New finding may help in dengue fever fight

Washington, May 7 (ANI): A new study by scientists from Imperial College London has found that some of the human immune system”s defences against the virus that causes dengue fever actually help the virus to infect more cells.

According to the researchers, their new findings could help with the design of a vaccine against the dengue virus.

The study also brings scientists closer to understanding why people who contract dengue fever more than once usually experience more severe and dangerous symptoms the second time around.

Dengue fever is transmitted by a mosquito bite and is prevalent in sub-tropical and tropical regions including South East Asia and South America. Symptoms include high fever, severe aching in the joints and vomiting. The dengue virus can also cause hemorrhagic fever, which can be fatal.

Professor Gavin Screaton, the lead author of the study from Imperial College London, and his colleagues identified a set of antibodies, produced by the human immune system to fight off the dengue virus, that they believe scientists should avoid including in any new vaccine to prevent dengue fever.

The new research shows that these precursor membrane protein (prM) antibodies do not do a very effective job of neutralising the virus. Moreover, these antibodies actually help the virus to infect more cells.

The study suggests that when a person who has already been infected with one strain of dengue virus encounters a different strain of dengue virus, the prM antibodies awakened during the first infection spring into action again. However, rather than protecting the body from the second infection, these prM antibodies help the virus to establish itself.

This activity of the prM antibodies could explain why a second infection with a different strain of the virus can cause more harm than the first infection. The researchers believe that if a dengue virus vaccine contained prM antibodies, this could cause similar problems.

The researchers reached their conclusions after analysing individual antibodies to the dengue virus extracted from blood samples donated by infected volunteers.

The new research has been published in the journal Science. (ANI)

Ex-Soviet general”s interview reveals that USSR was almost defeated by the Nazis

London, May 5 (ANI): In a frank revelation, a former general of the Soviet Army has revealed that the Soviet Union was very close to being defeated by Adolf Hitler’s Nazis during the Second World War.

Recorded in 1966, Marshal Georgy Zhukov said in the interview that the Soviet Union nearly lost the war in 1941 and suffered from poor planning.

General Zhukov, the most decorated general in the history of both Russia and the Soviet Union, admitted that Soviet generals were not confident that they could hold the German forces at the Mozhaisk defence line outside Moscow.

“Did the commanders have confidence we would hold that line of defence and be able to halt the enemy? I have to say frankly that we did not have complete certainty,” The Telegraph quotes him, as saying in the interview.

“It would have been possible to contain the initial units of the opponent, but if he quickly sent in his main group, he would have been difficult to stop,” General Zhukov told Soviet writer Konstantin Simonov.

Zhukov also revealed details of his exchanges with Joseph Stalin, the wartime leader, in the interview broadcast on state-run Channel One.

He recalled that a flu-struck Stalin summoned him to Moscow in October 1941 to salvage what until then had been a stuttering defence on the Western front outside Moscow.

After arriving at the front, Zhukov found that the defences in place were “absolutely insufficient”.

“It was an extremely dangerous situation. In essence, all the approaches to Moscow were open,” he said. “Our troops on the Mozhaisk defence line could not have stopped the enemy if he moved on Moscow.”

“I telephoned Stalin. I said the most urgent thing is to occupy the Mozhaisk defence line, as in parts of the Western front in essence there are no (Soviet) troops.

Shortly afterwards, Stalin phoned Zhukov back to inform him he had been made commander of the Western Front.

The relationship between the two men would end in acrimony when Stalin became suspicious of Zhukov”s popularity after the war, giving him obscure posts in Odessa and the Urals.

Zhukov had been given the honour of leading the Red Army victory parade in 1945, riding into Red Square on a white stallion, and some historians believe Stalin feared being upstaged by the charismatic general.

After Stalin”s death, Zhukov served as defence minister but remained a controversial figure and the Soviet authorities ordered the tape of his interview with Simonov to be destroyed. However one archive copy survived.

The broadcast of the banned interview comes ahead of a huge parade on May 9 to mark the 65th anniversary of the defeat of Nazi Germany and as Russia appears to be cautiously eroding several taboos surrounding its war victory. (ANI)

Ferrer ends Murray’s good run at Rome Masters

London, Apr 30 (ANI): British tennis ace Andy Murray’s hopes of an extended run at the Rome Masters where dashed by David Ferrer who defeated him in straight sets 6-3, 6-4 in the third-round.

