River spills into Bangkok, floods the Grand Palace

BANGKOK: The main river in Thailand’s capital swelled to a record high on Friday, spilling over its banks and sending water rippling into the grounds of the Grand Palace , a primary historical monument of temples and gilded spires.

The amount of water entering the palace grounds was small, but the breach was symbolically significant as Bangkok enters a crucial period when high tides to the south are pushing back at runoff from the north that has breached the city’s outer defences and is now flooding some outlying districts.

“The crisis we’re facing today is the most critical natural disaster that ever happened in Thai history,” PM Yingluck Shinawatra said.

Chinatown, not far from the palace, was flooded, and concerns grew that floodwaters could reach the commercial center of the city, with its banks and shopping malls and five-star hotels, scene of the “red shirt” protests early last year that were Thailand’s most recent crisis. The commercial center was quiet on Friday as Bangkok residents continued to flee by the thousands after the government warned that there was little more that it could do to stop deluge.

“What we’re doing today is resisting the force of nature ,” the prime minister had said on Thursday. “We cannot resist all of it.” A huge mass of flood water has coursed down over recent weeks from the north, following an unusually heavy monsoon season , taking a steep economic toll as it inundated cities and industrial estates. Several feet of stagnant water continue to paralyse the ancient capital of Ayutthaya, to the north of Bangkok. With bad news continuing , and the prospects for recovery becoming an increasingly steep challenge, the Bank of Thailand cut its economic growth forecast for 2011 to 2.6% from 4.1%.

“The widespread flood, now affecting not only agricultural production but also manufacturing activity, is likely to weigh on the fourth quarter’s growth substantially ,” the central bank said. Floodwater breached the defences of the domestic airport , Don Muang, earlier this week. Airport director, Kanpat Mangkalasiri, said that 90% of the airport was now flooded. The main international airport, Suvarnabhumi , continued to function normally.

©2011 The New York Times News Service

HIV uses several routes to escape immune system pressure

Washington, September 19 (ANI): Researchers at the Emory Vaccine Center have shown that HIV relies upon a number of strategies rather than use any preferred escape route to escape immune system pressure.

The human immune system has the ability to temporarily overpower HIV in early infection.

Studies conducted in the recent past have shown that most newly infected patients develop neutralizing antibodies. These are blood proteins that glob onto the virus and would allow patients to defend themselves – if they were facing only one target.

However, the problem occurs when HIV mutates, and disguises itself enough to get away from the antibodies. The virus eventually wears down the immune system into exhaustion.

The Emory team’s findings attain significance as they suggest that even if any scientist succeeds in identifying a vaccine component that can stimulate neutralizing antibodies, HIV’s capacity for rapid mutation could still be a confounding factor.

Dr. Cynthia Derdeyn, associate professor of pathology at Emory University School of Medicine, Emory Vaccine Center and Yerkes National Primate Research Center, says that a single type of neutralizing antibody may not be enough to contain HIV.

“These neutralizing antibodies work really well – they hit the virus fast and hard. But so far, every time we look, the virus escapes,” she says.

During the study, the researchers took blood samples from the participants a few weeks after infection occurred, and then later as two participants’ immune responses continued.

They isolated individual viruses over the first two years of HIV infection, and tested how well the patients’ own antibodies could neutralize them.

“In one patient where we had very early samples, there was evidence that neutralizing antibody came up within weeks, and that’s earlier than what was previously thought,” Derdeyn says.

In both patients, some viruses mutated part of their outer proteins so that after the mutation, an enzyme would be likely to attach a sugar molecule to it.

Though the sugar molecule interferes with antibody attack, this tactic, known as the “glycan shield”, was not observed in all cases.

Other viruses mutated the part of the outer protein that the neutralizing antibodies stick to directly. In both patients, many changes in the virus’ genetic code were necessary for escape.

“We need to understand early events in the immune response if we are going to figure out what a potential vaccine should have in it. What we can show is that even in one patient, several escape strategies are going on,” Derdeyn says.

According to her, that means that in order to be immune to HIV infection, someone may need to have several types of neutralizing antibodies ready to go.

Seeing how the virus mutates will allow researchers to choose the best parts to put in a vaccine, she says.

The results are online and scheduled for publication in the September issue of the journal Public Library of Science Pathogens.(ANI)

Negative public opinion about foreign countries an early warning signal for terrorism

Washington, September 18 (ANI): People’s negative views toward the leadership and policies of other countries may be an indication that a terrorist act may be carried out, say researchers.

