Professor Norman Pace, lead study author, says that about 30 percent of the devices were found to harbour significant levels of Mycobacterium avium, a pathogen linked to pulmonary disease that most often infects people with compromised immune systems, but which can occasionally infect healthy people.

The study showed that some M. avium and related pathogens were clumped together in slimy “biofilms” that clung to the inside of showerheads at more than 100 times the “background” levels of municipal water.

“If you are getting a face full of water when you first turn your shower on, that means you are probably getting a particularly high load of Mycobacterium avium, which may not be too healthy,” Pace said.

He pointed out that research at National Jewish Hospital in Denver indicated that increases in pulmonary infections in the US in recent decades from so-called “non-tuberculosis” mycobacteria species, such as M. avium, could be attributed to people taking more showers and fewer baths.

He said that water spurting from showerheads could distribute pathogen-filled droplets that suspend themselves in the air, and could easily be inhaled into the deepest parts of the lungs.

“There have been some precedents for concern regarding pathogens and showerheads. But until this study we did not know just how much concern,” said Pace.

In Denver, according to the researcher, one showerhead with high loads of Mycobacterium gordonae was cleaned with a bleach solution in an attempt to eradicate it, but tests conducted several months later showed that the bleach treatment ironically caused a three-fold increase in the pathogen, indicating a general resistance of mycobacteria species to chlorine.

Ask Pace whether it is dangerous to take showers, and he says: “Probably not, if your immune system is not compromised in some way. But it’s like anything else-there is a risk associated with it.”

He stresses that plastic showerheads appear to “load up” with more pathogen-enriched biofilms, and thus metal showerheads may be a good alternative.

“There are lessons to be learned here in terms of how we handle and monitor water. Water monitoring in this country is frankly archaic. The tools now exist to monitor it far more accurately and far less expensively that what is routinely being done today,” said Pace.

A research article on his study has been published in the online edition of the Proceedings of the National Academy of Sciences. (ANI)

No toxic substance found in Urumqui’s latest syringe attack victims’ body

Urumqui, Sep. 14 (ANI): The blood samples of Urimqui’s latest syringe attack victims showed no trace of radioactive, toxic or viral substances, such as AIDS, an expert at a Beijing-based laboratory has said.

However, Director of Disease Control and Biological Security Office with China’s Academy of Military Medical Sciences, Qian Jun, has said that the victims have showed signs of depression.

“Although no radioactive or toxic substances were found, some patients showed various levels of anxiety and depression and have been recommended for psychological counselling,” China daily quoted Quian, as saying.

Meanwhile, the first group of syringe attack suspects were prosecuted in Urumqi, capital of the Xinjiang Uygur autonomous region.

At least 500 cases of attacks have surfaced in the city since mid-August.

Two men and a woman were given sentences ranging from seven to 15 years in jail for syringe stabbings or robberies in which they threatened their victims with needles.

The court sentenced 19-year-old Yilipan Yilihamu to 15 years in prison for injecting a woman with a hypodermic needle on August 28 at a roadside fruit stall. (ANI)

Master gene that switches on disease-fighting cells identified

London, Sep 14 (ANI): British scientists have identified the master gene, called E4bp4, that causes blood stem cells to turn into disease-fighting ‘Natural Killer’ (NK) immune cells.

The discovery, by researchers at Imperial College London, UCL and the Medical Research Council’s National Institute for Medical Research, could one day help scientists boost the body’s production of these frontline tumour-killing cells, creating new ways to treat cancer.

By ‘knocking out’ E4bp4 in a mouse model, the researchers created the world’s first animal model entirely lacking NK cells, but with all other blood cells and immune cells intact.

The breakthrough model should help solve the mystery of the role that Natural Killer cells play in autoimmune diseases, such as diabetes and multiple sclerosis.

According to many scientists, these diseases are a result of malfunctioning NK cells that turn on the body and attack healthy cells, which cause disease instead of fighting it.

They believe that clarifying NK cells’ role could lead to new ways of treating these conditions.

Natural Killer cells – a type of white blood cell – are a major component of the human body’s innate, quick-response immune system, providing a fast frontline defence against tumours, viruses and bacterial infections.

