Scientists unravel chemistry of Titan’s hazy atmosphere

Washington, September 16 (ANI): In a new research, a team of scientists has unraveled the chemical evolution of the orange-brownish colored atmosphere of Saturn’s moon Titan, the only solar system body besides Venus and Earth with a solid surface and thick atmosphere.

Scientists at University of Hawai’i at Manoa carried out the research.

The UH Manoa team, including Xibin Gu and Seol Kim, conducted simulation experiments mimicking the chemical reactions in Titan’s atmosphere utilizing crossed molecular beams in which the consequence of a single collision between molecules can be followed.

The team’s experiments indicate that triacetylene can be formed by a single collision of a “radical” ethynyl molecule and a diacetylene molecule.

An ethynyl radical is produced in Titan’s atmosphere by the photodissociation of acetylene by ultraviolet light.

Photodissociation is a process in which a chemical compound is broken down by photons.

“Surprisingly, the photochemical models show inconsistent mechanisms for the production of polyynes,” said Kaiser, who is the principal investigator of this study.

The mechanism involved in the formation of triacetylene, was also confirmed by accompanying theoretical calculations by Alexander Mebel, a theoretical chemist at Florida International University.

These theoretical computations also provide the 3D distribution of electrons in atoms and thus the overall energy level of a molecule.

To apply these findings to the real atmosphere of Titan, Danie Liang and Yuk Yung, planetary scientists at Taiwan’s Academia Sinica and California Institute of Technology (Caltech), respectively, performed photochemical modeling studies of Titan’s atmosphere.

All data together suggest that triacetylene may serve as a building block to form more complex and longer polyynes and produce potential precursors for the aerosol-based layers of haze surrounding Titan.

The study demonstrated for the first time that a sensible combination of laboratory simulation experiments with theory and modeling studies can shed light on decade old unsolved problems crucial to understand the origin and chemical evolution of the solar system.

The researchers hope to unravel next the mystery of the missing ethane lakes on Titan – postulated to exist for half a century, but not detected conclusively within the framework of the Cassini-Huygens mission.

In the future, the UH Manoa team will combine the research results with terrestrial-based observations of Titan’s atmosphere. (ANI)

Scientists make first high-resolution 3D images of a polymer solar cell’s insides

Washington, September 14 (ANI): Researchers from the Eindhoven University of Technology and the University of Ulm in Germany have made the first high-resolution 3D images of the inside of a polymer solar cell.

This gives them important new insights in the nanoscale structure of polymer solar cells and its effect on the performance.

The investigations shed new light on the operational principles of polymer solar cells.

These solar cells do not have the high efficiencies of their silicon counterparts yet. Polymer cells, however, can be printed in roll-to-roll processes, at very high speeds, which makes the technology potentially very cost-effective.

Added to that, polymer cells are flexible and lightweight, and therefore suitable to be used on vehicles or clothing or to be incorporated in the design of objects.

In these hybrid solar cells, a mixture of two different materials, a polymer and a metal oxide are used to create charges at their interface when the mixture is illuminated by the sun.

The degree of mixing of the two materials is essential for its efficiency.

Intimate mixing enhances the area of the interface where charges are formed but at the same time obstructs charge transport because it leads to long and winding roads for the charges to travel.

Larger domains do exactly the opposite.

The vastly different chemical nature of polymers and metal oxides generally makes it very difficult to control the nanoscale structure.

The Eindhoven researchers have been able to largely circumvent this problem by using a precursor compound that mixes with the polymer and is only converted into the metal oxide after it is incorporated in the photoactive layer.

This allows better mixing and enables extracting up to 50 percent of the absorbed photons as charges in an external circuit.

The importance of the degree of mixing was clearly demonstrated by visualization of the structure of these blends in three dimensions.

Traditionally such visualization has been extremely challenging, but by using 3D electron tomography, the team has been able to resolve the mixing with unprecedented detail on a nanoscale.

From these images, the researchers at the Institute of Stochastics in Ulm have been able to extract typical distances between the two components, relating to the efficiency of charge generation, and analyze the percolation pathways, that is, how much of each component is connected to the electrode.

These quantitative analyses of the structure matched perfectly with the observed performance of the solar cells in sunlight. (ANI)

New method to monitor early sign of oxidative stress that triggers cancer

Washington, Sept 12 (ANI): Scientists from University of Michigan have developed a new method to monitor early sign of oxidative stress that triggers cancer spread.

