New air filter system can destroy up to 99.9 per cent of bugs on aircraft

London, September 16 (ANI): British researchers have developed an air filter system that destroys up to 99.9 per cent of infectious viruses and bacteria as well as pollutants that can circulate in the confines of an aircraft, especially on long-haul flights.

According to a report in The Times, the machine has been developed by aerospace giant BAE Systems, in collaboration with Quest International, a small company based in Cheadle, South Manchester, UK.

The device, called AirManager, uses a controlled electric field to filter out and destroy any airborne particles or germs as they pass through an aircraft’s air conditioning system, emitting only clean, sterilized air.

After four years of development and tests, BAE says it has received its first orders from a major European airline and announced the technology is also being considered for use in NHS hospitals as a way to stop the spread of “superbugs” such as MRSA and Clostridium difficile.

The air on board a passenger jet must be pressurized in order for passengers to be able to breathe, but scientists and lobby groups have previously claimed that passengers can be exposed to toxins as a result of the “bleed air” system that is used to redirect air from the engines to the cabin and cockpit.

Air inside the cabin is then circulated and re-circulated up to 30 times an hour, far more than in conventional air conditioning systems, meaning that infectious viruses and bacteria can quickly spread.

Unlike conventional filters, which are designed to sieve out particles from the air as it passes through perforated barriers at high speed, David Hallam, an engineer and founder of Quest International, said that the AirManager used an “avalanche of electrons” emitted in a closed electric field to break down and destroy the atomic structure of any pollutants or germs.

“This works with swine flu, avian flu, norovirus, MRSA, even a modified form of anthrax,” Hallam said.

Hallam said that he originally designed the “close coupled field” in the late 1990s to rid nursing homes of biological odours caused by bacteria.

But, the filter was later found to have an effect in reducing the airborne transmission of bacteria such as MRSA (methicillin-resistant Staphylococcus aureus) and Clostridium difficile.

BAE Systems expressed interest in the technology four years ago for use on aircraft and the system was recently tested on the flight deck and cabin air systems of Boeing 757 and Avro RJ passenger jets by five European airlines, with successful results. (ANI)

Mozart ‘killed by superbug like MRSA, not poison’

London, Aug 18 (ANI): Austrian composer Wolfgang Amadeus Mozart was killed by a bacterial infection akin to MRSA, claim Dutch researchers.

Mozart died at age 35 – young by even 18th century standards. His untimely death has remained a mystery ever since he passed away in the early hours of 5 December 1791.

Some claimed he was poisoned, others said he simply wore himself out by composing more than 600 pieces during his short life.

Now, a group of boffins has suggested that he died from a bacterial infection spread by soldiers which was rife in Vienna at the time, reports The Telegraph.

The researchers, who studied the city’s death register, found that the three most common causes of death among men of his age were tuberculosis, severe weight loss and a condition called ‘oedema’ or ‘dropsy’ – an accumulation of fluids causing the body to swell up.

And, Mozart’s symptoms match the last of the three, according to Dr Richard Zeger, from the Academic Medical Centre in Amsterdam, who said it could have been caused by a bacterial infection.

He said: “I think you can compare this to a superbug like MRSA or C.difficile.”

Mozart’s sister-in-law Sophie Haibel, who saw him days before he died, said he was covered in a rash – consistent with a bacterial infection – and severely swollen – consistent with oedema or dropsy.

At the time Vienna was full of soldiers from the Austro-Turkish war who had been struck down by disease.

Zeger said: “Austria was at war at the time so people were living in a bad condition and most of the deaths were among soldiers. You can see there was clearly an epidemic and we found that it started in a military hospital. There was some kind of inflammatory disease that almost everyone contracted and some people died. It was an epidemic of oedema, which is a collection of fluid.

“When your kidneys fail, they can’t secrete body fluids so fluid accumulates in your body, which causes people to swell up and get worse and worse.”

This kind of a condition could have been caused by being infected with bacteria from the Staphylococcus aureus (SA) family, or which MRSA is a more recent member.

“Mozart’s body had swollen up so badly he was not able to turn around any more in his bed, showing he had post-streptococcal complications,” said Zeger.

In those times, antibiotics like penicillin were nowhere present, so strictly speaking the bacteria would not have been a ‘super’ bug as it could not have developed any resistance in the way that methicillin-resistant Staphylococcus aureus (MRSA) has done.