The gene E4bp4 is the ‘master gene’ for NK cell production, which means it is the primary driver that causes blood stem cells in the bone marrow to differentiate into NK cells.

Led by Dr Hugh Brady, the researchers are hoping to progress with a drug treatment for cancer patients which reacts with the protein expressed by their E4bp4 gene, causing their bodies to produce a higher number of NK cells than normal, to increase the chances of successfully destroying tumours.

“If increased numbers of the patient’s own blood stem cells could be coerced into differentiating into NK cells, via drug treatment, we would be able to bolster the body’s cancer-fighting force, without having to deal with the problems of donor incompatibility,” Nature quoted Brady as saying.

The researchers proved the pivotal role E4bp4 plays in NK production when they knocked the gene out in a mouse model.

Without E4bp4 the mouse produced no NK cells whatsoever but other types of blood cell were unaffected.

“Now finally, with our discovery of the NK cell master gene and subsequent creation of our mouse model, we will be able to find out if the progression of these diseases is impeded or aided by the removal of NK cells from the equation. This will solve the often-debated question of whether NK cells are always the ‘good guys’, or if in certain circumstances they cause more harm than good,” said Brady.

The study has been published in Nature Immunology. (ANI)

Viagra laced fruit juices flowing in Malaysia!

Kuala Lumpur, Sept 14 (ANI): After being detected in coffee mixtures and sweets, Viagra has now been found in fruit juices.

After raiding more than 30 retailers and distributors dealing in the fruit juice, enforcement officers from the Health Ministry in Malaysia seized several hundred thousand ringgit worth of the product.

This followed after the ministry sent samples of the product for tests which confirmed the presence of sildenafil, reports The New Straits Times Online.

Sildenafil citrate, sold as Viagra, Revatio and various other trade names, is a drug used to treat erectile dysfunction.

According to a Health Ministry source, this was the first time they had encountered a case where sildenafil had been mixed with fruit juices.

The mixture is potent and deadly to people suffering from heart disease and high blood pressure.

“It was brought to our attention after several people complained to the ministry about the suspicious fruit juice,” the source said.

“The producer and distributor had claimed that the fruit juice had been produced from selected natural herbs which could improve sexual performance of men and women,” the source added.

Following test results, investigations were conducted to identify retailers and distributors involved in selling the fruit juice.

“More than 30 simultaneous raids were carried out nationwide. Officers were also concerned that the retailers and distributors would hide their stocks as the product had also been sold via direct selling,” the source said.

“At the raid at the company’s headquarters in Subang Jaya, three marketing officers and the store caretaker were questioned by authorities,” the source added.

Investigations revealed that the fruit juice had been in the local market for the past six months and had received good response from consumers.

The consumer needs to mix the powder with water before drinking. (ANI)

Scientists develop ‘electronic nose’ that can sniff out toxins by changing colors

Washington, September 14 (ANI): A team of scientists has developed a sensor that works as an ‘electronic nose’ in sniffing out some known poisonous gases and toxins, simply by changing colors.

Support for the development and application of this electronic nose comes from the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

Once fully developed, the sensor could be useful in detecting high exposures to toxic industrial chemicals that pose serious health risks in the workplace or through accidental exposure.

While physicists have radiation badges to protect them in the workplace, chemists and workers who handle chemicals do not have equivalent devices to monitor their exposure to potentially toxic chemicals.

The investigators hope to be able to market the wearable sensor within a few years.

“The project fits into the overall goal of a component of the GEI Exposure Biology Program that the NIEHS has the lead on, which is to develop technologies to monitor and better understand how environmental exposures affect disease risk,” said NIEHS Director Linda Birnbaum.

“This paper brings us one step closer to having a small wearable sensor that can detect multiple airborne toxins,” she added.

Kenneth S. Suslick, the M.T. Schmidt Professor of Chemistry at the University of Illinois at Urbana-Champaign, and his colleagues have created what they refer to as an optoelectronic nose, an artificial nose for the detection of toxic industrial chemicals (TICs) that is simple, fast, inexpensive, and works by visualizing colors.