Lead researcher Kate Carroll suggests that being able to monitor a marker of oxidative stress that is associated with the activation of tumor cell growth pathways, particularly at an early stage, and then tailor treatments accordingly would allow for more targeted studies and might improve the odds of success with antioxidants and pro-oxidants.

The new method detects sulfenic acid in proteins-a tip off to early oxidative stress and to a specific protein modification associated with cell growth pathways.

Sulfenic acid is produced when a particular oxidant, hydrogen peroxide, reacts with the protein building block cysteine. But because the chemical modification involved is so small and transient, it has been difficult to detect.

To get around that problem, Carroll and Seo used a chemical probe that “traps” sulfenic acid and tags it for recognition by an antibody.

The antibody is labeled with a fluorescent dye that glows when observed with a fluorescence microscope.

The researchers then used the method to assess sulfenic acid levels as a marker of oxidative stress in several systems, including a panel of breast cancer cell lines.

“For each line, we saw a very distinct pattern of sulfenic acid modifications,” indicating different oxidative stress levels and hinting at differences in the underlying molecular events associated with tumor growth,” said Carroll, assistant professor of chemistry and a research assistant professor in the Life Sciences Institute.

“Whether the patterns we see will correlate with response to antioxidant treatment or other therapies that modulate oxidative stress level remains to be seen, but now we at least have a way to investigate that question,” the expert added.

The study appears in Proceedings of the National Academy of Sciences. (ANI)

Men’s sweat ‘boosts their attractiveness in the eyes of women’

London, Sept 11 (ANI): A naturally present chemical in men’s sweat may act as a primitive love potion that increases their attractiveness in women’s eyes, says a new study.

The substance is derived from the male sex hormone testosterone.

To reach the conclusion, Tamsin Saxton of the University of St Andrews studied the influence of androstadienone by dabbling a drop of it on the upper lip of 50 women who took part in the evening trial before they “dated” a series of men.

From analyses, researchers found that women of all ages rated the men slightly higher on a scale of attractiveness when given the substance, compared to water or clove oil, but the effect was greatest in younger women aged between 18 and 22, reports The Independent.

“For some of the women we gave them androstadienone and we put it in clove oil solution so they just smelt clove oil. Some of the women had clove oil alone, and the third group had just water so there was no odour at all,” she told the British Science Festival.

“We got the women to mark how attractive they thought the men were on a one to seven scale after they interacted with each man,” she said.

“We found that the women given androstadienone had given slightly higher ratings of attractiveness to the men. That suggested this constituent of sweat does seem to have some kind of impact on attraction,” she told the festival.

“Some people don’t seem to be able to smell it all, some people say it smells OK or a bit sweaty, whereas others say it smells really awful, like babies’ nappies,” Saxton said.

According to the expert, one hypothesis is that it could be a “pheromone”, or chemical messenger that acts between individuals in much the same way that hormones act as messengers within the body.

“It’s something that people investigate on the topic of pheromones. When you talk of animal pheromones, they are involved in very specific reactions,” Saxton said.

“People do value somebody’s natural skin smell and it’s worth bearing in mind that this may be part of your appeal – how you smell naturally,” she told the festival. (ANI)

Newly developed thin films show promise for solar applications

Washington, September 9 (ANI): Researchers at Ben-Gurion University (BGU) of the Negev in Israel have developed thin films that exhibit carrier multiplication (CM), which shows promise future solar applications.

The films were synthesized at BGU by Professor Yuval Golan and PhD student Anna Osherov of the Department of Materials Engineering and the Ilse Katz Institute for Nanoscale Science and Technology.

One of the important factors limiting solar-cell efficiency is that incident photons generate only one electron-hole pair, irrespective of the photon energy.

Any excess photon energy is lost as heat.

Carrier Multiplication (CM) has been thought to be enhanced significantly in nanocrystalline materials such as quantum dots, owing to their discrete energy levels and enhanced Coulomb interactions.

The BGU team demonstrated that contrary to this expectation, for a given photon energy, carrier multiplication occurs more efficiently in bulk PbS and PbSe films than in nanocrystalline films of the same materials.

“Films developed at BGU show CM, in which each incoming photon (tiny quantity of sunlight) creates more than one electron-hole pair,” Golan explained.

“This can potentially be used for making more efficient solar cells. The new physics behind this work are that while CM has been mostly demonstrated in nanocrystalline materials (“quantum dots”), we now show that CM can be obtained also in single crystal (‘bulk’) films of lead sulfide and lead selenide,” he said.