Alan Krueger, a Princeton University economist, and Jitka Maleckova, of Charles University in the Czech Republic, came to this conclusion after analysing public opinion polls and terrorist activity in 143 pairs of countries.

Writing about their findings in the journal Science, the researchers say that there is a strong relationship between attitudes expressed toward a foreign country — indicated in surveys on foreign leaders’ performance-and the occurrence of terrorism against that country.

“Public opinion appears to be a useful predictor of terrorist activity,” said Krueger, the Bendheim Professor in Economics and Public Policy.

“This is the first study to relate public opinion across countries to concrete actions such as terrorism,” he added.

He pointed out that the notion that public attitudes can contribute to terrorism has been inadequately explored to date.

According to him, the study’s findings attain significance as they suggest that public opinion may provide a valuable early warning signal of terrorism, and help researchers better understand the causes of terrorism.

The researchers carried out their study by mining public opinion polls of residents in 19 countries in the Middle East and northern Africa conducted by Gallup.

They asked the respondents whether they approved of the job performance of the leaders of nine large countries.

According to the researchers, the countries selected for the study are world powers in terms of size, population or military strength, are the United States, Canada, China, France, Germany, India, Japan, Russia and the United Kingdom.

The opinions, both positive and negative, were linked to the number of terrorist attacks conducted against the nine world powers by people from the 19 countries between 2004 and 2008. The terror attacks were compiled by the National Counterterrorism Center.

Based on the findings, Krueger says that there is not a direct connection between poverty and terrorism, contrary to a popular view.

He adds that economic status has more to do with target countries than it does with the states where the attacks originate.

He says that countries with advanced economies as well as a high degree of civil liberties are most likely to be the targets of terrorism.

The researchers admits that the study does not explain whether terrorists act in response to public opinion or whether they are simply reacting just like the larger public to external events.

However, he insists that, in either case, public opinion surveys can provide a powerful indication of the likelihood of terrorist activity.

Krueger believes that greater disapproval of another country’s leaders or policies may result in more terrorist acts because it increases the number of people who provide material support and encouragement for terrorism, and increases the number of people interested in joining cells and carrying out terrorist acts themselves. (ANI)

Natural hydrogel may boost spinal cord healing

Washington, Sep 18 (ANI): A jab of biomaterial gel into a spinal cord injury site may significantly improve healing, according to researchers at the Barrow Neurological Institute at St. Joseph’s Hospital and Medical Center.

Dr. Mark Preul and Dr. Alyssa Panitch have found in a study that injection of an engineered hydrogel made up mainly of hyaluronic acid (a naturally-occurring body substance) into the spinal cord injury site decreases scarring, and promotes a realignment of the spinal cord fibres around the injury site.

The hyaluronic acid, which forms a scaffold-like configuration may help to structurally stabilize the spinal cord injury site.

The researchers traced cells in the brain stem after injury, and found much higher levels in the hydrogel treated animals as compared to animals that did not receive the treatment, and approached nearly normal levels.

Treated animals had higher functional scores than their non-treated counterparts.

“Spinal cord injury is devastating to civilian and military populations – especially to the young. There has been little progress toward paradigms of regeneration and few results that show real, sustained functional recovery. We’ve been so pre-occupied with regeneration, but that is a highly complicated and difficult to define goal. This project is a synergy of neurosurgeons and bioengineers that attempts repair of the SCI lesion cavity using a tissue-engineering biomaterials approach,” says Preul.

He added that the team aimed at finding ways to structurally allow the body to better heal itself.

“In this project we did not add anything to the hyaluronic acid. It may be that adding growth factors or cells into the gel matrix may allow even better results,” he said.

Preul said that the results show “we may be on a practical path that can give hope to the many people who suffer this sort of injury.”

The work was presented at the Annual Meeting of the American Association of Neurological Surgeons in San Diego where it won the Synthes Prize for Spine Research. (ANI)

NASA’s Swift satellite makes best-ever ultraviolet portrait of Andromeda galaxy

Washington, September 17 (ANI): NASA’s Swift satellite has acquired the highest-resolution view of a neighboring spiral galaxy ever attained in the ultraviolet.

The galaxy, known as M31 in the constellation Andromeda, is the largest and closest spiral galaxy to our own.