Murray was satisfied with his performance in the second round but was unable to break down the stout defences of the world No 17, who has now won more matches than anyone else on the circuit in 2010.

Ferrer has also recorded more victories on clay than anyone else and he notched up another here to prevent Murray regaining the world No.4 ranking from Argentina’s Juan Martin Del Potro, The Telegraph reports.

“I played well today. I had a lot of 0-30 games on his serve and the only disappointing thing was that I couldn’t take advantage. But the way I was striking the ball was way, way better than in my last two matches and if I keep playing like that I will start going deep in tournaments again soon,” Murray said.

One break in each set was enough to give Ferrer victory but his speed around the court made him dominate the match.

Murray hit seven aces but was never able to dominate on serve and the Spaniard continually put him under pressure. (ANI)

Desperate Crows recall Knights early

Adelaide has rushed the pivotal Chris Knights back into its side to play Melbourne on Sunday despite concerns about underdone players already in the team.

Knights suffered a pre-season stress fracture in his left foot and played one game in the SANFL before his recall, joining the likes of Brett Burton, Jason Porplyzia, Bernie Vince and Scott Thompson as players coming off interrupted preparations for 2010.

Senior coach Neil Craig said there was no point second-guessing the decision to recall Knights as the Crows try to gather some kind of momentum after abject defeats in their opening two rounds.

Among all the players on the Crows’ list, Knights is among the most important when at his best, offering a long-kicking forward option while tiring opposition defences with his hard tackling and boundless running.

“I watched him play a half last week for Woodville West Torrens and his form was pretty sound,” said Craig.

“He’s fit, he’s healthy, he’s fresh, he hasn’t played a lot of footy obviously, but that’s another one of those category players we’ve got.

“But in the end if we go with them we’ll go with it aggressively and get judged on performance.”

Craig accepted he should be held responsible if the players he has selected do not show themselves to be ready for battle – Burton and Porplyzia looked particularly ginger against Sydney in round two.

“I’ve always got a choice, I can elevate a rookie to play (instead),” he said.

“I’ve got choices and I make those choices and if they don’t work out the coach is always responsible.”

Another problem area for the Crows has emerged via the news that key forward Kurt Tippett is going to have to manage knee tendonitis this year, limiting his training load.

“Kurt’s got some knee soreness, some tendonitis but there are going to quite a few guys in the AFL with that,” Craig said.

“He trained fully today and the way we’ve tried to manage him is we’re happy for him to have a bit more recovery early in the week, but he needs to be able to do a full session on Wednesday or Thursday and he does very little in our last session.

“Then we back him in to be able to perform on that sort of program.”

Tippett’s goal-kicking has been notably off in the first two rounds, kicking 1.5 in two games while battling to have his expected impact, but Craig denied this was knee-related.

“No. I think that’d be too easy a way out,” he said.

“I think you saw uncharacteristically Jason Porplyzia last week, I would’ve nearly put my house on Jason kicking that goal, so we’ve got to keep strong with all that, because that’s often what happens, and we’ll just work through it.”

The Crows have elevated the former Brisbane Lions midfielder Chris Schmidt from their rookie list and named him in the 25-man squad.

They have also called in young tall Shaun McKernan to replace the hamstrung James Sellar, pointedly ignoring the more senior ruckman Jon Griffin, who was dropped after a poor display against Fremantle.

Bushfire compo case ‘complex and unpredictable’

“This area of the law, the tort or negligence liability of public bodies is actually quite complex and unpredictable.

“Some people would say it is even unprincipled but I think that goes a bit far.”

That is barrister Barbara McDonald’s assessment of the 2003 Canberra bushfires compensation hearing underway in the ACT Supreme Court.

More than 120 bushfire victims are seeking about $75 million in damages from the ACT and New South Wales governments.

Barbara McDonald is a Professor of Law at the University of Sydney and is widely regarded as an expert in Australian negligence law.

The hearing will determine whether the ACT or NSW authorities are liable for damages.

Professor McDonald says there are three key legal issues facing the plaintiffs and the two governments.

“Firstly, is there a duty of care in law to the individuals concerned?” she said.

“Secondly, was that legal duty of care breached?