Notably, the films were prepared using chemical solution deposition, an attractive, inexpensive deposition technique for which the Golan group at BGU has received considerable recognition. (ANI)

Fat-rich junk food may alter genes linked with type II diabetes

London, September 8 (ANI): A team of scientists in Sweden have warned that gorging too much on fat-rich junk food may cause drastic changes to a gene that helps muscle cells burn fat.

Juleen Zierath, of the Karolinska Institute in Stockholm, says that her team’s findings may help improve the scientific understanding of how type II diabetes develops in adulthood.

“Somehow, the environment plays on the genes we have,” says the lead researcher, adding that her study provides new clues to how this happens.

She says that it may be possible that the altered cells become so engorged with unburnt fat that they become “diabetic”, and stop accepting signals from the hormone insulin, which normally triggers the absorption of glucose from the bloodstream.

However, proving that components in the diet can permanently alter genes is itself a breakthrough, as it provides the first evidence that the food people eat may change the function of their DNA, a process scientifically known as “epigenetics”.

During the study, the researchers observed that the DNA itself remained unchanged, except for a masking process called methylation that can permanently mothball a gene by capping individual chemical units or bases.

Before the researchers undertook this research, they had already found in a previous study that muscle cells from people with type II diabetes showed such telltale epigenetic alterations to their DNA, particularly in the PGC-1 gene, which orchestrates metabolic programmes critical to the burning of fat in mitochondria, the chambers in cells that generate energy.

In the current study, the researchers achieved the most significant result when they exposed the healthy muscle cells to the edible fatty acid, palmitic acid.

The team found that the PGC-1 gene became methylated, just as it is in people with diabetes.

“The palmitic acid essentially switches off the gene,” New Scientist magazine quoted Zierath as saying.

She says that the fact that fat produces such an effect is highly significant, as it means that over-consumption of junk food may cause the same response.

“It suggests that if you eat a fat-rich diet, something in that – either the fat itself or the build up of metabolites – triggers the methylation of genes. The net effect is that it switches off the gene,” says Zierath.

The team’s analyses also reveal that the shutdown of PGC-1 led to inactivation of other genes vital for burning or transporting fat.

Zierath says that her team’s next step will be to find out how different diets affect the methylation status of PGC-1 and other genes vital for burning energy, hoping that their efforts will lead to the discovery of a potential mechanism by which type II diabetes develops.

A research article on her study has been published in the journal Cell Metabolism. (ANI)

Xinjiang riots: Urumqi party chief, Xinjiang police chief removed

Urumqi, Sep. 6 (ANI): In the aftermath of Xinjiang riots that erupted on July 5, the party chief of Urumqi and police chief of northwest China’s Xinjiang Uygur Autonomous Region have been sacked.

According to a decision by the CPC Xinjiang Autonomous Regional Committee, Li Zhi, secretary of the Urumqi Municipal Committee of the Communist Party of China (CPC), was replaced by Zhu Hailun.

Xinjiang’s police chief Liu Yaohua was also replaced by Zhu Changjie, party chief of Xinjiang’s Aksu Prefecture, Xinhua reports.

Fresh protests broke out this week after hundreds of Urumqi residents said that they were attacked by syringes. Five people were killed in the following protests.

Local hospitals had dealt with 531 victims of hypodermic syringe stabbings by Thursday, 106 of whom showed obvious signs of needle attacks.

Chinese military medical experts on Saturday ruled out the possibility that radioactive substance, anthrax and toxic chemical were used in recent syringe attacks in Urumqi City.

“According to the preliminary test results, such possibilities can be ruled out,” said Qian Jun, director of Disease Control and Biological Security Office with China’s Academy of Military Medical Sciences.

Samples had been sent to Beijing for further test, he added.

Xinjiang police has captured 25 suspects amid the syringe scare. (ANI)

Why broccoli, cabbage, cauliflower are good for heart

Washington, Sept 5 (ANI): Here’s why broccoli, cabbage and cauliflower are good for the heart – a chemical found in these vegetables can boost a natural defence mechanism to protect arteries from disease.

The build up of fatty plaques in arteries called atherosclerosis leads to heart disease.

The Imperial College London team has shown that a protein that usually protects against plaque build up called Nrf2 is inactive in areas of arteries that are prone to disease.

Treatment with a chemical found in green “brassica” vegetables such as broccoli can activate Nrf2 in these disease-prone regions.

“We found that the innermost layer of cells at branches and bends of arteries lack the active form of Nrf2, which may explain why they are prone to inflammation and disease,” BBC News quoted lead researcher Dr Paul Evans as saying.

