Broccoli may help fight breast cancer

Washington, May 4 (ANI): A broccoli compound may help prevent or treat breast cancer by targeting cancer stem cells, according to a new study.

Stem cells are the small number of cells that fuel a tumor”s growth.

The study from researchers at the University of Michigan Comprehensive Cancer Center tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures.

Researchers found sulforaphane targeted and killed the cancer stem cells and prevented new tumors from growing.

“Sulforaphane has been studied previously for its effects on cancer, but this study shows that its benefit is in inhibiting the breast cancer stem cells. This new insight suggests the potential of sulforaphane or broccoli extract to prevent or treat cancer by targeting the critical cancer stem cells,” says study author Duxin Sun, Ph.D., associate professor of pharmaceutical sciences at the U-M College of Pharmacy and a researcher with the U-M Comprehensive Cancer Center.

Results of the study appear in the May 1 issue of Clinical Cancer Research. (ANI)

Obesity a factor in how kids metabolize drugs

Washington, April 28 (ANI): Children who are overweight or obese metabolize drugs differently than normal-weight kids, according to a new study.

As part of the study, researchers from the University of Minnesota College of Pharmacy evaluated drug metabolism in sixteen healthy weight children and nine obese children.

“We have known for years that drugs metabolize differently in obese adults as compared to healthy weight adults. But, there has been very little, if any, information available that specifically addresses the consequences of obesity on drug metabolism in children. Without this information, our ability to identify optimal drug dosing in children often relies on trial and error approaches,” said L”Aurelle Johnson in the Department of Experimental and Clinical Pharmacy.

In the study, Johnson and co-author Manoj Chiney examined drug metabolizing enzyme activity in healthy weight and obese children, age 6 to 10 years old.

Specifically, they looked at how the children metabolized caffeine and dextromethorphan, a key ingredient in the cough suppressant Robitussin DM.

They found that obese children metabolized both drugs at different rates than healthy weight children.

Johnson said this finding is the first of many steps in determining the overall effect of obesity on drug absorption, distribution, metabolism and elimination in children.

She plans to conduct additional research to define the activity of other drug metabolizing enzymes that may also be altered in the pediatric population as a result of obesity.

“Collectively, such knowledge concerning key factors that impact activity of drug metabolizing enzymes in children will have a significant positive impact on the development of optimal drug dosing regiments in children in order to maximize efficacy, while minimizing potential adverse drug effects, in the treatment of serious diseases such as cancer,” said Johnson.

Johnson will present the research at the American Society for Pharmacology and Experimental Therapeutics annual meeting. (ANI)

‘Indestructible’ plastics decompose quickly to toxify world’s oceans

Washington, August 20 (ANI): A new study has determined that plastics, which are reputed to be virtually indestructible, decompose with surprising speed and release potentially toxic substances into the water.

This is the first study to look at what happens over the years to the billions of pounds of plastic waste floating in the world’s oceans.

Scientists always believed that plastics in the oceans were unsightly, but a hazard mainly to marine animals that eat or become ensnared in plastic objects.

“Plastics in daily use are generally assumed to be quite stable,” said study lead researcher Katsuhiko Saido.

“We found that plastic in the ocean actually decomposes as it is exposed to the rain and sun and other environmental conditions, giving rise to yet another source of global contamination that will continue into the future,” he said.

He said that polystyrene begins to decompose within one year, releasing components that are detectable in the parts-per-million range.

Those chemicals also decompose in the open water and inside marine life.

However, the volume of plastics in the ocean is increasing, so that decomposition products remain a potential problem.

According to Saido, a chemist with the College of Pharmacy, Nihon University, Chiba, Japan, his team found that when plastic decomposes, it releases potentially toxic bisphenol A (BPA) and PS oligomer into the water, causing additional pollution.

Plastics usually do not break down in an animal’s body after being eaten. However, the substances released from decomposing plastic are absorbed and could have adverse effects.

BPA and PS oligomer are sources of concern because they can disrupt the functioning of hormones in animals and can seriously affect reproductive systems.

Some studies suggest that low-level exposure to BPA released from certain plastic containers and the linings of cans may have adverse health effects.

Saido described a new method to simulate the breakdown of plastic products at low temperatures, such as those found in the oceans.

