Chelsea Therapeutics to Present at 9th Annual Needham Healthcare Conference

CHARLOTTE, N.C., June 3, 2010 (GLOBE NEWSWIRE) — Chelsea Therapeutics
International, Ltd. (Nasdaq:CHTP) is scheduled to present at the 9th Annual
Needham Healthcare Conference at 2:00 PM ET on Wednesday June 9, 2010 at the New
York Palace Hotel in New York City.

Dr. Simon Pedder, Chelsea’s president and chief executive officer, will provide
a brief overview of the company’s product pipeline, clinical development status
and upcoming milestones.

Dr. Pedder’s presentation will be webcast live and archived for 30 days on
Chelsea’s website, www.chelseatherapeutics.com.

About Chelsea Therapeutics

Chelsea Therapeutics is a biopharmaceutical development company that acquires
and develops innovative products for the treatment of a variety of human
diseases. Chelsea’s most advanced drug candidate, Northera(TM) (droxidopa), is
an orally active synthetic precursor of norepinephrine initially being developed
for the treatment of neurogenic orthostatic hypotension. In addition to
Northera, Chelsea is also developing a portfolio of metabolically inert oral
antifolate molecules engineered to have potent anti-inflammatory and anti-tumor
activity to treat a range of immunological disorders, including two clinical
stage product candidates: CH-1504 and CH-4051. Preclinical and clinical data
suggest superior safety and tolerability, as well as increased potency versus
methotrexate (MTX).

This press release contains forward-looking statements regarding future events.
These statements are just predictions and are subject to risks and uncertainties
that could cause the actual events or results to differ materially. These risks
and uncertainties include risks and costs of drug development, risk of
regulatory approvals, our reliance on our lead drug candidates droxidopa and
CH-4051, reliance on collaborations and licenses, intellectual property risks,
our need to raise additional operating capital in the future, our history of
losses, competition, market acceptance for our products if any are approved for
marketing, and reliance on key personnel including specifically Dr. Pedder.

CONTACT: Chelsea Therapeutics
Investor/Media Relations
Kathryn McNeil
718-788-2856

Chelsea Therapeutics to Host Conference Call to Discuss Fourth Quarter and Full Year…

Chelsea Therapeutics to Host Conference Call to Discuss Fourth Quarter and Full
Year 2009 Results

CHARLOTTE, N.C., March 3, 2010 (GLOBE NEWSWIRE) — Chelsea Therapeutics
International, Ltd. (Nasdaq:CHTP) announced that it will release fourth quarter
and full year results for the period ended December 31, 2009 after the market
closes on Wednesday, March 10, 2010. Chelsea management will host a conference
call and live webcast to discuss these financial results and provide an update
on each of its development programs that afternoon at 4:30 PM ET.

Interested investors may participate in the conference call by dialing
877-638-9567 (domestic) or 720-545-0009 (international). A replay will be
available for one week following the call by dialing 800-642-1687 for domestic
participants or 706-645-9291 for international participants and entering
passcode 60600587 when prompted. Participants may also access both the live and
archived webcast of the conference call on Chelsea’s web site at
www.chelseatherapeutics.com.

About Chelsea Therapeutics

Chelsea Therapeutics is a biopharmaceutical development company that acquires
and develops innovative products for the treatment of a variety of human
diseases. Chelsea’s most advanced drug candidate, Droxidopa, is an orally active
synthetic precursor of norepinephrine initially being developed for the
treatment of neurogenic orthostatic hypotension. In addition to Droxidopa,
Chelsea is also developing a portfolio of metabolically inert oral antifolate
molecules engineered to have potent anti-inflammatory and anti-tumor activity to
treat a range of immunological disorders, including two clinical stage product
candidates: CH-1504 and CH-4051. Preclinical and clinical data suggest superior
safety and tolerability, as well as increased potency versus methotrexate (MTX).

This press release contains forward-looking statements regarding future events.
These statements are just predictions and are subject to risks and uncertainties
that could cause the actual events or results to differ materially. These risks
and uncertainties include reliance on collaborations and licenses, risks and
costs of drug development, regulatory approvals, intellectual property risks,
our reliance on our lead drug candidate CH-1504, our history of losses and need
to raise more money, competition, market acceptance for our products if any are
approved for marketing, reliance on key personnel including specifically Dr.
Pedder, management of rapid growth, and the need to acquire or develop
additional products.

CONTACT: Chelsea Therapeutics
Investors & Media:
Kathryn McNeil
718-788-2856
mcneil@chelseatherapeutics.com