“Treatment with the natural compound sulforaphane reduced inflammation at the high-risk areas by ‘switching on’ Nrf2.

“Sulforaphane is found naturally in broccoli, so our next steps include testing whether simply eating broccoli, or other vegetables in their ‘family’, has the same protective effect.

“We also need to see if the compound can reduce the progression of disease in affected arteries,” he added.

Professor Peter Weissberg, medical director of the British Heart Foundation, which funded the research said that the new findings provide a possible mechanism by which eating vegetables protects against heart disease.

During the study, the researchers genetically engineered mice to lack the Nrf2 protein.

The research found that in straight sections of arteries Nrf2 was present in the endothelial ‘lining’ cells. Through its action on other proteins, it prevented the cells from becoming inflamed, an early stage in the development of atherosclerosis.

The study appears in Arteriosclerosis Thrombosis and Vascular Biology. (ANI)

Indian-origin scientists find novel therapeutic target for autoimmune diseases

London, Sept 2 (ANI): A research team led by Indian-origin scientists from University of Michigan have discovered a new mechanism that would help in future therapies for conditions ranging from autoimmune diseases to organ transplants to cancer.

U-M biochemistry professor Ruma Banerjee and her colleagues have identified a mechanism that keeps a check on aggressive immune cells that can attack the body’s own cells.

They found that immune system’s regulatory T cells influence aggressive immune cells by regulating the chemical environment between cells.

“Now we know that the redox environment outside the cell is a very important dynamic. It regulates cell function,” Nature quoted Banerjee as saying.

The processes known as redox chemistry are fundamental to the way cells derive and consume energy.

She said that regulatory T cells appear to alter the chemical environment around their aggressive cousins, known as autoreactive T cells, which either curb them or cause them to proliferate.

This mechanism is likely to be involved in inflammatory bowel disease (IBD) and ulcerative colitis.

The study conducted over live mouse immune cells showed that important redox communication occurs between dendritic cells, which are the first immune cells to detect a foreign agent, and autoreactive T cells.

Dr Sanjay Garg, a research investigator in the U-M Department of Biological Chemistry, said that the dendritic cells alter the chemical environment outside cells in a way that promotes activation of the T cells.

But then T regulatory cells “intervene in the redox chatter” and suppress that effect.

Banerjee insists that she needs to conduct more study to fully understand the process before they can use their insights to block or encourage T regulatory cell activity in animal studies of IBD or another autoimmune disease.

The study appears in Nature Chemical Biology. (ANI)

US report reveals Pak enhancing nuke weapon capability to target India

Washington, Sep.1 (ANI): Top US nuclear scientists have shockingly revealed in a report that Pakistan is enhancing its nuclear weapons and production capabilities.

According to the report, which is yet to enter the public domain, Pakistan is readying a new nuclear capable ballistic missile for deployment and two nuclear capable cruise missiles.

It also says that Pakistan is building two new plutonium production reactors and a second chemical separation facility at Chasma, Khushab and Dera Ghazi Khan in southern Punjab.

Pakistan is also renewing work on a partially built separation plant at Chasma.

It is believed that this secretive and substantial arsenal build-up is targeted at India.

Based on official estimates of Pakistan’s current uranium and plutonium technology, scientists had so far thought the country far short of having a 100 nuclear warheads in its kitty.

The new report, however, suggests that Pakistan has exceeded earlier estimates, and from being able to build 30-40 nuclear weapons it actually could possess as many as 70-90 – a disturbing figure from India’s point of view and that of the US, currently debating financial and military aid to its friend in keeping with the AFPAK agreement.

Moreover, if this report is true Pakistan is clearly going beyond the moratorium existing as an unwritten code of conduct in South Asia to halt the arms race. (ANI)

New ultrasensitive electronic sensor to speed up DNA testing (corrected)

Washington, Sept 1 (ANI): Singapore scientists have developed a new ultrasensitive electronic sensor that would speed up DNA testing for disease diagnosis and biological research.

The novel electronic sensor array would be rapid, accurate and cost-efficient.

According to lead researcher Dr Zhiqiang Gao, from Singapore’s Institute of Bioengineering and Nanotechnology (IBN), the Nanogap Sensor Array has shown “excellent” sensitivity at detecting trace amounts of DNA.

“By saving time and lowering expenses, our newly developed Nanogap Sensor Array offers a scalable and viable alternative for DNA testing,” said Gao.

The biosensor translates the presence of DNA into an electrical signal for computer analysis.

