Cellular defect that leads to cancer discovered

Washington, March 17 (ANI): Scientists at the University of California, San Francisco researchers have found that a key cellular defect that disturbs the production of proteins in human cells can lead to cancer susceptibility.

They also discovered that a new generation of inhibitory drugs offers promise in correcting this defect.

According to researchers, their finding has broad clinical implications in the fight against cancer and could affect treatment of lymphoma and many other forms of the disease, including prostate cancer, breast cancer, colorectal cancer, brain cancer and multiple myeloma.

The discovery was made in the laboratory of UCSF faculty scientist Davide Ruggero, whose lab team is doing research in the burgeoning field of study on how defects in protein synthesis can lead to cancer susceptibility.

“Our work has the potential to create real, tangible benefits for the medical community,” said Ruggero.

The researchers focused on a multi-protein unit known as mTOR, which stands for the “mammalian target of rapamycin.” mTOR controls several important processes in mammalian cells, including cell survival and proliferation.

One of the most significant of these processes is the production of proteins within a cell, the control of which is known as translational control. mTOR integrates information about the cell’s nutritional and energy needs, and prompts the cell to manufacture key proteins for cell growth. Cancer cells exploit this signal for their own growth.

According to the researchers, when the cells in the body lose the ability to control mTOR activity, mTOR is considered “hyperactivated.”

This hyperactivation causes protein synthesis rates to climb. Cells begin to proliferate without limits and simultaneously become immortal, all of which leads to tumour formation.

The findings are featured as the cover story in the March 16, 2010 issue of the scientific journal Cancer Cell. (ANI)

Now, a computational method to detect top genetic cancer suspects

Washington, September 2 (ANI): Johns Hopkins engineers have come up with a new computational method that can help scientists to sift through hundreds of genetic mutations to highlight the DNA changes that are most likely to promote cancer.

The computational method is called CHASM, short for Cancer-specific High-throughput Annotation of Somatic Mutations.

According to its inventors, the purpose behind making it is to provide critical help to researchers who are poring over numerous newly discovered gene mutations, many of which are harmless or have no connection to cancer.

They say that the new software will enable scientists to focus more of their attention on the mutations that are most likely to trigger tumours.

They have even reported the results of a test of the method on brain cancer DNA in the journal Cancer Research.

Rachel Karchin, an assistant professor of biomedical engineering, and doctoral student Hannah Carter have revealed that the new process focuses on missense mutations, meaning protein sequences that each possess a single tiny variation from the normal pattern.

A small percentage of these genetic errors can reduce the activity of proteins that usually suppress tumours or hyperactivate proteins that make it easier for tumours to grow, thereby allowing cancer to develop and spread.

However, it can prove very difficult to find these genetic offenders.

“It’s very expensive and time-consuming to test a huge number of gene mutations, trying to find the few that have a solid link to cancer. Our new screening system should dramatically speed up efforts to identify genetic cancer risk factors and help find new targets for cancer-fighting medications,” said Karchin.

Karchin and Carter plan to post their system on the Web, and will allow researchers worldwide to use it freely to prioritise their studies.

They hope that it could easily be adapted to rank the mutations that might be linked to different forms of the disease, such as breast cancer or lung cancer. (ANI)

Phoenix pastor who prays for Obama’s death faces flak

Washington, Sep. 1 (ANI): Protestors have started voicing their opposition outside the congregation of a Phoenix-based pastor, who tells his parishioners that he prays for President Obama’s death.

Phoenix-based Pastor Steven Anderson attracted widespread attention after he delivered a sermon titled, “Why I Hate Barack Obama,” and encouraged his parishioners to join him in praying for the president’s death.

“I hope that God strikes Barack Obama with brain cancer so he can die like Ted Kennedy and I hope it happens today,” Fox News quoted him, as saying.

He called his message “spiritual warfare” and said he does not condone killing.

However, some protesters gathered around his church on Sunday, calling Anderson’s words “incomprehensible.”

According to the report, Anderson has also received some death threats.

Anderson’s provocative message stems from Obama’s abortion-rights stance.

In his controversial sermon, delivered at his Faithful Word Baptist Church in Tempe before Obama arrived for a speech in Phoenix earlier in the month, the pastor had said he wants the president to “melt like a snail” with salt on it.

“I’m gonna pray that he dies and goes to hell when I go to bed tonight. That’s what I’m gonna pray,” he told his congregation.

The last time fierce opposition to Obama’s abortion position drew widespread attention was when Obama delivered the commencement address at the University of Notre Dame, the report said.