The process involves modeling plastic decomposition at room temperature, removing heat from the plastic and then using a liquid to extract the BPA and PS oligomer.

Typically, styrofoam is crushed into pieces in the ocean and finding these is no problem, he said.

But, when the study team was able to degrade the plastic, it discovered that three new compounds not found in nature formed, which are highly toxic. (ANI)

Online prescription drug purchase may endanger your health, warns expert

Washington, July 12 (ANI): An expert at The University of Texas at Austin warns that prescription drugs’ purchase via the Internet, though more convenient, may endanger the buyer’s health.

“There’s a big problem with rogue Web sites,” says Dr. Marv Shepherd, the Klinck Centennial Professor in the College of Pharmacy and director of the Center for Pharmoeconomic Studies at the university.

“It’s very difficult to determine whether a Web site represents an authentic pharmacy or a counterfeit drug pharmacy. You can’t tell the good guys from the bad guys,” adds Shepherd, whose research and expertise on drug importation and drug counterfeiting has been featured on CNN, NPR and in Newsweek, Time, U.S. News and World Report, the New York Times, Washington Post and USA Today, among others.

Shepherd reports that the Food and Drug Administration (FDA) surveyed Canadian pharmacy Web sites, and found 11,000 Web sites claiming to be Canadian sites selling pharmaceuticals.

However, according to the researcher, closer analysis revealed that only 214 pharmacies in Canada sell pharmaceuticals over the Web.

As regards the other 10,000-plus sites, he said that they included website in Pakistan, Southeast Asia, Mexico and even Washington State.

He warned that consumer ordering pharmaceuticals from them might receive counterfeit drugs with incorrect dosage, false labeling, no pharmaceutical benefit or worse.

“For many counterfeit products, it is difficult to distinguish the genuine product from the counterfeit product without a forensic test. They may have the brand name on them, but they aren’t the brand name product,” Shepherd says.

He says that people can avoid the risk by confirming if a pharmacy is licensed in the state, by checking the National Association of Boards of Pharmacy (NABP) for links to their state board.

He says that people can also look for the Verified Internet Pharmacy Practice Sites seal on the site. By clicking on the seal, he adds, a visitor is linked to a site where information about the pharmacy is maintained by the NABP. (ANI)

Novel genetic regulator involved in head, throat cancers discovered

Washington, Apr 29 (ANI): In a major scientific advancement, pharmacy researchers at Oregon State University have discovered a genetic regulator, called CTIP2, which is expressed at higher levels in the most aggressive types of head and neck cancers.

The study might help in the identification of these cancers earlier or even offer a new therapy at some point in the future.

In a recent research, the “transcriptional regulator” CTIP2 was demonstrated to be a master regulator that has important roles in many biological functions, ranging from the proper development of enamel on teeth to skin formation and the possible treatment of eczema or psoriasis.

But, in the latest study, scientists found for the first time that levels of CTIP2 were more than five times higher in the “poorly differentiated” tumour cells that caused the most deadly types of squamous cell carcinomas in the larynx, throat, tongue and other parts of the head.

The researchers even found a high correlation between greater CTIP2 expression and the aggressive nature of the cancer.

They said that head and neck squamous cell cancers are the sixth most common cancers in the world, and a significant cause of mortality. They have been linked to such things as tobacco use and alcohol consumption.

“Serious head and throat cancer is pretty common, and mortality rates from it haven’t improved much in 20 years, despite new types of treatments. With these new findings, we believe it should be possible to create an early screening and diagnostic tool to spot these cancers earlier, tell physicians which ones need the most aggressive treatments and which are most apt to recur,” said Gitali Indra, an assistant professor in the OSU College of Pharmacy.

The scientists hope that the work could lead to new therapeutic approaches.

Also they said that this genetic regulator could be involved in both skin development and these types of cancer makes some sense, as both originate from epithelial cells.

The study speculated that CTIP2 could help regulate the growth of what is believed to be a cancer “stem” or “progenitor” cell, which has a greater potential to generate tumours through the stem cell processes of self-renewal and differentiation into multiple cell types.

Therefore, targeting cancer stem cells holds promise for improvement of survival and quality of life of cancer patients.

The study is published in PLoS ONE a professional journal. (ANI)