The distinctively designed sensor chip has the ability to detect DNA more efficiently by “sandwiching” the DNA strands between the two different surfaces.

“The novel vertical nanostructure design and two different surfaces of the sensor allow ultrasensitive detection of DNA,” said Gao.

“This sensitivity is best-in-class among electrical DNA biosensors. The design of the sensor also took into consideration the feasibility of mass production in a cost-effective way for expanded usage,” the expert added.

Presently, human DNA is detected through the use of polymerase chain reaction (PCR), which while effective, is also expensive, cumbersome and time-consuming for widespread use.

Although effective, tests involving PCR may not be optimal for situations such as a pandemic outbreak.

The biosensor captures DNA strands more effectively. This is possible because the two surfaces of the sensor are coated with a chemically treated “capture probe” solution through an electrochemical technique specially developed by IBN.

This allows DNA strands to “stick” more easily to the sensor, resulting in a faster and more accurate analysis.

“This new biosensor holds significant promise to speed up on-going efforts in the detection and diagnosis of debilitating diseases such as cancer, cardiovascular problems and infectious viruses,” said Dr Jackie Y. Ying, Executive Director of IBN, one of the research institutes of Singapore’s Agency for Science, Technology and Research (A*STAR).

“We aim to make healthcare accessible to the masses with early disease diagnosis as the critical driving force behind the research we undertake here at IBN,” she added.

The study appears in Journal of the American Chemical Society. (ANI)

Ahmedabad victims died of drinking chemical not hooch: Police

Ahmedabad (Gujarat), Aug 29(ANI): Ahmedabad Police on Saturday clarified that two people who died on Friday, died due to consumption of drinks having chemical content.

Police has dismissed assumption that they were victims of country-made liquor known as ‘hooch’, and said that the Forensic Science Laboratory report confirmed that they took a substance having chemicals.

“I don’t know what they thought of it while drinking the substance. We don’t want to defend them, but those two people who died and those who were admitted to hospital not because they drank poisonous alcohol but they consumed chemical,” said Shabbir Hussain Khandwawala, Director General of Police (DGP) of Gujarat.

“I don’t know whether they drank it thinking it was alcohol, it’s a matter of investigation,” he added.

Three others, who fell ill after consuming the drink, were being treated in a hospital. (ANI)

Hooch claims two lives in Ahmedabad

Ahmedabad, Aug 29 (ANI): Ahmedabad police recovered the bodies of two persons who died after allegedly consuming illicit liquor on Friday.

Three other persons are undergoing treatment at the hospital.

Relatives of victims accused the government of not taking steps to prevent the vending of illicit liquor.

“My father was complaining of a headache so I asked him to go to hospital but he didn’t want to go there then I said that take some tea. When we went for tea then we saw the dead body of a man who consumed liquor a day before, he died today after complaining of vomiting and stomach ache…there is no one to take care of poor, every one cares of rich people,” said Seema Ben, daughter of a victim.

However, police officials said that whether the victims had died after consuming illicit or poison could be ascertained only after reviewing post mortem reports.

“We can’t say that the victims consumed illicit liquor or not at this moment of time. However, doctors at the VS Hospital are said that the victims consumed some chemical but we would only say something on this only after reviewing post mortem reports,” said H. K. Mehta, additional commissioner of Police, Ahmedabad.

At least 132 people died of consuming illicit liquor in Ahmedabad in July.

Illicit liquor, also known as grog or hooch, is a flourishing beverage in India, particularly in states like Gujarat where prohibition is in force.

The illicit liquor is much cheaper as compared to the licensed drinks, which cannot be afforded by most of the people from the poorer sections of society. (ANI)

Novel method to make safer human stem cells uses just one gene

London, Aug 29 (ANI): Inching closer to curing diseases like Parkinson’s using cells generated from a patient’s own body, researchers have successfully reprogrammed human nerve cells back to an embryo-like state by using just a single gene.

It is known that embryonic stem cells are pluripotent – they can develop into any of the body’s cell types.

But such cells are not available in large numbers, as they can only be harvested from a donated egg or embryo, and, for ethical reasons, most countries have laws restricting their use.

In 2006, Shinya Yamanaka and his colleagues at Kyoto University in Japan successfully made mouse cells pluripotent by reprogramming skin cells into a state like embryo cells.

They did so by using retroviruses to insert four genes – known as “factors” – into the cells’ DNA.

They repeated the trick a year later with human cells.

However, using genes and retroviruses in this way increases the risk of the cell becoming cancerous, not just because tinkering with DNA has that effect, but also because two of the four factors are known to cause cancer.