“Were the fire authorities actually negligent in the circumstances?”

Professor McDonald says both questions are complicated because public bodies often have multiple responsibilities.

“Another aspect is that courts are very reluctant to review policy decisions of public bodies. There is a divide between what are called policy decisions and operational activities,” she said.

“The third issue is whether or not there are some special defences under local legislation which gives public bodies a good faith defence if they behave in a certain way,”

Vulnerability

Professor McDonald says vulnerability has become a key issue in negligence cases, including the current Canberra hearing.

“Were the plaintiffs vulnerable and couldn’t look after themselves? Were they very dependant on the defendant taking care?” she said.

She says these issues are crucial to bushfires plaintiff Wayne West’s case.

Mr West’s affidavit to the hearing described how helicopters used by NSW fire authorities took water from a dam on his property to fight fires elsewhere.

“The landowners own water stocks were appropriated by the fire service for everybody, but that of course made the individuals more vulnerable and less able to look after themselves and more dependant,” said Professor McDonald.

Uphill battle

Professor McDonald says the hearing will have major implications for Australian negligence law.

“If the plaintiffs win it will be an important example of a case where plaintiffs have succeeded against a public body,” she said.

Such wins are not common in liability cases domestically and internationally.

“It’s an uphill battle to bring a negligence case against any sort of public body,” Professor McDonald said.

“If the plaintiffs lose, it will reinforce the difficulty and reinforce the fact that it is very difficult to succeed,” she adds.

Professor McDonald says the case could encourage victims of Victoria’s Black Saturday bushfires to pursue legal action.

“A decision that one fire service was negligent is no precedent as to whether or not another fire service is negligent in different circumstances,” she said.

“But success in one place will greatly encourage others,” she adds.

Issues and recommendations

Professor McDonald says the case raises important philosophical and social issues for law and the public.

“Whether public bodies like a fire service should be treated differently from private citizens?” she says as an example.

“Whether the public interest in letting them get on with the job for the future should take priority over paying damages to individuals?”

Professor McDonald says once the case concludes recommendations will probably be made to other public bodies.

She says the recommendations are likely to include how they could avoid repeat cases.

“Negligence claims can have a regulatory effect on the way public bodies deal with the public in the future and deal with their resources,” she said.

“It is unlikely the court will get into reviewing policy decisions.

Hearing continues

Meanwhile, scores of plaintiffs and more than a dozen expert witnesses will continue to give evidence to the hearing over the next 10 weeks.

ACT Chief Justice Terence Higgins is then expected to reserve his judgment until later this year.

US taking Musharraf’s expose on aid use against India seriously

Washington, Sep.15 (ANI): The United States has said that it is taking revelations by former Pakistan President Pervez Musharraf that aid provided by America for the war against terrorism was diverted during his tenure to strengthen defences against India seriously.

State Department spokesman Ian Kelly told reporters here on Monday that Washington takes all such allegations seriously and there is a procedure to investigate any violation, diversion of its aid by any country. But Kelly refused to confirm if any investigation in this regard was already on.

He also said that the allegations were not specific and as of now the US was not aware of any such violations.

“This is a former President who has made these allegations. We take seriously any allegations like this. But simply we don’t have the details to be able to respond to the allegations,” Kelly said at a news briefing.

In an interview to a Pakistani news channel, Musharraf admitted that he had violated the rules governing the use of the military aid, but justified his action, saying he had “acted in the best interest of Pakistan”.

India’s Minister of State for External Affairs, Shashi Tharoor, said Musharraf’s revelation did not come as a surprise.

“We have for some years now arguing that the only problem we have with the US military aid to Pakistan is its misuse against us,” Tharoor said in New Delhi. (ANI)

Tharoor says US should monitor Pak aid in wake of Musharraf’s admission

New Delhi, Sep.14 (ANI): Minister of State for External Affairs Shashi Tharoor on Monday said he was not surprised by former Pakistan President Pervez Musharraf’s admission that the military aid the U.S. gave to Pakistan was used to strengthen defences against India rather than fighting the war on terror on Pakistan’s borders with Afghanistan.

Speaking to reporters outside his South Block office, Tharoor said: “We know Pakistan has been misusing US aid for years. I am not surprised by former President Musharraf’s statement. This confirms India’s stand on the misuse of aid. The United States should monitor aid given to Pakistan more carefully.”

