Genetic discovery could pave way for obesity, diabetes treatments

Washington, Aug 27 (ANI): Researchers at University of Central Florida have identified a new genetic mechanism that controls the body’s fat-building process, paving way for treatments for obesity and type 2 diabetes.

The discovery has the potential to help hundreds of millions of people and dramatically cut health care costs.

Led by Pappachan Kolattukudy, director of UCF’s Burnett School of Biomedical Sciences in the College of Medicine, found that a gene called MCPIP (Monocyte Chemotactic Protein-1 Induced Protein) controls the development of fat cells.

Until now, a different protein, known as peroxisome proliferator-activated receptor gamma (PPAR gamma), has been universally accepted as the master controller of fat cell formation, known as adipogenesis.

But the new findings has opened new doors for scientists looking forward to develop drugs that could benefit the more than 300 million people worldwide who are clinically obese, and who have much higher risks of suffering from chronic disease and disability.

Besides, it is projected that more than 300 million people will be diabetic by the year 2025.

Kolattukudy said MCPIP is potentially an ideal target for drugs that would prevent the body from becoming resistant to insulin and prone to type 2 diabetes.

“Our research has shown that MCPIP is a regulator of fat cell formation and blood vessel formation that feeds the growing fat tissue. Therefore, a drug that can shut down its function can prevent obesity and the major inflammatory diseases resulting from obesity, including diabetes and cardiovascular diseases,” the expert said.

For the study, the researchers introduced MCPIP to living cells from mice that had been stripped of the PPAR gamma gene and found that the cells still completed the developmental process necessary to build fat.

Now, the researchers are planning to explore chemical combinations to discover drugs that are effective at shutting down the novel gene.

The development of new drugs that can block or slow down the formation of MCPIP likely would take several years.

The findings will be published in the October issue of the Journal of Biological Chemistry. (ANI)

Soon, a vaginal cream to fight against HIV

Washington, Apr 28 (ANI): While there are many methods to prevent transmission of HIV, scientists have now claimed that a new vaginal cream containing a reawakened protein could someday prevent the transfer of the deadly virus.

Researchers at the University of Central Florida in Orlando have revived a dormant gene found in humans and coaxed it to produce retrocyclin-a protein that resists HIV.

In the study, led by Alexander Cole, researchers used aminoglycosides- drugs commonly used to fight bacterial infections- to trigger the production of the sleeping protein expressed by the retrocyclin gene.

“It could make a huge difference in the fight against HIV. Much more work would be needed to demonstrate the safety and effectiveness of this approach. We would certainly have to have human trials, but these findings represent a promising step in that direction,” said Cole. ole embarked on his three-year investigation while he was a postdoctoral fellow in the Department of Medicine at the University of California at Los Angeles, and discovered that similar retrocyclin proteins found in early primates appeared to prevent HIV infections in cell cultures.

Although the same gene exists in humans, but because of a mutation, it no longer produces the protein.

And now, Cole’s team has found that restoring the production of retrocyclins prevents HIV entry.

They found a way to get the gene to produce the retrocyclins and then showed that the retrocyclins appear to prevent the transmission of HIV.

They then applied aminoglycoside antibiotics to vaginal tissues and cervical cells in the lab and found that the antibiotic appears to stimulate those cells and tissues to produce retrocyclins on their own.

He is positive that the aminoglycoside antibiotics could be used in a cream or gel format that could someday be a simple way to prevent the transmission of HIV from men to women.

The findings of the study have been published in this month’s PLOS Biology, a well-respected scientific journal. (ANI)

Workers share ‘already-known’ information while working in teams

Washington, Mar 24 (ANI): While many reckon the benefits of working in teams, a new research has shown that people working in groups do share information, but they only discuss things they already know.

The analysis of 22 years of applied psychological research has also shown that “talkier” teams are less effective.

“We’re seeing a widespread trend toward a more virtual and globalized world and this is transforming the way people in the workplace communicate,” said the article’s lead author, Jessica Mesmer-Magnus, PhD, of the University of North Carolina Wilmington.

She added: “We need to better understand how teams will perform in this new setting and, to do that, we need to look at how they’ve worked in the past.”

For the study, Mesmer-Magnus and Leslie DeChurch, PhD, an organizational psychologist at the University of Central Florida, analysed research on information sharing in the workplace, consisting of studies of approximately 4,800 groups and more than 17,000 people.

The analysis revealed that teams, which spent time sharing new information performed better overall in their tasks.

But they also found that most teams spent their time discussing information that was already known by the rest of the group.

Groups whose members talked more openly during meetings were on better terms with one another but that did not necessarily mean they performed better.

“What this suggests is that teams who talk more amongst themselves aren’t necessarily sharing useful information. Therefore, they’re not actually coming to a better result. Rather, it’s more important what the teams are talking about, than how much they are talking,” said Mesmer-Magnus.

Also, the researchers discovered that teams communicate better when they engage in tasks where they are instructed to come up with a correct, or best, answer rather than a consensual solution.