In a bid to make these promising cells in a safe way, Hans Scholer’s team at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, has been working to achieve pluripotency using fewer factors.

Last year, they did this with the two factors that do not cause cancer, and now they have simplified the recipe further, doing it with just one.

“Remarkably, it turns out that three of these four essential factors are already expressed in human neural stem cells – although not in skin cells – so we only needed to add one factor, OCT4,” New Scientist quoted Boris Greber, a member of the team, as saying.

He said that the cells from neural tissue are much easier to reprogram than skin cells, and are less prone to mutations.

It is much harder to get a sample of neural stem cells than skin cells, as it can be done via extracting the cells from the dental pulp of teeth, said Greber.

Inserting even one gene into the chromosome of a cell still permanently modifies its DNA, which is why the new method will remain a lab tool instead of being allowed in the clinic.

However, the researchers are hoping that it will help them improve methods for producing embryonic stem cells.

“Ideally, we will be able to find a chemical that does the same job of expressing the factor without the need for a gene,” said Greber.

Earlier this year, researchers in California managed just that when they reprogrammed mouse fibroblasts using a cocktail of proteins.

That technique did not involve inserting genes, and, thus, shouldn’t raise the cancer risk. But that was far less efficient.

“Without stable intervention using viruses, the frequency of reprogramming goes down and you have to wait a long time. We don’t have the perfect method yet,” said Greber.

The study has been published in the journal Nature. (ANI)

Scientists uncover vulnerable enzyme that can be targeted to kill dangerous pathogens

Washington, August 28 (ANI): A collaborative study conducted by researchers from three institutions in the U.S. has shown that an enzyme, which is essential to many bacteria, can be targeted to kill dangerous pathogens.

Experts at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have also identified chemical compounds that can inhibit this enzyme, and suppress the growth of pathogenic bacteria.

Writing about their study in the journal Chemistry and Biology, the researchers say that their findings are essential to develop new broad-spectrum antibacterial agents to overcome multi-drug resistance.

Dr. Andrei Osterman, an associate professor in Burnham’s ioinformatics and Systems Biology program, targeted the acterial nicotinate mononucleotide adenylyltransferase (NadD), an essential enzyme for nicotinamide adenine dinculeotide (NAD) biosynthesis, which has many crucial functions in nearly all important pathogens.

The bacterial NadD differs significantly from the human enzyme.

“It’s clear that because of bacterial resistance, we need new, wide-spectrum antibiotics. This enzyme is indispensable in many pathogens, so finding ways to inhibit it could give us new options against infection,” said Dr. Osterman.

The research team used a structure-based approach to search for low-molecular-weight compounds that would selectively inhibit bacterial NadD, but not the human equivalent, by screening, in silico, more than a million compounds.

In their experiments, they tested the best predicted compounds against Escherichia coli and Bacillus anthracis (anthrax), which led them to a handful of versatile inhibitory chemotypes, which they explored in detail.

Using protein crystallography, a 3D structure of the enzyme in complex with one of the inhibitors was solved providing guidelines for further drug improvement.

“This is proof-of-concept that NadD is a good target to create antibacterial agents. This knowledge will be useful for both biodefense and public health. The next step is to find better inhibitors. We do not have a silver bullet yet, but we are certainly hitting a golden target,” said Dr Osterman.

The research was supported by a grant from the National Institute of Allergy and Infectious Diseases. (ANI)

Songs help skylarks differentiate between neighbours and strangers

Washington, Aug 28 (ANI): Through their songs, skylarks can differentiate between friendly neighbours and dangerous strangers, says a new study.

The study, conducted by scientists at Queen Mary, University of London, showed that male skylarks learn to recognize local dialects in their neighbours’ individual songs, remember where each neighbour is supposed to be and reprimand intruders who don’t belong in the neighbourhood.

Dr Elodie Briefer, a postdoctoral researcher at Queen Mary’s School of Biological and Chemical Sciences and her colleagues at the University of Paris South found that skylark neighbours are tolerated if they stay in their own territory, whereas strangers – skylarks who belong to another neighbourhood – are attacked if they intrude too close to the nest.

Researchers also observed the birds’ reactions when they heard the recorded song of another skylark from different directions.

The study showed how neighbouring birds who travel too far from their regular territory – a move which is seen as threatening – also run the risk of being attacked.

Males skylarks fiercely guard their chosen home territory, the area of land where they make their nest and hunt for food.

The size and position of the male’s territory is also important as female birds check it out before deciding who is going to make the best father to her chicks.