The Anderson sermon was also in news after it was reported that one man carrying an assault rifle outside the Phoenix arena where Obama spoke was a member of Anderson’s church, the report added. (ANI)

Kennedy led high quality of life up to his death, say doctors

Washington, Aug. 27 (ANI): Senator Edward M. Kennedy maintained a very good quality of life after he was diagnosed with brain cancer.

He continued speaking in front of Congress and making public appearances almost up until the time of his death on Wednesday morning at his home on Cape Cod.

“For a man in his 70s, he did very, very well,” Fox News quoted Dr. Michael Gruber, professor of neurology and neuro-surgery at NYU School of Medicine and Director of the Brain Tumor Center in Summit, New Jersey.

“He was walking unassisted (up until the end), he was lucid,” Dr. Gruber added.

Dr. Suriya Jeyapalan, a neuroncologist at Beth Israel Deaconess Medical Center in Boston, said that Kennedy’s condition was treatable, but not curable.

More than 18,000 primary malignant brain tumors are diagnosed each year in the United States; about 9,000 of those are malignant gliomas, according to the National Cancer Institute.

In general, half of all patients die within a year.

However, patients with malignant gliomas often maintain a very good quality of life after their diagnosis, Gruber said.

Gruber said the fate of a brain tumor patient depends on the location of the tumor. For example, if the tumor is located on the frontal or temporal lobe, then the patient’s speech might be affected.

Since Kennedy’s tumor was on the left parietal lobe, he suffered seizures. Other brain tumor patients may lose the ability to walk, lose vision or lose comprehension skills, depending on where the tumor lies or if the tumor invades other parts of the brain.

Kennedy underwent targeted brain surgery on June 2, 2008 at Duke University Medical Center. The surgery lasted for about 3 1/2 hours and Kennedy spent some of that time awake.

Targeted brain surgery is a delicate balance – removing as much tumor as possible improves cancer control, but there’s also the risk of harming the healthy brain tissue that lets patients walk and talk.

This is why doctors keep patients awake and talking during the surgery to make sure they’re steering clear of delicate areas of the brain. The surgery, considered a success, was followed by months of chemo and radiation therapy.

Kennedy has suffered other health problems over the years.

In October 2007, doctors performed surgery to clean out a partially blocked neck artery, which left untreated, could have trigged a stroke.

In 1964, Kennedy suffered several fractured bones in his back, broken ribs, and internal bleeding after he was involved in a plane crash.

Two people died in that crash. (ANI)

Obamas’ condole death of Edward Kennedy

Martha’s Vineyard (Virgina, US), Aug.26 (ANI): US President Barack Obama and his wife, Michelle, on Wednesday condoled the death of former Massachusetts Senator Edward Kennedy.

Kennedy, the family patriarch, died of complications arising out of brain cancer at his Hyannis Port home on Tuesday. He was 77.

In his statement, Obama said: ” Michelle and I were heartbroken to learn this morning of the death of our dear friend, Senator Ted Kennedy.

For five decades, virtually every major piece of legislation to advance the civil rights, health and economic well being of the American people bore his name and resulted from his efforts.

I valued his wise counsel in the Senate, where, regardless of the swirl of events, he always had time for a new colleague. I cherished his confidence and momentous support in my race for the Presidency. And even as he waged a valiant struggle with a mortal illness, I’ve profited as President from his encouragement and wisdom.

An important chapter in our history has come to an end. Our country has lost a great leader, who picked up the torch of his fallen brothers and became the greatest United States Senator of our time.

And the Kennedy family has lost their patriarch, a tower of strength and support through good times and bad.

Our hearts and prayers go out to them today-to his wonderful wife, Vicki, his children Ted Jr., Patrick and Kara, his grandchildren and his extended family. (ANI)

Ted Kennedy dies of brain cancer aged 77

Massachusetts (US), Aug, 26 (ANI): Senator. Edward Kennedy, the patriarch of the first family of Democratic politics, died late Tuesday at his home in Hyannis Port, Massachusetts, after a lengthy battle with brain cancer. He was 77.

“We’ve lost the irreplaceable center of our family and joyous light in our lives, but the inspiration of his faith, optimism and perseverance will live on in our hearts forever,” a family statement said.

“We thank everyone who gave him care and support over this last year, and everyone who stood with him for so many years in his tireless march for progress toward justice,” CNN quoted the statement as saying further.

Kennedy, nicknamed “Ted,” was the younger brother of slain President John F. Kennedy and New York Senator Robert Kennedy, who was gunned down while seeking the White House in 1968.

However, his own presidential aspirations were hobbled by the controversy around a 1969 auto accident that left a young woman dead, and a 1980 primary challenge to then-President Jimmy Carter that ended in defeat.

The longtime Massachusetts senator was considered one of the most effective legislators of the past few decades.