“Swift reveals about 20,000 ultraviolet sources in M31, especially hot, young stars and dense star clusters,” said Stefan Immler, a research scientist on the Swift team at NASA’s Goddard Space Flight Center in Greenbelt, Maryland.

“Of particular importance is that we have covered the galaxy in three ultraviolet filters. That will let us study M31′s star-formation processes in much greater detail than previously possible,” he added.

M31, also known as the Andromeda Galaxy, is more than 220,000 light-years across and lies 2.5 million light-years away.

On a clear, dark night, the galaxy is faintly visible as a misty patch to the naked eye.

Between May 25 and July 26, 2008, Swift’s Ultraviolet/Optical Telescope (UVOT) acquired 330 images of M31 at wavelengths of 192.8, 224.6, and 260 nanometers.

The images represent a total exposure time of 24 hours.

The task of assembling the resulting 85 gigabytes of images fell to Erin Grand, an undergraduate student at the University of Maryland at College Park who worked with Immler as an intern this summer.

“After ten weeks of processing that immense amount of data, I’m extremely proud of this new view of M31,” she said.

Several features are immediately apparent in the new mosaic.

The first is the striking difference between the galaxy’s central bulge and its spiral arms.

“The bulge is smoother and redder because it’s full of older and cooler stars,” Immler explained. “Very few new stars form here because most of the materials needed to make them have been depleted,” he added.

Dense clusters of hot, young, blue stars sparkle beyond the central bulge.

M31′s disk and spiral arms contain most of the gas and dust needed to produce new generations of stars.

Star clusters are especially plentiful in an enormous ring about 150,000 light-years across.

“Swift is surveying nearby galaxies like M31 so astronomers can better understand star- formation conditions and relate them to conditions in the distant galaxies where we see gamma-ray bursts occurring,” said Neil Gehrels, the mission’s principal investigator at NASA Goddard. (ANI)

Dial auto service launched in Chandigarh

Chandigarh, Sept 17 (ANI): In a bid to provide quick, hassle free and reasonably charged mode of transportation, a dial-an-auto service equipped with GPS navigation system has been launched for the first time in Chandigarh.

The neat and clean pink coloured motor rickshaws, known as Tuk Tuk, are changing the way people travel in the city.

The fleet of 10 dial-an-auto-rickshaw, which is only a phone call away, also boasts of two lady drivers, the first in Chandigarh.

Women passengers, who feel safer traveling with lady drivers, are appreciating their services.

“Chandigarh is one city where people are safe anyway. We have been told we are safe with the service,” said Alka Thapar, a lady auto driver.

One has to just dial 4242424 for calling an auto rickshaw to get it at your doorstep.

The autos are equipped with tamper proof fare meters to assure passengers of not being overcharged.

“We maintain our call center. Whenever any individual requires an auto he rings up and the call centre picks up the call. They record the call and then convey to the driver by selecting the vehicle nearby to pick up the customer. That’s the procedure and customer has to pay from the pick up point to the drive point only,” said VS Dhillon, Managing Director of the Tuk Tuk Auto Rickshaw Company.

The service aims at providing a quick, reliable and safe journey to people who can relax and sit back without the fear of getting fleeced by drivers.

“I’m using it for the first time It’s reasonably priced and I’m really liking it,” says Charanjit, a customer.

The new service is a welcome change for commuters. With the new service in place, passengers can hope for a change in the attitude of traditional auto drivers who are often accused of fleecing customers. By Sunil Sharma (ANI)

Spanking found to have negative effects on low-income toddlers

Washington, September 16 (ANI): Spanking negatively affects the behaviour of toddlers in low-income families, according to a new study.

Published in the journal Child Development, the longitudinal study looked at how low-income parents discipline their young children.

It showed that spanking 1-year-olds leads to more aggressive behaviours and less sophisticated cognitive development in the next two years.

Verbal punishment, however, was not found to be associated with such effects, especially when it was accompanied by emotional support from mothers.

Besides, 1-year-olds’ fussiness predicted spanking and verbal punishment at ages 1, 2, and 3.

The study explored whether mothers’ behaviours lead to problematic behaviour in children, whether children’s challenging behaviours elicit harsher discipline, or both.

It looked at more than 2,500 exclusively low-income White, African American, and Mexican-American mothers and their young children, interviewing and observing them at home when the children were 1, 2, and 3 years old.

All participants’ family incomes were at or below the federal poverty level.

Using their own interpretations of spanking, mothers reported how often anyone in the home had spanked their children in the past week.