Tharoor’s response came after Gen.(Retd.) Musharraf admitted that he had violated the rules governing the use of the military aid, but justified his action, saying he had “acted in the best interest of Pakistan.”

He did not want to compromise on Pakistan’s interests, he said.

In an interview to a news channel, he said he “did not care” whether the U.S. would be angered by his disclosure.

Musharraf said that had he not supported the U.S. in the war on terror after the September, 2001 attacks, American forces could have entered Pakistan to capture its nuclear assets; it was also possible that the U.S. and India could have jointly attacked the country. (ANI)

The chocolate bar that can render acne history

Melbourne, May 20 (ANI): They say it’s the worst enemy of clear skin, but eating chocolate could actually prove to be a lifesaver for people who abandon their social lives just because of acne.

Acne Care chocolate bars are said to deliver antioxidants and micro-nutrients that help clear the skin.

Makers of the revolutionary new chocolate, which is set to hit Australian shelves, claim that pimple-plagued sufferers will experience dramatic results within just two weeks of eating the chocolate.

Developed by US-based Frutels, the chocolate-coated treatment is believed to be the first of its kind and supports the body’s defences and clarifies the skin from within.

Frutels recommend consumers eat between two and five chocolates a day for the fastest results, reports News.com.au.

A company spokesman said: “This product takes beauty foods to another level by not only tackling acne care in an ingestible form, but by using a food that has been associated with causing acne to make these claims.

“Chocolate has long been taboo for acne sufferers.” (ANI)

Engineered viruses may help fight drug-resistant superbugs

London, Mar 3 (ANI): A virus that weakens bacterial defence systems is the latest weapon in the fight against drug-resistant superbugs.

Researchers in the United States have engineered viruses to weaken the bacteria, leaving the bugs more vulnerable to antibiotics, reports Nature.

The ‘bacteriophages’ or just ‘phages’ were programmed to target a DNA repair system that allows the bacteria to survive antibiotics.

Used alongside the drugs, the viruses wipe out bacterial defences and prevent resistance from developing.
With more bacteria becoming resistant to the most commonly used antibiotics, the viral approach could extend the useful lifetime of these drugs.

Bioengineer James Collins of Boston University in Massachusetts and his then graduate student, Timothy Lu, genetically engineered a phage called M13, which does not cause infected cells to explode, to produce a bacterial protein called lexA3 – which impairs a bacterium’s ability to repair damaged DNA.

When the modified M13 phage infects a bacterium, in this case Escherichia coli, it produces lexA3, which renders the bacterium more vulnerable to DNA-damaging drugs.

The researchers found that the phage increased the ability of the antibiotic ofloxacin to kill E. coli grown in culture, even when the bacteria were resistant to the antibiotic on its own.

The findings suggest that this type of phage therapy could rejuvenate antibiotics that have been deemed no longer effective.

The results of the study conducted on mice were also promising.

80 percent of animals that received both ofloxacin and the modified M13 phage survived infection with a disease-causing strain of E. coli, compared with only a 20 percent survival rate among infected mice treated with the antibiotic alone. (ANI)

Prehistoric Cambridge may have been a far bigger settlement than previously thought

London, Jan 28 (ANI): An archaeological dig has led to the surprising discovery of the site of a cemetery at Addenbrooke’s Hospital in Cambridge, England, which suggests that prehistoric Cambridge may have been a far bigger settlement than previously thought. iting this and other discoveries, a new book published by the Cambridge Archaeological Unit (CAU), has suggested that population density in the prehistoric and Roman eras may have been higher than earlier research had claimed.

Finds at the site ranged from the late Bronze Age to the middle Saxon period, and included a cemetery and a pottery kiln complex.

Archaeologists said small settlements may have been so close together that residents could wave to each other across the 300m stretches between their homes.

The book argues this knowledge should revolutionize understanding of the early society of Cambridge.

According to Christopher Evans, who put the book together, “The evidence from the huge-scale trench-survey projects that the unit has undertaken on both the adjacent Addenbrooke’s/ Clay Farm lands and other such projects in south-central Cambridgeshire indicate that the later prehistoric/Roman landscapes were much more densely settled than previously thought.”