Kennedy, who was known as the “Lion of the Senate,” played major roles in passage of the Civil Rights Act of 1964, the Voting Rights Act of 1965, the 1990 Americans with Disabilities Act and the 1993 Family and Medical Leave Act, and was an outspoken liberal standard-bearer during a conservative-dominated era from the 1980s to the early 2000s.

Kennedy recently urged Massachusetts officials to change a law to allow for an immediate temporary replacement should a vacancy occur for one of his state’s two Senate seats. Under a 2004 Massachusetts law, a special election must be held 145 to 160 days after a Senate seat becomes vacant. The winner of the election would serve the remainder of a senator’s unexpired term.

Kennedy asked Governor Deval Patrick and state leaders to “amend the law through the normal legislative process to provide for a temporary gubernatorial appointment until the special election occurs,” according to the letter, dated July 2.

Kennedy suffered a seizure in May 2008 at his home on Cape Cod. Shortly after, doctors diagnosed a brain tumor-a malignant glioma in his left parietal lobe.

Surgeons at Duke University Medical Center in Durham, North Carolina, removed as much of the tumor as possible the following month. Doctors considered the procedure a success, and Kennedy underwent follow-up radiation treatments and chemotherapy.

A few weeks later, he participated in a key vote in the Senate. He also insisted on making a brief but dramatic appearance at the 2008 Democratic convention, a poignant moment that brought the crowd to its feet and tears to many eyes.

“I have come here tonight to stand with you to change America, to restore its future, to rise to our best ideals and to elect Barack Obama president of the United States,” Kennedy told fellow Democrats in a strong voice.

Kennedy’s early support for Obama was considered a boon for the candidate, then a first-term senator from Illinois locked in a tough primary battle against former first lady Hillary Clinton.

Kennedy predicted Obama’s victory and pledged to be in Washington in January when Obama assumed office-and he was, though he was hospitalized briefly after suffering a seizure during a post-inaugural luncheon.

Kennedy was one of only six senators in U.S. history to serve more than 40 years. He was elected to eight full terms to become the second most-senior senator after West Virginia Democrat Robert Byrd.

He launched his political career in 1962, when he was elected to finish the unexpired Senate term of his brother, who became president in 1960. He won his first full term in 1964.

He seemed to have a bright political future, and many Democratic eyes turned to him after the killings of his brothers. But a July 18, 1969, car wreck on Chappaquiddick Island virtually ended his ambitions.

After a party for women who had worked on his brother Robert’s presidential campaign, Kennedy drove his car off a bridge on Chappaquiddick, off Cape Cod and across a narrow channel from Martha’s Vineyard. While Kennedy managed to escape, his passenger, Mary Jo Kopechne, drowned.

In a coroner’s inquest, he denied having been drunk, and said he made “seven or eight” attempts to save Kopechne before exhaustion forced him to shore. Although he sought help from friends at the party, Kennedy did not report the accident to police until the following morning.

Kennedy eventually pleaded guilty to leaving the scene of an accident. In a televised address to residents of his home state, Kennedy called his conduct in the hours following the accident “inexplicable” and called his failure to report the wreck immediately “indefensible.”

Despite the dent in his reputation and career, Kennedy remained in American politics and went on to win seven more terms in the Senate.

Kennedy championed social causes and was the author of “In Critical Condition: The Crisis in America’s Health Care.” He served as chairman of the Judiciary and Health, Education, Labor, and Pensions committees and was the ranking Democrat on the Judiciary and Armed Services committees during periods when Republicans controlled the chamber.

Obama named Kennedy as one of 16 recipients of the 2009 Presidential Medal of Freedom, America’s highest civilian honor. A White House statement explained that the 2009 honorees “were chosen for their work as agents of change.”

Born in Boston on February 22, 1932, Edward Moore Kennedy was the last of nine children of Joseph P. Kennedy, a prominent businessman and Democrat, and Rose Fitzgerald Kennedy.

Joseph Kennedy pushed his sons to strive for the presidency, a burden “Teddy” bore for much of his life as the only surviving Kennedy son.

His oldest brother, Joe Jr., died in a plane crash during World War II when Kennedy was 12. John was assassinated in Dallas, Texas, in 1963, and Robert was killed the night of the California primary in 1968.

Ted Kennedy delivered Robert’s eulogy, urging mourners to remember him as “a good and decent man who saw wrong and tried to right it; who saw suffering and tried to heal it; who saw war and tried to stop it.”

The family was plagued with other tragedies as well. One sister, Kathleen, was killed in a plane crash in 1948. Another sister, Rosemary, was born mildly retarded, but was institutionalized after a botched lobotomy in 1941. She died in 1986 after more than 50 years in mental hospitals.