Each skylark will usually have several neighbours, living in territories that border his own.

Bird songs are among the most complex sounds produced by animals and the skylark (Alauda arvensis) is one of the most complex of all.

The songs are composed of ‘syllables’, consecutive sounds produced in a complex way, with almost no repetition.

The male skylark can sing more than 300 different syllables, and each individual bird’s song is slightly different.

The new research found that the songs of neighbouring skylarks share more syllables with each other than they do with strangers, like a dialect.

“This may have evolved because it is safer for the birds to live close together, but they need a way to keep intruders out. By sharing a local dialect in their song, they can keep an ear out for other birds that live nearby and kick any strangers out of the neighbourhood,” she said.

The study has been published in the Springer journal Naturwissenschaften. (ANI)

‘Laughing gas’ leaves ozone layer in splits

Washington, August 28 (ANI): A new study has determined that nitrous dioxide, popularly known as ‘laughing gas’, has now become the largest ozone-depleting substance emitted through human activities, and is expected to remain the largest throughout the 21st century.

The study was authored by A.R. Ravishankara, J.S. Daniel and Robert W. Portmann of the NOAA Earth System Research Laboratory (ESRL) chemical sciences division.

For the first time, this study has evaluated nitrous oxide emissions from human activities in terms of their potential impact on Earth’s ozone layer.

As chlorofluorocarbons (CFCs), which have been phased out by international agreement, ebb in the atmosphere, nitrous oxide will remain a significant ozone-destroyer, the study found.

Today, nitrous oxide emissions from human activities are more than twice as high as the next leading ozone-depleting gas.

Nitrous oxide is emitted from natural sources and as a byproduct of agricultural fertilization and other industrial processes.

Calculating the effect on the ozone layer now and in the future, NOAA researchers found that emissions of nitrous oxide from human activities erode the ozone layer and will continue to do so for many decades.

ESRL tracks the thickness of the ozone layer, as well as the burden of ozone-depleting compounds in the atmosphere. It maintains a large portion of the world air sampling and measurement network.

NOAA scientists also conduct fundamental studies of the atmosphere and atmospheric processes to improve understanding of ozone depletion and of the potential for recovery the ozone layer.

“The dramatic reduction in CFCs over the last 20 years is an environmental success story. But manmade nitrous oxide is now the elephant in the room among ozone-depleting substances,” said Ravishankara, lead author of the study and director of the ESRL Chemical Sciences Division in Boulder, Colorado.

The ozone layer serves to shield plants, animals and people from excessive ultraviolet light from the sun.

Thinning of the ozone layer allows more ultraviolet light to reach the Earth’s surface where it can damage crops and aquatic life and harm human health.

Though the role of nitrous oxide in ozone depletion has been known for several decades, the new study is the first to explicitly calculate that role using the same measures that have been applied to CFCs, halons and other chlorine- and bromine-containing ozone-depleting substances.

According to scientists, nitrous oxide is also a greenhouse gas, so reducing its emission from manmade sources would be good for both the ozone layer and climate. (ANI)

Molecule having anti-fat, anti-cancer abilities found to be a turnoff for fat genes

Washington, Aug 28 (ANI): Researchers at Baylor College of Medicine have found that a small molecule, earlier found to have anti-fat and anti-cancer abilities, has the potential to put off fat-making genes.

Such action in mice genetically prone to obesity causes the animals to become leaner, they say.

The researchers have also found the molecule to lowers the amount of fat in the mice’s livers, along with their blood sugar and cholesterol levels.

“We are frankly very excited about it. It goes to the origin of [fat synthesis] – all the way back to gene expression,” said Salih Wakil at Baylor.

Unlike cholesterol-lowering statins in use today, which block a single enzyme in the pathway, the chemical the researchers call fatostatin, “hits fat from the very beginning,” said Motonari Uesugi.

As a result, fatostatin influences many of the genes involved in fat production and in various aspects of metabolic syndrome – a collection of risk factors including obesity, high cholesterol and insulin resistance – in one go.

Studies in cell culture showed that fatostatin, previously known only as 125B11, significantly lowers the activity of 63 genes, including 34 directly associated with fatty acid or cholesterol synthesis.

Many of these genes were known to be under the control of SREBP – a transcription factor which act as a well-known master controller of fat synthesis.

After more detailed analysis, the researchers found that the drug candidate blocked SREBP by preventing it from becoming active and entering the nucleus, where it would otherwise switch on the fat-making program.