Researchers also discovered that the site had been used for centuries by different groups.

“Under the pleasantly green and rolling landscape of the area there are multiple landscapes, and in the past, the area has hosted a lot of activity, both in terms of the scale of its Second World War defences and the density of its later prehistoric and Roman settlement, which included considerable industrial activity,” said Evans. (ANI)

How our body fights infection

Washington, Jan 6 (ANI): It is a well-known fact that our immune system adapts itself to every new microbe it encounters. Now, scientists from Wayne State University in Detroit have shed light on how human’s antibody-forming system makes “evolutionary leap” to stave off infection.

The study shows that a ”cluster mutations” help our antibody formation system adapt to infection.

The process involves altering the genes that code for antibodies to specific viruses or bacteria.

“We”ve known for a long time that our antibody-forming system adapts itself to every microbe we encounter but what we didn”t understand fully is exactly how this happens,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal.

“Now that we know, we can begin to find ways to manipulate this process so illnesses can be prevented or made significantly less dangerous,” he added.

When the body encounters a foreign invader, like a virus or bacterium, it immediately begins to find a way to neutralize it by means of cellular or antibody-mediated defences.

The process involves two types of genetic manipulation. One type changes a single gene at a time, and the other type changes multiple genes at the same time.

Scientists have explained how multiple genes can be modified simultaneously to make the “evolutionary leap” necessary to stave off infection.

During the study, the researchers treated DNA responsible for making antibody molecules with an enzyme, called activation-induced deaminase, while the DNA was being copied by RNA polymerase.

Like a scanner, RNA polymerase moves across the DNA to copy it. When this scanning process moved smoothly, there were either single mutations or no mutations.

When the researchers made the RNA polymerase stall along the DNA (under certain conditions), it caused several mutations at once (cluster mutations) in the DNA, adapting our antibodies for a rapid and effective response to a new microbial invader.

“As the planet warms, infectious diseases may be one the biggest threats to human survival,” Weissmann said.

“Nowadays, mosquitoes, parasites and viruses cause diseases in the United States that were once isolated to warmer parts of the world.

“They evolve, and – a la Darwin – so does our immune system each time we meet a new microbial invader,” he added.

The study appears in the FASEB Journal (ANI)

Sri Lankan Army attack on LTTE will aggravate tensions: Tamil leader

Chennai, Jan 3 (ANI): Tamil Nationalist Movement (TNM) leader Pazha Nedumaran has said that the Sri Lankan Army”s capture of Kilinochchi would intensify the LTTE”s movement in Sri Lanka.

“As the Kilinochchi is captured by the Sinhalese Army, it does not mean that the LTTE will stop the war, but it will be more dangerous to the Sinhalese Government. So far the LTTE followed the traditional way of fighting straight to straight but now they will go for guerrilla fight and no one can blame for this,” said opined Nedumaran.

Further, he said that the Sri Lankan President Mahinda Rajapakse had dishonoured the ceasefire with the LTTE and it is now difficult to predict the future outcome of present crisis.

“This capture of Kilinochchi has no meaning. It betrayed the cease-fire on the part of Rajapaksa. He did not honour the ceasefire. Henceforth, what will happen can”t be predicted. We hope Rajapaksa realises this,” added Nedumaran.

Sources from President Mahinda Rajapaksa”s office said that the
troops entered Kilinochchi from two locations and after a fierce confrontation with the tigers, the Lankan army was in control of the town.

On January 1, 2009 Lankan troops on captured Iranamadu junction, south of the LTTE”s self-proclaimed capital of Kilinochchi and Paranthan town to the north.

Sri Lanka”s military has been closing in on Kilinochchi since September last year. Over the past month, it has been assaulting Tiger defences encircling the town.

Meanwhile in Colombo, shortly after President Rajapakse”s announcement of the fall of Kilinochchi, a suspected suicide bomber attacked the headquarters of the Sri Lankan airforce killing atleast two persons and injuring about thirty others. (ANI)

Suicide bomb kills two near Sri Lankan Air Force headquarter in Colombo

Colombo, Jan.2 (ANI): At least two persons have died and 30 injured on Friday in the Sri Lanka capital after a Liberation Tigers of Tamil Eelam (LTTE) suicide bomber blew himself up near the Sri Lankan Air force headquarters.