Joseph Kennedy was incapacitated by a stroke in 1961 and died in November 1969, leaving the youngest son as head of the family. He was 37.

“I can’t let go,” Kennedy once told an aide. “If I let go, Ethel (Robert’s widow) will let go, and my mother will let go, and all my sisters.”

Kennedy himself survived a 1964 plane crash that killed an aide, suffering a broken back in the accident. But he recovered to lead the seemingly ill-starred clan through a series of other tragedies: Robert Kennedy’s son David died of a drug overdose in a Florida hotel in 1984; another of Robert’s sons, Michael, was killed in a skiing accident in Colorado in 1997; and John’s son John Jr., his wife Carolyn and sister-in-law Lauren Bessette died in a 1999 plane crash off Martha’s Vineyard.

In addition, his son Edward Jr. lost a leg to cancer in the 1970s, and daughter Kara survived a bout with the disease in the early 2000s.

Like brothers John and Robert, Edward Kennedy attended Harvard. He studied in the Netherlands before earning a law degree from the University of Virginia Law School, and worked in the district attorney’s office in Boston before entering politics.

Kennedy is survived by his second wife, Victoria Ann Reggie Kennedy, whom he married in 1992; his first wife, Joan Bennett; and five children-Patrick, Kara and Edward Jr. from his first marriage, and Curran and Caroline Raclin from his second. (ANI)

Scientists use titanium dioxide nanoparticles to kill cancer cells, sparing healthy ones

Washington, August 20 (ANI): Scientists in America have developed a way to target brain cancer cells using inorganic titanium dioxide nanoparticles bonded to soft biological material.

This achievement is a result of the joint efforts of scientists from the U.S. Department of Energy’s (DOE) and the University of Chicago’s Brain Tumor Center.

Thousands of people die from malignant brain tumours every year, and the tumors are resistant to conventional therapies.

The researchers say that their nano-bio technology may eventually provide an alternative form of therapy, which targets only cancer cells and does not affect normal living tissue.

“It is a real example of how nano and biological interfacing can be used for biomedical application. We chose brain cancer because of its difficulty in treatment and its unique receptors,” said scientist Elena Rozhkova with the DOE’s Argonne National Laboratory.

The novel approach relies upon a two-pronged approach.

The researchers describe titanium dioxide as a versatile photoreactive nanomaterial that can be bonded with biomolecules.

When linked to an antibody, they say, nanoparticles recognize and bind specifically to cancer cells.

When focused visible light is shined onto the affected region, the researchers add, the localized titanium dioxide reacts to the light by creating free oxygen radicals that interact with the mitochondria in the cancer cells.

Mitochondria act as cellular energy plants, and when free radicals interfere with their biochemical pathways, mitochondria receive a signal to start cell death.

“The significance of this work lies in our ability to effectively target nanoparticles to specific cell surface receptors expressed on brain cancer cells,” said Dr. Maciej S. Lesniak, Director of Neurosurgical Oncology at University of Chicago Brain Tumor Center.

“In so doing, we have overcome a major limitation involving the application of nanoparticles in medicine, namely the potential of these agents to distribute throughout the body. We are now in a position to develop this exciting technology in preclinical models of brain tumours, with the hope of one day employing this new technology in patients,” Lesniak added.

Using X-ray fluorescence microscopy at Argonne’s Advanced Photon Source, the researchers have also found that the tumours’ invadopodia, actin-rich micron scale protrusions that allow the cancer to invade surrounding healthy cells, can be also attacked by the titanium dioxide.

The researchers have thus far carried out tests on cells in a laboratory setting, but animal testing is planned for the next phase.

Results show an almost 100 percent cancer cell toxicity rate after six hours of illumination, and 80 percent after 48 hours.

Also, since the antibody only targets the cancer cells, surrounding healthy cells are not affected, unlike other cancer treatments such as chemotherapy and radiotherapy.

Rozhkova said that a proof of concept is demonstrated, and other cancers can be treated as well using different targeting molecules.

The expert, however, admits that the research is presently in the early stages. (ANI)

Robert Novak | Robert Novak Dies | Robert Novak Dead | Robert Novak Cancer | Novak | Robert Novak Bio | Robert NovakDeath | Robert Novak No More | Robert Novak Expired | Robert Novak Died due to Cancer | Robert Novak Columnist | Robert Novak Columnist Journalist Conservative Political Commentator | Robert Novak Brain Tumor

Robert Novak | Robert Novak Dies | Robert Novak Dead | Robert Novak Cancer | Novak | Robert Novak Bio | Robert NovakDeath | Robert Novak No More | Robert Novak Expired | Robert Novak Died due to Cancer | Robert Novak Columnist | Robert Novak Columnist Journalist Conservative Political Commentator | Robert Novak Brain Tumor

Robert David Sanders “Bob” Novak 26thFebruary 1931 – 18thAugust 2009 , was born in Joliet, Illinois, the son of Jane Sanders and Maurice Novak, a chemical engineer, his career in journalism to qualify him for a degree, and he became an Illinois graduate.