The study also looked at how often mothers verbally punished-scolded, yelled, or made negative comments-their children.

It showed that African American children were spanked and verbally punished significantly more than the other children in the study.

The authors speculated that that might be due to cultural factors, such as belief in the importance of children’s respect for elders and in the value of physical discipline to instil that respect.

Moreover, some African American mothers said that in preparing their children for a harsh, physically dangerous, and racially discriminating world, there was little room for error in their childrearing.

The study also shed light on information about the effects of such types of discipline.

“Our findings clearly indicate that spanking affects children’s development,” said Lisa J. Berlin, research scientist at the Center for Child and Family Policy at Duke University and the study’s lead author.

Specifically, children who were spanked more often at 1 behaved more aggressively when they were 2, and had lower scores on tests measuring thinking skills when they were 3.

Similar findings were made even after taking into consideration such family characteristics as mothers’ race and ethnicity, age, and education; family income and structure; and the children’s gender.

The study also found that children who were more aggressive at age 2, and had lower cognitive development scores at ages 1 and 2, were not spanked more at ages 2 and 3.

“So the mothers’ behaviours look more influential than the children’s,” said Berlin.

Unlike spanking, however, verbal punishment alone didn’t affect either children’s aggression or their cognitive development.

Interestingly, when verbal punishment was accompanied by emotional support from moms, the children did better on the tests of cognitive ability. (ANI)

NASA concludes tests for prototype Moon rovers

Washington, September 16 (ANI): NASA has concluded two weeks of technology development tests on two of the agency’s prototype lunar rovers.

“These tests provide us with crucial information about how our cutting edge vehicles perform in field situations approximating the moon,” said Rob Ambrose, Human Robotic Systems project lead at NASA’s Johnson Space Center in Houston.

“We learn from them, then go back home to refine the technology and plan the next focus of our research,” he added.

The annual studies featured an intensive, simulated 14-day mission.

Two crew members, an astronaut and a geologist, lived for more than 300 hours inside NASA’s prototype Lunar Electric Rover.

The explorers scouted the area for features of geological interest, then donned spacesuits and conducted simulated moonwalks to collect samples.

The crew also docked to a simulated habitat, drove the rover across difficult terrain, performed a rescue mission and made a four-day traverse across the lava.

Throughout the test, the crew provided updates via Twitter and posted pictures and video online.

Prior to the test, NASA’s K10 scout robot identified areas of interest for the crew to explore.

NASA’s heavy-lift rover Tri-ATHLETE – or All-Terrain Hex-Legged Extra-Terrestrial Explorer – carried a habitat mockup to which the rover docked. (ANI)

J and K Govt seeks Center’s clearance to construct concrete huts along LAC

Srinagar, Sep 16 (ANI): The Jammu and Kashmir Government has sought clearance from the Ministry of Defence to construct huts like along the Line of Actual Control (LAC) bordering China.

According to sources the State Government forwarded this proposal with the aim of strengthening the Indian presence along the LAC.

State Revenue Minister Raman Bhalla, said concrete huts would also help the nomadic shepherds to stay.

Nomadic shepherds are currently using mobile tents.

Recently Leh’s Deputy Commissioner Ajit Kumar Sahu said, the Chinese had threatened some shepherds in the remote regions of the district.

The State Government is also reportedly planning to house revenue officials and guards to monitor Chinese activities along the Pangong Lake, sources said.

Meanwhile, National Security Advisor M.K.Narayanan has called a meeting of the China Study Group of the Union Government on Wednesday, to discuss the situation along Indo-China border.

Cabinet Secretary K.M. Chandrasekhar, Defence Secretary Pradeep Kumar, Home Secretary G. K. Pillai, Foreign Secretary Nirupama Rao, Senior officials of the Army, the Air Force and the Navy, officials from the Intelligence Bureau (IB) would also attend the meeting. (ANI)

Popular stomach acid reducer ups patients’ risk of developing pneumonia threefold

Washington, September 15 (ANI): Researchers at Wake Forest University School of Medicine have found that a popular stomach-acid reducer, which is used to prevent stress ulcers in critically ill patients who need breathing machine support, triples the likelihood of contracting pneumonia among such patients.

Hospital-acquired pneumonia-the leading cause of infection-related deaths in critically ill patients-increases hospital stays by an average of seven to nine days, cost of care, and the risk of other complications.