According to them, it operates by binding another protein (called SCAP), which serves as SREBP’s escort into the nucleus.

It was found that obese mice injected with fatostatin show noticeable reductions in their weight despite little difference in their eating habits, the researchers report.

After four weeks of treatment, the animals weighed 12 percent less and had 70 percent lower blood sugar levels.

Their cholesterol levels (both LDL and HDL) were down too. The concentration of fatty acids in their blood was actually higher- a sign of their greater demand for fat to burn.

While the livers of the obese mice were heavy and pale with fat, treated animals’ livers were more than 30 percent lighter and were a healthy-looking red.

Although less obvious, the SREBP-blocking ability might also explain the molecule’s earlier reported effects against prostate cancer cells in culture as well.

They explained that cells need fatty acids and cholesterol to build their cell membranes and continue growing.

Researchers are optimistic that fatostatin could prove to be clinically useful in the context of obesity, and perhaps cardiovascular disease and diabetes as well.

“Hopefully down the road, fatostatin or a derivative of fatostatin may be helpful. It could have a broad impact on the key diseases we all suffer from,” said Wakil.

Uesugi said that fatostatin or its analogs may also serve a tool for gaining further insights into the regulation of SREBP and fat metabolism.

The study has been published in the journal Chemistry and Biology. (ANI)

Large variations exist in peoples’ ability to eliminate arsenic from body

Washington, Aug 27 (ANI): A new study has shown that large variations exist in peoples’ ability to eliminate potentially toxic substance arsenic from the body.

In the study, Kevin Francesconi and colleagues found that some people eliminate more than 90 percent of the arsenic consumed in the diet while others store arsenic in their bodies, where it can have harmful effects.

Health effects from chronic arsenic exposure include skin and internal cancers, cardiovascular disease, and possibly diabetes.

Researchers say that drinking water in many parts of the world, including some regions of the United States, contain amounts of arsenic that exceed the World Health Organization’s maximum acceptable levels.

The study also found that consumption of seafood is another major source of arsenic contamination.

The scientists describe monitoring arsenic excretion in the urine of human volunteers.

They found that ability to eliminate arsenic from the body varied greatly, with some participants excreting up to 95 percent of the ingested arsenic but others eliminating as little as four percent.

“This observed individual variability in handling [arsenic] exposure has considerable implications for the risk assessment of arsenic ingestion,” the study states.

It adds that further study is needed to assess potential risks to humans consuming seafood products.

“The data presented here suggest that the long held view that seafood arsenic is harmless because it is present mainly as organoarsenic compounds needs to be reassessed,” the study states.

The research is scheduled for the Sept. 21 issue of ACS’s Chemical Research in Toxicology, a monthly journal. (ANI)

Genetic discovery could pave way for obesity, diabetes treatments

Washington, Aug 27 (ANI): Researchers at University of Central Florida have identified a new genetic mechanism that controls the body’s fat-building process, paving way for treatments for obesity and type 2 diabetes.

The discovery has the potential to help hundreds of millions of people and dramatically cut health care costs.

Led by Pappachan Kolattukudy, director of UCF’s Burnett School of Biomedical Sciences in the College of Medicine, found that a gene called MCPIP (Monocyte Chemotactic Protein-1 Induced Protein) controls the development of fat cells.

Until now, a different protein, known as peroxisome proliferator-activated receptor gamma (PPAR gamma), has been universally accepted as the master controller of fat cell formation, known as adipogenesis.

But the new findings has opened new doors for scientists looking forward to develop drugs that could benefit the more than 300 million people worldwide who are clinically obese, and who have much higher risks of suffering from chronic disease and disability.

Besides, it is projected that more than 300 million people will be diabetic by the year 2025.

Kolattukudy said MCPIP is potentially an ideal target for drugs that would prevent the body from becoming resistant to insulin and prone to type 2 diabetes.

“Our research has shown that MCPIP is a regulator of fat cell formation and blood vessel formation that feeds the growing fat tissue. Therefore, a drug that can shut down its function can prevent obesity and the major inflammatory diseases resulting from obesity, including diabetes and cardiovascular diseases,” the expert said.

For the study, the researchers introduced MCPIP to living cells from mice that had been stripped of the PPAR gamma gene and found that the cells still completed the developmental process necessary to build fat.

Now, the researchers are planning to explore chemical combinations to discover drugs that are effective at shutting down the novel gene.

The development of new drugs that can block or slow down the formation of MCPIP likely would take several years.

The findings will be published in the October issue of the Journal of Biological Chemistry. (ANI)