During the Korean War, Novak served in the U.S. Army, and reached the rank of lieutenant. After the war, he joined the Associated Press (AP) and became a political correspondent in Indianapolis, Indiana. In 1957, Novak was transferred to Washington, D.C. where he reported on Congress; he left the AP to join the D.C. bureau of The Wall Street Journal in 1958, covering the Senate, and in 1961 becoming their chief congressional correspondent.

He was a syndicated columnist, journalist and conservative political commentator and for 45 years the author of what was during his lifetime the longest-running current syndicated column in U.S. political history. Over his career, Novak became well-known as a columnist  and as a television personality, appearing on many shows for CNN .

On August 4, 2008, Novak announced that he had been diagnosed with a brain tumor and that his prognosis was “dire”, and that he was retiring. However, on August 27, 2008, he resumed writing opinion columns distributed by Creators Syndicate.

Robert Novak died on Tuesday 18thAugust 2009,after a battle with brain cancer.

Scientists comparing human and canine genomes to find cure for brain cancer

Washington, July 7 (ANI): Researchers at North Carolina State University say that comparing human and canine genomes, they have come to the conclusion that a gene commonly believed to be involved in meningiomas-tumours-which affect the meninges (thin covering) of the human brain, and account for one out of four adult brain tumours-may not be as crucial for tumour formation as previously thought.

“The dog has been man’s best friend for centuries, and now the genome of the dog could well be man’s next best friend,” says Dr. Matthew Breen, professor of genomics at NC State.

“With so much genetic material to consider, one can see why figuring out which genes play a key role in meningiomas is extremely difficult. By looking at tumors seen in both humans and dogs we have a simple way to narrow the search: we compare the affected areas of a human chromosome with related areas on dog chromosomes.

This works because dogs and humans are genetically similar and both get the same kinds of cancers. While we share much of our genetic material, the DNA of a dog is organized differently to our own and this makes it possible to isolate smaller ‘shared’ regions of genetic data rather than looking at an entire chromosome,” he adds.

Breen, NC State colleagues Rachael Thomas and veterinary neurologist Natasha Olby, along with researchers from the University of California-Davis and the Wellcome Trust Sanger Institute in Cambridge, UK shared samples of canine meningiomas for research.

Studies conducted in the past have suggested that a particular tumour-suppressing gene on human chromosome 22, known as NF2, may be a possible contributor to meningioma. It is believed that the deletion of NF2, with its tumour suppressing abilities, may trigger tumour growth.

However, when Breen’s team compared human genome with its canine counterpart, they found that NF2 was rarely affected in dogs with meningioma.

Besides, the research team also looked at gliomas, another kind of brain tumour, and showed common genetic features shared between human and canine tumours that are now under further investigation.

“The data support that dog and human tumors are very similar at the genetic level, so both species will benefit from this research,” Breen says.

“It’s proof of the ‘One Medicine’ concept – the idea that human and animal health relies on a common pool of medical and scientific knowledge and is supported by overlapping technologies and discoveries,” he adds.

A research article on the study has been published in the Journal of Neurooncology. (ANI)

Cottonseed-based drug may help treat severe brain cancer

Washington, May 29 (ANI): Researchers at the University of Alabama at Birmingham (UAB) say that an experimental drug derived from cottonseeds appears to be efficacious in treating the recurrence of glioblastoma multiforme, which is considered to be the most lethal brain cancer.

The researchers came to this conclusion following the results of a Phase II clinical trial of AT-101, a pill manufactured from a potent compound in cottonseeds that overcomes the abnormal growth patterns of tumour cells.

Glioblastomas are more common in adults, and are considered fast-growing brain tumours that are very difficult to treat.

Research leader Dr. John Fiveash, an associate professor in the UAB Department of Radiation Oncology, said that the cottonseed-based agent was found to halt the cancer’s progression in many of the 56 patients.

He revealed that despite undergoing other treatments, including surgery, chemotherapy and radiation, the trial patients’ brain cancer had begun to grow again prior to starting AT-101 treatments.

The trial-monitored patients took only AT-101 daily for three out of four weeks.

“After getting this drug some of these patients went many months without any new growth in their tumours. We are able to do that with a well-tolerated oral medication, and that is a major benefit,” Fiveash said.