“This highlights the conundrum surrounding team tasks. There’s a separation in what teams actually do and what they should do in order to be effective,” said Mesmer-Magnus.

The findings are reported in the March issue of the Journal of Applied Psychology. (ANI)

Why kids with attention deficit hyperactivity disorder move around a lot

Washington, Mar 10 (ANI): A new study has explained why children with attention deficit hyperactivity disorder move around a lot – it helps them stay alert to complete challenging tasks. esearchers from University of Central Florida have discovered that children with ADHD need to move more to maintain the required level of alertness while performing tasks that challenge their working memory.

“We’ve known for years that children with ADHD are more active than their peers. What we haven’t known is why,” said psychology Professor Mark D. Rapport.

“They use movement to keep themselves alert.

“They have a hard time sitting still unless they’re in a highly stimulating environment where they don’t need to use much working memory,” he added.

During the study involving 8- to 12-year-old boys, those with and without ADHD sat relatively still while watching Star Wars and painting on a computer program.

While all of the children became more active when required to remember and manipulate computer-generated letters, numbers and shapes for a short time, kids with ADHD became significantly more active – moving their hands and feet and swivelling in their chairs.

The researchers suggest that parents and educators can use a variety of available methods and strategies to minimize working memory failures.

Providing written instructions, simplifying multi-step directions, and using poster checklists can help children with ADHD learn without overwhelming their working memories.

“When they are doing homework, let them fidget, stand up or chew um,” said Rapport

“Unless their behaviour is destructive, severely limiting their activity could be counterproductive,” he added.

The study appears in the Journal of Abnormal Child Psychology. (ANI)

Consumers can’t be fooled twice

Washington, Feb 24 (ANI): A high price tag, a label, or an ingredient can trick us into believing that the mediocre product we have bought is of high-quality, but one such mistake is enough for consumers to avoid being fooled by such tactics in the future, according to researchers.

In a new study, researchers have focussed on consumer responses to “biasing cues”-features that consumers assume are related to the quality of the item.

“Often consumers’ beliefs about the relationship between an attribute and product quality are correct,” wrote authors Wouter Vanhouche (University of Central Florida, Orlando) and Stijn van Osselaer (Rotterdam School of Management, Erasmus University).

They added: “For example, higher-priced products are often better quality products. However, in many other cases, those beliefs are incorrect. For example, many low-priced products are actually quite good and many high-priced products are actually quite bad. Some attributes are even just irrelevant to product quality or are completely meaningless. For example, putting silk in shampoo does not do anything for hair but consumers may nevertheless expect it to.”

Earlier, researchers demonstrated that biasing cues could successfully deceive consumers into buying items.

But in the new study, the researchers wanted to find out whether the same consumers would be deceived a second time.

By using laboratory experiments involving orange juice, polo shirts, and paper towels, it was found that biased quality expectations did not carry over to a second purchase.

In fact, participants learnt from those initial judgment mistakes.

“We found that consumers’ quality judgments were actually made more accurate by the presence of such attributes. The presence of a high price on a low-quality orange juice or a Florida (vs. New Jersey) bottling location on a low-quality juice did not make the consumers more positive about the product one week after trying the product, but helped them to remember that the high-priced or the Florida-bottled juice was bad,” said the authors.

Thus, marketers should keep in mind that consumers are not so easily duped.

“Marketers should think twice about trying to mislead consumers by putting high prices on low-quality products or by touting attributes that seem to signal quality but in reality are meaningless. Marketers using such attributes may succeed at getting consumers to try their products, but the misleading actions are likely to backfire at the time of repeat purchase,” wrote the authors.

The study has been published in the Journal of Consumer Research. (ANI)

Remote drug delivery devices may be hacked, warn researchers

Washington, February 8 (ANI): While scientists are trying to develop electronic implants that dispense medicines automatically or via a wireless medical network, a group of Aussie and American researchers have warned that such devices may have certain security risks.

YanYan Wang and Carey Thaldorf at the University of Central Florida in Orlando, and their colleague John Haynes of Charles Darwin University in Darwin, point out that any wireless communications technology may fall under the generic umbrella of hacking, including eavesdropping, jamming, and tampering.

They say that someone with malicious intent might spoof the sensor outputs of a Remote Intelligent Drug Delivery System (RIDDS).

Highlighting the security risks in the International Journal of Biomedical Engineering and Technology, the researchers said that having hijacked the RIDDS connection, such a person might trigger commands to release medication inappropriately to harm or even kill a patient.

“We have raised security concerns in relation to RIDDS, especially in the context of medical sensor networks, because, among other reasons, a failure to do so could risk the privacy and possibly the life of a patient,” the researchers say.

“The dilemma in RIDDS makes adoption of the technologies intimidating,” they add. The team concludes that, “Security mechanisms for RIDDS must be fully considered prior to the widespread deployment of such delivery systems,” they add. (ANI)