“We have a disposable 36-dye sensor array that changes colors when exposed to different chemicals. The pattern of the color change is a unique molecular fingerprint for any toxic gas and also tells us its concentration,” said Suslick.

“By comparing that pattern to a library of color fingerprints, we can identify and quantify the TICs in a matter of seconds,” he added.

The power of this sensor to identify so many volatile toxins stems from the increased range of interactions that are used to discriminate the response of the array.

To test the application of their color sensor array, the researchers chose 19 representative examples of toxic industrial chemicals.

Chemicals such as ammonia, chlorine, nitric acid and sulfur dioxide at concentrations known to be immediately dangerous to life or health were included.

The arrays were exposed to the chemicals for two minutes.

Most of the chemicals were identified from the array color change in a number of seconds and almost 90 percent of them were detected within two minutes. (ANI)

Natalizumab drug improves quality of life of MS patients

Washington, Sept 13 (ANI): A new study has found that multiple sclerosis patients taking Tysabri (Natalizumab) experienced a significant improvement in both their physical function and psychological well-being.

“The symptoms that an MS patient deals with on a daily basis result in significant psychological and physical effects that can adversely impact their quality of life,” said Dr William Stuart, medical director of the Multiple Sclerosis Center of Atlanta.

“In a previous pivotal trial, TYSABRI not only showed a reduction in relapse rates and disability progression, but also improved quality of life.

“Results from this observational study further demonstrate the impact of TYSABRI on improving MS patients’ well-being as reported by patients who live with this disease every day,” he added.

The study assessed the health outcomes from patients’ perspectives before starting TYSABRI and after the third, sixth and 12th infusions of TYSABRI.

After six TYSABRI infusions, patients reported statistically significant improvement in disease-specific quality of life (QoL), which measures the physical impact of MS in terms of mobility and self care, as well as the psychological impact of MS in terms of anxiety/depression.

The participants also scored higher in general health-related quality of life.

The findings were presented at the 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). (ANI)

Weight gain in adulthood linked to prostate cancer risk

Washington, Sep 12 (ANI): Body size and weight gain in younger and older adulthood may help weigh a man’s proneness to prostate cancer, according to a study by researchers at the University of Hawaii at Manoa’s Cancer Research Center of Hawaii.

Led by Dr. Brenda Hernandez, the researchers said that the risk varies among different ethnic groups

For the study, the researchers studied the relationship in a multiethnic population consisting of blacks, Japanese, Hispanics, Native Hawaiians and whites, and compared differences among age groups using the Multiethnic Cohort, a longitudinal study of men 45-75 years of age established in Hawaii and California from 1993-1996.

Of the 83,879 men who participated in the study, 5,554 developed prostate cancer.

Overall, men who were overweight or obese by age 21 had a decreased risk of localized and low-grade prostate cancer, according to Hernandez.

Their results suggested that being overweight in older adulthood was associated with increased prostate cancer risk among white and Native Hawaiian men, but a decreased risk among Japanese men.

While excessive weight gain between younger and older adulthood was observed to increase the risk of advanced and high-grade prostate cancers in white men and increase the risk of localized and low-grade disease in black men, it appeared to decrease the risk of localized prostate cancer in Japanese men.

“The relationship of certain characteristics, such as body size, with cancer risk may vary across ethnic groups due to the combined influence of both genes and lifestyle,” said Hernandez.

However, the relationship between body size and prostate cancer risk is not entirely understood.

Excess fat is associated with a number of conditions that contribute to cancer development including low-grade chronic inflammation, insulin resistance, metabolic abnormalities, and hormone imbalances.

These conditions may in turn contribute to more aggressive prostate malignancies.

Ethnic differences in cancer risk may be explained by differences in the distribution of stored body fat that could have a differential effect on the development of prostate cancer.

And the distribution of body fat may influence the specific way that excess fat influences cancer risk.

The study has been published in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research. (ANI)

Biocon limited, Amylin pharmaceuticals enter global development agreement

Bangalore/ California Sep 11(ANI/Business Wire India): Biocon, Limited (NSE: BIOCON) and Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN) announced today that they have entered into an exclusive agreement to jointly develop, commercialize and manufacture a novel peptide therapeutic for the potential treatment of diabetes.