He believes that the drug would likely work best in combination with radiation and chemotherapy to boost the cancer-fighting properties of those treatments.

Fiveash and his colleagues are also trying to determine which patients are most likely to benefit from AT-101.

The initial results of the drug trial would be presented on May 30, during the poster discussion of central nervous system tumours at the American Society for Clinical Oncology annual meeting in Orlando, Florida. (ANI)

Ted Kennedy’s brain cancer in remission

Washington, May 20 (ANI): Senator Ted Kennedy’s cancer is in remission, and he will be returning to the Senate after the Memorial Day recess, Senate Majority Leader Harry Reid told reporters here on Tuesday.

Reid indicated that he had spoken recently with Kennedy’s wife to discuss his condition. Asked by a reporter if the brain cancer was in remission, Reid said: “As far as I know it is, yes.”

Kennedy still has to undergo a few more treatments before returning to a full Senate schedule.

“He’s doing fine. He’s going through another regimen of treatment, which is not unusual. This is something that was expected. He wanted to have the treatment next week. They had to move it up a week, as I understand it,” Politico quoted Reid, as saying.

Hours after the Kennedy story hit several media outlets, a Reid spokesman later cautioned that the senator wasn’t giving a medical diagnosis.

“Senator Reid will leave the diagnosing to doctors,” spokesman Jim Manley said.

Kennedy has been largely absent from the Senate during his battle with brain cancer, even though he has returned for a few key events, like President Barack Obama’s Inauguration. (ANI)

NASA’s electronic nose can detect brain cancer cells

Washington, May 1 (ANI): Researchers have found that an electronic nose developed for air quality monitoring on Space Shuttle Endeavour can also be used to detect cancerous brain cells.

The finding can open up new possibilities for neurosurgeons to fight against brain cancer.

Neurosurgeons from the City of Hope Cancer Centre, along with scientists from the Brain Mapping Foundation in West Hollywood and the Jet Propulsion Laboratory (JPL) in Pasadena have found that NASA’s electronic nose can also be used to detect odour differences in normal and cancerous brain cells.

“This pilot study lays the groundwork for future research that may help us to better understand cellular trafficking, contribute to designing better approaches for the detection and differentiation of brain cancer, and understand the pathophysiology of intracranial gliomas,” said Babak Kateb, lead author of the paper, Chairman and Scientific Director of the Brain Mapping Foundation.

The electronic nose, which is to be installed on the International Space Station in order to automatically monitor the station’s air, can detect contaminants within a range of one to approximately 10,000 parts per million.

These experiments will help pave the way for more sophisticated biochemical analysis and experimentation.

The results of the pilot study are set to be published in an IBMISPS-NeuroImage. (ANI)

New cancer drug restricts neuroblastoma growth by 75 pct

Washington, April 24 (ANI): A research team has found a novel drug that reduces the growth of neuroblastoma, a childhood brain cancer, by more than 75 percent.

A study, conducted with human neuroblastoma cells transplanted into mice, showed how 3-BrOP, a glycolysis inhibitor, starved the cancer cells to death by shutting down their main energy source, glucose.

“We found that neuroblastoma cells, unlike healthy cells, are highly dependent on glycolysis for energy instead of more efficient means of energy production,” said Alejandro Levy, M.D., fellow at the Children’s Cancer Hospital at The University of Texas M. D. Anderson Cancer Center.

“Glycolysis is a process that breaks down sugar for energy, so by blocking that process with 3-BrOP, we are able to keep the tumors from producing energy, and this disrupts their ability to grow,” Levy added.

Pre-clinically, 3-BrOP has already been proven effective against other cancers including glioblastoma, colon cancer, lymphoma and acute leukemia. A Phase I clinical trial is planned to open this year for adult patients.

Patrick Zweidler-McKay, M.D., Ph.D., assistant professor at the Children’s Cancer Hospital and senior investigator of the study, said: “As we explore alternative options to standard chemotherapy agents, we are finding drugs, like 3-BrOP, that have the potential to destroy cancer cells while leaving healthy cells unharmed.”

“These drugs can often enhance the efficacy of other treatments, potentially leading to more successful combinations and better outcomes for our young patients,” Zweidler-McKay added.

The pre-clinical study was presented today in the plenary session at the 22nd annual meeting of the American Society of Paediatric Hematology/Oncology. (ANI)

Possible way to block deadly brain tumor spread discovered

Washington, Apr 18 (ANI): A possible way to stop the often-rapid spread of deadly brain tumors has been found by researchers at the Translational Genomics Research Institute (TGen).