“As best we can tell, patients who develop hospital-acquired pneumonia or ventilator-acquired pneumonia have about a 20 to 30 percent chance of dying from that pneumonia. It’s a significant event,” said senior study author Dr. David L. Bowton, professor and head of the Section on Critical Care in the Department of Anesthesiology.

During the study, the researchers compared treatment with two drugs that decrease stomach acid: ranitidine, marketed under the name ZantacTM, and pantoprazole, marketed under the name ProtonixTM or PrilosecTM.

Both drugs decrease stomach acid, but the newer pantoprazole is considered more powerful, and has become the drug of choice in many hospitals.

However, upon the analysis of 834 patient charts, the researchers came to the conclusion that the risk of developing pneumonia was thee times more in the hospitalised cardiothoracic surgery patients who had been treated with pantoprazole.

“We conducted this study, in part, because we thought we were seeing more pneumonias than we were used to having,” said study co-author Marc G. Reichert, pharmacy coordinator for surgery at Wake Forest University Baptist Medical Center.

The researchers say that their study suggests some other steps to keep critically ill patients from developing ventilator-associated pneumonia.

Bowton suggests that doctors consider whether an acid reducer is needed at all, and, in cases where it is needed, ranitidine is recommended because of the apparent decreased risk in developing pneumonia.

Doctors should stop using the drug as soon as the risk of bleeding passes – once the patient is off the breathing machine and eating, either on his/her own or through a feeding tube.

“Stopping the drugs earlier appears to be the best thing for patients,” Reichert said.

The study has been published in a recent issue of CHEST. (ANI)

Natalizumab drug improves quality of life of MS patients

Washington, Sept 13 (ANI): A new study has found that multiple sclerosis patients taking Tysabri (Natalizumab) experienced a significant improvement in both their physical function and psychological well-being.

“The symptoms that an MS patient deals with on a daily basis result in significant psychological and physical effects that can adversely impact their quality of life,” said Dr William Stuart, medical director of the Multiple Sclerosis Center of Atlanta.

“In a previous pivotal trial, TYSABRI not only showed a reduction in relapse rates and disability progression, but also improved quality of life.

“Results from this observational study further demonstrate the impact of TYSABRI on improving MS patients’ well-being as reported by patients who live with this disease every day,” he added.

The study assessed the health outcomes from patients’ perspectives before starting TYSABRI and after the third, sixth and 12th infusions of TYSABRI.

After six TYSABRI infusions, patients reported statistically significant improvement in disease-specific quality of life (QoL), which measures the physical impact of MS in terms of mobility and self care, as well as the psychological impact of MS in terms of anxiety/depression.

The participants also scored higher in general health-related quality of life.

The findings were presented at the 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). (ANI)

Taliban now terrorise 80% of Afghanistan after eight years of war: Report

Kabul, Sep. 11 (ANI): Almost eight years after the war began in Afghanistan in the aftermath of the 9/11 carnage, the Taliban insurgency has spread across 80 percent of the country.

The violent incidents this week have drawn attention to the deteriorating security situation of northern Afghanistan, which had largely remained peaceful so far, the Christian Science Monitor reports.

The northern provinces are facing difficult times as heavy insurgent activity has spread to 80 percent of the country – up from 54 percent two years ago, the report says.

The militants’ focus has shifted to northern parts following continuous pressure from their Pakistani counterparts to attack NATO’s second supply route situated here, it adds.

“[Militants] have been trying to widen the ground for the insurgency in Afghanistan and now they have got momentum. The militants are eager to target this route to prevent a smooth supply chain from northern Afghanistan,” the report quoted Waliullah Rahmani, executive director of the Kabul Center for Strategic Studies, as saying.

Last week’s airstrike targeted two fuel tankers headed to supply NATO troops in Kabul that had been hijacked by the Taliban.

Although the increase in violence is only a recent phenomenon, the conditions had worsened long ago, the report says.

The violence can be linked to districts with large Pashtun populations, whose grievances the government has failed to address – making them sympathetic to the Taliban, who share their ethnicity and language, it adds.

“The districts which are turning violent are those which have had a very recent history of abuses against the Pashtuns.

The government has allowed these conditions to go unaddressed and this is now being addressed by the population by giving shelter to the Taliban and other insurgents,”the report quoted Prakhar Sharma, the head of research at the Center for Conflict and Peace Studies, as saying.(ANI)

Weight gain in adulthood linked to prostate cancer risk

Washington, Sep 12 (ANI): Body size and weight gain in younger and older adulthood may help weigh a man’s proneness to prostate cancer, according to a study by researchers at the University of Hawaii at Manoa’s Cancer Research Center of Hawaii.