Amylin and Biocon will collaborate to develop the therapeutic potential of the compound and share development costs. Research will center on Amylin’s “phybrid” technology. A phybrid is a peptide hybrid molecule that combines the pharmacological effects of two peptide hormones into a single molecular entity.

Under the terms of the Development and Commercialization Agreement, Amylin will provide expertise in peptide hormone development, particularly in the area of phybrid technology, as well as metabolic disease therapeutics. Biocon will utilize its expertise in recombinant microbial expression to manufacture the compound and also leverage its experience in pre-clinical and clinical development of diabetes products.

“This agreement fully leverages the synergistic capabilities of the two companies,” said Kiran Mazumdar-Shaw, Chairman and Managing Director, Biocon, Ltd. “Amylin’s knowledge of peptide therapeutics and their leadership in the diabetes market, paired with Biocon’s capabilities in process development, manufacturing and clinical development, provides this global program with the potential to effectively bring a novel therapy to patients living with diabetes.”

“This program could unleash the potential of cutting-edge peptide science to transform the lives of patients with diabetes,” said Daniel M. Bradbury, President and Chief Executive Officer, Amylin Pharmaceuticals. “We are pleased to work with Biocon, a biologics innovator and world-class manufacturing expert, and look forward to collaborating with them on this exciting program.”

Amylin Pharmaceuticals is a biopharmaceutical company committed to improving lives through the discovery, development and commercialization of innovative medicines. (ANI)

Natalie Cole makes comeback after kidney transplant op

Washington, September 11 (ANI): R andB singer Natalie Cole made a comeback to the stage and performed at a concert in Hollywood after fighting severe health conditions for almost a year.

“I really do have to say … it really is a miracle time. It’s a miracle night for me. I never thought I’d be standing here healthy and whole and 100 percent,” People magazine quoted her as telling the crowd present.

The singer was diagnosed with Hepatitis C in April last year.

Apart from treating the liver disease with chemotherapy, she also battled kidney problems later that year.

However, she was back with a bang at the Hollywood Bowl belting out hits like ‘This Will Be,’ ‘Our Love,’ and ‘Unforgettable’

She said: “My heart is very full tonight, and I know a lot of you know why. It’s just good to be back. You know what I’m saying?

“You know, things don’t always go the way we want it to. Things happen unexpectedly. You got to take the good with the bad.”

Cole also brought the attention of the audience to health problems.

She said: “One in eight people has kidney failure. That’s a lot of people and I never thought it would happen to me, but here we are.”

She described the phase she was ill as “a real tough journey.” (ANI)

Exposure to second-hand tobacco smoke linked to liver disease

Washington, September 11 (ANI): People can develop liver disease even when they are exposed to second-hand tobacco smoke, according to a study.

Scientists at the University of California, Riverside (UCR) have found that exposure to second-hand tobacco smoke can lead to non-alcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury wherein fat accumulates in the liver of people who drink little or no alcohol.

For their study, the researchers exposed some mice to second-hand cigarette smoke for a year in the lab, and observed fat build-up in their liver cells, a sign of NAFLD that eventually leads to liver dysfunction.

The researchers focused on two key regulators of lipid (fat) metabolism that are found in many human cells as well: SREBP (sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine monophosphate kinase) that turns SREBP on and off.

They found that second-hand smoke exposure inhibits AMPK activity, which, in turn, causes an increase in activity of SREBP.

More active SREBP results in more fatty acids getting synthesized, they say.

The result is NAFLD induced by second-hand smoke, according to the researchers.

“Our study provides compelling experimental evidence in support of tobacco smoke exposure playing a major role in NAFLD development,” said Manuela Martins-Green, a professor of cell biology, who led the study.

“Our work points to SREBP and AMPK as new molecular targets for drug therapy that can reverse NAFLD development resulting from second-hand smoke. Drugs could now be developed that stimulate AMPK activity, and thereby inhibit SREBP, leading to reduced fatty acid production in the liver,” Martins-Green added.