A gene with the playful-sounding name NHERF-1 may be a serious target for drugs that could prevent malignant tumors from rapidly multiplying and invading other parts of the brain, according to a cover story in this month’s edition of Neoplasia, an international journal of cancer research.

Cancer cell movement and rapid division are key characteristics of malignant brain tumors known as glioblastoma multiforme, or GBM.

Dr. Michael Berens, Director of TGen’s Cancer and Cell Biology Division, said the recent findings are a major step toward devising a treatment for GBM, which because of its ability to rapidly grow within the brain often means patients have little time to survive.

“Controlling the actions of tumor cells by regulating NHERF-1 implicates it as a possible therapeutic target for treating brain cancer,” said Dr. Kerri Kislin, a scientist in TGen’s Cancer and Cell Biology Division.

“Our findings suggest a novel mechanism defining NHERF-1 as a ‘molecular switch’ that regulates the GBM tumor cell’s ability to migrate or divide,” said Dr. Kislin, the scientific paper’s lead author.

Dr. Berens, the paper’s senior author, said the advances made by TGen not only confirm NHERF-1 as a gene associated with brain tumors, but also pinpoint it as a possible cause for their rapid growth and spread of GBM.

“Dr. Kislin’s work has meant a fast maturation of NHERF-1 from a candidate gene associated with glioma invasion to positioning it as having a verified role in contributing to the malignant behavior of the disease,” Dr. Berens said.

TGen scientists are scheduled to present their findings at the 100th annual meeting of the American Association for Cancer Research, April 18-22 in Denver.

Glioblastomas are essentially incurable tumors, in part, because there is no way to remove them surgically and ensure that all of the invading tumor cells are gone, even when surgery is followed by radiation treatments and conventional anti-cancer drugs. (ANI)

Scorpion venom-nanoparticle combo slows brain cancer’s spread

Washington, April 17 (ANI): Scorpion venom has shown some promise to slow the spread of brain cancer, say researchers.

Scientists at the University of Washington have revealed that combining nanoparticles with chlorotoxin, a small peptide isolated from scorpion venom, they could halt the spread of cancerous cells by 98 per cent, compared to 45 per cent for the scorpion venom alone.

“People talk about the treatment being more effective with nanoparticles but they don’t know how much, maybe 5 percent or 10 percent. This was quite a surprise to us,” said Miqin Zhang, professor of Materials Science and Engineering.

She revealed that the study involved mouse brain-cancer cells that were grown in the lab.

Her team observed that the cells containing nanoparticle-chlorotoxin combo were unable to elongate, whereas those containing only nanoparticles or only chlorotoxin could stretch out.

Based on their observations, the researchers came to the conclusion that the nanoparticle-chlorotoxin combo disabled the machinery on the cell’s surface that allows cells to change shape, yet another step required for a tumour cell to slip through the body.

“We hypothesized the mechanism and we have all the data to prove our hypothesis,” Zhang said.

She revealed that her team’s future experiments would involve testing on mice.

A report describing the study has been published in the journal Small. (ANI)

Study says marijuana chemical has anti-cancer properties

According to a study released on Thursday, Spanish researchers from the Complutense University in Madrid, together with scientists of other universities, found that tetrahydrocannabinol (THC) – the main chemical in the infamous narcotic agent, marijuana – likely helps the annihilation of brain cancer cells.

The research, which proposes to bring to improve the prospects of anti-cancer therapies, said that THC causes cancer cells to go through a process called autophagy – the breakdown that takes place when the cells fundamentally self-digest.

Based on the findings of the research, which was first carried out on the laboratory mice, and then substantiated on two patients – suffering from the highly aggressive and recurrent brain tumor, glioblastoma multiforme – in an experimental trial, the scientists came to the conclusion that THC and associated “cannabinoids” depicted properties of being “a new family of potential anti-tumoral agent.”

The study which has been published in the April edition of the US Journal of Clinical Investigation, on of the scientists, Guillermo Velasco, reported: “We found that the anti-tumoral action of THC is based on its ability to activate an intracellular signalling pathway that promotes the activation of a cellular process called `autophagy’. The activation of this pathway leads to cancer cell death.”

Kids as young as 9 have mobile phones as parents seek safety

Melbourne, Apr 6 (ANI): While parents worry over the link between cell-phone and cancer, mobiles are making their way into the hands of kids as young as nine, according to a study.

The prevalence of mobiles among kids came to the fore at the time when the independence of Australia’s peak mobile phone research group was being questioned.

The group, known as the Australian Centre for RF Bioeffects Research, had earlier denied links between brain cancer and phone use.

The new study, carried out by the Commission For Children And Young People and the University of Sydney, enrolled 1500 children aged between 11 and 15.

It found that there was no chance that the 5-year-olds had been given a phone when aged nine.