Led by Dr. Brenda Hernandez, the researchers said that the risk varies among different ethnic groups

For the study, the researchers studied the relationship in a multiethnic population consisting of blacks, Japanese, Hispanics, Native Hawaiians and whites, and compared differences among age groups using the Multiethnic Cohort, a longitudinal study of men 45-75 years of age established in Hawaii and California from 1993-1996.

Of the 83,879 men who participated in the study, 5,554 developed prostate cancer.

Overall, men who were overweight or obese by age 21 had a decreased risk of localized and low-grade prostate cancer, according to Hernandez.

Their results suggested that being overweight in older adulthood was associated with increased prostate cancer risk among white and Native Hawaiian men, but a decreased risk among Japanese men.

While excessive weight gain between younger and older adulthood was observed to increase the risk of advanced and high-grade prostate cancers in white men and increase the risk of localized and low-grade disease in black men, it appeared to decrease the risk of localized prostate cancer in Japanese men.

“The relationship of certain characteristics, such as body size, with cancer risk may vary across ethnic groups due to the combined influence of both genes and lifestyle,” said Hernandez.

However, the relationship between body size and prostate cancer risk is not entirely understood.

Excess fat is associated with a number of conditions that contribute to cancer development including low-grade chronic inflammation, insulin resistance, metabolic abnormalities, and hormone imbalances.

These conditions may in turn contribute to more aggressive prostate malignancies.

Ethnic differences in cancer risk may be explained by differences in the distribution of stored body fat that could have a differential effect on the development of prostate cancer.

And the distribution of body fat may influence the specific way that excess fat influences cancer risk.

The study has been published in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research. (ANI)

Sea levels rose as much as 2 feet this summer along the US East Coast

Washington, September 12 (ANI): Reports indicate that sea levels rose as much as 2 feet (60 centimeters) higher than predicted this summer along the US East Coast, surprising scientists who forecast such periodic fluctuations.

According to National Geographic News, though the immediate cause of the unexpected rise has now been solved, the underlying reason remains a mystery.

Usually, predicting seasonal tides and sea levels is a pretty cut-and-dried process, governed by the known movements and gravitational influences of astronomical bodies like the moon, according to Rich Edwing, deputy director for the Center for Operational Oceanographic Products and Services at the US National Oceanic and Atmospheric Administration (NOAA).

But, NOAA’s phones began ringing this summer when East Coast residents reported higher than predicted water levels, much like those associated with short-term weather events like tropical storms.

These high seas persisted for weeks, throughout June and July.

The startling rise caused only minor coastal flooding, but puzzled scientists.

Now, a new report has identified the two major factors behind the high sea levels-a weakened Gulf Stream and steady winds from the northeastern Atlantic.

The Gulf Stream is a northward-flowing superhighway of ocean water off the US East Coast.

Running at full steam, the powerful current pulls water into its “orbit” and away from the East Coast.

But this summer, for reasons unknown, “the Gulf Stream slowed down,” Edwing said, sending water toward the coasts-and sea levels shooting upward.

Adding to the sustained surge, autumn winds from the northeastern Atlantic arrived a few months early, pushing even more water coastward.

The higher waters caused inconveniences for some anglers and boaters and rearranged a bit of shoreline.

“A couple of sand beaches we’d normally fish from were eaten up. And the volume of water was higher than it normally would be,” said Paulie Apostolides, owner of Paulie’s Tackle in Montauk on New York State’s Long Island.

Even before the new report, released by NOAA on September 2, Apostolides said that many local fishers had already attributed the sea level rise to the “ferocious” winds from the northeast. (ANI)

US marks eighth anniversary of 9/11 terror strike

New York, Sep 11(ANI): The eighth anniversary of the September 11, 2001 attacks on the World Trade Center twin towers in New York City and the Pentagon in Washington, which killed nearly 3,000 people, was observed here on Friday.

On September 11, 2001, four hijacked planes crashed into the twin Towers, the Pentagon, and a field in Pennsylvania.

Memorial ceremonies are to be held at these sites and four moments of silence are observed, at 8:46 a.m., 9:03 a.m., 9:59 a.m. and 10:29 a.m. ET, as these were the timings when the attacks took place.