A research article describing the study has been published in the Journal of Hepatology. (ANI)

Three genes linked to Lou Gehrig’s disease identified

Washington, Sep 10 (ANI): Researchers at Michigan Technological University have identified three genes that play a major role in the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig’s disease.

The team of mathematicians, led by Shuanglin Zhang, isolated the genes from the many thousands scattered throughout human DNA.

Zhang noted that the discovery does not mean an end to ALS, but it could provide scientists with valuable clues as they search for a cure.

“I felt very urgent to find the genes for ALS,” Zhang said.

“This is very nice work. It’s very challenging to map genes for complex diseases, and while many statistical methods have been developed, most don’t work well in practice. Zhang’s group has developed a method to detect genes and gene-gene interaction in complex diseases and provided evidence that it works,” said Xiaofeng Zhu, an associate professor of epidemiology at Case Western Reserve University’s School of Medicine.

“Their findings will need to be confirmed by other researchers, but I think this will be very useful for the investigators who are trying to find genes underlying complex diseases such as ALS,” said Zhu.

According to the ALS Association, only about 10 percent of patients have familial ALS, a directly inherited form of the usually fatal neuromuscular disorder, while the remaining 90 percent are diagnosed with the sporadic form of the disease.

While everyone has the three genes in question, but in people with sporadic ALS, they differ from those in people who don’t have ALS.

The mathematicians were not surprised when they tracked down the location of the genes.

“Everybody has 23 chromosomes, and the three genes on chromosomes 2, 4, and 10 interact. If you have this combination of the three genes, you are at high risk of developing the disease. It’s really exciting, especially because my husband has sporadic ALS. Maybe they can find a cure by blocking the genes,” explained Zhang’s wife Qiuying Sha.

ALS destroys the nerves in the brain and spinal cord that control voluntary movement, eventually leading to paralysis.

Zhang’s team used a new statistical method to analyse the genetic codes of 547 individuals, 276 with sporadic ALS and 271 without.

The method, a two-locus interaction analysis approach, allows the researchers to identify multiple genes associated with a complex illness.

The data set they analyzed was provided by National Institute of Neurological Disorders and Stroke (NINDS) Human Genetics Resource Center at the Coriell Institute, a publicly funded “bank” or repository for human cells, DNA samples, clinical data, and other information that aims to accelerate research on the genetics of nervous system disorders.

The study has been published in the open access journal BMC Medical Genetics. (ANI)

Men with high levels of bone lead 6 times more likely to die from heart disease

Washington, Sept 10 (ANI): Men with high levels of lead in bones are six times more likely to die from heart disease, according to a new study.

Researchers from the Harvard School of Public Health (HSPH) and the University of Michigan School of Public Health found that bone lead was associated with a higher risk of death from all causes, particularly from cardiovascular disease.

“The findings with bone lead are dramatic,” said Marc Weisskopf, assistant professor of environmental and occupational epidemiology at HSPH and lead author of the study.

“It is the first time we have had a biomarker of cumulative exposure to lead and the strong findings suggest that, even in an era when current exposures are low, past exposures to lead represent an important predictor of cardiovascular death, with important public health implications worldwide,” he added.

During the study, the researchers examined 868 participants in the Department of Veterans Affairs Normative Aging Study, a study of aging in men that began in 1963. Blood lead and bone lead were analyzed using X-ray fluorescence.

The results showed that the risk of death from cardiovascular disease was almost six times higher in men with the highest levels of bone lead compared to men with the lowest levels.

The risk of death from all causes was 2.5 times higher in men with the highest levels of lead compared to those with the lowest levels.

According to the authors, there are a number of mechanisms, such as increased oxidative stress, by which lead exposure may result in cardiovascular mortality.

They also note that, in addition to high blood pressure, exposure to lead has been associated with widened pulse-pressure (an indicator of arterial stiffening) and heart disease.

Given that bone lead may be a better biomarker of cumulative lead exposure than blood lead, it may be the best predictor of chronic disease from exposure to lead in the environment.

The study appears in journal Circulation. (ANI)