However, 11-year-olds interviewed had a 10 per cent chance of owning a phone at the age of nine.

Children’s commissioner Gillian Calvert said that while the results are now almost two years old, its is believed that the figure would be much more higher today, as mobile phones are finding their way into more younger hands.

However, the trend is positive in her eyes.

“The study spotlights the secret world of mobile phones and we’ve found that kids are doing what they always did, be kids,” the Daily Teelgraph quoted her as saying.

She added: “The message I got from the study is they help kids do what they have always done: Listen to music, reinforce their friendships and organise their lives. They are playing a very central and positive role in young people’s lives.” (ANI)

Active component of marijuana may fight brain cancer

Washington, April 2 (ANI): Cannabinoids such as the main active component of marijuana (THC) have anticancer effects on human brain cancer cells, a new study has found.

In the study, Guillermo Velasco and colleagues at Complutense University, Spain, found that THC induced the death of various human brain cancer cell lines and primary cultured human brain cancer cells by a process known as autophagy.

Consistent with the in vitro data, administration of THC to mice with human tumours decreased tumour growth and induced the tumour cells to undergo autophagy.

As analysis of tumours from two patients with recurrent glioblastoma multiforme (a highly aggressive brain tumour) receiving intracranial THC administration showed signs of autophagy.

The researchers suggest that cannabinoid administration may provide a new approach to targeting human cancers. (ANI)

Genetic mutations linked to childhood brain cancer identified

London, Mar 9 (ANI): Scientists have identified certain genetic mutations that appear to play a key role in medulloblastoma – the most common of childhood brain cancers.

The team led by Dr. Michael Taylor, a paediatric brain surgeon at Toronto’s Hospital for Sick Children, has found eight similar genes linked to the childhood brain cancer.

“When these eight genes are functioning normally, we believe their role is to make a protein which tells the developing brain when it’s time to stop growing. But when the genes are mutated, the brain may continue to grow out of control, leading to cancer,” Nature magazine quoted Dr. Taylor as saying.

“Drugs are already being developed that target these types of proteins.

“Our hope is that some of these drugs may be adapted and used effectively to treat medulloblastomas,” he added.

During the study, the researchers looked at more than 200 tumour samples.

Paul Northcott, a PhD student in Dr Taylor’s lab, analysed and interpreted all the data over a period of 3 1/2 years.

“We’ve learned more from this study about the genetic basis of this disease than from any other previous study,” said Northcott.

The gene mutations they found had not been suspected as culprits in cancer formation.

The findings have been published in journal Nature Genetics. (ANI)

Is Ted Kennedy ready to handover political baton to wife Vicki?

Boston (US), Feb.21 (ANI): Rumors are doing the rounds that a very sick Massachusetts Senator Ted Kennedy may pass on his political baton to wife Vicki, as he continues to battle with brain cancer.

Kennedy’s friends say that his battle with brain cancer has entered its final rounds, and that he is presently at an undisclosed location in Florida, resting and sailing.

“He’s someplace sunny, near the water, where he can rest and sail. Time is of the essence. It’s very sad,” the Boston Globe quoted one of his friends, as saying.

Kennedy was rushed to the hospital after he collapsed during a luncheon that followed President Obama’s inauguration, and returned to vote on the stimulus bill.

Although family members have said publicly that the senator is doing “good,” privately those close to Kennedy say he may only have a few months to live.

Kennedy was diagnosed last May with a malignant brain tumor and his prognosis was poor. According to pals, the senator spent every day that he could last summer on the waters off Hyannisport sailing his beloved yacht, Mya.

He has returned to Washington only sporadically since being diagnosed – most dramatically a month after his first seizure to cast the deciding vote on an important Medicare bill.

Because of Kennedy’s condition, there has been off-the-record speculation about the future of his Senate seat.

A Boston broadsheet described the former Victoria Reggie as “a great lawyer” with “tremendous political skills” and “great sense of humor.”

It portrayed her family as Kennedy doppelgangers and Vicki’s father, Edmund Reggie, as one of Ted’s closest companions.

No member of Ted’s family has said anything to the Globe on the record so far.

Word on the Hill is that some Kennedy staffers are quite unhappy with the rumors that are in circulation, finding it far too critical of Ted.

But, they also admit that Vicki has been a stabilizing influence on Ted. She is credited with helping him to secure re-election in a hard-fought battle with Mitt Romney after the near-career-destroying Palm Beach rape scandal.

Should Kennedy be unable to finish out his senate term, which ends in 2012, a special election must be held within 145 to 160 days of the seat becoming vacant.

The big question is: Will Kennedy make it known that he wants his wife to succeed him. (ANI)