President Barack Obama attended the wreath-laying ceremony at the Pentagon, where 184 people died.

The names of more than 2,700 victims from the site were also read by family members and volunteers at the New York ceremony, which was attended by U.S. Vice-President Joe Biden.

For the first time, the anniversary was designated as a National Day of Service. On Thursday, Obama issued a proclamation honouring those who died and had urged Americans to mark the anniversary with acts of community service.

Remembering those who lost their lives on the tragic day, New York City Mayor Michael Bloomberg, said: “It is the sacred duty of the living to carry within us the memories of those we lost. While there is pain in remembering the loss, there is sweetness in remembering their lives.” (ANI)

Biocon limited, Amylin pharmaceuticals enter global development agreement

Bangalore/ California Sep 11(ANI/Business Wire India): Biocon, Limited (NSE: BIOCON) and Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN) announced today that they have entered into an exclusive agreement to jointly develop, commercialize and manufacture a novel peptide therapeutic for the potential treatment of diabetes.

Amylin and Biocon will collaborate to develop the therapeutic potential of the compound and share development costs. Research will center on Amylin’s “phybrid” technology. A phybrid is a peptide hybrid molecule that combines the pharmacological effects of two peptide hormones into a single molecular entity.

Under the terms of the Development and Commercialization Agreement, Amylin will provide expertise in peptide hormone development, particularly in the area of phybrid technology, as well as metabolic disease therapeutics. Biocon will utilize its expertise in recombinant microbial expression to manufacture the compound and also leverage its experience in pre-clinical and clinical development of diabetes products.

“This agreement fully leverages the synergistic capabilities of the two companies,” said Kiran Mazumdar-Shaw, Chairman and Managing Director, Biocon, Ltd. “Amylin’s knowledge of peptide therapeutics and their leadership in the diabetes market, paired with Biocon’s capabilities in process development, manufacturing and clinical development, provides this global program with the potential to effectively bring a novel therapy to patients living with diabetes.”

“This program could unleash the potential of cutting-edge peptide science to transform the lives of patients with diabetes,” said Daniel M. Bradbury, President and Chief Executive Officer, Amylin Pharmaceuticals. “We are pleased to work with Biocon, a biologics innovator and world-class manufacturing expert, and look forward to collaborating with them on this exciting program.”

Amylin Pharmaceuticals is a biopharmaceutical company committed to improving lives through the discovery, development and commercialization of innovative medicines. (ANI)

Killer whales have to raise their voices to be heard over ship noise

Washington, September 11 (ANI): A new research has determined that killer whales have to raise their voices to be heard over ship noise, and the effort may be wearing the whales out as they try to find food amid dwindling numbers of salmon.

According to a report in National Geographic News, scientists at the National Oceanic and Atmospheric Administration (NOAA) carried out the research.

The research indicates that the killer whales of Puget Sound, a complex of inland marine waterways in the northwestern part of Washington, US, make more calls and clicks while foraging than while traveling, suggesting that such mealtime conservations are key to coordinating hunts.

“(The killer whales’) call exchange is incredibly important, and vessel noises have the potential to mask these calls,” said research leader Marla Holt of Seattle’s Northwest Fisheries Science Center, which is run by the National Oceanic and Atmospheric Administration (NOAA).

Holt and colleagues’ previous research had shown that some killer whales make louder calls to be heard over vessel rumblings-just as people raise their voices to talk over the din of a cocktail party.

Now, the researchers think the cacophony could be causing the region’s killer whales to use up more energy during hunts, even as their preferred prey, chinook salmon, are on the decline.

In Puget Sound, a small group of killer whales known as the Southern Residents has been found to be particularly well-suited to eating salmon-even down to the whales’ tooth size.

These animals don’t eat seals or other mammals, as do the transient killer whales that migrate through the sound.

In the mid- to late 1990s, the Southern Resident population mysteriously shrank by nearly 20 percent, from 97 to 88 animals. Today, there are 85 individuals.

In 2005, the federal government listed the population as endangered under the US Endangered Species Act.

No one knows for sure, but the cause was likely a combination of fewer salmon, exposure to toxic contaminants, and vessel noise, according to Lynne Barre of NOAA’s National Marine Fisheries Service Northwest Regional Office.

Holt’s work adds to existing data that have already prompted NOAA to propose a new killer whale protection law that would make all boats keep at least 600 feet (200 yards) away from the animals around Washington State.