The incident occurred after the news about Sri Lankan Army taking control of the LLTE’s de facto capital of Kilinochchi went public.

The explosion caused damage to a moving civilian bus in the area. The wounded have been rushed to nearby hospitals.

Meanwhile, Sri Lankan President Mahinda Rajapakse has termed the capture of LTTE-held Kilinochchi as an “unparalleled victory” for the forces.

Sources from President Mahinda Rajapaksa”s office said that the troops entered Kilinochchi from two locations and after a fierce confrontation with the tigers, the Lankan army was in control of the town.

“Presently the 57 division troops and one battalion of the Sri Lankan army have entered Kilinochchi town,” military spokesman Udaya Nanayakkara said.
On January 1, 2009 Lankan troops on captured Iranamadu junction, south of the LTTE”s self-proclaimed capital of Kilinochchi and Paranthan town to the north.
Sri Lanka”s military has been closing in on Kilinochchi since September last year.

Over the past month, it has been assaulting Tiger defences encircling the town. (ANI)

Sri Lankan army captures LTTE’s headquarter

Colombo, Jan.2 (ANI): The Sri Lankan army has seized the Tamil Tigers” de facto capital of Kilinochchi.

Sources from President Mahinda Rajapaksa”s office said that the
troops entered Kilinochchi from two locations and after a fierce confrontation with the tigers, the Lankan army was in control of the town.

“Presently the 57 division troops and one battalion of the Sri Lankan army have entered Kilinochchi town,” military spokesman Udaya Nanayakkara said.

On January 1, 2009 Lankan troops on captured Iranamadu junction, south of the LTTE”s self-proclaimed capital of Kilinochchi and Paranthan town to the north.

Sri Lanka”s military has been closing in on Kilinochchi since September last year. Over the past month, it has been assaulting Tiger defences encircling the town.

Meanwhile in Colombo, shortly after President Rajapakse”s announcement of the fall of Kilinochchi, a suspected suicide bomber attacked the headquarters of the Sri Lankan airforce killing atleast two persons and injuring about thirty others. (ANI)

Novel molecule that mounts two-pronged attack on skin cancer identified

Novel molecule that mounts two-pronged attack on skin cancer identifiedLondon, Nov 3: A novel designer molecule, created by researchers at the University of Bonn, can attack malignant melanoma via two completely different routes.

In the first route, the substance makes use of its structure, which is quite similar to components of viruses, to alert the immune system. At the same time, the own defences of the body are also strengthened against cancer cells.

The molecule also puts pressure on the tumour in a different way, and turns off a specific gene in the malignant cells, which ultimately leads them to suicide.

Thus, by using this two-pronged strategy, scientists have been able to fight metastases in the lungs of mice suffering from cancer.

For the study, the researchers resorted to a method called RNA interference, in which small RNA molecules can be used to target certain genes and switch them off.

“We used this method in order to drive the tumour cells to suicide,” Nature magazine quoted the Bonn dermatology researcher Professor Thomas Tuting as saying.

The scientists explained that each body cell is equipped with a corresponding suicide programme, which gets activated if the cell becomes malignant. But it dies before doing any more harm.

“But in tumours a gene is active that suppresses this suicide programme. We have pinpointed this gene and switched it off by using RNA interference,” Professor Tuting.

In fact, the scientists in the study also tried to deal with cancer by another route.

“We basically “disguised” our RNA. That is why the immune system took it for the genetic makeup of a virus,” said Professor Gunther Hartmann, director of the Institute of Clinical Chemistry and Pharmacology.

There are many viruses that use RNA to store information, thus, if the body discovers RNA fragments, which it takes to be the genetic makeup of a virus, it prepares an attack on them.

In this way, the body”s defences were prompted to tackle the tumour cells far more aggressively than normal.

”The beauty of this method is that we can attack the cancer with one designer molecule along two completely different routes. This way the tumour is deprived of opportunities of sidestepping the attack that make successful therapy so difficult in other cases,” said Professor Hartmann.

After conducting initial experiments in mouse models, the researchers found that the new molecule significantly inhibits growth of metastases in the lungs. The therapy even led to the secondary tumours becoming smaller or even disappearing entirely.

The study is published in the latest issue of Nature Medicine’s. (ANI)