Zeger postulated: “We still see the streptococcal infection today in close communities like schools and armies so that would be a good reason behind the epidemic.

“In Mozart’s time, several soldiers in the army were also musicians who might have performed in Vienna, where Mozart might have contracted it.” (ANI)

Infection control strategies for antibiotic-resistant organisms in hospitals

Washington, Mar 16 (ANI): Hand-washing, a clean environment, appropriate infection barriers, and early identification of patients at high risk of colonization with a transmissible microorganism are some of the infection control strategies adopted by hospitals for antibiotic-resistant organisms.

A review of the control strategies has revealed the above measures after looking at the most effective methods, and the supporting evidence to control hospital infection.

Risk factors associated with colonization of antibiotic-resistant microorganisms include increasing age of patient and severity of disease, increasing length of hospital stay, admission to an intensive care unit, and proximity to patients carrying an antimicrobial-resistant organism.

Use of broad-spectrum antibiotics and/or prolonged use of antibiotics are also risk factors.

Methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile (C.difficile), and vancomycin-resistant enterococci are the most common antimicrobial-resistant pathogens.

Resistance is more prevalent in hospital-acquired infections compared to community-acquired infections.

The detailed review is published in the latest issue of CMAJ. (ANI)

Scientists uncover workings of hospital superbug

London, Mar 3 (ANI): An international team of scientists has uncovered the workings of a superbug that kills elderly hospital patients worldwide.

The team, led by Monash University researchers, said that the discovery has the potential to save lives and health care systems billions of dollars each year.

The research unravelled ways to genetically modify the bacterium Clostridium difficile and solved the mystery surrounding its toxicity.

Professor Julian Rood from the Department of Microbiology and lead author, microbiologist Dr Dena Lyras, made a major scientific breakthrough, which allowed mutants of the superbug to be made.

They then identified which of two suspected toxic proteins was essential for the bacterium to cause severe disease.

“Contrary to previously accepted scientific belief, our results show that toxin B, which was considered the less important toxin is actually the toxin that causes disease. This discovery will lead to new methods for the control and prevention of this disease,” Rood said.

The study has been published in the prestigious scientific journal Nature. (ANI)

Breakthrough study may lead to new ways to battle C-Diff superbug

London, Mar 2 (ANI): Scientists have achieved a major breakthrough that may pave the way for new approaches to combat superbug Clostridium difficile (C-diff), a spore-forming bacterium that was discovered in 1978 to be the cause of antibiotic-associated diarrhoea and colitis.

The researchers behind this work say that, since a long time, scientists have been focusing on the wrong toxin that is released by the bacteria in the colon.

The toxin was known to cause severe diarrhoea and life-threatening colitis that could lead to the surgical removal of the colon.

“For 20 years, we have been focusing on Toxin A. But it turns out the real culprit is Toxin B. This is a major finding in how C-diff causes disease in humans. It completely flips our whole concept of what the important toxin is with this disease,” Nature magazine quoted study co-author Dr. Dale Gerding as saying.

When the normal bacteria that live in the colon are disturbed, usually as a result of antibiotic treatment, and a patient ingests C-diff spores, the bacteria can multiply and release the two toxins.

The epidemic strain now rivals the superbug known as MRSA as one of the top emerging disease threats to humans. Since its discovery, C-diff has grown increasingly resistant to antibiotics.

C-diff infection is spread by spores that contaminate the hospital environment, or by hands of healthcare workers who can transmit the spores to patients.

But the resistance of the spores to hospital cleaning agents, and to alcohol hand disinfectants, makes it extremely difficult to eradicate.

Gerding pointed out that a human clinical trial using a drug that bound Toxin A more than it bound Toxin B failed to treat C-diff effectively.

“There’s probably a good reason why the trial failed. We now know that Toxin B should have been the primary target,” said Gerding.

The researchers claimed that the study has major implications for the future development of treatments and preventative measures for C-diff.

“The more you understand the way an organism causes disease, the better you can target treatment or preventative measures,” said one of the co-authors of the study.

The breakthrough in the study came after co-authors in Australia engineered mutant strains of the bacteria that were tested by Gerding and other Loyola researchers.

“It turns out that in the strain in which Toxin A was knocked out, the organism was fully virulent. It caused disease. When they knocked the Toxin B out in another set of experiments, the organism didn’t cause disease. This is probably the best evidence to date about the relative importance of these two toxins,” said the authors.

The study has been published in the journal Nature. (ANI)