The existing law allows boats to approach as close as 300 feet (100 yards), and some research has shown this influences the whales’ behavior.

“A lot of people would argue, Why focus on these vessel regulations?” Holt said. “But it’s one thing we can do immediately,” he added. (ANI)

Three genes linked to Lou Gehrig’s disease identified

Washington, Sep 10 (ANI): Researchers at Michigan Technological University have identified three genes that play a major role in the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig’s disease.

The team of mathematicians, led by Shuanglin Zhang, isolated the genes from the many thousands scattered throughout human DNA.

Zhang noted that the discovery does not mean an end to ALS, but it could provide scientists with valuable clues as they search for a cure.

“I felt very urgent to find the genes for ALS,” Zhang said.

“This is very nice work. It’s very challenging to map genes for complex diseases, and while many statistical methods have been developed, most don’t work well in practice. Zhang’s group has developed a method to detect genes and gene-gene interaction in complex diseases and provided evidence that it works,” said Xiaofeng Zhu, an associate professor of epidemiology at Case Western Reserve University’s School of Medicine.

“Their findings will need to be confirmed by other researchers, but I think this will be very useful for the investigators who are trying to find genes underlying complex diseases such as ALS,” said Zhu.

According to the ALS Association, only about 10 percent of patients have familial ALS, a directly inherited form of the usually fatal neuromuscular disorder, while the remaining 90 percent are diagnosed with the sporadic form of the disease.

While everyone has the three genes in question, but in people with sporadic ALS, they differ from those in people who don’t have ALS.

The mathematicians were not surprised when they tracked down the location of the genes.

“Everybody has 23 chromosomes, and the three genes on chromosomes 2, 4, and 10 interact. If you have this combination of the three genes, you are at high risk of developing the disease. It’s really exciting, especially because my husband has sporadic ALS. Maybe they can find a cure by blocking the genes,” explained Zhang’s wife Qiuying Sha.

ALS destroys the nerves in the brain and spinal cord that control voluntary movement, eventually leading to paralysis.

Zhang’s team used a new statistical method to analyse the genetic codes of 547 individuals, 276 with sporadic ALS and 271 without.

The method, a two-locus interaction analysis approach, allows the researchers to identify multiple genes associated with a complex illness.

The data set they analyzed was provided by National Institute of Neurological Disorders and Stroke (NINDS) Human Genetics Resource Center at the Coriell Institute, a publicly funded “bank” or repository for human cells, DNA samples, clinical data, and other information that aims to accelerate research on the genetics of nervous system disorders.

The study has been published in the open access journal BMC Medical Genetics. (ANI)

Forgotten memories still exist in the brain

Washington, Sept 10 (ANI): A new research by UC Irvine neuroscientists suggests that memories exist even when forgotten.

With the help of advanced brain imaging techniques, the study’s scientists discovered that a person’s brain activity while remembering an event is very similar to when it was first experienced, even if specifics can’t be recalled.

“If the details are still there, hopefully we can find a way to access them,” said Jeff Johnson, postdoctoral researcher at UCI’s Center for the Neurobiology of Learning and Memory and lead author of the study, appearing Sept. 10 in the journal Neuron.

“By understanding how this works in young, healthy adults, we can potentially gain insight into situations where our memories fail more noticeably, such as when we get older,” he said.

“It also might shed light on the fate of vivid memories of traumatic events that we may want to forget,” he added.

In collaboration with scientists at Princeton University, Johnson and colleague Michael Rugg, CNLM director, used functional magnetic resonance imaging to study the brain activity of students.

Inside an fMRI scanner, the students were shown words and asked to perform various tasks: imagine how an artist would draw the object named by the word, think about how the object is used, or pronounce the word backward in their minds. The scanner captured images of their brain activity during these exercises.

About 20 minutes later, the students viewed the words a second time and were asked to remember any details linked to them. Again, brain activity was recorded.

Utilizing a mathematical method called pattern analysis, the scientists associated the different tasks with distinct patterns of brain activity. When a student had a strong recollection of a word from a particular task, the pattern was very similar to the one generated during the task.

When recollection was weak or nonexistent, the pattern was not as prominent but still recognizable as belonging to that particular task.

“The pattern analyzer could accurately identify tasks based on the patterns generated, regardless of whether the subject remembered specific details,” Johnson said.

“This tells us the brain knew something about what had occurred, even though the subject was not aware of the information,” the expert added. (ANI)